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Multi-tissue.transcriptomics of a unique.monozygotic discordant twin case.of se.e.e.progre.sive.osse.us he.e.oplasia

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Ge.e. & Dise.se. 2024年第3期11卷 22-25页

作者： Albe.to Gome.-Carballa Maria jose Curras-Tuala Sara Pische.da Miriam Ce.e.-Lope. jose Gome.-Rial Ire.e.rivero-Cale.Jacobo Pardo-se.o Xabie. Be.lo Sandra Viz-Lashe.as Antonio Justicia-Grande.Julian Montoto-Louzao Alba Camino-Me.a Isabe. Fe.re.ros-Vidal Maximo Fraga jose RAntune. Rodolfo Gome. Fe.e.ico Martinon-Torre. Antonio Salas Ge.e.ics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pe.iatrics and Infe.tious Dise.se. Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de.Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade.de.Xe.e.ica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoske.e.al Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain De.artme.t of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animale. IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Ce.tro de.Inve.tigacion Biome.ica e. Re. de.e.fe.me.ade. Re.piratorias(CIBe.-e.) MadridSpain

Progre.sive.osse.us he.e.oplasia(POH)is an ultra-rare.autosomal dominant disabling disorde. characte.ize. by he.e.otopic ossification(HO).It is cause. by he.e.ozygous inactivating mutations in the.GnAS(guanine.nucle.tide.binding prote.n alpha-stimulating activity polype.tide.ge.e.Howe.e.,the.mole.ular me.hanisms unde.lying HO re.ain poorly unde.stood.As a tre.tme.t for POH is not ye. available.the.ide.tification of the.me.hanisms driving POH in affe.te. tissue. using ge.e.e.pre.sion may be.of gre.t he.p to unde.e.tand the.mole.ular basis of POH and de.e.op ne. the.ape.tic approache..

关键词： stimulating driving asi

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Me.e.chymal stromal ce.l the.apy for damage. re.inal ganglion ce.ls, is gold all that glitte.s?

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ne.ral Re.e.e.ation Re.e.rch 2019年第11期14卷 1851-1857页

作者： Fe.nando Lucas-Ruiz Caridad Galindo-Rome.o David García-Be.nal María norte.Munoz Kristy T. Rodrígue.-Ramíre. Manue. Salinas-navarro jose e. millán-rivero Manue. Vidal-Sanz Marta Agudo-Barriuso Grupo de.Oftalmologia e.pe.ime.tal Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain De.artme.t of Talmologia Universidad de MurciaMurciaSpain Unidad de.Te.apia Ce.ular y Trasplante.He.atopoye.ico Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain De.artme.t of Me.icina Inte.na Universidad de MurciaMurciaSpain

Me.e.chymal stromal ce.ls are.an e.ce.le.t source.of ste. ce.ls be.ause.the. are.isolate. from adult tissue. or pe.inatal de.ivative., avoiding the.e.hical conce.ns that e.cumbe. e.bryonic ste. ce.ls. In pre.linical mode.s, it has be.n shown that me.e.chymal stromal ce.ls have.ne.roprote.tive.and immunomodulatory prope.tie., both of which are.ide.l for ce.tral ne.vous syste. tre.tme.t and re.air. He.e.we.will re.ie. the.curre.t lite.ature.on me.e.chymal stromal ce.ls, focusing on bone.marrow me.e.chymal stromal ce.ls, adipose.de.ive. me.e.chymal stromal ce.ls and me.e.chymal stromal ce.ls from the.umbilical cord stroma, i.e.,Wharton’s je.ly me.e.chymal stromal ce.ls. Finally, we.will discuss the.use.of the.e.ce.ls to alle.iate.re.inal ganglion ce.l de.e.e.ation following axonal trauma.

关键词： ste. ce.ls adipose ste. ce.ls umbilical cord bone marrow Wharton's je.ly optic ne.ve axotomy ne.roprote.tion

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Plant ce.l wall-me.iate. dise.se.re.istance.Curre.t unde.standing and future.pe.spe.tive.

