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SYNTHESIS AND CHARACTERIZATION OF HYDROPHOBIC-HYDROPHILIC MULTIBLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS

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Chinese Journal of Polymer Science 1999年第2期17卷 113-122页

作者： Yong Kiel Sung Yong joo kim Sung Wan kim Department of Chemistry College of Natural Science Dongguk University 3Ga 26 PhildongJunggu Seoul 100-715 KoreaReliability Technology Division NITQ 2 Chungangdong Kwachoncity Kyunggido 427-010 KoreaCenter for Controlled Chemical Delivery University of Utah Salt Lake City Utah 84112 U. S. A.

The synthesis and characterization of amphiphilic copolymers of poly（dimethyl siloxane）(PDMS),poly（ethylene oxide）(PEO), and heparin（Hep） were investigated. These multiblock copolymers wereidentified using;H-NMR, FTIR, end group analysis, and sulfur elemental analysis. The multiblockcopolymers were characterized by using DSC and X-ray diffractometry. The glass transition temperature,crystalline melting characteristics, annealing effect, and cold crystallization of the block copolymers weredetermined by DSC. The crystallinity of the block copolymers was also determined by X-ray diffractionmethod.

关键词： Heparinized block copolymer Biomedical polymer Synthesis Characterization

Prospective comparison of prophylactic antibiotic use between intravenous moxifloxacin and ceftriaxone for high-risk patients with post-ERCP cholangitis

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 512-518页

作者： Nam Hee kim Hong joo kim Ki Bae Bang Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital Department of Internal Medicine Dankook University Hospital

BACKGROUND: The use of prophylactic antibiotics before endoscopic retrograde cholangiopancreatography(ERCP) is recommended by all major international gastroenterological societies, especially in the presence of an obstructed biliary system. This study compared the occurrence rate of post-procedural complications, including cholangitis and septicemia between prophylactic intravenous moxifloxacin and ceftriaxone in patients with bile duct obstruction scheduled for therapeutic ***: From November 2013 to July 2015, 86 consecutive patients with biliary obstruction with one or more factors predicting benefits of antibiotic prophylaxis prior to ERCP were included in the current randomized open-label non-inferiority trial(Clinical *** identifier NCT02098486). Intravenous moxifloxacin(400 mg/day) or ceftriaxone(2 g/day)were given 90 minutes before ERCP, and were administered for more than 3 days if the patient developed symptoms and signs of cholangitis or septicemia. Recalcitrant cholangitis was defined as persistence of cholangitis for more than 5 days after ERCP or recurrence of cholangitis within 30 days after ***: Recalcitrant cholangitis occurred in 1(2.3%) and 2(4.8%) patients receiving intravenous moxifloxacin and ceftriaxone group, respectively(P=0.612). Septicemia was noted in1(2.3%) and 1(2.4%) patient in intravenous moxifloxacin and ceftriaxone group, respectively(P=1.0). The mean hospital stay was also not significantly different between the moxifloxacin and ceftriaxone groups(8.8±7.2 vs 9.1±9.4 days, P=0.867). Antibiotic resistance of the isolated pathogens by in vitro activity assay was noted in 1(2.3%) and 2(4.8%) patients in the moxifloxacin and ceftriaxone group, respectively(P=0.612). CONCLUSION: Intravenous moxifloxacin is not inferior to intravenous ceftriaxone for the prophylactic treatment of post-ERCP cholangitis and cholangitis-associated morbidity.

