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Regulating the microenvironment with nanomaterials:Potential strategies to ameliorate COVID-19

Acta Pharmaceutica Sinica B 2023年第9期13卷 3638-3658页

作者： Zhicheng Liu Zhuolei Han Xin Jin Jusung An Jaewon kim Wenting Chen jong seung kim Ji Zheng Jun Deng Department of Urology Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China Department of Urology Urological Surgery Research InstituteSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Burn Research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryChongqing Key Laboratory for Disease ProteomicsThird Military Medical University(Army Medical University)Chongqing 400038China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Chemistry Korea UniversitySeoul 02841South Korea Department of Rheumatology and Clinical Immunology Army Medical CenterThird Military Medical University(Army Medical University)Chongqing 400042China

COVID-19,caused by SARS-CoV-2,has resulted in serious economic and health *** treatments remain inadequate to extinguish the epidemic,and efficient therapeutic approaches for COVID-19 are urgently being ***,accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in *** addition,recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection,providing new insight into COVID-19 *** literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 *** fill this gap,this review systematically discusses alterations of homeostasis in COVID-19 patients and potential ***,advances in nanotechnology-based strategies for promoting homeostasis restoration are ***,we discuss the challenges and prospects of using nanomaterials for COVID-19 *** review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.

关键词： Coronavirus disease 19 Severe acute respiratory syndrome coronavirus 2 Therapeutic approaches Nanotechnology Nanomaterial technologies Microenvironment Microenvironmental disorder Altered homeostasis

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A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery Special Issue:Emerging Investigators

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Aggregate 2024年第2期5卷 112-129页

作者： Fariba Mehvari Vahid Ramezanzade Parvin Asadi Nem Singh Jaewon kim Mohammad Dinari jong seung kim Department of Chemistry Isfahan University of TechnologyIsfahanIslamic Republic of Iran Department of Medicinal Chemistry School of Pharmacy and Pharmaceutical SciencesIsfahan University of Medical SciencesIsfahanIslamic Republic of Iran Department of Chemistry Korea UniversitySeoulSouth Korea

The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs,particularly for aggressive and difficult-totreat *** organic frameworks(COFs)are emerging as innovative porous nanomaterials in drug delivery systems(DDS),due to their unique properties,including the metal-free organic skeleton,predetermined structures and pore geometries,high porosity,large surface area,facile surface modification potential,and good *** characteristics make COFs excellent candidates for improving drug delivery by enhancing drug loading capacity and enabling precise *** review emphasizes the importance of donor-acceptor-based COFs,which provide channels for charge transportation,and we also explore how theπ-conjugated skeleton of COFs enhances its long-acting fluorescent properties and facilitates drug uptake via cell *** this review primarily focuses on recent advancements in COF-based targeted DDS,it also acknowledges the challenges posed by the diverse pore geometries in porous materials and discusses potential ***,it underlines the potential of developing future drug carriers that can successfully and specifically target cancer cells,improving treatment efficiency while reducing adverse side effects.

关键词： cancer treatment controlled release covalent organic frameworks nanotechnology photodynamic therapy targeted drug delivery

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Picomolar-sensitiveβ-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulatedπ-elongated dioxaborine-dyes

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Bioactive Materials 2022年第7期7卷 239-248页

作者： Jusung An Peter Verwilst Hira Aziz Jinwoo Shin Sungsu Lim Ilwha kim Yun Kyung kim jong seung kim Department of Chemistry Korea UniversitySeoul02841South Korea KU Leuven Rega Institute for Medical ResearchMedicinal Chemistry3000LeuvenBelgium Convergence Research Center for Diagnosis Treatment and Care System of DementiaBrain Science InstituteKorea Institute of Science and Technology(KIST)Seoul02792South Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792South Korea

The pathological origin of Alzheimer’s disease(AD)is still shrouded in mystery,despite intensive worldwide research *** selective visualization ofβ-amyloid(Aβ),the most abundant proteinaceous deposit in AD,is pivotal to reveal AD *** date,several small-molecule fluorophores for Aβspecies have been developed,with increasing binding *** the current work,two organic small-molecule dioxaborine-derived fluorophores were rationally designed through tailoring the hydrophobicity with the aim to enhance the binding affinity for Aβ_(1-42) fibrils-while concurrently preventing poor aqueous solubility-via biannulate donor motifs in D-π-A *** unprecedented sub-nanomolar affinity was found(K_(d)=0.62±0.33 nM)and applied to super-sensitive and red-emissive fluorescent staining of amyloid plaques in cortical brain tissue ex *** fluorophores expand the dioxaborine-curcumin-based family of Aβ-sensitive fluorophores with a promising new imaging agent.

