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World Journal of Orthopedics 2024年第8期15卷 704-712页

作者： Somar Soufan joenne al khoury Zahi Hamdan Mohamad ali Rida Department of Medicine University of BalamandBeirut 00000Lebanon Department of Internal Medicine Clemenceau Medical CenterBeirut 12345Lebanon

Osteoarthritis(OA)poses a substantial burden on patients,leading to pain,functional decline,and reduced quality of *** conventional treatments focus on symptom management,disease-modifying interventions are yet to be *** review explores the efficacy of intra-articular interventions,particularly hyaluronic acid(HA),mesenchymal stem cells(MSCs),and platelet-rich plasma(PRP),in the context of OA *** injections,with diverse formulations like Hylan G-F20,sodium hyaluronate,and hyaluronan,present varying outcomes,necessitating a nuanced understanding of their effectiveness and *** therapy,derived from adipose tissue,umbilical cord,or bone marrow,shows promising results in clinical improvement,with adipose-derived MSCs demonstrating efficacy in maintaining benefits over 6 ***,bone-marrow-derived MSCs show limited effectiveness,highlighting the need for sourcespecific *** has emerged as a superior option for long-term pain reduction and quality of life improvement,with leukocyte-poor formulations and a critical platelet count of 10 billion demonstrating optimal *** comprehensive analysis underscores the potential of intra-articular interventions in OA management,emphasizing the need for personalized and evidence-based approaches to enhance treatment efficacy and patient outcomes.

关键词： Osteoarthritis,Viscosupplementation Platelets Hyaluronic acid Stem cell

Yield of alarm features in predicting significant endoscopic findings among hospitalized patients with dyspepsia

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World Journal of Gastroenterology 2024年第26期30卷 3210-3220页

作者： Lama Ibrahim Maamoun Basheer Tawfik khoury Wisam Sbeit Department of Internal Medicine Galilee Medical CenterNahariya 22001Israel Department of Gastroenterology Galilee Medical CenterNahariya 22001Israel Azrieli Faculty of Medicine Bar-Ilan UniversitySafed 1311502Israel

BACKGROUND Dyspepsia is a very prevalent upper gastrointestinal tract symptoms *** of these symptoms might arise from serious underlying diseases,so the promotion of evidence-based guidelines could potentially better align evaluation and *** To determine the value of alarm features as a predictive factor for significant endoscopic findings(SEFs)among hospitalized patients presenting with *** We conducted a retrospective case-control study including information about 6208 endoscopic procedures performed for hospitalized *** were divided into two groups,with and without SEFs,and compared to elucidate the ability of the different alarm features to predict *** During the study,605 patients fulfilled the inclusion *** the demographics and clinical characteristics of the two groups were compared,tachycardia(Palbuminemia(Palarm features,upper gastrointestinal bleeding,persistent vomiting,odynophagia[odds ratio(OR)=3.81,Palignancy as an endoscopic finding(OR=2.05;Palized patients with dyspepsia.

关键词： Dyspepsia Endoscopy Weight loss Anti-aggregate medications Persistent vomiting Odynophagia

Deep Morphea in an Immunosuppressed Patient With Anti-U1RNP Myositis:A Case Report

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International Journal of Dermatology and Venereology 2024年第2期7卷 111-114页

作者： Ahmad Berjawi Laure L.Irani Jinane R.El khoury Department of Dermatology Gilbert and Rose Marie Chagoury School of MedicineLebanese American UniversityBeirut 1100Lebanon Department of Rheumatology Division of Internal MedicineGilbert and Rose Marie Chagoury School of MedicineLebanese American University Medical CenterBeirut 1100Lebanon

