检索结果-南通市图书馆

Development of high damage threshold laser-machined apodizers and gain filters for laser applications

在线全文

学校读者我要写书评

暂无评论

High Power laser Science and Engineering 2016年第3期4卷 113-119页

作者： Patrick Rambo Jens Schwarz Mark Kimmel john l.Porter Sandia National laboratories

We have developed high damage threshold filters to modify the spatial profile of a high energy laser beam. The filters are formed by laser ablation of a transmissive window. The ablation sites constitute scattering centers which can be filtered in a subsequent spatial filter. By creating the filters in dielectric materials, we see an increased laser-induced damage threshold from previous filters created using ‘metal on glass' lithography.

关键词： apodization laser beam shaping laser micro-machining spatial filtering

Response to ‘Monotreme middle ear is not primitive for Mammalia’

在线全文

学校读者我要写书评

暂无评论

National Science Review 2021年第10期8卷 12-14页

作者： john R.Wible Sarah l.Shelley Shundong Bi Section of Mammals Carnegie Museum of Natural History Centre for Vertebrate Evolutionary Biology Yunnan University School of Geosciences University of Edinburgh Department of Biology Indiana University of Pennsylvania

To date, a complete auditory apparatus(with malleus, incus, stapes, ectotympanic and perhaps surangular) is known for only three Mesozoic mammals, the haramiyidan Arboroharamiya allinhopsoni [1], the multituberculate Sinobaatar pani [2] and the zhangheotheriid Origolestes lii [3], with subsets of these bones preserved in a handful more,

关键词： EVOlUTION

Strategies For Being A Successful Physician Administrator Of A Rehabilitation Program

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国康复医学杂志 2008年第11期23卷 961-964页

作者： john l. Melvin Department of Rehabilitation Medicine Jefferson Medical Collegeof Thomas Jefferson University

INTRODUCTION Purpose:The purpose of this paper is to provide rehabili-tation physicians with suggestions that will assist themin becoming successful program leaders/managers/

关键词：内科医师医疗卫生事业医院管理康复医学

A little goes a long way: ClE peptides mediate phloem initiation

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2019年第10期61卷 1034-1035页

作者： Amala john Zachary l.Nimchuk Department of Biology University of North Carolina at Chapel Hill

The root system of a tree can often extend many-fold the diameter of the tree;it provides physical support, dissolved minerals and water but relies on a constant supply of nutrients from photosynthetically active tissues in aboveground organs. The phloem is re-sponsible for such transport and the success of a plant relies heavily on the integrity of the phloem in its root system.

关键词： ClE peptides mediate initiation

Circadian rhythms in liver metabolism and disease

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2015年第2期5卷 113-122页

作者： Jessica M.Ferrell john Y.l.Chiang Department of Integrative Medical Sciences Northeast Ohio Medical University

Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and ***, these associations are reviewed with respect to liver metabolism and disease.

关键词： Circadian rhythm liver Metabolic syndrome Type 2 diabetes

Synthesis and crystal structure of a neodymium coordination polymer with 2,6-anthraquinonedisulfonate

在线全文

学校读者我要写书评

暂无评论

Particuology 2010年第3期8卷 221-224页

作者： Jennifer l. Nicholls john Bacsa Andrew M. Fogg Department of Chemistry University of Liverpool Crown Street Liverpool L69 7ZD United Kingdom

The coordination polymer, （Nd（H2O）5）2（2,6-AQDS）3.2H2O where 2,6-AQDS = 2,6- anthraquinonedisulfonate, has been synthesised via a hydrothermal route. Structurally, it consists of layers of monomeric Nd polyhedra which are linked by 2,6-AQDS anions forming a polymeric, three-dimensional network. Each Nd atom is nine coordinate, bonding to five water molecules and to four oxygen atoms from four 2,6-AODS anions which in turn pillar the layers by bridging two Nd atoms in one layer, and coordinating to a single Nd in the other.

