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Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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molecular Plant 2021年第9期14卷 1489-1507页

作者： Cristina Navarro Cristian mateo-Elizalde Thotegowdanapalya C.mohan Eduardo Sanchez-Bermejo Oscar Urrutia maria Nieves Fernandez-muniz jose m.garcia-mina Riansares munoz Javier Paz-Ares Gabriel Castrillo Antonio Leyva Department of Plant molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Environmental Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Department of Analytical Chemistry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Department of Biotechnology and Bioinformatics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with them.This is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and arsenate.In this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the cell.We showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator PHR1.Once arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is recovered.Furthermore,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 degradation.We found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to arsenate.Collectively,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytoremediation

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葡聚糖和腐植酸:对免疫系统的协同作用

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腐植酸 2015年第6期 34-40页

作者： Vaclav Vetvicka Roberto Baigorri Angel m.Zamarre?o jose m.garcia-mina Jean-Claude Yvin 周霞萍樊兴明美国路易斯维尔大学病理学系肯塔基州40292 钛美农业国际鲁利耶集团研发部奥尔科延999019 西班牙纳瓦拉大学化学和土壤化学系潘普洛纳999023 法国钛美农业国际研发部迪纳尔999019 华东理工大学科学技术发展研究院上海200237

腐植酸是由有机物质分解产生的混合物。尽管它们普遍存在,但对它们的生物学效应了解有限,且目前的研究结果存在争议。因此对来源不同且具有不同的生化特性的两种类型的腐植酸的免疫效果进行评估。单独使用这两种腐植酸或与已知发酵衍生... 详细信息

腐植酸是由有机物质分解产生的混合物。尽管它们普遍存在,但对它们的生物学效应了解有限,且目前的研究结果存在争议。因此对来源不同且具有不同的生化特性的两种类型的腐植酸的免疫效果进行评估。单独使用这两种腐植酸或与已知发酵衍生的免疫调节剂葡聚糖结合使用,并测其在细胞(吞噬作用和肿瘤抑制)和体液(抗体的产生和细胞因子的分泌)的免疫反应。研究结果表明,腐植酸是具有生物活性的免疫调节剂,影响体液免疫和细胞免疫反应。此外,本文研究的两种腐植酸在免疫反应的刺激下具有协同效应,为这些天然免疫调节剂的进一步研究提供了支持。

关键词：葡聚糖腐植酸免疫力吞噬作用

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A Single JAZ Repressor Controls the Jasmonate Pathway in marchantia polymorpha

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molecular Plant 2019年第2期12卷 185-198页

作者： Isabel monte jose m. Franco-Zorrilla Gloria garcia-Casado Angel m. Zamarreno jose m. garcia-mina Ryuichi Nishihama Takayuki Kohchi Roberto Solano Department of Plant molecular Genetics Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas (CNB-CSIC) 28049 Madrid Spain Genomics Unit Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas (CNB-CSIC) 28049 Madrid Spain Environmental Biology Department University of Navarra Navarre Spain Graduate School of Biostudies Kyoto University Kyoto 606-8502 Japan

JAZ proteins are negative regulators of jasm onate responses,acting both as repressors of transcription factors and as co-receptors of JA-lle. The high redundancy of JAZ genes in angiosperms has hindered the characterization of a complete depletion of JAZ function. moreover, the recent discovery that dn- OPDA is the jasmonate ligand in marchantia polymorpha demonstrates that JA-lle is not the sole COI1/ JAZ ligand in land plants and highlights the importance of studying JAZ co-receptors in bryophytes? Here, we have exploited the low gene redundancy of the liverwort m. polymorpha to characterize the single mpJ4Z in this early diverging plant lineage. We clarify the phylogenetic history of the TIFY family, demonstrate that mpJAZ is the ortholog of AtJAZ with a conserved function, and characterize its repressor activity of dn-OPDA resp on ses. Our results show that, con sistent with previous findings in Arabidopsis, mpJAZ represses jasmonates biosynthesis, senescence, and plant defenses, and promotes cell growth and reproductive fitness, highlighting the power of studies in marchantia.

