Adaptable hydrogel with reversible linkages for regenerative medicine:Dynamic mechanical microenvironment for cells

作     者：Zongrui Tong Lulu Jin Joaquim Miguel Oliveira Rui LReis Qi Zhong Zhengwei Mao Changyou Gao 

作者机构：MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China 3B’s Research GroupI3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017Barco GMRPortugal ICVS/3B’s-PT Government Associate LaboratoryBraga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision MedicineHeadquarters at University of MinhoAvepark4805-017BarcoGuimarãesPortugal Key Laboratory of Advanced Textile Materials&Manufacturing TechnologyMinistry of EducationNational Base for International Science and Technology Cooperation in Textiles and Consumer-Goods ChemistryZhejiang Sci-Tech University310018HangzhouChina 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第5期

页      面：1375-1387页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0836[工学-生物工程] 

基　　金：support of the National Key Research and Development Program of China(2016YFE0132700) National Natural Science Foundation of China(51822306,51673171) Science Technology Department of Zhejiang Province(2020C03042) the Fundamental Research Funds for the Central Universities of China 

主　　题：Adaptable hydrogel Dynamic mechanical microenvironment Supramolecular chemistry Dynamic covalent chemistry Yes-associated protein 

摘      要：Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular *** materials are starting to play important roles in regenerative medicine because of their similarities to native matrix in water content and *** would be very advantagoues for researchers to be able to regulate cell behavior and fate with specific hydrogels that have tunable mechanical properties as biophysical *** developments in dynamic chemistry have yielded designs of adaptable hydrogels that mimic dynamic nature of extracellular *** current review provides a comprehensive overview for adaptable hydrogel in regenerative medicine as ***,we outline strategies to design adaptable hydrogel network with reversible linkages according to previous findings in supramolecular chemistry and dynamic covalent ***,we describe the mechanism of dynamic mechanical microenvironment influence cell behaviors and fate,including how stress relaxation influences on cell behavior and how mechanosignals regulate matrix ***,we highlight techniques such as bioprinting which utilize adaptable hydrogel in regenerative *** conclude by discussing the limitations and challenges for adaptable hydrogel,and we present perspectives for future studies.