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中医杂志:英文版 2023年第4期43卷 686-694页

作者： Dong-Wook Kang Jae-Gyun Choi Hee Ju song Jaehyuk Kim Miae Lee Taehee Kim suk-Yun Kang Yeonhee Ryu Hwa Seung Yoo Jin Sun Lee Jin Bong Park Sang Do Lee Hyun-Woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

Multiple malignant extragastrointestinal stromal tumors of the greater omentum and results of immunohistochemistry and mutation analysis:A case report

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World Journal of Gastroenterology 2007年第24期13卷 3392-3395页

作者： jong-Han Kim Yoon-Jung Boo Cheol-Woong Jung Sung-Soo Park Seung-Joo Kim Young-Jae Mok Sang-Dae Kim Yang-suk Chae Chong-suk Kim Kim Korea University Hospital Seoul 136-705 Korea Deparment of Surgery Pathology KoreaUniversity College of medicine Seoul 136-705 Korea

To report an extragastrointestinal stromal tumor （EGIST） that occurs outside the gastrointestinal tract and shows unique clinicopathologic and immunohistochemical features. In our case, we experienced multiple soft tissue tumors that originate primarily in the greater omentum, and in immunohistochemical analysis, the tumors showed features that correspond to malignant EGIST. Two large omental masses measured 15 cm×10 cm and 5 cm×4 cm sized and several small ovoid fragments were attached to small intestine, mesentery and peritoneum. On histologic findings, the masses were separated from small bowel serosa and had high mitotic count （115/50 HPFs）. In the results of immunohistochemical stains, the tumor showed CDl17 （c-kit） positive reactivity and high Ki-67 labeling index. On mutation analysis, the c-kit gene mutation was found in the juxtamembrane domain （exon 11）and it was heterozygote. Platelet-derived growth factor receptor （PDGFR） gene mutation was also found in the juxtamemembrane （exon 12） and it was polymorphism. From above findings, we proposed that there may be several mutational pathways to malignant EGIST, so further investigations could be needed to approach this unfavorable disease entity.

关键词： Extragastrointestinal stromal tumor Greater omentum c-kit Platelet-derived growth factor receptor Mutation

Transarterial chemoembolization in Barcelona Clinic Liver Cancer Stage 0/A hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第3期20卷 745-754页

作者： Heung Cheol Kim Ki Tae suk Dong Joon Kim Jai Hoon Yoon Yeon Soo Kim Gwang Ho Baik Jin Bong Kim Chang Hoon Kim Hotaik Sung jong Young Choi Kwang Hyub Han Seung Ha Park Department of Radiology Hallym University College of Medicine Department of Internal Medicine Hallym University College of Medicine College of Medicine Upstate Medical UniversityState University of New York Department of Biology Stanford University Department of Internal Medicine Catholic University College of Medicine Liver Cirrhosis Clinical Research Center Yonsei University College of Medicine Department of Internal Medicine Inje University College of Medicine

AIM: To evaluate the clinical characteristics of patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 and A hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).

关键词： Carcinoma Hepatocellular Chemoembolization Therapeutic Survival Stage Efficacy

Tuning the inhomogeneous charge transport in ZnO interfaces for ultrahigh on/off ratio top-gated field-effect-transistor arrays

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Nano Research 2020年第11期13卷 3033-3040页

作者： Thanh Luan Phan Dinh Loc Duong Tuan Khanh Chau Sidi Fan Won Tae Kang Thi Suong Le Hyun Yong song Linfeng Sun Van Tu Vu Min Ji Lee Quoc An Vu Young Hee Lee Woo jong Yu Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Center for Integrated Nanostructure Physics(CINAP) Institute for Basic Science(IBS)Suwon16419Republic of Korea Department of Energy Science Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Physics Sungkyunkwan UniversitySuwon16419Republic of Korea