关键词： endoscopic retrograde cholangiopancreatography cholangitis moxifloxacin ceftriaxone recalcitrant cholangitis

Nanodendrites of platinum-group metals for electrocatalytic applications

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Nano Research 2018年第12期11卷 6111-6140页

作者： Nitin K.Chaudhari Jinwhan joo Hyuk-bu Kwon Byeongyoon kim Ho Young kim Sang Hoon joo Kwangyeol Lee Department of Chemistry Korea UniversitySeou102841Republic of Korea Research Institute of Natural Sciences (RINS) Korea UniversitySeou102841Republic of Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST)Ulsan44919Republic of Korea

Developing highly efficient and durable catalysts for future electrochemical and energy applications is one of the main subjects of current studies in renewable energy generation. In the past several years, researchers have developed Pt-based alloy electrocatalyst nanomaterials that exhibit promising electrocatalytic properties for various electrochemical applications. The efficient structural and morphological control of Pt-based alloy materials plays a decisive role in achieving these enhanced electrocatalytic properties. The present review article emphasizes the recent progress and important developments in the synthesis and electrocatalytic applications of Pt-group-based nanodendrite materials. The following review will help the exploration and development of better catalysts for practical applications and aims to elucidate the nanodendrite structure of Pt-group metals.

关键词： nanodendrites platinum-group metals electrochemical and energy conversion nanostructure

Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control

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Journal of Sport and Health Science 2024年第4期13卷 559-568,F0003页

作者： Kyung-Min kim joo-Sung kim Alan R.Needle Department of Sport Science Sungkyunkwan UniversitySuwon-si 16419Republic of Korea Department of Health and Human Performance Texas State UniversitySan MarcosTX 78666USA Department of Public Health&Exercise Science Appalachian State UniversityBooneNC 28608USA Department of Rehabilitation Science Appalachian State UniversityBooneNC 28608USA

Background:Acute lateral ankle sprains(ALAS)are associated with long-term impairments and instability tied to altered neural *** muscle inhibition(AMI)has been observed in this population;however,relationships with injury-related impairments are unclear,potentially due to the resting,prone position in which AMI is typically *** AMI during bipedal stance may provide a better understanding of this ***:AMI was assessed in 38 young adults(19 ALAS within 72 h of injury:10 males,21.4±2.7 years;19 healthy controls:10 males,21.9±2.2 years;mean±SD)using the Hoffmann reflex(H-reflex)during bipedal *** stimulation was administered to identify the _(max)imal H-reflex(H_(max))and _(max)imal motor response(M_(max))from the soleus,fibularis longus,and tibialis anterior *** primary outcome measure was the H_(max)/M_(max) *** outcomes included acute symptoms(pain and swelling),postural control during bipedal stance,and self-reported ***:No significant group-by-limb interactions were observed for any ***,a significant group main effect was observed in the soleus muscle(F(1,35)=6.82,p=0.013),indicating significantly lower H_(max)/M_(max) ratios following ALAS(0.38±0.20)compared to healthy controls(0.53±0.16).Furthermore,lower H_(max)/M_(max) ratios in the soleus significantly correlated with acute symptoms and self-reported function but not with postural ***:This study supports previous evidence of AMI in patients with ALAS,providing insight into neurophysiologic impacts of musculoskeletal *** results suggest that assessing AMI in a standing position following acute injury may provide valuable insight into how AMI develops and guide potential therapeutic options to curb and offset the formation of joint instability.

关键词： Acute injuries Balance Hoffmann reflex Neural excitability Patient-reported outcomes

Multiple malignant extragastrointestinal stromal tumors of the greater omentum and results of immunohistochemistry and mutation analysis:A case report

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World Journal of Gastroenterology 2007年第24期13卷 3392-3395页

作者： jong-Han kim Yoon-Jung Boo Cheol-Woong Jung Sung-Soo Park Seung-joo kim Young-Jae Mok Sang-Dae kim Yang-Suk Chae Chong-Suk kim kim Korea University Hospital Seoul 136-705 Korea Deparment of Surgery Pathology KoreaUniversity College of medicine Seoul 136-705 Korea

