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In vitro differentiation capacity of human breastmilk stem cells:A systematic review

World Journal of Stem Cells 2019年第11期11卷 1005-1019页

作者： Camila Maria Ribeiro Pacheco Priscila Elias Ferreira Claudia Sayuri Sacaki Luana Alves Tannous Idiberto jose Zotarelli-filho Luiz Cesar Guarita-Souza Katherine Athayde Teixeira de Carvalho Cell Therapy and Biotechnology in Regenerative Medicine Department Pele Pequeno Príncipe InstituteChild and Adolescent Health Research and Pequeno Príncipe FacultyCuritiba 80.240-020ParanáBrazil PUCPR-Institute of Biological and Health Sciences CCBSCuritiba 80.215-901ParanáBrazil Post Graduate and Continuing Education(Unipos) Department of Scientific ProductionSao Jose do Rio Preto 15.020-040Sao PauloBrazil

BACKGROUND Mesenchymal stem cells are pluripotent cells that have the ability to generate cells from a cell line or in other cell types from different tissues but from the same *** those cells have more limited differentiation capacity than embryonic stem cells,they are easily obtained from somatic tissue and can be grown in large *** characteristic of undifferentiated stem cells differentiating into different cell lines arouses strategies in regenerative medicine for the treatment of different diseases such as neurodegenerative *** To evaluate the cell differentiation capacity of human breastmilk stem cells for the three germ layers by a systematic *** The searched databases were PubMed,EMBASE,OVID,and COCHRANE LIBRARY,published between 2007 and 2018 in the English *** were in vitro studies for analysis of the"cell differentiation potential"in the literature using the keywords“human breastmilk,”“stem cells,”and keywords combined with the Boolean operator“NOT”were used to exclude those articles that had the word“CANCER”and their respective synonyms,which were previously consulted according to medical subject heading *** 2009 guidelines were followed in this *** A total of 315 titles and abstracts of articles were *** these,21 were in common with more than one database,leaving 294 articles for *** that total,five publications met the inclusion *** analyzing the publications,it was demonstrated that human breastmilk stem cells have a high cellular plasticity,exhibiting the ability to generate cells of all three germ layers,endoderm,mesoderm,and ectoderm,demonstrating their *** cells expressed the genes,TRA-1-60/81,octamer-binding transcription factor 4,and NANOG,of which NANOG,a critical regulator for self-renewal and maintenance,was the most highly *** cells have the ability to differentiate in vitro into adipocytes,chondrocytes,osteocytes,oligod

关键词： Human breastmilk Stem cells Cell differentiation Pluripotency Stemness

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Application of micro-morphology in the physical characterization of urban road dust

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Particuology 2021年第1期19卷 146-155页

作者： Jithin jose B.Srimuruganandam School of Civil Engineering Vellore Institute of TechnologyVellore 632014Tamil NaduIndia

Urban road dust was collected from Vellore City,Tamil Nadu,India,and *** electron microscopy(SEM)was used to examine road dust from nine sampling locations in the study *** image analysis was used to identify various shape factors of collected dust *** equivalent spherical diameter of most particles was between 10μm and 30μ*** particles had greater concentrations at locations with higher traffic *** were categorized into four classes based on their shape factors,viz.,spherical,mineral,elongated,or *** particles had the smallest mean equivalent diameter(1.95μm)and mineral particles had the largest diameter(33.3μm).Spherical particles made up the smallest portion of road dust(0-12%)in the study region and mineral particles made up the largest(45-65%).Elongated and irregular particles,each made up 23-30%of road *** dispersive X-ray spectroscopy analysis was used to identify the elemental composition of dust *** particles were mostly from combustion sources and mineral particles were largely of crustal *** individual source was found for irregular and elongated *** debris was the major source of irregular particles.