The interface between oxide/oxide layers shows an inhomogeneous charge transport behavior,which reveals a high conductivity owing to *** typical example is the hetero-interface between ZnO film and other wide band gap oxides(e.g.,Al_(2)O_(3),TiO_(2),and HfO_(2)).It is thus quite evident that the ZnO/other oxides hetero-interface contains high density electron carriers effectively screening the gate-induced electric ***,an extremely weak gate modulation in ZnO film was showed,resulting in very low on/off ratio of 1.69 in top-gate field-effect-transistor(TG-FET)***,to extend the usage of ZnO TG-FET is not quite possible toward further practical ***,we clarified the correlation of inhomogeneous region in oxide/oxide hetero-junction by systematically *** work suggests that a self-assembly of molecules(SAM)buffer layer is suitable for tuning the inhomogeneous charge transport in ZnO film,which not only reduces the interface trap density,but also effectively enhances the gate electric field modulation at the *** further report the robust fabrication of TG-FET arrays based on ZnO thin film,using an ultra-thin alkylphosphonic acid molecule monolayer as buffer *** device demonstrates a pronounced ultrahigh on/off ratio of≥10^(8),which is 8-order of magnitude higher than that of a device without buffer *** the highly reliable arrays,our device exhibits a high yield of over 93%with an average on/off ratio of^10^(7) across the entire wafer scale,mobility(18.5 cm^(2)/(V·s)),an extended bias-stressing(~2,000 s)and long-stability(~150 days)under ambient conditions.

关键词： zinc oxides thin-film field-effect-transistor self-assembly molecule inhomogeneous charge transport interface engineering

Radar Cross Section Analysis Using Physical Optics and Its Applications to Marine Targets

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Journal of Applied Mathematics and Physics 2015年第2期3卷 166-171页

作者： Joon-Tae Hwang suk-Yoon Hong Jee-Hun song Hyun-Wung Kwon Department of Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Chonnam National University Yeosu Republic of Korea Department of Naval Architecture and Ocean Engineering Kojecollege Koje Republic of Korea

Radar Cross Section (RCS) is one of the most considerable parameters for ship stealth design. As modern ships are larger than their predecessors, RCS must be managed at each design stage for its reduction. For predicting RCS of ship, Radar Cross Section Analysis Program (RACSAN) based on Kirchhoff approximation in high frequency range has been developed. This program can present RCS including multi-bounce effect in exterior and interior structure by combination of geometric optics (GO) and physical optics (PO) methods, coating effect by using Fresnel reflection coefficient, and response time pattern for detected target. In this paper, RCS calculations of ship model with above effects are simulated by using this developed program and RCS results are discussed.

关键词： Radar Cross Section (RCS) Kirchhoff Approximation Multi-Bounce Effect Response Time Pattern

Modeling and implementation of tandem polymer solar cells using wide-bandgap front cells

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Carbon Energy 2020年第1期2卷 131-142页

作者： Seo-Jin Ko Hyosung Choi Quoc Viet Hoang Chang Eun song Pierre-Olivier Morin Jungwoo Heo Mario Leclerc Sung Cheol Yoon Han Young Woo Won suk Shin Bright Walker Jin Young Kim Division of Advanced Materials Korea Research Institute of Chemical Technology(KRICT)DaejeonSouth Korea Department of Chemistry and Research Institute for Natural Sciences Hanyang UniversitySeoulSouth Korea Vietnam Certification Centre Directorate for StandardsMetrology and Quality(STAMEQ)HanoiVietnam Department of Chemistry Laval UniversityQuebec CityCanada Department of Energy Engineering Ulsan National Institute of Science and Technology(UNIST)UlsanSouth Korea Department of Chemistry Korea UniversitySeoulSouth Korea Department of Chemistry Kyung Hee UniversitySeoulSouth Korea

Tandem device architectures offer a route to greatly increase the maximum possible power conversion efficiencies(PCEs)of polymer solar cells,however,the complexity of tandem cell device fabrication(such as selecting bandgaps of the front and back cells,current matching,thickness,and recombination layer optimization)often result in lower PCEs than are observed in single-junction *** this study,we analyze the influence of front cell and back cell bandgaps and use transfer matrix modeling to rationally design and optimize effective tandem solar cell structures before actual device *** approach allows us to estimate tandem device parameters based on known absorption coefficients and open-circuit voltages of different active layer materials and design devices without wasting valuable time and *** this approach,we have investigated a series of wide bandgap,high voltage photovoltaic polymers as front cells in tandem devices with PTB7-Th as a back *** this way,we have been able to demonstrate tandem devices with PCE of up to 12.8%with minimal consumption of valuable photoactive materials in tandem device *** value represents one of the highest PCE values to date for fullerene-based tandem solar cells.

