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Engineering nanoparticles for targeting rheumatoid arthritis： Past, present, and future trends

Nano Research 2018年第9期11卷 4489-4506页

作者： Isabel Matos oliveira Cristiana Goncalves Rui Lufs Reis joaquim miguel.ol.veira B's Research Group - Biomatefials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark 4805-017 Barco Guimaraes Portugal ICVS/3B's-PTGovernment Associate Laboratory University of Minho Campus de Gualtar 4710-057 Braga Portugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of Minho Avepark 4805-017 Barco Guimaraes Portugal

Rheumatoid arthritis （RA） is a chronic inflammatory disease characterized by synovial joint inflammation and cartilage and bone tissue destruction. Although there exist some treatment strategies for RA, they are not completely safe and effective. Therefore, it is important to develop and test new drugs for RA that specifically target inflamed/swollen joints and simultaneously attenuate other possible damages to healthy tissues. Nanotechnology can be a good alternative to consider when envisioning predse medication for treating RA. Through the use of nanopartides, it is possible to increase bioavailability and bioactivity of therapeutics and enable selective targeting to damaged joints. Herein, recent studies using nanoparticles for the treatment of RA, namely with liposomes, polymeric nanoparticles, dendrimers, and metallic nanoparticles, have been reviewed. These therapeutic strategies have shown great promise in improving the treatment over that by traditional drugs. The results of these studies confirm that feasibility of the use of nanopartides is mainly due to their biocompatibility, low toxicity, controlled release, and selective drug delivery to inflamed tissues in animal RA models. Therefore, it is possible to claim that nanotechnology will, in the near future, play a crucial role in advanced treatments and patient-specific therapies for human diseases such as RA.

关键词： nanoparticles liposomes dendrimers rheumatoid arthritis

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Current advances in solid free-form techniques for osteochondral tissue engineering

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Bio-Design and Manufacturing 2018年第3期1卷 171-181页

作者： Joao Bebiano Costa Joana Silva-Correia Rui Luis Reis joaquim miguel.ol.veira B's Research Group I3Bs - Research Institute onBiomaterials Biodegradables and Biomimetics University ofMinho Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine AveParkParque de Ciencia e Tecnologia Zona Industrial da Gandra4805-017 Barco Guimaraes Portugal ICVS/3B's-PT Government Associate Laboratory Braga Guimarfies Portugal The Discoveries Centre for Regenerative and PrecisionMedicine Headquarters at University of MinhoAvepark 4805-017 Barco Guimaraes Portugal

Osteochondral （OC） lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds＇ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form （SFF） techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

关键词： Solid free-form Osteochondral Tissue engineering Scaffolds

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Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin Models

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Journal of Bionic Engineering 2023年第1期20卷 105-118页

作者： Tian Jiao Qin Lian Weilong Lian Yonghui Wang Dichen Li Rui L.Reis joaquim miguel.ol.veira State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an710049China Shaanxi Ketao-AM Technology Co. Ltd.Xi’an710100China B’s Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoBarco4805-017GuimarãesPortugal ICVS/3B’s–PT Government Associate Laboratory Barco4805-017GuimarãesPortugal

3D printing technology has great potential for the reconstruction of human ***,the reconstructed skin has some differences from natural skin,largely because the hydrogel used does not have the appropriate biological and physical properties to allow healing and *** study examines the swelling,degradability,microstructure and biological properties of Collagen/Sodium Alginate(Col/SA)hydrogels of differing compositions for the purposes of skin *** the content of sodium alginate causes the hydrogel to exhibit stronger mechanical and swelling properties,a faster degradation ratio,smaller pore size,and less favorable biological *** optimal 1%collagen hydrogel was used to print bi-layer skin in which fibroblasts and keratinocytes showed improved spreading and proliferation as compared to other developed *** Col/SA hydrogels presented suitable tunability and properties to be used as a bioink for bioprinting of skin aiming at finding applications as 3D models for wound healing research.

关键词： Bioink Bioprinting-Collagen sodium alginate hydrogel-Skin Wound healing Bionic

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Adaptable hydrogel with reversible linkages for regenerative medicine:Dynamic mechanical microenvironment for cells

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Bioactive Materials 2021年第5期6卷 1375-1387页

作者： Zongrui Tong Lulu Jin joaquim miguel.ol.veira Rui LReis Qi Zhong Zhengwei Mao Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017Barco GMRPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017BarcoGuimarãesPortugal Key Laboratory of Advanced Textile Materials&Manufacturing Technology Ministry of EducationNational Base for International Science and Technology Cooperation in Textiles and Consumer-Goods ChemistryZhejiang Sci-Tech University310018HangzhouChina

Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular *** materials are starting to play important roles in regenerative medicine because of their similarities to native matrix in water content and *** would be very advantagoues for researchers to be able to regulate cell behavior and fate with specific hydrogels that have tunable mechanical properties as biophysical *** developments in dynamic chemistry have yielded designs of adaptable hydrogels that mimic dynamic nature of extracellular *** current review provides a comprehensive overview for adaptable hydrogel in regenerative medicine as ***,we outline strategies to design adaptable hydrogel network with reversible linkages according to previous findings in supramolecular chemistry and dynamic covalent ***,we describe the mechanism of dynamic mechanical microenvironment influence cell behaviors and fate,including how stress relaxation influences on cell behavior and how mechanosignals regulate matrix ***,we highlight techniques such as bioprinting which utilize adaptable hydrogel in regenerative *** conclude by discussing the limitations and challenges for adaptable hydrogel,and we present perspectives for future studies.

