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Role of platelets and breast cancer stem cells in metastasis

World Journal of Stem Cells 2020年第11期12卷 1237-1254页

作者： Gretel Mendoza-Almanza Luis Burciaga-Hernandez Vilma Maldonado jorge Melendez-Zajgla jorge Olmos CONACYT Universidad Autónoma de Zacatecas.Zacatecas 98060Mexico Maestría en Ciencias Biomédicas Universidad Autónoma de ZacatecasZacatecas 98160Mexico Laboratorio de Epigenética Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Génómica funcional del cáncer Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Biotecnología Marina Centro de Investigación Científica y de Estudios Superiores de EnsenadaEnsenada 22860Mexico

The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer cells,resistance to chemotherapy and radiotherapy,and tumor regression *** recent years,it has been shown that the presence of breast cancer stem cells is closely associated with the migration and metastatic ability of cancer cells,as well as with their resistance to chemotherapy and *** tumor microenvironment is one of the main molecular factors involved in cancer and metastatic processes development,in this sense it is interesting to study the role of platelets,one of the main communicator cells in the human body which are activated by the signals they receive from the microenvironment and can generate more than one *** can ingest and release RNA,proteins,cytokines and growth *** the platelets interact with the tumor microenvironment,they are called"tumor-educated platelets."Tumor-educated platelets transport material from the tumor microenvironment to sites adjacent to the tumor,thus helping to create microenvironments conducive for the development of primary and metastatic *** has been observed that the clone capable of carrying out the metastatic process is a cancer cell with stem cell *** stem cells go through a series of processes,including epithelial-mesenchymal transition,intravasation into blood vessels,movement through blood vessels,extravasation at the site of the establishment of a metastatic focus,and site ***-educated platelets support all these processes.

关键词： Breast cancer stem cells Platelets Metastasis Tumor microenvironment Epithelial-mesenchymal transition

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Pairs of integers which are mutually squares

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Science China Mathematics 2017年第9期60卷 1633-1646页

作者： CHAKRABORTY Kalyan JIMENEZ URROZ jorge PAPPALARDI Francesco Department of Mathematics Harish Chandra Research InstituteAllahabad 211019India Department of Mathemdticas Universidad Politecnica de CatalunyaBarcelona 08034Spain Dipartimento di Matematica Universith Roma TreRoma 1-00146Italy

We derived an asymptotic formula for the number of pairs of integers which are mutually squares. Earlier results dealt with pairs of integers subject to the restriction that they are both odd, co-prime and squarefree. Here we remove all these restrictions and prove （similar to the best known one with restrictions） cx2/log X with an absolute constant c that the number of such pair of integers upto a large real X is asymptotic to which we give explicitly. Our error term is also compatible to the best known one.

关键词： quadratic reciprocity mutually squares Jacobi symbol

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Portugal's first major forensic case and the genesis of forensic toxicology:10 years of research to reconstruct the event

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Forensic Sciences Research 2019年第1期4卷 69-81页

作者： Ricardo jorge Dinis-Oliveira Department of Sciences IINFACTS–Institute of Research and Advanced Training in Health Sciences and TechnologiesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal UCIBIO-REQUIMTE Laboratory of ToxicologyDepartment of Biological SciencesFaculty of PharmacyUniversity of PortoPortoPortugal Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal

The"Crime of Flores Street"is one of the most famous cases of poisoning to divide public opinion in Portugal in the late 19th century, and it also demonstrated the weaknesses of the Portuguese medicolegal system and attested to the importance of toxicological analysis. Vicente Urbino de Freitas was a prominent doctor, graduating from the Faculty of Medicine of the University of Coimbra in 1875. He later became Professor of Physiology at the Porto Medical-Surgical School and author of a number of books on leprosy. In 1877, he married Maria das Dores Basto Sampaio Freitas, and this was followed by the death of a number of her close relatives in suspicious circumstances, notably her brother José António Sampaio Junior and nephew Mário Guilherme Augusto de Sampaio. This review aims to retell the story of Portugal's first significant medicolegal case as well as the accompanying judicial drama that gave birth to Forensic Toxicology in Portugal and prompted the medicolegal organization that exists today. This research was carried out over a 10-year period and repre-sents undeniable historical value given the rarity of the facts compiled. At the heart of this forensic case was the use of toxicological analyses in court for which the Chemist Antònio Joaquim Ferreira da Silva played a key role. This toxicological report revealed high concen-trations of morphine, delphinine and narceine in viscera and in Mario's urine. The Mario's cause of death was attributed to poisoning by opium alkaloids. Despite the strong judicial evidence, doubts still remains as to whether Vicente Urbino de Freitas was a"monster"or a victim of circumstances and a hapless martyr.