关键词： polymer solar cells solar cells tandem solar cells

Different cutoff values of methacholine bronchial provocation test depending on age in children with asthma

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World Journal of Pediatrics 2017年第5期13卷 439-445页

作者： Eun Lee Young-Ho Kim Seungbong Han song-I Yang Young-Ho Jung Ju-Hee Seo Hyo-Bin Kim So Yeon Lee Ji-Won Kwon Soo-jong Hong Department of Pediatrics Chonnam National University HospitalGwangjuKorea Department of Pediatrics Gyeongsang National University Changwon HospitalChangwonKorea Department of Applied Statistics Gachon UniversitySeongnamKorea Department of Pediatrics Hallym University Sacred Heart HospitalAnyangKorea Department of Pediatrics Bundang CHA Medical CenterCHA University School of MedicineSeongnamKorea Department of Pediatrics Dankook University College of MedicineCheonanKorea Department of Pediatrics Inje University Sanggye Paik HospitalSeoulKorea Department of Pediatrics Childhood Asthma Atopy CenterResearch Center for Standardization of Allergic DiseasesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pediatrics Seoul National University Bundang HospitalSeongnamKorea

Background:Bronchial hyperresponsiveness (BHR) is a fundamental pathophysiological characteristic of *** several factors such as airway caliber can affect BHR,no study has established age-dependent cutoff values of BHR to methacholine for the diagnosis of asthma in *** investigated the cutoff values of the methacholine challenge test (MCT) in the diagnosis of asthma according to ***:A total of 2383 individuals aged from 6 to 15 years old were included in this *** using the five-breath technique were performed in 350 children with suspected asthma based on symptoms by pediatric allergists and in 2033 healthy children from a general population-based *** determined the provocative concentration of methacholine producing a 20% decrease in forced expiratory volume in 1 second from baseline (PC20).A modified Korean version of the International Study of Asthma and Allergies in Childhood questionnaire was used to distinguish asthmatics and healthy *** characteristic curve analysis was used to assess the cutoff value of PC20 for the diagnosis of ***:Cutoff values of methacholine PC20,which provided the best combination of diagnostic sensitivity and specificity,showed an increasing pattern with age:5.8,9.1,11.8,12.6,14.9,21.7,23.3,21.1,21.1,and 24.6 mg/mL at ages 6,7,8,9,10,11,12,13,14,and 15 years,***:The application of different cutoff values of methacholine PC20 depending on age might be a practical modification for the diagnosis of asthma in children and adolescents with asthmatic symptoms.

关键词： asthma bronchial hyperresponsiveness cutoff value receiver-operator characteristics

Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms

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World Journal of Stem Cells 2020年第9期12卷 1032-1049页

作者： Yunejin song Jung-Yeon Lim Taekyu Lim Keon-Il Im Nayoun Kim Young-Sun Nam Young-Woo Jeon jong Chul Shin Hyun Sun Ko In Yang Park Seok-Goo Cho Institute for Translational Research and Molecular Imaging College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Laboratory of Immune Regulation Convergent Research Consortium for Immunologic DiseaseCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Biomedicine and Health Sciences College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Precision Immunology Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Hematology Oncology Department of Internal MedicineVeterans Health Service Medical CenterSeoul 05368South Korea Department of Hematology Catholic Blood and Marrow Transplantation CenterSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Obstetrics and Gynecology CHA Bundang Medical CenterCHA UniversitySeongnam 13496South Korea Department of Obstetrics and Gynecology College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Division of Hematology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Mesenchymal stem cells(MSCs)are an attractive tool to treat graft-versus-host disease because of their unique immunoregulatory *** human bone marrow-derived MSCs(BM-MSCs)were the most widely used MSCs in cell therapy until recently,MSCs derived from human umbilical cords(UC-MSCs)have gained popularity as cell therapy material for their ethical and noninvasive *** To investigate the difference in mechanisms of the immunosuppressive effects of UC-MSCs and *** To analyze soluble factors expressed by MSCs,such as indolamine 2,3-dioxygenase,cyclooxygenase-2,prostaglandin E2 and interleukin(IL)-6,inflammatory environments in vitro were reconstituted with combinations of interferon-gamma(IFN-γ),tumor necrosis factor alpha and IL-1βor with IFN-γ*** T cells were cocultured with MSCs treated with indomethacin and/or *** assess the ability of MSCs to inhibit T helper 17 cells and induce regulatory T cells,induced T helper 17 cells were cocultured with MSCs treated with indomethacin or *** graft-versus-host disease was induced in NOG mice(NOD/Shi-scid/IL-2Rγnull)and UC-MSCs or BM-MSCs were treated as cell *** Our data demonstrated that BM-MSCs and UC-MSCs shared similar phenotypic characteristics and immunomodulation ***-MSCs expressed more indolamine 2,3-dioxygenase after cytokine stimulation with different combinations of IFN-γ,tumor necrosis factor alpha-αand IL-1βor IFN-γ***-MSCs expressed more prostaglandin E2,IL-6,programmed death-ligand 1 and 2 in the in vitro inflammatory ***-2 and IL-10 were key factors in the immunomodulatory mechanisms of both *** addition,UC-MSCs inhibited more T helper 17 cells and induced more regulatory T cells than ***-MSCs and BM-MSCs exhibited similar effects on attenuating graft-versus-host *** UC-MSCs and BM-MSCs exert similar immunosuppressive effects with different mechanisms