To report an extragastrointestinal stromal tumor （EGIST） that occurs outside the gastrointestinal tract and shows unique clinicopathologic and immunohistochemical features. In our case, we experienced multiple soft tissue tumors that originate primarily in the greater omentum, and in immunohistochemical analysis, the tumors showed features that correspond to malignant EGIST. Two large omental masses measured 15 cm×10 cm and 5 cm×4 cm sized and several small ovoid fragments were attached to small intestine, mesentery and peritoneum. On histologic findings, the masses were separated from small bowel serosa and had high mitotic count （115/50 HPFs）. In the results of immunohistochemical stains, the tumor showed CDl17 （c-kit） positive reactivity and high Ki-67 labeling index. On mutation analysis, the c-kit gene mutation was found in the juxtamembrane domain （exon 11）and it was heterozygote. Platelet-derived growth factor receptor （PDGFR） gene mutation was also found in the juxtamemembrane （exon 12） and it was polymorphism. From above findings, we proposed that there may be several mutational pathways to malignant EGIST, so further investigations could be needed to approach this unfavorable disease entity.

关键词： Extragastrointestinal stromal tumor Greater omentum c-kit Platelet-derived growth factor receptor Mutation

VANET Jamming and Adversarial Attack Defense for Autonomous Vehicle Safety

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Computers, Materials & Continua 2022年第5期71卷 3589-3605页

作者： Haeri kim jong-Moon Chung Department of Vehicle Convergence Engineering Yonsei UniversitySeoul03722Korea School of Electrical&Electronic Engineering Yonsei UniversitySeoul03722Korea

The development of Vehicular Ad-hoc Network(VANET)technology is helping Intelligent Transportation System(ITS)services to become a *** can use VANETs to communicate safety messages on the road(while driving)and can inform their location and share road condition information in ***,intentional and unintentional(e.g.,packet/frame collision)wireless signal jamming can occur,which will degrade the quality of communication over the channel,preventing the reception of safety messages,and thereby posing a safety hazard to the vehicle’s *** this paper,VANET jamming detection applying Support Vector Machine(SVM)machine learning technology is used to classify jamming and non-jamming *** analysis is based on two cases which include normal traffic and heavy traffic conditions,where the results show that the probability of packet dropping will increase when many vehicles are using the wireless channel *** using SVM classification,the most appropriate feature set applied in determining a jamming situation shows an accuracy of 98%or ***,more advanced jamming attacks need to be considered for preparation of more reliable and safer autonomous ITS *** research can use vehicular communication transmission and reception data based on selected published *** this paper,an additional adversarial defense algorithm using the Density-Based Spatial Clustering of Applications with Noise(DBSCAN)method is proposed,which assumes that evolutionary attacks of the jammer will attempt to confuse the trained *** simulation results show that applying DBSCAN can improve the accuracy by elimination of outliers before conducting classification testing.

关键词： Vehicle safety VANET jamming SVM adversarial defense

Gastrointestinal tuberculosis is not associated with proton pump inhibitors:A retrospective cohort study

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World Journal of Gastroenterology 2013年第2期19卷 258-264页

作者： Kyoung Sup Hong Seung joo Kang jong Kyoung Choi Ju Han kim Heewon Seo Suehyun Lee Jae-Woo Jung Hye-Ryun Kang Sang-Heon Cho joo Sung kim Department of Internal Medicine Drug Safety Monitoring CenterSeoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Division of Biomedical Informatics Systems Biomedical Informatics Research CenterSeoul National University College of MedicineSeoul 110799South Korea