关键词： Road dust Scanning electron microscopy Shape factors Silt load Size distribution Particle shapes

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Acoustic streaming and Sun's meridional circulation

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Research in Astronomy and Astrophysics 2016年第9期16卷 101-106页

作者： jose Manuel Valverde Faculty of Physics University of Seville

A vast number of physical processes involving oscillations of a bounded viscous fluid are relevantly influenced by acoustic streaming. When this happens a steady circulation of fluid develops in a thin boundary adjacent to the interface. Some examples are refracted sound waves, a fluid inside a spherical cavity undergoing torsional oscillations or a pulsating liquid droplet. Steady streaming around circular interfaces consists of a hemispherically symmetric recirculation of fluid from the equatorial plane to the polar axes closely resembling the meridional circulation pattern observed in the Sun＇s convection zone that determines the solar cycle. In this paper, it is argued that the acoustic pulsations exhibited by the Sun would lead to acoustic streaming in the boundary of the convection zone. A simple estimation using a typical dominant frequency of 3 mHz and the observed surface oscillation amplitude yields a steady streaming velocity Us - 10 m s^-1, which is on the order of the meridional circulation velocity observed in the Sun＇s convection zone.

关键词： Sun general -- Sun helioseismology -- Sun granulation -- Sun oscillations -- Sun fun-damental parameters -- Sun activity

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Current status and future perspectives of radiomics in hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第1期29卷 43-60页

作者： Joao Miranda Natally Horvat Gilton Marques Fonseca jose de Arimateia Batista Araujo-filho Maria ClaraFernandes Charlotte Charbel Jayasree Chakraborty Fabricio Ferreira Coelho Cesar Higa Nomura Paulo Herman Department of Radiology University of Sao PauloSao Paulo 05403-010Brazil Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNY 10065United States Department of Gastroenterology University of Sao PauloSao Paulo 05403-000Brazil Department of Radiology Hospital Sirio-LibanesSao Paulo 01308-050Brazil Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNY 10065United States Department of Radiology University of Sao PauloSao Paulo 05403-000Brazil

Given the frequent co-existence of an aggressive tumor and underlying chronic liver disease,the management of hepatocellular carcinoma(HCC)patients requires experienced multidisciplinary team ***,imaging plays a key role in the diagnosis,staging,restaging,and surveillance of ***,imaging assessment of HCC entails the assessment of qualitative characteristics which are prone to inter-reader *** is an emerging field that extracts high-dimensional mineable quantitative features that cannot be assessed visually with the naked eye from medical *** main potential applications of radiomic models in HCC are to predict histology,response to treatment,genetic signature,recurrence,and *** the encouraging results to date,there are challenges and limitations that need to be overcome before radiomics implementation in clinical *** purpose of this article is to review the main concepts and challenges pertaining to radiomics,and to review recent studies and potential applications of radiomics in HCC.

关键词： Radiomics Hepatocellular carcinoma Texture analysis Radiology

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Magnetic field assisted fluidization:A modified Richardson-Zaki equation

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China Particuology 2007年第1期5卷 61-70页

作者： jose Manuel Valverde Antonio Castellanos Faculty of Physics Universidad de Sevilla Avenida Reina Mercedes s/n 41012 Sevilla Spain

Magnetic particles can be uniformly fluidized by coupling the gas flow with an externally imposed magnetic field. Interparticle forces generated by the magnetic field cause aggregation of the particles in chain-like structures preferentially oriented along the magnetic field lines. In the present paper, we study the implications of the formation of these special types of aggregates on the empirical Richardson-Zaki （RZ） equation, originally proposed to describe the expansion of fluidized beds of non-aggregated particles. We have addressed two important issues, namely the flow regime, which is a function of the size of the aggregates, and the effect of shape and orientation of the chain-like aggregates with respect to gas flow on fluid drag. We propose a modified RZ equation （MRZE） in which the velocity scale, given by the terminal settling velocity of the individual aggregates, and the RZ exponent are predetermined as a function of the chain length. The chain length depends on the ratio of the magnetic energy to gravitational energy, and is estimated from the magnetic field intensity, and particle magnetization, size and density. Predictions of the MRZE are successfully compared with published results in the literature on the expansion of magnetic particles in the presence of externally applied magnetic fields.