Introduction:Morphea is an inflammatory skin disease characterized by skin thickening due to increased collagen deposition in the dermis or subcutaneous ***-U1RNP myositis is a newly described entity characterized by myositis,arthritis,interstitial lung disease,and Raynaud *** present a case of a unique combination of deep morphea in a patient with anti-U1RNP *** presentation:A 64-year-old male with 5-year history of proximal muscle weakness,polyarthritis,Raynaud phenomenon,and dyspnea on multiple immunosuppressives presented with localized infiltrated,tight,and hyperpigmented plaques over the posterior thighs and mid-to-lower back developing over the last 2 years and limiting his *** workup revealed a positive ANA,anti-U1RNP antibody,anti-Jo1 antibody,and anti-Ro52 *** workup showed restrictive lung disease,kidney disease,and *** was diagnosed with anti-U1RNP *** biopsy of the back lesion showed deep ***:Association of deep morphea with anti-U1RNP myositis is not described prior in the *** of morphea is challenging since the patient is already on immunosuppressive *** patient failed methotrexate prior and is currently on Mycophenolate mofetil and Deflazacort which are reported as potential treatment for ***,physical therapy plus topical Tacrolimus were suggested as an initial measure to preserve the range of motion of his posterior thighs and *** is a case of progressive deep morphea developing in a patient with a unique autoimmune profile on immunosuppressive ***:Anti-U1RNP myositis is a challenging diagnosis and should be always thought of in patients with positive anti-U1RNP,myositis,interstitial lung disease,arthritis,kidney disease,and Raynaud ***,deep morphea treatment in immunosuppressed patients is challenging and different measures should be considered.

关键词： deep morphea immunosuppression anti-U1RNP myositis case report

Formation Mechanisms of Some Features in Siliceous Upper Cretaceous-Lower Tertiary Beds of Jordan-Undulations, Geodes, Boudinages

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Open Journal of Geology 2024年第4期14卷 569-577页

作者： Elias Salameh Hani khoury Department of Geology University of Jordan Amman Jordan

Geode, boudinage, and undulation structures are widely distributed in the siliceous beds of the Upper Cretaceous/Tertiary rocks in Jordan. Their formation was attributed to tectonic forces, syngenetic processes, organic disintegration processes, subaquatic gliding, compaction and settlement, and meteoritic impacts. In this work, the structural features in the siliceous beds of Jordan are attributed to an interplay of load and directed pressures, and mineralogical transformation processes (opal-A to opal-CT to quartz), governed by pH changes. Tectonic directed pressure was acting in an ESE-WSW direction and is common in the silicified limestone of Upper Cretaceous.

关键词： Undulations Geodes Boudinages Opal-A Porcelanite Chert Transformations pH Changes Stress Fields Jordan

Endodontic irrigants from a comprehensive perspective

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World Journal of Clinical Cases 2024年第21期12卷 4460-4468页

作者： Rayana Duarte khoury Lara Steffany de Carvalho Mauro Felipe Rios do Nascimento Fadi alhussain AmjadAbu Hasna Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil School of Dentistry The National Institute of Higher Education and Postgraduate Studies Padre Gervásio-INAPÓSPouso Alegre 37550-121MGBrazil School of Dentistry Syrian Private UniversityAl Kiswah 877C+P2DamascusSyria School of Dentistry Universidad Espíritu SantoSamborondón 092301Ecuador

This review article explores the fundamental principles of modern endodontics with a focus on root canal cleaning and *** reviews commonly used endodontic irrigant,namely sodium hypochlorite(NaOCl),herbal extracts,chlorhexidine(CHX),and chelating agents,highlighting their properties,applications,and potential ***,a key antimicrobial agent,demonstrates effectiveness against various microorganisms but poses challenges such as high *** extracts,gaining recognition in endodontics,present an alternative with potential advantages in preserving dentin ***,known for its broad-spectrum antimicrobial activity,is discussed in both liquid and gel formulations,emphasizing its role in reducing smear layer formation and preserving hybrid layer *** agents,specifically ethylenediaminetetraacetic acid and citric acid,play a vital role in removing the smear layer,enhancing dentin permeability,and facilitating the penetration of antimicrobial *** review article underscores the importance of careful application and consideration of each irrigant's properties to ensure safe and effective endodontic *** serves as a valuable guide for clinicians in selecting appropriate irrigants based on specific treatment requirements.