关键词： Jasmonate repressors marchantia Hormone signaling evolution gene redundancy

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Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas maria A.garcia-Lopez jose m.Olano Gabriel Sanguesa-Barreda miguel garcia-Hidalgo Susana Gomez-Gonzalez Roberto Lopez-Rubio jose m.Fernandez-Palacios Ignacio garcia-Gonzalez Laura Lozano-Lopez Paula garcia-Gonzalez Ana I.garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human activities.In the past,Canary laurel forests have been greatly altered by logging,livestock and agriculture.The remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic disturbances.Using dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife Island.Wood cores were collected from over 80 trees per stand at three stands per forest.We used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed growth.Twelve tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and morella faya being the most common species.Although some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism economy.Some trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past decades.Strong growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure macaronesia management cessation Tree rings

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Nanostructured biohybrid material with wide-ranging antiviral action

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Nano Research 2023年第8期16卷 11455-11463页

作者： Noelia Losada-garcia Angela Vazquez-Calvo David Ortega-Alarcon Olga Abian Adrian Velazquez-Campoy Pilar Domingo-Calap Antonio Alcami jose m.Palomo Instituto de Catálisis y Petroleoquímica(ICP) CSICC/Marie Curie 2.Madrid 28049Spain Centro de Biología molecular Severo Ochoa Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Autónoma de Madrid(UAM)Madrid 28049Spain Institute of Biocomputation and Physics of Complex Systems(BIFI) Joint Unit GBsC-CSIC-BIFIUniversity of ZaragozaZaragoza 50018Spain Fundación Instituto de Investigación Sanitaria de Aragón(IIS Aragón) Zaragoza 50009Spain CIBERehd Madrid 28029Spain Instituto de Biología Integrativa de Sistemas I2SyBioUniversitat de València-CSICValència E-46071Spain

Respiratory pathogens kill more people than any other infectious agent each year worldwide.Development of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major challenge.Herein,we describe a nanostructured material composed of very small crystalline phosphate copper nanoparticles synthesized using a new biohybrid technology that employs a biological agent for its formation at room temperature in aqueous media.The evaluation of different enzymes in the final preparation of the nanomaterial or even in synthetic methods was performed.Biochemical characterization revealed the formation of Cu species in the protein network.The best biomaterial synthesized using a lipase called BioCuNPs showed excellent inhibition capacity against functional proteins of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);for example,assent 3-chymotrypsin like protease(3CLpro)complete inhibition was achieved by using 5µg/mL,or acetone(ACE)–spike protein interaction was inhibited by more than 80%in the presence of 400µg/mL of BioCuNPs.Taking these in vitro results into account,an efficacy analysis against human coronavirus 229E(HCoV-E229)coronavirus was performed.A virus reduction of 99%was obtained in 5 min.Additionally,SARS-CoV-2 virus was tested to demonstrate high efficiency,with>99%inhibition in 15 min using 500 microgram of material.To determine the wide applicability of this nanohybrid against viruses,an evaluation was carried out against a non-enveloped virus such as Human Rhinovirus(HRV-14),obtaining a virus reduction of 99.9%in 5 min.Finally,the virucidal capacity against different bacteriophages was also evaluated,obtaining an excellent inhibition effect against PhageΦX174(99.999%reduction in 5 min).

关键词： antiviral compound coronaviruses copper nanoparticles nanobiotechnology viruses

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Acute hepatitis with autoimmune features after COVID-19 vaccine:coincidence or vaccine-induced phenomenon?

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Gastroenterology Report 2022年第1期10卷 628-631页

作者： jose m.Pinazo-Bandera Alicia Hernandez-Albujar Ana Isabel garcia-Salguero Isabel Arranz-Salas Raul J.Andrade mercedes Robles-Diaz Division of Gastroenterology and Hepatology Instituto de Investigacion Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalagaSpain Division of Anatomical Pathology Hospital Universitario Virgen de la VictoriaMalagaSpain Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd) MadridSpain

Introduction Autoimmune diseases result from a breach of immunological self-tolerance and tissue damage by autoreactive T lymphocytes.Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is characteriz... 详细信息