关键词： Mesenchymal stem cells Graft-versus-host disease Umbilical cord Cell therapy Xenogeneic mouse model Immunomodulation

Effect of tamsulosin on ejaculatory function in BPH/LUTS

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Asian Journal of Andrology 2011年第6期13卷 846-850页

作者： Sang Hoon song Hwancheol Son Kwang Taek Kim Sae Woong Kim Du Geon Moon Ki Hak Moon Kwangsung Park jong Kwan Park Sung-Won Lee Jae Seog Hyun Nam Cheol Park Jeungpyung Health Center Jeungpyung-gun Chungbuk 368-900 Korea Department of Urology Seoul Metropolitan Boramae Hospital Seoul 156-707 Korea Aerospace Medical Center Cheongwon Chungbuk 363-840 Korea Catholic University of Korea College of Medicine Seoul 137-701 Korea Korea University College of Medicine Seoul 152-703 Korea Department of Urology Yeungnam University College of Medicine Daegu 705-717 Korea Department of Urology Chonnam National University Medical School Gwangju 501-757 Korea Department of Urology Medical School and Institute for Medical Sciences Chonbuk National University Chonbuk 561-712 Korea Research Institute of Clinical Medicine and CTC for Medical Device of Chonbuk National University Hospital Chonbuk 561-712 Korea Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea Gyeongsang National University Gyeongnam 660-702 Korea pusan National University College of Medicine Pusan 602-739 Korea

This study was undertaken to determine the impact on ejaculatory function of tamsulosin （0.2 mg） given once daily （OD） for 12 weeks and to identify risk factors for ejaculatory dysfunction in patients undergoing this treatment. Males with an International Prostatic Symptom Score （IPSS） ≥ 8 were enrolled in this study. All participants completed questionnaires, including the IPSS and the Male Sexual Health Questionnaire （MSHQ）, and serum prostate-specific antigen, transrectal ultrasound and uroflowmetry with post-void residual were measured. After initiating 0.2 mg OD tamsulosin, patients were re-evaluated on the fourth and twelfth weeks of medication. The chi-squared test, the independent t-test and one-way ANOVA were used to compare means. Binary logistic regression analysis was used to calculate the odds ratio for all risk factors. A total of 177 men constituted the study cohort. No significant difference was observed between baseline and follow-up for the erectile function, ejaculatory function, satisfaction, sexual activity and desire domains （EFD, EjFD, SDA and ADD） or for erectile or ejaculatory bother mean scores. After 12 weeks, the overall incidence of ejaculatory dysfunction （EjD） was 13.4%. Incidences of the seven different types of EjD （decreased frequency, delay, dryness, decreased strength/force, decreased volume, decreased pleasure and pain at ejaculation） were 2.4%, 3.1%, 3.9%, 3.9%, 6.3%, 7.1% and 3.1%, respectively. Baseline EjFD scores were higher for I PSS responders than for non-responders （26.09 vs. 24.06, P=0.03）. An EjFD score reduction was more frequent in IPSS responders. The incidence of EjD was small, but not negligible and was more frequent in patients with less lower urinary tract symptoms, a smaller prostate, higher baseline MSHQ totals and higher EjFD scores.

关键词： alpha-1 adrenergic receptors benign prostatic hyperplasia ejaculation lower urinary tract symptom Male Sexual HealthQuestionnaire prostatic hyperplasia tamsulosin