关键词： Root canal irrigants Sodium hypochlorite Chlorhexidine Chelating agents Plant extracts

Deuterated dextromethorphan/quinidine for agitation in alzheimer's disease

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Neural Regeneration Research 2022年第5期17卷 1013-1014页

作者： Rita khoury Department of Psychiatry and Clinical Psychology Saint George Hospital University Medical Center-BeirutLebanon.Adjunct FacultyDepartment of Psychiatry and Behavioral NeuroscienceSaint Louis University School of MedicineSt.LouisMIUSA

alzheimer's disease(AD)is the most common type of neurode generative disorder;it affects around 47 million individuals worldwide(Prince et al.,2013).AD rose from the 12 th most burdensome disease in the United States ... 详细信息

关键词： alzheimer agitation

Endoscopic ultrasound guided radiofrequency ablation for pancreatic tumors: A critical review focusing on safety, efficacy and controversies

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World Journal of Gastroenterology 2023年第1期29卷 157-170页

作者： Tawfik khoury Wisam Sbeit Bertrand Napoléon Department of Gastroenterology Galilee Medical CenterNahariya 2210001Israel Department of Endoscopy Unit Private Hospital Jean MermozLyon 69008France

The role of endoscopic ultrasound(EUS)in the last two decades has shifted from a diagnostic tool to an important therapeutic tool treating mainly pancreatobiliary *** recent years,its applications for treating pancreatic diseases have broadened,including the implementation of radiofrequency ablation(RFA),which has been traditionally used for treating solid *** this critical indepth review,we summarized all the papers throughout the literature regarding EUS-RFA for pancreatic neuroendocrine neoplasms,adenocarcinoma,and pancreatic cystic ***,for pancreatic neuroendocrine neoplasms we identified 16 papers that reported 96 patients who underwent EUS-RFA,with acceptable adverse events that were rated mild to moderate and a high complete radiological resolution rate of 90%.For pancreatic adenocarcinoma,we identified 8 papers with 121 *** events occurred in 13%of patients,mostly rated ***,no clear survival benefit was *** pancreatic cystic lesions,we identified 4 papers with 38 *** adverse events were mostly mild and occurred in 9.1%of patients,and complete or partial radiological resolution of the cysts was reported in 36.8%.Notably,the procedure was technically feasible for most of the ***,a long road remains before this technique finds its definite place in guidelines due to several ***-RFA for pancreatic tumors seems to be safe and effective,especially for pancreatic neuroendocrine neoplasms,but multicenter prospective trials are needed to consider this treatment as a gold standard.

关键词： Endoscopic ultrasound Radiofrequency ablation Efficacy Safety Pancreas Tumors

Endoscopic ultrasound role in pancreatic adenocarcinoma treatment:A review focusing on technical success,safety and efficacy

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World Journal of Gastroenterology 2022年第3期28卷 332-347页

作者： Wisam Sbeit Bertrand Napoléon Tawfik khoury Department of Gastroenterology Galilee Medical CenterFaculty of Medicine in the GalileeBar-Ilan UniversityNahariya 2221006Israel

The impressive technological advances in recent years have rapidly translated into the shift of endoscopic ultrasound(EUS)from diagnostic modality into an interventional and therapeutic *** the great advance in its diagnosis,the majority of pancreatic adenocarcinoma cases are inoperable when diagnosed,thus demanding alternative optional *** has emerged as an easy,minimally invasive modality targeting this carcinoma with different interventions that have been reported *** this review we summarize the evolving role of interventional therapeutic EUS in pancreatic adenocarcinoma management.