AIM:To evaluate the effect of proton pump inhibitors(PPIs) on the development of gastrointestinal ***:All patients who were more than 20 years old and who had received a prescription for PPIs among those who visited Seoul National University Hospital from January 1,2005 to December 31,2009 were *** to the low sensitivity of the microbiologic test and the nonspecific pathologic findings,the diagnosis of gastrointestinal tuberculosis was confirmed through the presence of active ulcerations and the responses to anti-tuberculosis *** patients were divided into two groups according to treatment duration(group 1:≤ 3 mo;group 2:> 3 mo) and were followed up from the time they took the first prescription of PPIs until their last *** regression analysis was used to calculate the relative risks(RR) and 95%CI,adjusting for ***:Among the 61 834 patients exposed to PPIs(50 534 in group 1;11 300 in group 2),21 patients were diagnosed with PPI-associated gastrointestinal tuberculosis during 124 274 person-years of *** 21 patients,the 12 who revealed only scar changes in the colonoscopy were excluded from the statistical *** those who remained,2 were excluded because they underwent gastrointestinal endoscopy within 4 wk of the first prescription for *** exposure to PPI was associated with a higher mean age(55.0 ± 14.5 in group 1 vs 58.2 ± 13.3 in group 2,P < 0.001) and a higher Charlson co-morbidity index(0.50 ± 0.93 in group 1 vs 0.77 ± 1.14 in group 2,P < 0.001).The true incidence of active gastrointestinal tuberculosis was 0.65 per 1000 person-years in group 1 and 0.03 per 1 000 person-years in group *** the less-than-three-month PPI treatment period in group 1,the over-three-month PPI therapy period in group 2 was not associated with increased risk of acquiring gastrointestinal tuberculosis,after adjusting for age and co-morbidities,whereas the Charlson co-morbidity index was associated

关键词： Proton pump inhibitor Acid suppression Tuberculosis Gastrointestinal tuberculosis Tuberculous colitis

Unexpected role of complement component 8 gamma chain in the inflamed brain

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Neural Regeneration Research 2023年第12期18卷 2655-2656页

作者： jong-Heon kim Kyoungho Suk Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation,an intricate inflammatory process occurring in the central nervous system(CNS),plays an important role in host *** cells,including astrocytes and microglia,along with cytokines,chemokines,and the complement system are important components of neuroinflammation.A low level of neuroinflammation is associated with and contributes to various homeostatic and neuroprotective processes,such as removing pathogens or cellular debris and promoting tissue repair after brain injury.

关键词： inflammation protective removing

Expression of protein S100A4 is a predictor of recurrence in colorectal cancer

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World Journal of Gastroenterology 2010年第31期16卷 3897-3904页

作者： Jung Myun Kwak Hyun joo Lee Seon Hahn kim Han Kyeom kim Young Jae Mok Young Tae Park jong Sang Choi Hong Young Moon Department of Surgery Korea University Anam Hospital Department of Pathology Korea University Guro Hospital Department of Surgery Korea University Guro Hospital Department of Gastroenterology Korea Uni-versity Guro Hospital

AIM: To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS: A cohort of archival formalin-fixed paraff inembedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between April 2000 and March 2004 at the Department of Surgery, Korea University Guro Hospital. The expression of protein S100A4 was evaluated according to the proportion of positively stained cancer cells. In each case, three core biopsies with a diameter of 2 mm were punched out and positioned in a recipient paraff in array block. Four-μm sections of these tissue array blocks were used for immunohistochemical analysis of protein S100A4, E-cadherin, and p53. Clinicopathological data were based on the original histopathologic reports and clinical records of patients. RESULTS: In normal colorectal mucosa, protein S100A4 immunoreactivity was clearly absent in both cytoplasm and nucleus. However, positive immunoreactivity of protein S100A4 was detected in 45 (35.4%) of the tumor cases. There was no significant association between positive immunoreactivity of protein S100A4 and clinicopathological parameters such as tumor differentiation or TNM stage, and also no correlation between the reactivity and E-cadherin or p53 expression. However, positive immunoreactivity of protein S100A4 was found to be associated with tumor recurrence (P = 0.004), and was also associated with significantly worse overall survival in the Kaplan-Meyer survival analysis (P = 0.044). After adjustment for tumor differentiation, tumor depth and nodal status, however, it failed to achieve statistical significance (P = 0.067). CONCLUSION: The expression of protein S100A4 is associated with tumor recurrence and poor overall survival in patients with colorectal cancer.

关键词： S100A4 E-cadherin p53 Prognostic factor Colorectal cancer