关键词： Adaptable hydrogel Dynamic mechanical microenvironment Supramolecular chemistry Dynamic covalent chemistry Yes-associated protein

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An alternative practical design method for structures with viscoelastic dampers

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Earthquake Engineering and Engineering Vibration 2018年第3期17卷 459-473页

作者： joaquim Mimusse Tchamo Zhou Ying State Key Laboratory of Disaster Reduction in Civil Engineering Tongji University

Viscoelastic dampers（VEDs） are one of the most common passive control devices used in new and retrofit building projects which reduce the structure responses and dissipate seismic energy during an *** methods to design this kind of dampers have been proposed based on the desired level of additional damping,eigenvalue assignment,modal strain energy,linear quadratic regulator control theories,and other *** the current engineering practice,the popular method is the one based on the modal strain energy that uses the inter-story lateral stiffness as one of the main variables for damper ***,depending on the configuration of the structure,in some cases the resulting interstory lateral stiffness can be very ***,the dampers size would also be large producing much more damping than that effectively necessary,resulting in an increase of the overall cost of the supplemental damping system and causing excessive stress on the structural elements connected to the *** this paper an alternative practical design method for structures with VEDs is *** method uses the inter-story shear forces as one of the main variables to accomplish the damper design compared to what was done in previous *** time-history analyses were conducted on a 7-story reinforced concrete（RC） structure to check the reliability and effectiveness of the proposed *** on the seismic performance between the structure without dampers and that equipped with VEDs were carried *** is concluded that the proposed method results in a very suitable size of dampers,which are able to improve the performance of the structure at all levels of earthquake ground motions and satisfying the drift requirement prescribed in the codes.

关键词： viscoelastic dampers passive control seismic design method inter-story shear forces earthquake engineering

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Iterated Inverse Images of Plane Curve Singularities

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Acta Mathematica Sinica,English Series 2011年第12期27卷 2319-2328页

作者： Eduardo CASAS-ALVERO joaquim ROE Departament d＇Algebra i Geometria Universitat de Barcelona Gran Via 585 08007 Barcelona Spain Departament de Matematiques Universitat Autonoma de Barcelona 08193 Bellaterra （Barcelona） Spain

We describe the evolution of certain multiplicities and intersection numbers of plane curve singularities under the iterated action of an analytic morphism.

关键词： Plane curve singularity analytic morphism dynamics of intersection

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Fabrication of cost-effective, highly reproducible large area arrays of nanotriangular pillars for surface enhanced Raman scattering substrates

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Nano Research 2016年第10期9卷 3075-3083页

作者： Kudilatt Hasna Aldrin Antony joaquim Puigdollers Kumaran Rajeev Kumar Madambi Kunjukuttan Jayaraj Nanophotonic & Optoelectronic Devices Laboratory Department of Physics Cochin University of Science & Technology Kochi 682 022 India Department of Instrumentation Cochin University of Science & Technology Kochi 682 022 India Department of Energy Science and Engineering Indian Institute of Technology Bombay Maharashtra 400 076 India Department of Enginyeria Electronica Universitat Politecnica Catalunya C/Jordi Girona 31 Modul C4 Barcelona 08034 Spain

Development of cost-effective, highly reproducible non-conventional fabrication techniques for anisotropic metal nanostructures is essential to realizing potential applications of plasmonic devices, photonic devices, and surface enhanced Raman scattering （SERS） phenomenon based sensors. This report highlights the fabrication of nanotriangle arrays via nanoimprinting to overcome difficulties in creating large-area SERS active substrates with uniform, reproducible Raman signals. Electron beam lithography of anisotropic nanostructures, formation of arrays of nanotriangles in silicon and the transfer of triangular shapes to polymethylmethacrylate （PMMA） sheets via nanoimprinting have not been reported elsewhere. The reuse of silicon masters offers potential for production of low cost SERS substrates. The SERS activity and reproducibility of nanotriangles are illustrated and a consistent average enhancement factor of up to -2.9 × 1011, which is the highest value reported for a patterned SERS substrate, is achieved.