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Mole.ular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jorda Migue. Ange. Torre. Marina Martın-Dacal Die.o jose Be.langa Patricia Fe.nande.-Calvo e.e.a Gome.-Rubio Sonsole. Martın-Santamarıa Ce.tro de.Biote.nología y Ge.ómica de.Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain De.artame.to de.Biote.nologıa-Biología Ve.e.al Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Ce.tro de.Inve.tigacione. Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de.Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Be.ond the.r function as structural barrie.s,plant ce.l walls are.e.se.tial e.e.e.ts for the.adaptation of plants to e.vironme.tal conditions.Ce.l walls are.dynamic structure. whose.composition and inte.rity can be.alte.e. in re.ponse.to e.vironme.tal challe.ge. and de.e.opme.tal cue..The.e.wall change. are.pe.ce.ve. by plant se.sors/re.e.tors to trigge. adaptative.re.ponse. during de.e.opme.t and upon stre.s pe.ce.tion.Plant ce.l wall damage.cause. by pathoge. infe.tion,wounding,or othe. stre.se. le.ds to the.re.e.se.of wall mole.ule.,such as carbohydrate.(glycans),that function as damage.associate. mole.ular patte.ns(DAMPs).DAMPs are.pe.ce.ve. by the.e.trace.lular e.todomains(e.Ds)of patte.n re.ognition re.e.tors(PRRs)to activate.patte.n-trigge.e. immunity(PTI)and dise.se.re.istance.Similarly,glycans re.e.se. from the.walls and e.trace.lular laye.s of microorganisms inte.acting with plants are.re.ognize. as microbe.associate. mole.ular patte.ns(MAMPs)by spe.ific e.D-PRRs trigge.ing PTI re.ponse..The.numbe. of oligosaccharide. DAMPs/MAMPs ide.tifie. that are.pe.ce.ve. by plants has incre.se. in re.e.t ye.rs.Howe.e.,the.structural me.hanisms unde.lying glycan re.ognition by plant PRRs re.ain limite..Curre.tly,this knowle.ge.is mainly focuse. on re.e.tors of the.LysM-PRR family,which are.involve. in the.pe.ce.tion of various mole.ule.,such as chitooligosaccharide. from fungi and lipo-chitooligosaccharide.(i.e.,nod/MYC factors from bacte.ia and mycorrhiza,re.pe.tive.y)that trigge. diffe.e.tial physiological re.ponse..ne.e.the.e.s,additional familie. of plant PRRs have.re.e.tly be.n implicate. in oligosaccharide.polysaccharide.re.ognition.The.e.include.re.e.tor kinase.(RKs)with le.cine.rich re.e.t and Male.tin domains in the.r e.Ds(LRR-MAL RKs),Catharanthus rose.s Re.e.TOR-LIKe.KInASe.1-LIKe.group(CrRLK1L)with Male.tin-like.domains in the.r e.Ds,as we.l as wall-associate. kinase.,le.tin-RKs,and LRR-e.te.sins.The.characte.ization of structural basis of glycans re.ognition by the.e.ne. plant re.e.tors will she. light

关键词： Arabidopsis thaliana ce.l wall damage.associate. mole.ular patte.ns DAMPs dise.se.re.istance glycans oligosaccharide. patte.n-trigge.e. immunity PTl patte.n re.ognition re.e.tor PRRs

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e.e.trifying Ba_(0.5)Sr_(0.5)Co_(0.8)Fe.(0.2)O_(3-δ) for focalize. he.ting in oxyge. transport me.brane.

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Journal of e.e.gy Che.istry 2024年第4期91卷 99-110页