关键词： autoimmune vaccine acute

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A versatile microfluidic device for multiple ex vivo/ in vitro tissue assays unrestrained from tissue topography

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microsystems & Nanoengineering 2020年第1期6卷 806-819页

作者： jose m.de Hoyos-Vega Alan m.Gonzalez-Suarez jose L.garcia-Cordero Unidad monterrey Centro de Investigacion y de Estudios Avanzados del IPNVia del conocimiento 201Parque PIITApodacaNL 66628Mexico

Precision-cut tissue slices are an important in vitro system to study organ function because they preserve most of the native cellular microenvironments of organs,including complex intercellular connections.However,during sample manipulation or slicing,some of the natural surface topology and structure of these tissues is lost or damaged.Here,we introduce a microfluidic platform to perform multiple assays on the surface of a tissue section,unhindered by surface topography.The device consists of a valve on one side and eight open microchannels located on the opposite side,with the tissue section sandwiched between these two structures.When the valve is actuated,eight independent microfluidic channels are formed over a tissue section.This strategy prevents cross-contamination when performing assays and enables parallelization.Using irregular tissues such as an aorta,we conducted multiple in vitro and ex vivo assays on tissue sections,including short-term culturing,a drug toxicity assay,a fluorescence immunohistochemistry staining assay,and an immune cell assay,in which we observed the interaction of neutrophils with lipopolysaccharide(LPS)-stimulated endothelium.Our microfluidic platform can be employed in other disciplines,such as tissue physiology and pathophysiology,morphogenesis,drug toxicity and efficiency,metabolism studies,and diagnostics,enabling the conduction of several assays with a single biopsy sample.

关键词： metabolism topography versatile

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mid and late Holocene forest fires and deforestation in the subalpine belt of the Iberian range,northern Spain

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Journal of mountain Science 2016年第10期13卷 1760-1772页

作者： jose m.garcia-RUIZ Yasmina SANJUAN Graciela GIL-ROmERA Penelope GONZALEZ-SAmPERIZ Santiago BEGUERIA jose ARNAEZ Paz COBA-PEREZ Amelia GOmEZ-VILLAR Javier ALVAREZ-mARTINEZ Noemi LANA-RENAULT Estela PEREZ-CARDIEL Carlos LOPEZ DE CALLE Instituto Pirenaico de Ecologfa Consejo Superior de Investigaciones Cientificas(IPE-CSIC)Campus de Aula DeiP.O.Box 13.03450.080-ZaragozaSpain Estacion Experimental de Aula Dei Consejo Superior de Investigaciones Cientificas(EEAD-CSIC)Campus de Aula DeiP.O.Box 13.03450.080-ZaragozaSpain Area of Physical Geography University ofLa Rioja26.004-LogronoSpain Centro de Investigaciones en Geografia Ambiental Universidad Nacional Autonoma de MexicoUnidad MoreliaAntigua Carretera a Patzcuaro 870158190-MoreliaMichoacanMexico Departamento de Geografia y Geologia Faeultad de Filosofia y LetrasUniversidad de LeonCampus de Vegazana24.071-LeonSpain Departamento de Ingenieria Agricola y Forestal Universidad de ValladolidCampus La Yutera34.071-PalenciaSpain Department of Geography and Land management University of Zaragoza50.009-ZaragozaSpain Freelance archaeologist Auda.Colon426003-LogronoSpain

The conversion of subalpine forests into grasslands for pastoral use is a well-knownphenomenon, although for most mountain areas the timing of deforestation has not been determined. The presence of charcoal fragments in soil profiles affected by shallow landsliding enabled us to date the occurrence of fires and the periods of conversion ofsubalpine forest into grasslands in the Urbión mountains, Iberian Range, Spain. We found that the treeline in the highest parts of the northwestern massifs of the Iberian Range(the Urbión, Demanda, Neila, and Cebollera massifs) is currently between 1500 and 1600 m a.s.l., probably because of pastoral use of the subalpine belt, whereas in the past it would have reached almost the highest divides(at approximately 2100–2200 m a.s.l.). The radiocarbon dates obtained indicate that the transformation of the subalpine belt occurred during the Late Neolithic, Chalcolithic, Bronze Age, Iron Age, and middle Ages. Forest clearing was probably moderate during fires prior to the middle Ages, as the small size of the sheep herds and the local character of the markets only required small clearings, and therefore more limited fires. Thus, it is likely that the forest recovered burnt areas in a few decades; this suggests the management of the forest and grasslands following a slash-andburn system. During the middle and modern Ages deforestation and grassland expansion affected most of the subalpine belt and coincided with the increasing prevalence of transhumance, as occurred in other mountains in the Iberian Peninsula(particularly the Pyrenees). Although the occurrence of shallow landslides following deforestation between the Neolithic and the Roman Period cannot be ruled out, the most extensive shallow landsliding processes would have occurred from the middle Ages until recent times.

