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Journal of Animal Science and Biotechnology 2017年第2期8卷 391-404页

作者： Sandra J.A.van Kuijk josé c.del río Jorge rencoret Ana Gutiérrez Anton S.M.Sonnenberg Johan J.P.Baars Wouter H.Hendriks John W.cone Animal Nutrition Group Wageningen UniversityDe Elst 16708 WD WageningenThe Netherlands Instituto de recursos Naturales y Agrobiologica de Sevilla(IrNAS-cSIc) Avenida Reina Mercedes1042012 SevilleSpain Plant Breeding Wageningen UniversityDroevendaalsesteeg 16708 PB WageningenThe Netherlands

Background： The present work investigated the influence of lignin content and composition in the fungal treatment of lignocellulosic biomass in order to improve rumen degradability. Wheat straw and wood chips,differing in lignin composition, were treated with Lentinula edodes for 0, 2, 4, 8 and 12 wk and the changes occurring during fungal degradation were analyzed using pyrolysis-gas chromatography-mass spectrometry and detergent fiber ***： L. edodes preferentially degraded lignin, with only limited cellulose degradation, in wheat straw and wood chips, leaving a substrate enriched in cellulose. Syringyl（S）-lignin units were preferentially degraded than guaiacyl（G）-lignin units, resulting in a decreased S/G ratio. A decreasing S/G ratio（wheat straw： r =-0.72, wood chips： r =-0.75） and selective lignin degradation（wheat straw： r =-0.69, wood chips： r =-0.88） were correlated with in vitro gas production（IVGP）, a good indicator for rumen ***： L. edodes treatment increased the IVGP of wheat straw and wood chips. Effects on IVGP were similar for wheat straw and wood chips indicating that lignin content and 3D-structure of cell walls influence in vitro rumen degradability more than lignin composition.

关键词： Fungal treatment In vitro rumen degradability Lignocellulosic biomass Py-Gc/MS

Plant peroxisomes at the crossroad of No and H2o2 metabolism

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Journal of Integrative Plant Biology 2019年第7期61卷 803-816页

作者： Francisco J.corpas Luis A.del río josé M.Palma Group of Antioxidants Free Radicals and Nitric Oxide in Biotechnology Food and Agriculture Department of Biochemistry Cell and Molecular Biology of Plants Estación Experimental del Zaidín CSIC

Plant peroxisomes are subcellular compartments involved in many biochemical pathways during the life cycle of a plant but also in the mechanism of response against adverse environmental *** organelles have an active nitro-oxidative metabolism under physiological conditions but this could be exacerbated under stress ***,peroxisomes have the capacity to proliferateand also undergo biochemical adaptations depending on the surrounding cellular *** important characteristic of peroxisomes is that they have a dynamic metabolism of reactive nitrogen and oxygen species(rNS and roS)which generates two key molecules,nitric oxide(No)and hydrogen peroxide(H2o2).These molecules can exert signaling functions by means of post-translational modifications that affect the functionality of target molecules like proteins,peptides or fatty *** review provides an overview of the endogenous metabolism of roS and rNS in peroxisomes with special emphasis on polyamine and uric acid metabolism as well as the possibility that these organelles could be a source of signal molecules involved in the functional interconnection with other subcellular compartments.

关键词： Plant peroxisomes No H2o2 metabolism

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLrP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural regeneration research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues carla Perpiñá-clérigues Francisco García-García Victoria Moreno-Manzano consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

our previous studies have reported that activation of the NLrP3(NoD-,Lrr-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSc-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLrP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLrP3 inflammasome complex and other NLrs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and c–X3–c motif chemokine ligand 1)and mirNAs(mir-21a-5p,mir-146a-5p,and mir-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of mir-21a-5p and mir-146a-5p with inflammatory target genes and NoD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSc-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLrP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NoD-,Lrr-and pyrin domain-containing protein 3(NLrP3)

NASH EQUILIBrIA WITHoUT coNTINUITY oF THE cHoIcE rULES

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Acta Mathematica Scientia 2011年第4期31卷 1535-1540页

作者： josé c. r. Alcantud Facultad de Economía y Empresa Universidad de Salamanca Campus Miguel de Unamuno E 37007 Salamanca

The proposal in Alcantud and Alo′s-Ferrer [1], where players that express their tastes according to choice rules facing a competitive situation, is further exploited here. We prove that, under lack of continuity of the choice rules it is also possible to ensure the existence of equilibrium. We shall appeal to general situations that are fulfilled by well-established models, where players have non-transitive preferences of various types.

关键词： Nash equilibrium choice rules continuity Kakutani’s theorem

Steatosis and insulin resistance in hepatitis c: A way out for the virus?

