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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： Fernando jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

Role of artificial intelligence in cardiology

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World Journal of Cardiology 2023年第4期15卷 116-118页

作者： Rafael Vidal-Perez jose Manuel vazquez-Rodriguez Servicio de Cardiología Unidad de Imagen y Función CardíacaComplexo Hospitalario Universitario A Coruña Centro de Investigación Biomédica en Red-Instituto de Salud Carlos ⅢA Coruña 15006A CoruñaSpain Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006A CoruñaSpain

Artificial intelligence(AI)is the process of having a computational program that can perform tasks of human intelligence by mimicking human thought *** is a rapidly evolving transdisciplinary field which integrates many elements to develop algorithms that aim to simulate human intuition,decision-making,and object *** overarching aims of AI in cardiovascular medicine are threefold:To optimize patient care,improve efficiency,and improve clinical *** cardiology,there has been a growth in the potential sources of new patient data,as well as advances in investigations and therapies,which position the field well to uniquely benefit from *** this editorial,we highlight some of the main research priorities currently and where the next steps are heading us.

关键词： Artificial intelligence Machine learning Deep learning Electrocardiography Cardiac imaging

Analysis and Validation for an Inverter-side Current Controller in LCL Grid-connected Power Systems

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 387-398页

作者： jose MSosa Panfilo R.Martinez-Rodriguez Gerardo Escobar Gerardo vazquez Andres A.Valdez-Fernandez Juan F.Martinez-Garcia the Tecnologico Nacional de Mexico/ITS de Irapuato(TecNM/ITESI) IrapuatoGTO 36821Mexico the School of Sciences Autonomous University of San Luis Potosi(UASLP)San Luis PotosiSLP 78290Mexico Tecnologico de Monterrey N.L.64849Mexico

Transformerless grid-connected inverters offer greater efficiencies when transferring power from renewable energy sources to the electrical *** the grid-inverter connection is done with an LCL filter,high attenuation of switching harmonics is achieved while preserving a small-size output ***,damping must be included in the controller to assure closed-loop *** paper proposes a reference computation methodology for the inverter-side current feedback in a photovoltaic(PV)generation system connected to the grid through an LCL *** analysis of the closed-loop system stability and of the steady-state performance are presented as well as experimental validation of the closed-loop *** feedback controller includes active damping and relies on a resonant control structure which improves the ability of dealing with grid harmonic *** controller uses a reduced set of measurements,which requires the inverter-side current and grid voltage only,and assures a power factor close to unity.

关键词： LCL filter transformerless inverter grid connection inverter-side current feedback

Nanostructured biohybrid material with wide-ranging antiviral action

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Nano Research 2023年第8期16卷 11455-11463页

作者： Noelia Losada-Garcia Angela vazquez-Calvo David Ortega-Alarcon Olga Abian Adrian Velazquez-Campoy Pilar Domingo-Calap Antonio Alcami jose M.Palomo Instituto de Catálisis y Petroleoquímica(ICP) CSICC/Marie Curie 2.Madrid 28049Spain Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Autónoma de Madrid(UAM)Madrid 28049Spain Institute of Biocomputation and Physics of Complex Systems(BIFI) Joint Unit GBsC-CSIC-BIFIUniversity of ZaragozaZaragoza 50018Spain Fundación Instituto de Investigación Sanitaria de Aragón(IIS Aragón) Zaragoza 50009Spain CIBERehd Madrid 28029Spain Instituto de Biología Integrativa de Sistemas I2SyBioUniversitat de València-CSICValència E-46071Spain

Respiratory pathogens kill more people than any other infectious agent each year *** of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major ***,we describe a nanostructured material composed of very small crystalline phosphate copper nanoparticles synthesized using a new biohybrid technology that employs a biological agent for its formation at room temperature in aqueous *** evaluation of different enzymes in the final preparation of the nanomaterial or even in synthetic methods was *** characterization revealed the formation of Cu species in the protein *** best biomaterial synthesized using a lipase called BioCuNPs showed excellent inhibition capacity against functional proteins of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);for example,assent 3-chymotrypsin like protease(3CLpro)complete inhibition was achieved by using 5µg/mL,or acetone(ACE)–spike protein interaction was inhibited by more than 80%in the presence of 400µg/mL of *** these in vitro results into account,an efficacy analysis against human coronavirus 229E(HCoV-E229)coronavirus was performed.A virus reduction of 99%was obtained in 5 ***,SARS-CoV-2 virus was tested to demonstrate high efficiency,with>99%inhibition in 15 min using 500 microgram of *** determine the wide applicability of this nanohybrid against viruses,an evaluation was carried out against a non-enveloped virus such as Human Rhinovirus(HRV-14),obtaining a virus reduction of 99.9%in 5 ***,the virucidal capacity against different bacteriophages was also evaluated,obtaining an excellent inhibition effect against PhageΦX174(99.999%reduction in 5 min).

