Construction of a 980 nm laser-activated Pt(Ⅱ)metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

作     者：Yuling Xu Chonglu Li Jusung An Xin Ma Jingfang Yang Lishi Luo Yun Deng Jong Seung Kim Yao Sun 

作者机构：Key Laboratory of Pesticides and Chemical BiologyMinistry of EducationInternational Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Department of ChemistryKoreaUniversitySeoul 02841Republic of Korea Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesHubei UniversityWuhan 430062China State Key Laboratory of Chemo/Biosensing and ChemometricsHunan UniversityChangsha 410082China Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of EducationJianghan UniversityWuhan 430056China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第1期

页      面：155-163页

核心收录：

学科分类：080901[工学-物理电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080401[工学-精密仪器及机械] 0804[工学-仪器科学与技术] 0803[工学-光学工程] 

基　　金：supported by National Natural Science Foundation of China(22022404,22074050,21904103) the Fundamental Research Funds for the Central Universities(CCNU22QN007) the Open Research Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics(2021005) the Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University(KLSAOFM2111) the Opening Project of Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education,Jianghan University(JDGD-202209) the Open Project Program of Key Laboratory for Analytical Science of Food Safety and Biology,Ministry of Education(FS2202) supported by the CRI project of National Research Foundation of Republic of Korea(2018R1A3B1052702,JSK) 

主　　题：supramolecular chemistry metallacycle NIR-Ⅱfluorescence imaging phototheranostics deep penetration 

摘      要：Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo *** therefore synthesized a novel Pt(Ⅱ)metallacycle(Pt1110)that can be activated with a 980 nm laser for photodiagnosis/treatment in deep *** found that Pt1110 significantly improved photothermal conversion(95%improvement)and ^(1)O_(2) generation(ΦΔ75%increase)compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation(0.72 W/cm^(2)).In addition,Pt1110 has little to no toxicity to *** incorporated into liposome,Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation,which was accurately observed by NIR-Ⅱfluorescence *** novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.