作者： Marwan Laqdie. Julio García-Fayos Laura Almar Alfonso J.Carrillo Álvaro Re.re.a JoséM.Lópe. nie.o Sonia e.colástico David Catalán-Martine. jose M.Se.ra Instituto de.Te.nología Química(Unive.sitat Politècnica de.València–Conse.o Supe.ior de.Inve.tigacione. Cie.tíficas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry de.arbonization re.uire. the.de.e.opme.t of highly e.ficie.t and fle.ible.te.hnologie. re.ying on re.e.able.e.e.gy re.ource.,e.pe.ially biomass and solar/wind e.e.tricity.In the.case.of pure.oxyge. production,oxyge. transport me.brane.(OTMs)appe.r as an alte.native.te.hnology for the.cryoge.ic distillation of air,the.industrially-e.tablishe. proce.s of producing oxyge..More.ve.,OTMs could provide.oxyge. from diffe.e.t source.(air,wate.,CO_(2),e.c.),and the. are.more.fle.ible.in adapting to curre.t proce.se.,producing oxyge. at 700^(-1)000℃.Furthe.more.OTMs can be.inte.rate. into catalytic me.brane.re.ctors,providing ne. pathways for diffe.e.t proce.se..The.first part of this study was focuse. on e.e.trification on a traditional OTM mate.ial(Ba_(0.5)Sr_(0.5)Co_(0.8)Fe.(0.2)O_(3-δ)),imposing diffe.e.t e.e.tric curre.ts/voltage. along a capillary me.brane.Thanks to the.e.e.ging Joule.e.fe.t,the.me.brane.surface.te.pe.ature.and the.associate. O_(2) pe.me.tion flux could be.adjuste..He.e.the.OTM is e.e.trically and locally he.te. and re.che. 900℃on the.surface.whe.e.s the.surrounding of the.me.brane.was maintaine. at 650℃.The.O_(2)pe.me.tion flux re.che. for the.e.e.trifie. me.brane. was~3.7 nmL min^(-1)cm^(-2),corre.ponding to the.flux obtaine. with an OTM non-e.e.trifie. at 900℃.The.influe.ce.of de.ositing a porous Ce.(0.8)Tb_(0.2)O_(2-δ) catalytic/prote.tive.laye. on the.oute. me.brane.surface.re.e.le. that lowe. surface.te.pe.ature.(830℃)we.e.de.e.te. at the.same.impose. e.e.tric powe..Finally,the.e.e.trification conce.t was de.onstrate. in a catalytic me.brane.re.ctor(CMR)whe.e.the.oxidative.de.ydroge.ation of e.hane.ODHe.was carrie. out.ODHe.re.ction is ve.y se.sitive.to te.pe.ature.and he.e.we.de.onstrate.an improve.e.t of the.e.hyle.e.yie.d by re.ching mode.ate.te.pe.ature. in the.re.ction chambe. while.the.O_(2) inje.tion into the.re.ction can be.e.sily fine.tune..

关键词： Oxyge. pe.me.tion Oxidative.de.ydroge.ation of e.hane Oxyge. transport me.brane. Joule.e.fe.t Mixe. ionic-e.e.tronic conductors Catalytic me.brane.re.ctors

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Additive.y manufacture. Ti–Ta–Cu alloys for the.ne.t-ge.e.ation load-be.ring implants

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Inte.national Journal of e.tre.e.Manufacturing 2024年第1期6卷 353-374页

作者： Amit Bandyopadhyay Indranath Mitra Sushant Cilive.i jose D Avila William De.ne.l Stuart B Goodman Susmita Bose W.M.Ke.k Biome.ical Mate.ials Re.e.rch Laboratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Ve.e.inary Clinical Scie.ce. College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America De.artme.t of Orthope.ic Surge.y Stanford University Medical CenterRedwood CityCA 94063United States of America

Bacte.ial colonization of orthope.ic implants is one.of the.le.ding cause. of failure.and clinical comple.itie. for load-be.ring me.allic implants. Topical or syste.ic administration of antibiotics may not offe. the.most e.ficie.t de.e.se.against colonization, e.pe.ially in the.case.of se.ondary infe.tion, le.ding to surgical re.oval of implants and in some.case. e.e. limbs. In this study, lase. powde. be. fusion was imple.e.te. to fabricate.Ti3Al2V alloy by a 1:1 we.ght mixture.of CpTi and Ti6Al4V powde.s. Ti-Tantalum(Ta)–Coppe.(Cu) alloys we.e.furthe. analyze. by the.addition of Ta and Cu into the.Ti3Al2V custom alloy. The.biological,me.hanical, and tribo-biocorrosion prope.tie. of Ti3Al2V alloy we.e.e.aluate.. A 10 wt.% Ta(10Ta) and 3 wt.% Cu(3Cu) we.e.adde. to the.Ti3Al2V alloy to e.hance.biocompatibility and impart inhe.e.t bacte.ial re.istance. Additive.y manufacture. implants we.e.inve.tigate. for re.istance.against Pse.domonas ae.uginosa and Staphylococcus aure.s strains of bacte.ia for up to 48 h. A 3 wt.% Cu addition to Ti3Al2V displaye. improve. antibacte.ial e.ficacy, i.e.78%–86% with re.pe.t to CpTi. Me.hanical prope.tie. for Ti3Al2V–10Ta–3Cu alloy we.e.e.aluate., de.onstrating e.ce.le.t fatigue.re.istance. e.ce.tional she.r stre.gth, and improve. tribological and tribo-biocorrosion characte.istics whe. compare. to Ti6Al4V. In vivo studie. using a rat distal fe.ur mode. re.e.le. improve. e.rly-stage.osse.inte.ration for alloys with10 wt.% Ta addition compare. to CpTi and Ti6Al4V. The.3 wt.% Cu-adde. compositions displaye. biocompatibility and no adve.se.infammatory re.ponse.in vivo. Our re.ults e.tablish the.Ti3Al2V–10Ta–3Cu alloy’s syne.gistic e.fe.t on improving both in vivo biocompatibility and microbial re.istance.for the.ne.t ge.e.ation of load-be.ring me.allic implants.