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World Journal of Gastroenterology 2009年第40期15卷 5014-5019页

作者： josé A del campo Manuel romero-Gómez Unit for The clinical Management of Digestive Diseases and cIBErehd Hospital Universitario de Valme

The hepatitis c virus (HcV) induces lipid accumulation in vitro and in vivo. The pathogenesis of steatosis is due to both viral and host factors. Viral steatosis is mostly reported in patients with genotype 3a, whereas meta-bolic steatosis is often associated with genotype 1 and metabolic syndrome. Several molecular mechanisms responsible for steatosis have been associated with the HcV core protein, which is able to induce gene expres-sion and activity of sterol regulatory element binding protein 1 (SrEBP1) and peroxisome proliferator-activat-ed receptor γ (PPArγ), increasing the transcription of genes involved in hepatic fatty acid synthesis. Steatosis has been also implicated in viral replication. In infected cells, HcV core protein is targeted to lipid droplets which serve as intracellular storage organelles. These studies have shown that lipid droplets are essential for virus assembly. Thus, HcV promotes steatosis as an eff icient mechanism for stable viral replication. chronic HcV in-fection can also induce insulin resistance. In patients with HcV, insulin resistance is more strongly associated with viral load than visceral obesity. HcV seems to lead to insulin resistance through interference of intracellular insulin signalling by HcV proteins, mainly, the serine phosphorylation of insulin receptor-1 (IrS-1) and im-pairment of the downstream Akt signalling pathway. The HcV core protein interferes with in vitro insulin signal-ling by genotype-specif ic mechanisms, where the role of suppressor of cytokine signal 7 (SocS-7) in genotype 3aand mammalian target of rapamycin (mTor) in geno-type 1 in IrS-1 downregulation play key roles. Steatosis and insulin resistance have been associated with f ibrosis progression and a reduced rate of sustained response to peginterferon plus ribavirin.

关键词： Steatosis Insulin resistance Hepatitis cvirus

Modulation of host lipid metabolism by hepatitis c virus: role of new therapies

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World Journal of Gastroenterology 2015年第38期21卷 10776-10782页

作者： josé A del campo Manuel romero-Gómez Digestive Diseases and cIBErehd Valme University Hospital

It is well established that hepatitis c virus(HcV) infection and replication relies on host lipid metabolism. HcV proteins interact and associate with lipid droplets to facilitate virion assembly and production. Besides,circulating infective particles are associated with verylow-density lipoprotein. on the other hand,higher serum lipid levels have been associated with sustained viral response to pegylated interferon and ribavirin therapy in chronic HcV infection,suggesting a relevant role in viral clearance for host proteins. Host and viral genetic factors play an essential role in chronic infection. Lipid metabolism is hijacked by viral infection and could determine the success of viral replication. recently development of direct acting antiviral agents has shown a very high efficacy(> 90%) in sustained viral response rates even for cirrhotic patients and most of the viral genotypes. HcV rNA clearance induced by Sofosbuvir has been associated with an increased concentration and size of the low-density lipoprotein particles. In this review,host genetic factors,viral factors and the interaction between them will be depicted to clarify the major issues involved in viral infection and lipid metabolism.

关键词： Hepatitis c virus Lipid metabolism Direct acting a

recent Advances on Early-Stage Fire-Warning Systems: Mechanism, Performance, and Perspective

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Nano-Micro Letters 2022年第12期14卷 106-136页

作者： Xiaolu Li Antonio Vazquez-Lopez jose Sanchez del rio Saez De-Yi Wang IMDEA Materials Institute C/Eric Kandel228906 GetafeMadridSpain E.T.S.de Ingenieros de caminos Universidad Politecnica de MadridCalle Profesor Aranguren 328040 MadridSpain Departamento de Ingenieria Electrica Electronica Automatica y Fisica AplicadaETSIDIUniversidad Politecnica de MadridRonda de Valencia 328012 MadridSpain

Early-stage fire-warning systems(EFWSs)have attracted significant attention owing to their superiority in detecting fire situations occurring in the pre-combustion *** progress on EFWSs has been achieved recently,and they have presented a considerable possibility for more evacuation time to control constant unintentional fire hazards in our daily *** review mainly makes a comprehensive summary of the current EFWSs,including the working mechanisms and their *** to the different working mechanisms,fire alarms can be classified into graphene oxide-based fire alarms,semiconductor-based fire alarms,thermoelectric-based fire alarms,and fire alarms on other working ***,the challenge and prospect for EFWSs are briefly provided by comparing the art of state of fire *** work can propose a more comprehensive understanding of EFWSs and a guideline for the cutting-edge development direction of EFWSs for readers.