关键词： antiviral compound coronaviruses copper nanoparticles nanobiotechnology viruses

Recent Advances on Early-Stage Fire-Warning Systems: Mechanism, Performance, and Perspective

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Nano-Micro Letters 2022年第12期14卷 106-136页

作者： Xiaolu Li Antonio vazquez-Lopez jose Sanchez del Rio Saez De-Yi Wang IMDEA Materials Institute C/Eric Kandel228906 GetafeMadridSpain E.T.S.de Ingenieros de Caminos Universidad Politecnica de MadridCalle Profesor Aranguren 328040 MadridSpain Departamento de Ingenieria Electrica Electronica Automatica y Fisica AplicadaETSIDIUniversidad Politecnica de MadridRonda de Valencia 328012 MadridSpain

Early-stage fire-warning systems(EFWSs)have attracted significant attention owing to their superiority in detecting fire situations occurring in the pre-combustion *** progress on EFWSs has been achieved recently,and they have presented a considerable possibility for more evacuation time to control constant unintentional fire hazards in our daily *** review mainly makes a comprehensive summary of the current EFWSs,including the working mechanisms and their *** to the different working mechanisms,fire alarms can be classified into graphene oxide-based fire alarms,semiconductor-based fire alarms,thermoelectric-based fire alarms,and fire alarms on other working ***,the challenge and prospect for EFWSs are briefly provided by comparing the art of state of fire *** work can propose a more comprehensive understanding of EFWSs and a guideline for the cutting-edge development direction of EFWSs for readers.

关键词： Smart thermosensitive fire sensors Working mechanism Response time Signal conversion

ISCHEMIA trial:How to apply the results to clinical practice

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World Journal of Cardiology 2021年第8期13卷 237-242页

作者： Rafael Vidal-Perez Alberto Bouzas-Mosquera Jesus Peteiro jose Manuel vazquez-Rodriguez Servicio de Cardiologia Unidad de Imagen y Funcion CardiacaComplexo Hospitalario Universitario A Coruna(CHUAC)Centro de Investigacion Biomedica en Red(CIBERCV)-Instituto de Salud Carlos IIIA Coruna 15006Spain Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006Spain

During the last years two questions have been continuously asked in chronic coronary syndromes:(1)Do revascularization procedures(coronary artery bypass grafting or percutaneous coronary intervention)really improve symptoms of angina?and(2)Do these techniques improve outcomes,*** they prevent new myocardial infarction events and cardiovascular death?Therefore,there was a need for a large definitive *** study was the ISCHEMIA trial,a large,multicentric trial sponsored by the National Heart,Lung,and Blood *** main trial compared coronary revascularization and optimal medical treatment(OMT)vs OMT alone in 5179 patients enrolled after a stress *** a median 3.2-year follow-up,318 primary outcome events occurred;the adjusted hazard ratio for the invasive strategy as compared with the conservative strategy was 0.93(95%confidence interval 0.80-1.08,P=0.34).The ISCHEMIA trial deeply disrupted many of our prior attitudes regarding management strategies for patients with stable coronary artery *** findings underscore the benefits of disease-modifying OMT for stable coronary artery disease *** main purposes of ischemia assessment before this trial were:Diagnostic purposes,assessment of outcome,and adding to decision-making ***,this changed after the trial *** results of ISCHEMIA might challenge the current diagnostic approach for stable angina patients recommended in the last European Society of Cardiology guidelines on chronic coronary disease that were based on studies published before the ISCHEMIA *** this editorial we propose our approach based on the ISCHEMIA study and the pretest probability for a positive test in patients with chronic coronary syndromes.

关键词： Stable angina Chronic coronary syndrome ISCHEMIA Stress testing Therapy Diagnosis

MXene multi-functionalization of polyrotaxane based PCMs and the applications in electronic devices thermal management

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Nano Materials Science 2024年第5期6卷 495-503页

作者： Guangzhong Yin Alba Marta Lopez Ignacio Collado Antonio vazquez-Lopez Xiang Ao jose Hobson Silvia G.Prolongo Deyi Wang Escuela Politecnica Superior Universidad Francisco de VitoriaCtra.Pozuelo-Majadahonda Km 1.80028223 Pozuelo de AlarconMadridSpain IMDEA Materials Institute C/Eric Kandel228906GetafeMadridSpain Materials Science and Engineering Area Escuela Superior de Ciencias Experimentales y TecnologíaUniversidad Rey Juan CarlosC/Tulipan s/n28933MadridSpain Universidad Carlos III de Madrid Departamento de Ciencia e Ingeniería de Materiales e Ingeniería QuímicaIAAB.Avda.Universidad3028911LeganesMadridSpain Instituto de Tecnologías para la Sostenibilidad Universidad Rey Juan CarlosC/Tulipan s/n28933MadridSpain