关键词： Forensic sciences forensic toxicology Vicente Urbino de Freitas António Joaquim Ferreira da Silva Medical-Surgical School Mário Guilherme Augusto de Sampaio

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Evaluating Oblique Shock Waves Characteristics on a Double-Wedge Airfoil

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Engineering（科研） 2016年第12期8卷 862-871页

作者： jorge Luis Garrido Tellez Eusebio Hernandez-Martinez Miguel Toledo velazquez Jose Angel Ortega Herrera Pedro Quinto-Diez Instituto Politecnico Nacional SEPI ESIME Ticoman Ciudad de Mexico Mexico Instituto Politecnico Nacional SEPI ESIME Zacatenco Ciudad de Mexico Mexico

Numerical and experimental study to evaluate aerodynamic characteristics in supersonic ow over a double wedge airfoil is carried out using Fluent software and a supersonic wind tunnel, respectively. The Schlieren visualization method was also used to develop the experimental step of this study. The supersonic wind tunnel reached a proximately a Mach number of 1.8. The result got showed oblique shock waves visualization on double-wedge airfoil and the numerical simulation, the flow behavior as function of Mach number, pressure, temperature and density in the flow field on the computational model. The simulation allowed to observe the shock wave and the expansion fan in the leading and tailing edge of double-wedge airfoil. From the numerical and experimental comparison, an agreement at the shock wave angle and Mach number was observed, with a difference about 1.17% from the experimental results.

关键词： Oblique Shock Waves Supersonic Airfoil Flow Visualization Numerical Simulation Schlieren Method

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An Input–Output Ex Ante Regional Model to Assess the Short-Term Net Effects of the 16 April 2016 Earthquake in Ecuador

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International Journal of Disaster Risk Science 2021年第4期12卷 510-527页

作者： jorge Salgado JoséRamírez-Álvarez Diego Mancheno Faculty of Economics Pontificia Universidad Católica del Ecuador17012184QuitoPichinchaEcuador

The 16 April 2016 earthquake in Ecuador exposed the significant weaknesses concerning the methodological designs to compute—from an economic standpoint—the consequences of a natural hazard-related disaster for productive exchanges and the accumulation of capital in *** study addressed one of these challenges with an innovative ex ante model to measure the partial and net short-term effects of a natural hazard-related catastrophe from an interregional perspective,with the 16 April 2016 earthquake serving as a case *** general,the specified and estimated model follows the approach of the extended Miyazawa model,which endogenizes consumption demand in a standard input–output model with the subnational interrelations and resulting *** to the country’s limitations in its regional account records the input–output matrices for each province of Ecuador had to be estimated,which then allowed transactions carried out between any two sectors within or outside a given province to be identified by means of the RAS *** estimations provide evidence that the net short-term impact on the national accounts was not significant,and under some of the simulated scenarios,based on the official information with respect to earthquake management,the impact may even have had a positive effect on the growth of the national product during 2016.