关键词： metal nanostructures localized surface plasmon resonance (LSPR) surface enhanced Ramanscattering (SERS) substrate enhancement factor

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Updating of the hierarchical rock mass rating(HRMR) system and a new subsystem developed for weathered granite formations

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International Journal of Mining Science and Technology 2014年第6期24卷 769-775页

作者： Miranda Tiago e Sousa L.Ribeiro Tinoco joaquim ISISE University of Minho Guimar?es 4800-058 Portugal State Key Laboratory of Geomechanics and Deep Underground Engineering China University of Mining & Technology University of Porto Porto 4200 Portugal

The RMR system is still very much applied in rock mechanics engineering context. It is based on the evaluation of six weights to obtain a final rating. To obtain the final rating a considerable amount of information is needed concerning the rock mass which can be difficult to obtain in some projects or project stages at least with accuracy. In 2007 an alternative classification scheme based on the RMR, the Hierarchical Rock Mass Rating(HRMR) was presented. The main feature of this system was the adaptation to the level of knowledge existent about the rock mass to obtain the classification of the rock mass since it followed a decision tree approach. However, the HRMR was only valid for hard rock granites with low fracturing degrees. In this work, the database was enlarged with approximately 40% more cases considering other types of granite rock masses including weathered granites and based on this increased database the system was updated. Granite formations existent in the north of Portugal including Porto city are predominantly granites. Some years ago a light rail infrastructure was built in the city of Porto and surrounding municipalities which involved considerable challenges due to the high heterogeneity levels of the granite formations and the difficulties involved in their geomechanical characterization. In this work it is intended to provide also a contribution to improve the characterization of these formations with special emphasis to the weathered horizons. A specific subsystem applicable to the weathered formations was developed. The results of the validation of these systems are presented and show acceptable performances in identifying the correct class using less information than with the RMR system.

关键词： Rock mass classification system Decision tree Weathered granite formations

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Evaluation of Relative Permeability in Fractured Reservoir Rocks

Evaluation of Relative Permeability in Fractured Reservoir R...

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作者： Chimalizene joaquim David Chuva 中国石油大学(北京)

学位级别：硕士

Relative permeability is measurement of the ability of two or more fluid phases to pass through reservoir ***’s law is often used to describe the fluid flow through reservoir *** is a parameter in Darcy’s law to represent the capability of the rock to conduct single phase *** there are more phases coexist,each phase has its own permeability which is also named as effective *** permeability,the ratio of effective permeability to absolute permeability,adapts the Darcy’s law to multiphase *** can significantly affect the mechanism of oil and gas production from petroleum *** improve the permeability of a reservoir that has poor matrix porosity and permeability,fracture network controls both fluid flow and storage in tight rocks with little or no matrix *** are the major flow channels for fluid in fractured reservoir,so the accurate prediction of multiphase flow in fracture is highly *** 1966,Romm firstly established relative permeability mode ls for fractures based on the water experimental results and he suggested that two phase flow in fractures can be modeled by *** 1998,Fourar and Lenormand proposed an analytical model on Stokes equation to describe gas-water relative permeability in fracture *** et al.（2013）proposed a model to improve relative permeability on coal reservoir and there shows that the relative permeability for coal is also affected by the porosity change,consequently the evolution of wetting phase saturation and the gas production can significantly be *** work I analysis the characteristics of relative permeability of two phases in different reservoirs and I fit the data with relative permeability model and we will make comparison of relative permeability evaluation in different fractured reservoir rock.I verified the Chen et ***,made comparison with Brooks-Corey Model and obtain two get a *** the end we wil

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Development of a Balanced Adaptive Time‑Stepping Strategy Based on an Implicit JFNK‑DG Compressible Flow Solver

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Communications on Applied Mathematics and Computation 2022年第2期4卷 728-757页

作者： Yu Pan Zhen‑Guo Yan joaquim Peiró Spencer J.Sherwin Department of Aeronautics Imperial College LondonLondonUK State Key Laboratory of Aerodynamics China Aerodynamics Research and Development CenterMianyang 621000SichuanChina

A balanced adaptive time-stepping strategy is implemented in an implicit discontinuous Galerkin solver to guarantee the temporal accuracy of unsteady simulations.A proper relation between the spatial,temporal and iterative errors generated within one time step is *** an estimate of temporal and spatial error using an embedded RungeKutta scheme and a higher order spatial discretization,an adaptive time-stepping strategy is proposed based on the idea that the time step should be the maximum without obviously infuencing the total error of the *** designed adaptive time-stepping strategy is then tested in various types of problems including isentropic vortex convection,steady-state fow past a fat plate,Taylor-Green vortex and turbulent fow over a circular cylinder at Re=*** results indicate that the adaptive time-stepping strategy can maintain that the discretization error is dominated by the spatial error and relatively high efciency is obtained for unsteady and steady,well-resolved and under-resolved simulations.

关键词： Adaptive time-stepping Unsteady simulations High order Discontinuous Galerkin Implicit time integration

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