关键词： Fluidization Geldart B Magnetic particles Aggregation Richardson-Zaki equation

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Extending dynamic models of mining subsidence

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中国有色金属学会会刊：英文版 2011年第S3期21卷 536-542页

作者： Andrew JAROSZ jose SAAVEDRA-ROSAS Western Australian School of Mines Curtin University

The movement and deformation processes of the overburden strata and ground surface, induced by underground mining, are affected by mining method, spatial relationships, geotechnical conditions of the rock strata and time. The authors reviewed and extended an existing classical prediction model of the dynamic subsidence, and proposed potential new research avenues offered by Cellular Automata (CA) models. The Knothe's influence function model and the significance of subcritical mining geometry were analyzed. The prediction results were verified against the subsidence field survey data to assess their quality and acceptability.

关键词： dynamic subsidence subsidence prediction cellular automata

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The Effect of the Atmospheric and Cloud Properties on the Retrieval of Fog Microphysics at Night for MSG/SEVIRI: A Sensitivity Test Using LibRadtran

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Atmospheric and Climate Sciences 2021年第3期11卷 441-457页

作者： Aliton Oliveira da Silva Augusto jose Pereira filho Hugo Abi Karam Departamento de Ciências Atmosféricas Instituto de Astronomia Geofísica e Ciências Atmosféricas Universidade de S&#227 o Paulo S&#227 o Paulo Rua do Mat&#227 o 1226 S&#227 o Paulo Brazil Centro de Ciências Matemáticas e da Natureza Instituto de Geociências Federal Universidade Federal do Rio de Janeiro Rio de Janeiro Rua Athos da Silveira Ramos 274 Rio de Janeiro Brazil

The simplest way of building a look-up table (LUT) for the retrieval of cloud microphysical properties is to use a standard atmospheric profile and vertically uniform cloud microphysics. Such an assumption has been demonstrated to be incoherent with in-cloud observations. This paper aims to show the effect of some atmospheric conditions associated with fog as well as its macro-and microstructure on brightness temperature (BT) for the MSG/ SEVIRI satellite using libRadtran. The sensitivity tests were performed by gradually changing some features from the initial data, such as cloud cover, total water vapor column, thermal inversion intensity, fog depth, fog microstructure, and others. The results revealed that some variables can cause significant variations on BT and, consequently, discrepancies in the retrieval of fog microphysical properties. Also, a variation as high as 0.5°C was found on BT just by switching uniform to the non-uniform profile of fog microphysics depending on the channel, the droplet size, and optical thickness.

关键词： Fog Microphysics MSG/SEVIRI Sensitivity Test LibRadtran

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Changes in Olsen P in Relation to P Balance in Contrasting Agricultural Soils

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Pedosphere 2016年第5期26卷 636-642页

作者： Isabel DIAZ jose TORRENT Departamento de Ingeniería Aeroespacial y Mecánica de Fluidos Escuela Tdcnica Superior de Ingeniería Agronómica(ETSIA)Universidad de SevillaCtra de Utrera km 141013 Sevilla(Spain) Departamento de Agronomia Universidad de CordobaEdificio C4Campus de Rabanales14071 Cordoba(Spain)

Maintaining soil phosphorus （P） at adequate levels for plant growth requires assessing how the long-term P balance （viz., the difference between P inputs and outputs） results in changes in soil test P. The hypothesis that routinely measured soil properties can help predict the conversion factor of P balance into Olsen P was tested at 39 sites in agricultural areas of the Mediterranean region in Spair~. A set of soil samples from each site was analyzed for Olsen P, inorganic P （P extracted using 0.5 mol L-1 H2SO4）, pseudototal P （P extracted using 0.5 mol L-1 H2SO4 following ignition at 550 ~C）, and organic P （the difference between pseudototal P and inorganic P）. Organic and Olsen P were uncorrelated in most of the 39 soil sets, which suggests that organic P content changed little with P inputs and outputs. The slopes of the regression lines of Olsen P against pseudototal and inorganic P, which were used as two different measures of the conversion factor, ranged widely （from 0.03 to 0.25 approximately）, with their average values （about 0.10） being similar to those found in long-term experiments conducted in temperate areas. Neither conversion factor was significantly correlated with any routinely measured soil property; however, the conversion factor for inorganic P was significantly lower for calcareous soils than for noncalcareous soils. Our negative results suggest the need to isolate the influence of soil properties from that of management systems and environmental factors relating to P dynamics in future studies.

