Intra-articular interventions in osteoarthritis:Navigating the landscape of hyaluronic acid,mesenchymal stem cells,and plateletrich plasma

作     者：Somar Soufan Joenne Al Khoury Zahi Hamdan Mohamad Ali Rida 

作者机构：Department of MedicineUniversity of BalamandBeirut 00000Lebanon Department of Internal MedicineClemenceau Medical CenterBeirut 12345Lebanon 

出 版 物：《World Journal of Orthopedics》 (世界骨科杂志（英文版）)

年 卷 期：2024年第15卷第8期

页      面：704-712页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Osteoarthritis,Viscosupplementation Platelets Hyaluronic acid Stem cell 

摘      要：Osteoarthritis(OA)poses a substantial burden on patients,leading to pain,functional decline,and reduced quality of *** conventional treatments focus on symptom management,disease-modifying interventions are yet to be *** review explores the efficacy of intra-articular interventions,particularly hyaluronic acid(HA),mesenchymal stem cells(MSCs),and platelet-rich plasma(PRP),in the context of OA *** injections,with diverse formulations like Hylan G-F20,sodium hyaluronate,and hyaluronan,present varying outcomes,necessitating a nuanced understanding of their effectiveness and *** therapy,derived from adipose tissue,umbilical cord,or bone marrow,shows promising results in clinical improvement,with adipose-derived MSCs demonstrating efficacy in maintaining benefits over 6 ***,bone-marrow-derived MSCs show limited effectiveness,highlighting the need for sourcespecific *** has emerged as a superior option for long-term pain reduction and quality of life improvement,with leukocyte-poor formulations and a critical platelet count of 10 billion demonstrating optimal *** comprehensive analysis underscores the potential of intra-articular interventions in OA management,emphasizing the need for personalized and evidence-based approaches to enhance treatment efficacy and patient outcomes.