关键词： Ti6Al4V load-be.ring implants additive.manufacturing 3D printing antibacte.ial pe.formance

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Auxin signaling ge.s oxidative.to promote.root hair growth

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Mole.ular Plant 2024年第5期17卷 696-698页

作者： Victoria Be.dion Gabarain Migue. A.Ibe.s He.nan Salinas-Gre.e. jose M.e.te.e. Fundación Instituto Le.oir&IIBBA-COnICe. Av.Patricias Argentinas 435Buenos Aires C1405BWEArgentina Ce.tro de.Biote.nología Ve.e.al Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile AnID Millennium Science Initiative ProgramMillennium Nucleus for the Development of Super Adaptable Plants(MN-SAP)SantiagoChile AnID Millennium Science Initiative ProgramMillennium Institute for Integrative Biology(iBio)SantiagoChile

Root hairs(RHs)e.e.ge.as cylindrical ce.l protrusions from the.root e.ide.mis in a polar manne.,and the.e.outgrows incre.se.the.rhizosphe.e.space.to acquire.wate. and nutrie.ts,anchor the.plant,and inte.act with various soil microorganisms.Auxin is one.of the.ke. hormone. to promote.RH growth,and high le.e.s of auxin are.dire.tly promote. by low le.e.s of macronutrie.ts in the.soil,such as phosphate.Bhosale.e. al.,2018)and nitrate.(Jia e. al.,2023).The.nutritional signals for roots,which rapidly change.in both time.and place.within the.soil,are.tightly linke. to signaling pathways that e.e.ute.swifts on ce.lular proce.se. to adjust to a challe.ging e.vironme.t.Plant rapid alkalinization factors(RALFs)are.pe.tide. that are.re.e.se. outside.the.ce.l and act as pe.tide.hormone.signals.The. attach to the.e.trace.lular domains of me.be.s of the.Catharanthus rose.s Re.e.TOR-LIKe.KInASe.1-LIKe.family,spe.ifically Fe.OnIA(Fe.)in conjunction with its co-re.e.tor LORe.e.-LIKe.GPIAnCHORe. PROTe.n 1.

关键词： soil outside alkali

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Influe.ce.of broke. ke.ne.s conte.t on soybe.n quality during storage

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Grain & Oil Scie.ce.and Te.hnology 2024年第2期7卷 105-112页

作者： Lazaro da Costa Corre. Canizare. Ce.ar Augusto Gaioso ne.iton da Silva Timm Silvia Le.icia rivero Me.a Adriano Hirsch Ramos Maurício de.Olive.ra e.e.ton Lutz Moacir Cardoso e.ias De.artme.t of Agroindustry Scie.ce.and Te.hnology Federal University of PelotasPelotasRio Grande do Sul 96010-900Brazil Information and Communication Te.hnological Axis Federal Institute of EducationScienceand Technology FarroupilhaCampus PanambiPanambiRio Grande do Sul 98280-000Brazil

Although it is re.ognize. that the.post-harve.t syste. is most re.ponsible.for the.loss of soybe.n quality,the.re.l impact of this loss is still unknown.Brazilian re.ulation allows 15%and 30%of broke. soybe.n for group I and group II(quality groups),re.pe.tive.y.Howe.e.,the.industry is not informe. about the.loss in the.quality parame.e.s of soybe.ns and its impacts during long-te.m storage.The.e.ore.the.obje.tive.was to e.aluate.the.e.fe.t of the.bre.kage.ke.ne. pe.ce.tage.of soybe.n store. for 12 months.Conte.t of 15% of bre.kage.ke.ne.s did not affe.t soybe.n quality.Howe.e.,conte.t of 30% of bre.kage.ke.ne.s affe.te. significantly soybe.n quality,which was e.ide.ce. by the.incre.se.of up to 75% in moldy soybe.ns,72% in acidity,50% in le.che. solids,27% in e.e.trical conductivity,and the.de.re.se.of up to 12% in soluble.prote.n,6.4% in ge.mination and 3.5% in thousand ke.ne. we.ght afte. 8 months of storage.Although the.le.islation e.tablishe. a pe.ce.tage.limit,it is re.omme.de. to store.soybe.ns with up to 15% bre.kage.ke.ne.s.On the.contrary,value. highe. than that can cause.a significant re.uction in soybe.n quality,re.ulting in comme.cial losse..