关键词：福雷斯特开火 Holocene 亚高山带的草地浅山崩美化变化伊比利亚人范围

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Bioleaching of zinc from gold ores using Acidithiobacillus ferrooxidans

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International Journal of minerals,metallurgy and materials 2009年第4期16卷 368-374页

作者： Pakawadee Kaewkannetra Francisco jose garcia-garcia Tze Yen Chiu Department of Biotechnology Faculty of TechnologyKhon Kaen University Corrosion and Protection Centre School of MaterialsThe University of Manchester Centre of Water Science Cranfield University

The present work investigated microbial leaching of zinc from ore using Acidithiobacillus ferrooxidans （ATCC 14859）. The ore samples, consisted of 13wt% zinc, were obtained from a gold mine in north-eastern Thailand. A shake flask study was performed on the ore samples using a rotary shaker under the following fixed conditions （250 r·min^-1, 30℃ for 16 d）. The influence of various conditions, namely medium type （with and without iron）, particle ore size （〈20, 20-40, 40-60, 60-100, and 〉100 mesh）, ore density （20 kg·m^-3, 50 kg·m^-3, and 100 kg·m^-3）, and pH of the medium （2, 2.5, 2.8, and 3）, were investigated. The microbial leaching was assessed by determining the concentration of zinc in the medium and compared with the initial sample concentration. The results show that Acidithiobacillus ferrooxidans can successfully leach zinc by as much as 6 times compared with the control experiment （without Acidithiobacillus ferrooxidans ferrooxidans）. The maximum efficiency （92.3%） for microbial leaching is obtained in iron-containing medium, 20-40 mesh ore sizes, 20 kg·m^-3 ore density at pH 2.8, and the zinc content is found in the medium at about 120 mg·m^-1.

关键词： bioleaching Acidithiobacillusferrooxidans gold ores gold mine

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Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： jose m de la Torre Hernandez Ramon Lopez Palop Jesus m Jimenez mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika garcia San Roman Silvio Leal Ginés martínez Cáceres jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues jose m Vegas Valle Hélder Pereira Armando Perez de Prado Cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology Department Hospital Universitario San JuanAlicanteSpain Cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology Department Hospital Universitario Puerta del MarCadizSpain Cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology Department Hospital Universitario de CrucesBilbaoSpain Cardiology Department Hospital Regional Universitario de MálagaMalagaSpain Cardiology Department Hospital Universitario Puerta de HierroMadridSpain Cardiology Department Hospital Alvaro CunqueiroVigoSpain Cardiology Department Hospital Juan Ramon JimenezHuelvaSpain Cardiology Department Hospital Universitario de BadajozBadajozSpain Cardiology Department Hospital Universitario Lucus AugustiLugoSpain Cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology Department Hospital Santa CruzLisboaPortugal Cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology Department Hospital Universitario Miguel ServetZaragozaSpain Cardiology Department Hospital Germans Trias i PujolBadalonaSpain Cardiology Department Hospital de MeridaMeridaSpain Cardiology Department Hospital São BernardoSetúbalPortugal Cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital do Espirito SantoEvoraPortugal Cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology Department Hospital de CabueñesGijonSpain Cardiology Department Hospital Garcia de OrtaAlmadaPortugal Cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).mETHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT score.Co-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as control.RESULTS Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex PCI.Co-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored therapy.No stent thrombosis reported in the subgroup with 1-3 months DAPT duration.As compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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