关键词： β-Amyloid Small-molecular fluorescent probe Dioxaborine-dye Hydrophobicity tailoring Alzheimer’s disease

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Construction of a 980 nm laser-activated Pt(Ⅱ)metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

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Science China Chemistry 2023年第1期66卷 155-163页

作者： Yuling Xu Chonglu Li Jusung An Xin Ma Jingfang Yang Lishi Luo Yun Deng jong seung kim Yao Sun Key Laboratory of Pesticides and Chemical Biology Ministry of EducationInternational Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Department of Chemistry KoreaUniversitySeoul 02841Republic of Korea Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei UniversityWuhan 430062China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan UniversityChangsha 410082China Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education Jianghan UniversityWuhan 430056China

Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo *** therefore synthesized a novel Pt(Ⅱ)metallacycle(Pt1110)that can be activated with a 980 nm laser for photodiagnosis/treatment in deep *** found that Pt1110 significantly improved photothermal conversion(95%improvement)and ^(1)O_(2) generation(ΦΔ75%increase)compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation(0.72 W/cm^(2)).In addition,Pt1110 has little to no toxicity to *** incorporated into liposome,Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation,which was accurately observed by NIR-Ⅱfluorescence *** novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.

关键词： supramolecular chemistry metallacycle NIR-Ⅱfluorescence imaging phototheranostics deep penetration

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Activated aggregation-induced emission therapeutics agents for triggering regulated cell death

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Aggregate 2024年第3期5卷 50-77页

作者： Yu-Qiang Zhao Le Yu Lanyun Zhang Huan Liu Ying Zhou jong seung kim School of Chemical Science and Technology Yunnan UniversityKunmingChina Department of Chemistry Korea UniversitySeoulRepublic of Korea

The induction of regulated cell death(RCD)through photo/ultrasound sensiti-zation therapeutic agents has gained significant attention as a vital approach to combat drug resistance in ***-induced emission(AIE)therapeutic agents generate reactive oxygen species through photo/ultrasound activation,which can synergize with RCD inducers or directly induce RCD,ultimately resulting in the death of tumor *** presented comprehensive review delves into recent advancements in AIE therapeutic agents designed to trigger RCD or synergize with RCD inducers,encompassing apoptosis,necroptosis,pyroptosis,immunogenic cell death,autophagy,ferroptosis,and ***,the intricate regula-tory mechanisms through which activatory-AIE therapeutics influence distinct RCD pathways are examined.A forward-looking perspective on future developments and pertinent challenges within this exciting realm is presented,anticipating the con-tinued evolution of activatable AIE therapeutics as a transformative approach to enhance tumor therapy.

关键词： aggregation-induced emission phototherapy regulated cell death sonodynamic therapy therapeutic agents

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Electronic structure tuning of layered double hydroxides for electrochemical sensing and its biomedical applications

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Science China Chemistry 2024年第11期67卷 3614-3630页

作者： Kun Wang Zhiying Cao Qihang Ding Jiyoung Yoo Nem Singh Heemin Kang Lin Wang Lin Xu jong seung kim School and Hospital of Stomatology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingJilin UniversityChangchun 130021China State Key Laboratory on Integrated Optoelectronics Collage of Electronic Science and EngineeringJilin UniversityChangchun 130021China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Modifying the electrodes of electrochemical sensors is critical to enhance sensitivity,selectivity,and stability,ultimately improving both their effectiveness and *** this paper,recent advancements in electrochemical sensors are reviewed,focusing on the utilization of layered double hydroxides(LDHs).The first section explores the advantageous and disadvantageous aspects of electrochemical *** include rapid response,ease of operation,and cost-effectiveness,while drawbacks concern the potential instability of prolonged use,susceptibility to interference,and the risk of biomolecule *** this,the second section delves into the synthesis,constituents,and structure of ***,after introducing the chemical mechanisms and functions of LDHs in electrochemical sensors,we concentrate on diverse modifying materials of LDHs and their different ***,the applications of LDHs in electrochemical sensing across different fields are *** review aims to facilitate the continued advancement for applying LDHs in electrochemical sensors,as well as inspire the evolution of electrochemical sensing technology.

关键词： layered double hydroxides electrochemical sensor biological field modified electrode

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An ATP-responsive metal-organic framework against periodontitis via synergistic ion-interference-mediated pyroptosis

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National Science Review 2024年第8期11卷 196-208页

作者： Qijing Yang Xiaolin Sun Qihang Ding Manlin Qi Chengyu Liu Tingxuan Li Fangyu Shi Lin Wang Chunyan Li jong seung kim Department of Prosthodontics Jilin Provincial Engineering Laboratory of Intelligent Oral Treatment TechnologySchool and Hospital of Stomatology Jilin University Department of Chemistry Korea University

Periodontitis involves hyperactivated stromal cells that recruit immune cells,exacerbating *** study presents an ATP-responsive metal-organic framework(Mg/Zn-MOF) designed for periodontitis treatment,utilizing ion interference to modulate immune responses and prevent tissue *** the challenges of synergistic ion effects and targeted delivery faced by traditional immunomodulatory nanomaterials,the Mg/Zn-MOF system is activated by extracellular ATP—a pivotal molecule in periodontitis pathologyensuring targeted ion *** and zinc ions released from the framework synergistically inhibit membrane pore formation by attenuating Gasdermin D(GSDMD)expression and *** action curtails pyroptosis,lactate dehydrogenase and IL-1β release,thwarting the onset of inflammatory ***,Mg/Zn-MOF intervenes in both the NLRP3/Caspase-1/GSDMD and Caspase-11/GSDMD pathways to mitigate *** vivo assessments confirm its effectiveness in diminishing inflammatory cell infiltration and preserving collagen integrity,thereby safeguarding against periodontal tissue damage and bone *** investigation highlights the promise of ion-interference strategies in periodontitis immunotherapy,representing a significant stride in developing targeted therapeutic approaches.