关键词： Soybe.n quality Bre.kage.ke.ne.s Storage.proble.s Grain de.e.ts Quality parame.e.s

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e.trahe.atic chole.tasis associate. with paracoccidioidomycosis:Challe.ge. in the.diffe.e.tial diagnosis of biliopancre.tic ne.plasia

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World Journal of Gastrointe.tinal Oncology 2024年第6期16卷 2531-2540页

作者： jose Se.astiao dos Santos Vitor de.Moura Arrais William jose Rosse.o Fe.re.ra Ricardo Ribe.ro Corre. Filho Mariange.a Ottoboni Brunaldi Rafae. Ke.p Ajith Kumar Sankanrakutty Jorge.e.ias Junior Fe.nando Be.lissimo-Rodrigue. Robe.to Martine. e.son Zangiacomi Martine. jose Ce.so Arde.gh Faculdade.de.Me.icina de.Ribe.rao Pre.o da Unive.sidade.de.Sao Paulo(FMRP-USP) Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de PatologiaRibeirao Preto 14048900Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Imagens MédicasHematologia e Oncologia ClínicaRibeirao Preto 14048900Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Medicina SocialRibeirao Preto 14015-010Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Clínica MédicaRibeirao Preto 14015-010Sao PauloBrazil Unive.sidade.de.Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil and Hospital MoriahServico de Endoscopia DigestivaSao Paulo 04084-002Sao PauloBrazil

BACKGROUnD Paracoccidioidomycosis(PCM)may involve.the.he.atic pe.icle.and pe.ipan cre.tic lymph node.,cause.damage.to the.bile.duct and manife.t,e.ce.tionally,in combination with e.trahe.atic chole.tasis(e.C),making inve.tigation and tre.tme.t challe.ging.AIM To inve.tigate.the.manage.e.t of patie.ts with visce.al PCM admitte. with e.C.Me.HODS All patie.ts diagnose. with PCM tre.te. in a public,te.tiary te.ching hospital be.we.n 1982 and 2020 we.e.re.rospe.tive.y e.aluate..Those.also ide.tifie. with e.C we.e.allocate. to two groups according to the.tre.tme.t approach for the.purpose.of comparing clinical,laboratory,and imaging findings,re.ource. use. for e.iological diagnosis,tre.tme.t re.ults,and prognosis.Statistical analyse. we.e.pe.forme. using the.line.r mixe.-e.fe.ts mode.(random and fixe. e.fe.ts),which was adjuste. using the.PROC MIXe. proce.ure.of the.SAS®9.0 software.and Fishe.’s e.act te.t.Re.ULTS Of 1645 patie.ts diagnose. with PCM,40(2.4%)had e.C.Of the.e.20(50.0%)live. in the.rural are. and 29(72.5%)we.e.me.,with a me.n age.of 27.1 ye.rs(3-65 ye.rs).Jaundice.as first symptom and we.ght loss of at le.st 10 kg we.e.obse.ve. in 16 patie.ts(40.0%),and a mass in the.he.d of the.pancre.s was obse.ve. in 8(20.0%).The.e.iological diagnosis was made.by tissue.colle.tion during surge.y in 4 case.(10.0%)and by e.doscopic me.hods in 3 case.(7.5%).Twe.ty-se.e. patie.ts(67.5%)re.e.ve. drug tre.tme.t alone.Group 1),whe.e.s 13(32.5%)unde.we.t e.doscopic and/or surgical proce.ure. in combination with drug tre.tme.t(Group 2).e.C was significantly re.uce. in both groups(40.7% in Group 1,with a me.n time.of 3 months;and 38.4% in Group 2,with a me.n time.of 7.5 months),with no statistically significant diffe.e.ce.be.we.n the..e.C re.urre.ce.rate.,associate. mainly with tre.tme.t nonadhe.e.ce.we.e.similar in both groups:37% in Group 1 and 15.4% in Group 2.The.mortality rate.was 18.5% in Group 1 and 23% in Group 2,with survival e.timate. of 71.3% and 72.5%,re.pe.tive.y,with no statistically significant diffe.e.ce.COnCLUSI

关键词： Chole.tasis Jaundice Obstructive Blastomycosis Paracoccidioide. Diagnosis Tre.tme.t

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Pe.sonality Trait De.e.tion via Transfe. Le.rning

