Different cutoff values of methacholine bronchial provocation test depending on age in children with asthma

作     者：Eun Lee Young-Ho Kim Seungbong Han Song-I Yang Young-Ho Jung Ju-Hee Seo Hyo-Bin Kim So Yeon Lee Ji-Won Kwon Soo-Jong Hong 

作者机构：Department of PediatricsChonnam National University HospitalGwangjuKorea Department of PediatricsGyeongsang National University Changwon HospitalChangwonKorea Department of Applied StatisticsGachon UniversitySeongnamKorea Department of PediatricsHallym University Sacred Heart HospitalAnyangKorea Department of PediatricsBundang CHA Medical CenterCHA University School of MedicineSeongnamKorea Department of PediatricsDankook University College of MedicineCheonanKorea Department of PediatricsInje University Sanggye Paik HospitalSeoulKorea Department of PediatricsChildhood Asthma Atopy CenterResearch Center for Standardization of Allergic DiseasesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of PediatricsSeoul National University Bundang HospitalSeongnamKorea 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2017年第13卷第5期

页      面：439-445页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Research of Korea Centers for Disease Control and Prevention 

主　　题：asthma bronchial hyperresponsiveness cutoff value receiver-operator characteristics 

摘      要：Background:Bronchial hyperresponsiveness (BHR) is a fundamental pathophysiological characteristic of *** several factors such as airway caliber can affect BHR,no study has established age-dependent cutoff values of BHR to methacholine for the diagnosis of asthma in *** investigated the cutoff values of the methacholine challenge test (MCT) in the diagnosis of asthma according to ***:A total of 2383 individuals aged from 6 to 15 years old were included in this *** using the five-breath technique were performed in 350 children with suspected asthma based on symptoms by pediatric allergists and in 2033 healthy children from a general population-based *** determined the provocative concentration of methacholine producing a 20% decrease in forced expiratory volume in 1 second from baseline (PC20).A modified Korean version of the International Study of Asthma and Allergies in Childhood questionnaire was used to distinguish asthmatics and healthy *** characteristic curve analysis was used to assess the cutoff value of PC20 for the diagnosis of ***:Cutoff values of methacholine PC20,which provided the best combination of diagnostic sensitivity and specificity,showed an increasing pattern with age:5.8,9.1,11.8,12.6,14.9,21.7,23.3,21.1,21.1,and 24.6 mg/mL at ages 6,7,8,9,10,11,12,13,14,and 15 years,***:The application of different cutoff values of methacholine PC20 depending on age might be a practical modification for the diagnosis of asthma in children and adolescents with asthmatic symptoms.