The aim of this work was to improve the thermal conductivity and electromagnetic shielding of the leakage proof phase change materials(PCMs),in which a polyrotaxane(PLR)was used as a support material to encapsulate PEG 1k or PEG 6k and MXene as multi-functional *** PCMs can be processed conveniently by a hot press and the PEG 1k containing samples showed excellent *** conducted a systematic evaluation of the phase transition behavior of the material,thermal conductivity and electromagnetic shielding performance ***,the PCMs achieved a high enthalpy values(123.9–159.6 J/g).The PCMs exhibited an increase of 44.3%,and 137.5%in thermal conductivity values with higher MXene content(5 wt%)for PLR-PEG6k and PLR-PEG1k,respectively,and show high shape stability and no leakage during and after phase *** introduction of MXene can significantly improve the electromagnetic shielding performance of PCM ***,higher conductive samples(samples which contain high MXene contents)offer a higher EMI SE shielding,reaching a maximum of 4.67 dB at 5.6 GHz for *** improvements solve the main problems of organic PEG based PCMs,thus making PLR-PEG-MXene based PCMs good candidates for thermoregulators of both solid-state disks and smart *** is worth pointing out that the sample PLR-1k-MX5 can decrease 4.3C of the reference temperature during cellphone ***,the temperature of the protecting sheet in the simulated solid state disk with PCM was significantly lower(showing a decreasing of 7.9℃)compared with the blank sample.

关键词： Phase change materials Thermal regulation MXene Polyrotaxane Nanocomposites

Simultaneous optimization of even flow and land and timber value in forest planning:a continuous approach

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Forest Ecosystems 2021年第4期8卷 645-658页

作者： jose M.Gonzalez-Gonzalez Miguel E.vazquez-Mendez Ulises Dieguez-Aranda Departamento de Enxenaria Agroforestal Universidade de Santiago de Compostela.Escola Politecnica Superior de EnxenariaR/Benigno Ledo27002 LugoSpain Departamento de Matematica Aplicada Instituto de MatematicasUniversidade de Santiago de Compostela.Escola Politecnica Superior de EnxenariaR/Benigno Ledo27002 LugoSpain

Background:Forest management planning involves deciding which silvicultural treatment should be applied to each stand and at what time to best meet the objectives established for the *** this,many mathematical formulations have been proposed,both within the linear and non-linear programming frameworks,in the latter case generally considering integer variables in a combinatorial *** present a novel approach for planning the management of forests comprising single-species,even-aged stands,using a continuous,multi-objective formulation(considering economic and even flow)which can be solved with gradient-type ***:The continuous formulation has proved robust in forest with different structures and different number of *** results obtained show a clear advantage of the gradient-type methods over heuristics to solve the problems,both in terms of computational time(efficiency)and in the solution obtained(effectiveness).Their improvement increases drastically with the dimension of the problem(number of stands).Conclusions:It is advisable to rigorously analyze the mathematical properties of the objective functions involved in forest management planning *** continuous bi-objective model proposed in this paper works with smooth enough functions and can be efficiently solved by using gradient-type *** advantages of the new methodology are summarized as:it does not require to set management prescriptions in advance,it avoids the division of the planning horizon into periods,and it provides better solutions than the traditional combinatorial ***,the graphical display of trade-off information allows an a posteriori articulation of preferences in an intuitive way,therefore being a very interesting tool for the decision-making process in forest planning.

关键词： Even-aged forest management Forest-level optimization Continuous optimization Gradient-type algorithms

Current role and future perspectives of artificial intelligence in echocardiography

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World Journal of Cardiology 2023年第6期15卷 284-292页

作者： Rafael Vidal-Perez Julia Grapsa Alberto Bouzas-Mosquera Ricardo Fontes-Carvalho jose Manuel vazquez-Rodriguez Servicio de Cardiología Unidad de Imagen y Función CardíacaComplexo Hospitalario Universitario A Coruña Centro de Investigación Biomédica en Red-Instituto de Salud Carlos ⅢA Coruña 15006Spain Department of Cardiology Guys and St Thomas NHS TrustLondon SE17EHUnited Kingdom Cardiology Department Centro Hospitalar de Vila Nova de Gaia/EspinhoVilanova de Gaia 4434-502Portugal Cardiovascular R&D Centre-UnIC@RISE Department of Surgery and PhysiologyFaculty of Medicine of the University of PortoPorto 4200-319Portugal Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006Spain

Echocardiography is an essential tool in diagnostic cardiology and is fundamental to clinical *** intelligence(AI)can help health care providers serving as a valuable diagnostic tool for physicians in the field of echocardiography specially on the automation of measurements and interpretation of *** addition,it can help expand the capabilities of research and discover alternative pathways in medical management specially on *** this review article,we describe the current role and future perspectives of AI in echocardiography.

关键词： Echocardiography Artificial intelligence Machine learning Deep learning Prognosis