关键词： Smart thermosensitive fire sensors Working mechanism response time Signal conversion

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural regeneration research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-ortega Mar Pérez joséMcabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHcII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Ultrastructural analysis of the loss of desiccation tolerance in germinating Eremanthus erythropappus seeds

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Journal of Forestry research 2019年第4期30卷 1331-1336页

作者： rayana S.Martins Anderson c.josé josé Marcio r.Faria Wilson V.S.Pereira Department of Forest Sciences Federal University of Lavras(UFLA)

Eremanthus erythropappus(Dc.)MacLeish is an important forest species native to the Brazilian savanna biome,an environment with well-defined rainy and dry *** seeds are desiccation tolerant,non-dormant and dispersed at the end of dry *** exposes them to the first sporadic rains that can trigger germination but the subsequent dry days can compromise survival of the newly germinated *** study evaluates if the damages caused by drying of germinating *** seeds,at the stage when they have lost desiccation tolerance,are *** percentage of normal seedlings was evaluated when seeds with different imbibition times were dried to their initial water content and then pre-humidified and *** tolerance was fully lost after 0.5 mm of hypocotyl-radicle protrusion(approximately 72 h)when the radicle had root hairs,a possible indicator of sensitivity to *** of cell contents and ultrastructural damage to the seeds subjected to drying were observed by electron scanning *** hairs disappeared after drying,reappearing after pre-humidification,possibly an attempt to increase the surface area of the radicle for water ***,the hypocotylradicle axis became darkened,probably by antioxidant system failure,causing seed death.

关键词： candeia Drying Desiccation tolerant seeds rehydration Scanning electron microscopy

Asterohyptis stellulata: Phytochemistry and wound healing activity

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Food Bioscience 2022年第6期50卷 2067-2076页

作者： Nallely Álvarez-Santos Edgar Antonio Estrella-Parra josé del carmen Benítez-Flores rocío Serrano-Parrales Tomás Ernesto Villamar-Duque Martha Angelica Santiago-Santiago María del rosario González-Valle josé Guillermo Avila-Acevedo Ana María García-Bores Phytochemistry Laboratory UBIPROSuperior Studies Faculty (FES)-IztacalaNational Autonomous University of Mexico (UNAM)Tlalnepantla de BazMexico State54090Mexico Postgraduate Biological Sciences Postgraduate Studies UnitNational Autonomous University of Mexico (UNAM)CoyoacanMexico City04510Mexico Histology Laboratory 1 UMFSuperior Studies Faculty (FES)-IztacalaNational Autonomous University of Mexico (UNAM)Tlalnepantla de BazMexico State54090Mexico Natural Products Bioactivity Laboratory UBIPROSuperior Studies Faculty (FES)-IztacalaNational Autonomous University of Mexico (UNAM)Tlalnepantla de BazMexico State54090Mexico Bioterium Superior Studies Faculty (FES)-IztacalaNational Autonomous University of Mexico (UNAM)Tlalnepantla de BazMexico State54090Mexico Plant Physiology Laboratory UBIPROFES-IztacalaUNAMTlalnepantla de BazMexico State54090Mexico

Wound healing is a fast and efficient process. However, several factors can inhibit healing, causing scars and chronic wounds. This affects patients in their physical integrity, economic and emotional stability. Many plants that are used in wound healing treatment have antioxidant/anti-inflammatory activity through roS regulation and antibacterial activity. Asterohyptis stellulata is used for wound treatment. Nonetheless, this activity has not been evaluated and its secondary metabolites are unknown. Therefore, the objective of this study was to analyze its phytochemical composition and evaluate the healing activity of A. stellulata. For the identification of secondary metabolites, the following were carried out: phytochemical screening, quantification of total phenols, and HPLc/MS analysis. The antibacterial and antioxidant activities were also determined. Next, to evaluate the healing activity of topical application of A. stellulata, the extract was mixed with the Beeler base to form an emulsion and an irritability test was performed. The emulsion was evaluated on incisional wounds of cD1 et/et mice, with tests of tensile strength, total re-epithelialization time, wound closure speed, and histological analysis. The phytochemical analysis showed that A. stellulata has phenolic compounds, two quercetin derivatives and a glycoside rosmarinic acid as main compounds. The extract exhibited medium antibacterial and antioxidant activities. A. stellulata emulsion was non-irritating, promoted closure speed of wound (1.479 ± 0.043 mm/day), increased tensile strength (980 ± 89.44 g), and histological analysis showed it promoted mice skin regeneration, compared to the controls (recoveron® and Beeler base). This study confirms the traditional use of the A. stellulata.

关键词： Asterohyptis stellulata Phytochemistry Skin regeneration Wound healing