关键词： Earthquake impact Ecuador Input–output RAS method Regional model

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The technical and the social:challenges in the conservation of earthen vernacular architecture in a changing world(Jujuy,Argentina)

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Built Heritage 2021年第3期5卷 36-48页

作者： jorge Tomasi Julieta Barada CONICET‑Laboratorio de Arquitecturas Andinas y Construcción con Tierra Instituto de Investigaciones sobre la Naturaleza y la Cultura“Rodolfo Kusch”Universidad Nacional de JujuyRivadavia 642TilcaraProvincia de JujuyArgentina

Vernacular earthen architecture presents a series of relevant conservation challenges that involve designing solutions for diferent kinds of alterations and *** challenges of a social nature simultaneously arise and are related,among other factors,to the participation of local communities and the actions of diferent institutional *** these phenomena has generally been approached from perspectives that take technical considera‑tions and social dynamics as separate *** current global context has resulted in an acceleration of changes in these dynamics,in terms of both techniques and management models,giving rise to the need to develop compre‑hensive conceptual and methodological approaches through which these challenges should be addressed jointly by recombining the technical and the *** paper will analyse the main problems afecting vernacular architectures in three communities in northern Argentina,where earthen techniques have been very *** will refect on various potentially useful theoretical frameworks,incorporating concepts from the anthropology of technology and methodological approaches from an ethnography of conservation as a way to work with multiple ontologies.

关键词： Heritage ethnography Vernacular architecture Anthropology of techniques

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Electrochemical Multicomponent Cascade Radical Process Enabling Synthesis of lodomethyl Spiropyrrolidinyl-Oxindoles

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Chinese Journal of Chemistry 2024年第15期42卷 1691-1698页

作者： Jingrui He Haibo Mei jorge Escorihuela Jianlin Han Jiangsu Co-lnnovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjingForestryUniversityNanjingJiangsu210037China Departamento de Quimica Organica Universitat de ValenciaAvda.Vicente Andres Estelles s/nBurjassot 46100ValenciaSpain

A novel electrochemical multicomponent cascade reaction of indole-tethered alkenes with CF_(3)SO_(2)Na and n-BuaNI has been developed,which enables the rapid assembly of spiropyrrolidinyl-oxindoles in good *** experimental results and DFT calculations suggest that this reaction proceeds through the oxidation of CF_(3)SO_(2)Na,radical coupling with alkene,spirocyclization,oxidation of sulfinate,iodide substitution,and water *** strategy features mild reaction conditions,easy-to-handle reactants,and good chemical *** finding not only enriches the research contents of indole-tethered alkenes but also provides a green strategy for the construction of spiropyrrolidinyl-oxindoles compared with the existing methodologies.

关键词： Spiropyrrolidinyl-oxindoles Electrosynthesis Indole-tethered alkenes CF_(3)SO_(2)Na DFT calculation Multicomponent reaction Radical reactions Cross-Coupling Greenchemistry

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Influence of a non-rotating shoulder on heat generation,microstructure and mechanical properties of dissimilar AA2024/AA7050 FSW joints

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Journal of Materials Science & Technology 2018年第1期34卷 119-127页

作者： Alessandro Barbini Jan Carstensen jorge F.dos Santos Helmholtz-Zentrum Geesthacht Institute of Materials Research Materials Mechanics Solid-State Joining Processes (WMP)

Friction stir welding （FSW） and stationary shoulder friction stir welding （SSFSW） were carried out for the butt joining of dissimilar AA2024-T3 and AA7050-T7651 aluminium alloys with thicknesses of 2 mm. A comparison between the two processes was performed by varying the welding speed while keeping the rotational speed constant, Through the analysis of the force and torque produced during welding and a simple analytical model, it was possible to show that in SSFSW there is more effective coupling with the tool and the heat produced is more efficiently distributed. This process decreases both the welding area and the diffusion at the interface of the two alloys compared with FSW. The minimum microhardness occurred at the advancing side （AS） at the interface between the thermo-mechanically affected zone （TMAZ） and the stir zone （SZ） in both processes, although the decrease was more gradual in SSFSW. This interface is also where all specimens failed for both welding technologies. An increase in tensile strength was measured in SSFSW compared with standard FSW. Furthermore, it was possible to establish the mechanical performance of the material in the fracture zone using digital image correlation.