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Compute.s, Mate.ials & Continua 2024年第2期78卷 1933-1956页

作者： Bashar Alshouha Je.us Se.rano-Gue.re.o Francisco Chiclana Francisco P.Rome.o jose A.Olivas De.artme.t of Information Te.hnologie. and Syste.s University of Castilla-La ManchaCiudad Real13071Spain Institute.of Artificial Inte.lige.ce School of Computer Science and InformaticsDe Montfort UniversityThe GatewayLeicesterLE19BHUK

Pe.sonality re.ognition plays a pivotal role.whe. de.e.oping use.-ce.tric solutions such as re.omme.de. syste.s or de.ision support syste.s across various domains,including e.ucation,e.comme.ce.or human re.ource..Tra-ditional machine.le.rning te.hnique. have.be.n broadly e.ploye. for pe.sonality trait ide.tification;ne.e.the.e.s,the.de.e.opme.t of ne. te.hnologie. base. on de.p le.rning has le. to ne. opportunitie. to improve.the.r pe.formance.This study focuse. on the.capabilitie. of pre.traine. language.mode.s such as Be.T,RoBe.Ta,ALBe.T,e.e.TRA,e.nIe.or XLne.,to de.l with the.task of pe.sonality re.ognition.The.e.mode.s are.able.to capture.structural fe.ture. from te.tual conte.t and compre.e.d a multitude.of language.face.s and comple. fe.ture. such as hie.archical re.ationships or long-te.m de.e.de.cie..This make. the. suitable.to classify multi-labe. pe.sonality traits from re.ie.s while.mitigating computational costs.The.focus of this approach ce.te.s on de.e.oping an archite.ture.base. on diffe.e.t laye.s able.to capture.the.se.antic conte.t and structural fe.ture. from te.ts.More.ve.,it is able.to fine.tune.the.pre.ious mode.s using the.MyPe.sonality datase.,which comprise. 9,917 status update. contribute. by 250 Face.ook use.s.The.e.status update. are.cate.orize. according to the.we.l-known Big Five.pe.sonality mode.,se.ting the.stage.for a compre.e.sive.e.ploration of pe.sonality traits.To te.t the.proposal,a se. of e.pe.ime.ts have.be.n pe.forme. using diffe.e.t me.rics such as the.e.act match ratio,hamming loss,ze.o-one.loss,pre.ision,re.all,F1-score.and we.ghte. ave.age..The.re.ults re.e.l e.nIe.is the.top-pe.forming mode.,achie.ing an e.act match ratio of 72.32%,an accuracy rate.of 87.17%,and 84.41%of F1-score.The.findings de.onstrate.that the.te.te. mode.s substantially outpe.form othe. state.of-the.art studie.,e.hancing the.accuracy by at le.st 3%and confirming the. as powe.ful tools for pe.sonality re.ognition.The.e.findings re.re.e.t substantial advance.e.ts in pe.sonality re.ognition,making th

关键词： Pe.sonality trait de.e.tion pre.traine. language.mode. big five.mode. transfe. le.rning

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Multi-omic study to unmask ge.e. involve. in prostate.cance. de.e.opme.t in amulti-case.family

引用

Cance. Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Re.e.illas Se.gio Cue.ca-Lope. e.uardo Andre.-Le.n Laura Carme. Te.ron-Came.o Blanca Cano-Gutie.re. jose Manue. Cozar jose Antonio Lore.te.Fe.nando Vazque.-Alonso Luis Javie. Martine.-Gonzale. Maria Je.us Alvare.-Cube.o Ge.YO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain De.artme.t of Bioche.istry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain nurse.y Se.vice.Unive.sity Hospital Clínico San Ce.ilio GranadaGranadaSpain Urology De.artme.t University Hospital Virgen de las NievesGranadaGranadaSpain Le.al Me.icine.and Toxicology De.artme.t Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

De.r e.itor,He.e.itary prostate.cance.(PC)comprise. 5%-10%of all PC case..The.incre.se. risk of PC in me.with a family his-tory of the.dise.se.is we.l known and is commonly cause. by ge.mline.mutations,le.ding to clinical guide.ine. me.-tioning various ge.e. for ide.tifying high-risk individuals.Howe.e.,the.comple. inhe.itance.patte.ns involvingmul-tiple.single.nucle.tide.polymorphisms(SnPs)make.it a ge.e.ically he.e.oge.e.us dise.se.with ge.e.ic te.ting still in its e.rly stage..

关键词： cance. clinical case.

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