关键词： calcareous soils conversion factor inorganic P noncalcareous soils organic P pseudototal P soil property soil test P

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A neural network to predict reactor core behaviors

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Nuclear Science and Techniques 2014年第1期25卷 75-80页

作者： Juan jose Ortiz-Servin David A.Pelta jose Alejro Castillo Instituto Nacional de Investigaciones Nucleares Carretera Mexico Toluca S/NLa Marquesa OcoyoacacEstado de Mexico ETS Ingenieria Informatica y Telecomunicaciones Universidad de GranadaC/Daniel Saucedo Aranda

The global fuel management problem in BWRs(Boiling Water Reactors) can be understood as a very complex optimization problem,where the variables represent design decisions and the quality assessment of each solution is done through a complex and computational expensive *** last aspect is the major impediment to perform an extensive exploration of the design space,mainly due to the time lost evaluating non promising *** this work,we show how we can train a Multi-Layer Perceptron(MLP) to predict the reactor behavior for a given *** trained MLP is able to evaluate the configurations immediately,thus allowing performing an exhaustive evaluation of the possible configurations derived from a stock of fuel lattices,fuel reload patterns and control rods *** our particular problem,the number of configurations is approximately 7.7×10^(10);the evaluation with the core simulator would need above 200 years,while only 100hours were required with our approach to discern between bad and good *** later were then evaluated by the simulator and we confirm the MLP *** good core configurations reached the energy requirements,satisfied the safety parameter constrains and they could reduce uranium enrichment costs.

关键词：神经网络预测行为质量评估堆芯沸水反应堆多层感知器 MLP 优化问题

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Whole body vibration and auriculotherapy improve handgrip strength in individuals with knee osteoarthritis

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Journal of Traditional Chinese Medicine 2019年第5期39卷 707-715页

作者： Eloa Moreira-Marconi Carla F Dionello Danielle S Morel Danubia C Sa-Caputo Cintia R Sousa-Goncalves Laisa L Paineiras-Domingos Ygor Teixeira-Silva Mario jose dos Santos Pereira Mario Bernardo-filho Postgraduate Program in Clinical and Experimental Physiopathology University of the State of Rio de JaneiroRio de JaneiroRJBrazil Department of Biophysics and Biometrics Laboratory of Mechanical Vibrations and Integrative Practices-LAVIMPIInstitute of Biology Roberto Alcantara GomesRio de Janeiro State UniversityRio de JaneiroRJBrazil Postgraduate Program in Medical Sciences Rio de Janeiro State UniversityRio de JaneiroRJBrazil Danubia C Sa-Caputo Faculdade Bezerra de AraujoRio de JaneiroBrazilCentro Universitario Serra dos OrgaosTeresopolisRio de JaneiroBrasil Universidade do Estado do Rio de Janeiro Rio de JaneiroRJBrazil-Department of Biophysics and BiometricsInstitute of Biology Roberto Alcantara Gomes-Department of Physiological Sciences

OBJECTIVE: To verify the action of non-pharmacological interventions, whole body vibration exercise (WBVE) and auriculotherapy (AT) on the management of knee osteoarthritis (KOA) analyzing the handgrip strength (HS). METHODS: One hundred twelve participants with KOA were allocated in (a) WBVE group with peak-to-peak displacement of 2.5 to 7.5 mm, frequency from 5 up to 14 Hz, acceleration peak from 0.12 up to 2.95 g (2 d/weekly for 5 weeks),(b) AT group, points of both ears (Kidney, Knee-correspondent point and Shenmen) were stimulated with seeds,(c) WBVE + AT group and (d) respective control groups. HS was assessed in all the participants, in acute and cumulative responses. RESULTS: The intervention with WBVE alone and combined with AT improved (P < 0.05), in a cumulative response, the HS. CONCLUSION: WBVE alone or combined with AT might promote biological effects that interfere with the HS in individuals with KOA.

关键词： Osteoarthritis,knee Exercise therapy Physical and rehabilitation medicine Auriculotherapy Muscle strength dynamometer

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