关键词： lanthanide layered materials Sulfonate Coordination polymer

Role of lPS/CD14/TlR4-mediated inflammation in necrotizing enterocolitis:Pathogenesis and therapeutic implications

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第38期15卷 4745-4752页

作者： Kwong l Chan Kwong F Wong john M luk Department of Surgery The University of Hong Kong Division of Paediatric Surgery Queen Mary Hospital Department of Pharmacology and Department of Surgery National University Health SystemNational University of SingaporeMD11 #05-1210 Medical Drive

AIM:To establish the roles of lipopolysaccharide (lPS)/CD14/toll-like receptor 4 (TlR4)-mediated inflammation in a rat model of human necrotizing enterocolitis (NEC).METHODS: Six pairs of intestinal samples from human NEC were collected before and after recovery for histological and molecular analysis of inflammatory cytokines and signaling components. In the rat NEC model, we isolated 10-cm jejunum segments and divided them into six groups (n=6) for sham operation, treatment with lPS, bowel distension, combined bowel distension and lPS stimulation, and two therapeutic groups. The potential eff icacy of a recombinant CD18 peptide and a monoclonal CD14 antibody was evaluated in the latter two groups. The serum and tissue levels of several inflammatory mediators were quantified by real-time polymerase chain reaction, ElISA and ***: Human acute phase NEC tissues displayed significant increases (Plevels of TlR4, CD14, myeloid differentiation protein (MD)-2, tumor necrosis factor (TNF)-α and nuclear factor-κB when compared to those after recovery. The histological and inflammatory picture of human NEC was reproduced in rats that were treated with combined bowel distension and lPS, but not in the sham-operated and other control rats. Serum levels of interleukin-6 and TNF-α were also elevated. The NEC pathology was attenuated by treating the NEC rats with a monoclonal CD14 antibody or an lPS-neutralizing ***:lPS and distension are required to produce the histological and inflammatory features of NEC. A potential treatment option is blocking lPS activation and leukocyte infi ltration.

关键词： CD14 antigen lipopolysaccharide Necrotizing enterocolitis Pathogenesis Therapy Toll-like receptor 4

The role of organic electron donors in the initiation of BHAS base-induced coupling reactions between haloarenes and arenes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2019年第11期62卷 1425-1438页

作者： Andrew J.Smith Darren l.Poole john A.Murphy Department of Pure and Applied Chemistry University of StrathclydeStrathclydeGlasgow G11XLUnited Kingdom Flexible Discovery Unit GlaxoSmithKline Medicines Research CentreStevenageSG12NYUnited Kingdom

Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discovery in *** organic structures act as additives that assist these *** additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions,which proceed by radical chain *** review provides an overview of the initiation stages of these reactions.

关键词： organic electron donor potassium tert-butoxide electron transfer base-promoted homolytic aromatic substitution(BHAS) coupling benzyne

The gut's feeling on bile acid signaling in NAFlD

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2018年第2期7卷 151-153页

作者： john Y.l.Chiang Department of Integrative Medical Sciences College of MedicineNortheast Ohio Medical UniversityRootstownOHUSA

The gut to live axis plays a critical role in regulation of hepatic bile acid synthesis and metabolic homeostasis(1).Non-alcoholic fatty liver disease(NAFlD)is the most common chronic liver disease with a high prevalence of^35%in *** can progress from simple steatosis to non-alcoholic steatohepatitis(NASH),cirrhosis and hepatocellular *** is associated with insulin resistance,obesity and type 2 *** acid-activated farnesoid X receptor(FXR)and G protein-coupled bile acid receptor-1(Gpbar-1,aka TGR5)have been shown to regulate lipid,glucose and energy metabolism and activation of FXR by agonists have been shown to improve hepatic metabolism and metabolic disorder in several mouse models of NASH(2).However,the role of bile acid signaling in pathogenesis and treatment of NASH is not clear.

关键词： NAFlD metabolism bile