Role of platelets and breast cancer stem cells in metastasis

作     者：Gretel Mendoza-Almanza Luis Burciaga-Hernandez Vilma Maldonado Jorge Melendez-Zajgla Jorge Olmos 

作者机构：CONACYTUniversidad Autónoma de Zacatecas.Zacatecas 98060Mexico Maestría en Ciencias BiomédicasUniversidad Autónoma de ZacatecasZacatecas 98160Mexico Laboratorio de EpigenéticaInstituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Génómica funcional del cáncerInstituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Biotecnología MarinaCentro de Investigación Científica y de Estudios Superiores de EnsenadaEnsenada 22860Mexico 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第11期

页      面：1237-1254页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Breast cancer stem cells Platelets Metastasis Tumor microenvironment Epithelial-mesenchymal transition 

摘      要：The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer cells,resistance to chemotherapy and radiotherapy,and tumor regression *** recent years,it has been shown that the presence of breast cancer stem cells is closely associated with the migration and metastatic ability of cancer cells,as well as with their resistance to chemotherapy and *** tumor microenvironment is one of the main molecular factors involved in cancer and metastatic processes development,in this sense it is interesting to study the role of platelets,one of the main communicator cells in the human body which are activated by the signals they receive from the microenvironment and can generate more than one *** can ingest and release RNA,proteins,cytokines and growth *** the platelets interact with the tumor microenvironment,they are calledtumor-educated platelets.Tumor-educated platelets transport material from the tumor microenvironment to sites adjacent to the tumor,thus helping to create microenvironments conducive for the development of primary and metastatic *** has been observed that the clone capable of carrying out the metastatic process is a cancer cell with stem cell *** stem cells go through a series of processes,including epithelial-mesenchymal transition,intravasation into blood vessels,movement through blood vessels,extravasation at the site of the establishment of a metastatic focus,and site ***-educated platelets support all these processes.