关键词： metal–organic framework periodontitis pyroptosis immunotherapy ion-interference therapy

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Ultrasound activatable antiangiogenic sonosensitizer for VEGFR associated glioblastoma tumor models

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Aggregate 2021年第4期2卷 137-143页

作者： Subin Son Chuangli Zhang Miae Won Paramesh Jangili Minhyeok Choi Jiasheng Wu jong seung kim Department of Chemistry Korea UniversitySeoulKorea Key Laboratory of Photochemical Conversion and Optoelectronic Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijingChina

Angiogenic signaling pathway is a major contributing factor in cancer recurrence and progression,which can cause significantly reduced treatment outcomes,especially in the oxygen-dependent photo-and sonodynamic *** and its receptor(VEGFR)play a crucial role in angiogenesis progression;precisely,upregulated VEGF signaling ismainly associated with angiogenesis progression in many types of ***,we report a sunitinib-conjugated sonosensitizer(TK-RB:tyrosine kinase-rose bengal)to enhance the anticancer efficacy through VEGF inhibitionmediated antiangiogenesis in conjunction with cellular/tumor damage by ROS generated under ultrasound ***-RB reveals good selectivity and cytotoxicity toward VEGFR-positive cells(U87MG)over VEGFR-negative cells(MCF-7).The fluorescent imaging analysis in vivo/ex vivo and the tumor growth investigation in nude mice with U87MG glioblastoma tumor xenografts demonstrate that rose bengal having tyrosine kinase inhibitor(TK-RB)provides an enhanced antitumor *** current strategy will make a great contribution to optimizing anticancer performance by utilizing sonodynamic therapy together with antiangiogenics in several different malignancies.

关键词： antiangiogenesis glioblastoma sonodynamic therapy VEGFR blockage

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A Plasma Membrane Polarity Sensor Harnessing Conjoined Twisted Intramolecular Charge Transfer Modulation and Charge Number Control Strategy

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CCS Chemistry 2024年第3期6卷 733-748页

作者： Yu-Qiang Zhao Le Yu Liping Zhu Jinsong Liang Ying Zhou jong seung kim College of Chemical Science and Technology Yunnan UniversityKunming 650091 Department of Chemistry Korea UniversitySeoul 02841 TheranoChem Incorporation Seoul 02856

Polarity is a critical microenvironmental factor of the plasma membrane,which can offer valuable insights into various biological ***,we proposed a novel strategy for the construction of fluorescent agents to measure plasma membrane polarity by conjoining twisted intramolecular charge transfer(TICT)modulation and charge number *** is shown that compounds with a stronger TICT tendency are more sensitive to polarity shifts due to the number of dialkylated amino groups present(from 1 to 3),and the molecules with two or more charged centers remain in the plasma ***,we developed two fluorescent agents with high polarity sensitivity,excellent turn-on ratios,and superior ability,to target the plasma *** the wash-free fluorescence imaging and fluorescence lifetime tests,our designed agent could detect plasma membrane polarity with high precision,allowing effective distinction between cancer cells and normal cells based on their differences in plasma membrane ***,both fluorescence and fluorescence lifetime changes of the plasma membrane in the ferroptosis model established by Sorafenib confirmed an increase in plasma membrane polarity during cell ferroptosis.

关键词： membrane polarity fluorescence agents fluorescence imaging fluorescence lifetime imaging

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Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

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Chinese Chemical Letters 2024年第9期35卷 223-226页

作者： Gongcheng Ma Qihang Ding Yuding Zhang Yue Wang Jingjing Xiang Mingle Li Qi Zhao Saipeng Huang Ping Gong jong seung kim Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Korea UniversitySeoul 02841South Korea School of Chemical Engineering Northwest UniversityXi’an 710069China Cancer Center Institute of Translational MedicineFaculty of Health SciencesUniversity of MacaoMacao 999078China State Key Laboratory of Fine Chemicals College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China

Carbon monoxide(CO)is a vital intracellular gas messenger known for its cytoprotective and homeostatic *** plays a pivotal role in a myriad of biological ***,the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease *** herein introduce NFCOP,a state-of-the-art near-infrared(NIR)turn-on fluorescence(FL)probe that has been meticulously designed for highly sensitive,swift and selective imaging of *** NFCOP response occurred rapidly with CO,within just 10 s,and the calculated detection limit for CO was determined to be 0.32μmol/*** investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

关键词： Palladium-free Chemoselective probe Fluorescence imaging Carbon monoxide Near-infrared

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