关键词： Stationary shoulder friction stir welding Friction stir welding Dissimilar welded joints Process analysis Microstructure analysis Mechanical behaviour

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Corneal collagen cross‑linking epithelium‑on ***‑off:a systematic review and meta‑analysis

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Eye and Vision 2021年第6期8卷 338-352页

作者： Francesco D’Oria Antonio Palazón jorge L.Alio Vissum Innovation c/Cabañal103016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain

Background:The purpose of the study was to determine the advantages and disadvantages of epi-on corneal crosslinking(CXL)techniques compared with standard epi-off ***:We searched MEDLINE and EMBASE for randomized controlled trials(RCTs)and non-randomized studies of interventions(NRSIs)and we evaluated the selected papers according to the Cochrane risk of bias *** considered,as primary outcomes,average Kmax flattening,changes in uncorrected and corrected distance visual acuity(UDVA and CDVA);as secondary outcomes,we considered changes in pachymetry values and endothelial cell density(ECD).We also investigated adverse events related to the treatments and treatment ***-analysis was conducted with a fixed or random-effects model using weighted mean difference(MD)with 95%confidence interval(CI)as the effect ***:A total of 15 studies were included and among these 15 trials,9 were RCTs and 6 were NRSIs,but only 4 studies showed no high risk of bias and were included in this *** analysis revealed significant postoperative differences in CDVA(MD=0.07;95%CI 0.04 to 0.10;P0.05).Epi-on CXL protocol was found to be significantly less prompt to have risks of delay in epithelial healing(P=0.035)and persistent stromal haze(P=0.026).Conclusion:Epi-on CXL is as effective as epi-off *** for a higher significant improvement in CDVA with current epi-on protocols,our meta-analysis demonstrates that epi-on and epi-off CXL have comparable effects on visual,topographic,pachymetric,and endothelial ***-on CXL has clinical advantages in terms of comfort and avoidance of complications as it reduces the risk of developing delay in epithelial healing and persistent stromal haze.

关键词： Corneal collagen cross-linking Keratoconus Transepithelial CXL Epithelium-off CXL Epithelium-on CXL Iontophoresis

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Patients’dissatisfaction with multifocal intraocular lenses managed by exchange with other multifocal lenses of diferent optical profles

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Eye and Vision 2024年第1期10卷 31-40页

作者： Olena Al‑Shymali Colm McAlinden jorge L.Alio del Barrio Mario Canto‑Cerdan jorge L.Alio Research&Development Department VISSUM Innovation and Department of Cornea Cataract and Refractive SurgeryVISSUM CorporationAlicanteSpain Department of Ophthalmology Singleton HospitalSwansea Bay University Health BoardSwanseaUK Division of Ophthalmology School of MedicineVISSUM AlicanteUniversidad Miguel HernándezCalle Cabañal 103016 AlicanteSpain Cornea Cataract and Refractive Surgery DepartmentVISSUM CorporationAlicanteSpain

Background:The aim of the study was to evaluate the outcomes of dissatisfed patients reporting poor visual quality following implantation of multifocal intraocular lenses(MF-IOLs),managed by IOL exchange with another multifocal optical ***:This is a retrospective series of ***-IOL exchange was done in 15 dissatisfed patients(30 eyes)with the perception of poor visual quality for far distance afected by neuroadaptation *** underwent a bilateral exchange of a MF-IOL with another MF-IOL of a diferent optical *** outcomes and complications were *** including Quality of Vision(QoV),Visual Function Index-14(VF-14)and its Rasch-revised version(VF-8R)and a satisfaction questionnaire were also used for outcome ***:The mean elapsed time from implantation to explantation-reimplantation was 11.8 *** QoV scores improved signifcantly across all the three *** function improved with a change in VF-14 score from 60.41±24.81 to 90.16±10.91(P<0.001).The VF-8R score improved as *** uncorrected distance visual acuity improved from 0.24 to 0.12 logMAR after exchange(P<0.001)and corrected distance visual acuity improved from 0.15 to 0.04 logMAR(P<0.001).Safety and efcacy indexes reached 1.46 and 1.16,*** patients’satisfaction following MF-IOL exchange,80%of the patients reported they would have the MF-IOL reimplantation procedure ***:Patient dissatisfaction with neuroadaptation failure following MF-IOL implantation can be managed in 80%of our cases by MF-IOL exchange with a diferent MF-IOL optical profle.

关键词： Multifocal intraocular lenses IOL exchange Visual acuity Neuroadaptation failure

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