关键词： Endoscopic ultrasound Pancreas Cancer Management Palliative

Emergency department electric scooter injuries after the introduction of shared e-scooter services: A retrospective review of 3,331 cases

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World Journal of Emergency Medicine 2022年第1期13卷 5-10页

作者： Ittai Shichman Or Shaked Shai Factor Ahuva Weiss-Meilik Amal khoury Division of Orthopedics Tel-Aviv Sourasky Medical CenterAffi liated to the Sackler Faculty of Medicine Tel-Aviv UniversityTel Aviv 64239Israel Head of I-Medata AI Center Tel-Aviv Sourasky Medical CenterAffi liated to the Sackler Faculty of Medicine Tel-Aviv UniversityTel Aviv 64239Israel

BACKGROUND: To determine the frequency, characteristics, and use of resources related to electric scooter(e-scooter) injuries in the emergency department(ED) of a major metropolitan area ***: We performed a retrospective review of all ED presentations related to e-scooter injuries at a level I trauma center between May 2017 and February 2020. We identified ED presentation data, injury-related data, patients’ clinical course after evaluation, injury diagnosis, surgical procedures, and ED ***: A total of 3,331 patients with e-scooter injuries presented to the ED over a 34-month period. There was a 6-fold increase in e-scooter-related injuries presenting to the ED, from an average of 26.9 injuries per month before the introduction of shared e-scooter services in August 2018 to an average of 152.6 injuries per month after its introduction. The average injury rate during weekdays was 3.27 per day, with the majority of injuries occurring in the afternoon. The most common mechanism of injury was rider fall(79.1%). There were a total of 2,637 orthopedic injuries, of which 599(22.7%) were fractures. A total of 296(8.9%) patients were hospitalized following the initial ED admission, and 462 surgeries were performed within 7 days of ED ***: The introduction of the shared e-scooter services is associated with a dramatic increase in e-scooter injuries presenting to the ED. E-scooter use carries considerably underestimated injury risks of high-energy trauma and misunderstood mechanisms of injuries. These injuries challenge the healthcare system, with a major impact on both EDs and surgical departments.

关键词： E-scooter Scooter Emergency department

Predictors of recurrent bile duct stone after clearance by endoscopic retrograde cholangiopancreatography:A case-control study

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 50-55页

作者： Wisam Sbeit Anas Kadah Matta Simaan Amir Shahin Tawfik khoury Department of Gastroenterology Galilee Medical CenterNahariyaIsrael Faculty of Medicine in the Galilee Bar-Ilan UniversitySafedIsrael

Background:Recurrent common bile duct(CBD)stone is a long-term sequalae among patients who un-derwent endoscopic retrograde cholangiopancreatography(ERCP)with CBD stone *** regard-ing risk factors for recurrent CBD stone are *** aimed to identify predictors of recurrent CBD ***:We performed a retrospective case-controlled study from January 2010 to December ***-clusion criteria included patients who had recurrent CBD stone at least 6 months after the index ERCP,in which complete stone extraction was performed and normal cholangiogram was ***,457 patients were ***-two patients(9.2%)had recurrent CBD stone,and 415 patients(90.8%)did not have recurrent CBD ***:In univariate analysis,male sex[odds ratio(OR)=0.49,P=0.033]was a protective factor,while endoscopic stone extraction by basket ***(OR=2.55,P=0.005),older age(OR=1.03,P=0.003),number of CBD stones(OR=1.99,P=0.037),size of CBD stone(OR=4.06,P=0.003)and mechanical lithotripsy(OR=9.22,P=0.004)were risk factors for recurrent CBD *** multivariate logistic regression analysis,mechanical lithotripsy[OR=9.73,95%confidence interval(CI):1.69-55.89,P=0.010],basket clearance *** basket and balloon(OR=18.25,95%CI:1.05-318.35,P=0.046)and older age(OR=1.02,95%CI:1.00-1.05,P=0.023)were risk factors,and male sex(OR=0.39,95%CI:0.19-0.81,P=0.012)was a protective factor.

关键词： Endoscopic retrograde cholangiopancreatography Common bile duct Stone Recurrence