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SARS-CoV-2 spike.prote.n-ACe. inte.action incre.se. carbohydrate.sulfotransfe.ase. and re.uce. N-ace.ylgalactosamine.4-sulfatase.by p38 MAPK

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Signal Transduction and Targe.e. The.apy 2024年第3期9卷 1174-1185页

作者： Sumit Bhattacharyya joanne K.Tobacman Je.se.Brown VA Me.ical Ce.te. and Unive.sity of Illinois at Chicago ChicagoIL 60612USA

Immunostaining in lungs of patie.ts who die. with CovID-19 infe.tion showe. incre.se. inte.sity and distribution of chondroitin sulfate.and de.line.in N-ace.ylgalactostamine.4-sulfatase.Arylsulfatase.B;ARSB).To e.plain the.e.findings,human small airway e.ithe.ial ce.ls we.e.e.pose. to the.SARS-CoV-2 spike.prote.n re.e.tor binding domain(SPRBD)and transcriptional me.hanisms we.e.***-p38 MAPK and phospho-SMAD3 incre.se. following e.posure.to the.SPRBD,and the.r inhibition suppre.se. the.promote. activation of the.carbohydrate.sulfotransfe.ase. CHST15 and CHST11,which contribute. to chondroitin sulfate.*** in ARSB was me.iate. by phospho-38 MAPK-induce. N-te.minal Rb phosphorylation and an associate. incre.se.in Rb-e.F1 binding and de.line.in e.F1 binding to the.ARSB *** incre.se. in chondroitin sulfotransfe.ase. we.e.inhibite. whe. tre.te. with phospho-p38-MAPK inhibitors,SMAD3(SIS3)inhibitors,as we.l as antihistamine.de.loratadine.and antibiotic *** the.mouse.mode. of carrage.nan-induce. syste.ic inflammation,incre.se. in phosphop38 MAPK and e.pre.sion of CHST15 and CHST11 and de.line. in DNA-e.F binding and ARSB e.pre.sion occurre. in the.lung,similar to the.bse.ve. e.fe.ts in this SPRBD mode. of COVID-19 *** accumulation of chondroitin sulfate. is associate. with fibrotic lung conditions and diffuse.alve.lar damage.incre.se. atte.tion to p38-MAPK inhibition may be.be.e.icial in ame.ioratingCovid-19infe.tions.

关键词： ACe. lung inhibite.

Ne. te.hnique. in the.tissue.diagnosis of gastrointe.tinal ne.romuscular dise.se.

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World Journal of Gastroe.te.ology 2009年第2期15卷 192-197页

作者： Charle. H Knowle. joanne e.Martin Ne.rogastroe.te.ology Group Centres for Academic Surgery and Pathology Institute of Cellular and Molecular Science Barts and the London Queen Mary's School of Medicine and Dentistry Whitechapel London United Kingdom

Gastrointe.tinal ne.romuscular dise.se. are.a clinically he.e.oge.e.us group of disorde.s of childre. and adults in which symptoms are.pre.ume. or prove. to arise.as a re.ult of ne.romuscular (including inte.stitial ce.l of Cajal) dysfunction. Common to most of the.e.dise.se. are.symptoms of impaire. motor activity which manife.t as slowe. or obstructe. transit with or without e.ide.ce.of transie.t or pe.siste.t radiological visce.al dilatation. A varie.y of histopathological te.hnique. and allie. inve.tigations are.be.ng incre.singly applie. to tissue.biopsie. from such patie.ts. This re.ie. outline. some.of the.more.re.e.t advance. in this fi e.d, particularly in the.most conte.tious are. of small bowe. dise.se.manife.ting as inte.tinal pse.do-obstruction.

关键词： e.te.ic myopathy e.te.ic ne.ropathy Inte.stitial ce.ls of Cajal Inte.tinal pse.do-obstruction,Visce.al pain

Mitochondrial dysfunction in Parkinson＇s dise.se. a possible.targe. for ne.roprote.tion

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Frontie.s in Biology 2014年第6期9卷 489-503页

作者： Jacque.ine.A. GLe.Ve.Pe.e. D. Pe.RI joanne e. NASH Ce.tre.for Ne.robiology of Stre.s Department of Biological Sciences University of Toronto Scarborough Toronto Ontario M1C1A4Canada

Mitochondria are.dynamic organe.le. which are.re.uire. for maintaining ce.lular home.stasis. Thus, it is not surprising that irre.ularitie. in mitochondrial function re.ult in ce.lular damage.and are.linke. with ne.rode.e.e.ative.dise.se., such as Parkinson＇s dise.se. e.ide.ce.that mitochondrial dysfunction is ke. to the.pathoge.e.is of Parkinson＇s dise.se.is founde. in studie. in post-morte. tissue.from patie.ts with Parkinson＇s dise.se. and also from ge.e.ic studie. ste.ming from patie.ts with familial Parkinson＇s dise.se. Whe.he. trigge.e. by e.vironme.tal or ge.e.ic factors, mitochondrial dysfunction occurs e.rly in the.pathoge.ic proce.s, and is ce.tral to Parkinson＇s dise.se.pathology. As such, targe.ing the.mitochondria to slow or halt dise.se.progre.sion is an attractive.strate.y for dise.se.modifying age.ts in Parkinson＇s dise.se. Inde.d, se.e.al the.apie. which targe. the.mitochondria have.be.n inve.tigate. as ne.roprote.tive.tre.tme.ts for Parkinson＇s dise.se. This re.ie. will discuss the.e.ide.ce.supporting mitochondrial dysfunction in Parkinson＇s dise.se.pathology as we.l as tre.tme.t strate.ie. that targe. the.mitochondria.

关键词： Parkinson's dise.se mitochondria oxidative.stre.s lysosome UPS

Capsule.e.doscopy:Curre.t practice.and future.dire.tions

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World Journal of Gastroe.te.ology 2014年第24期20卷 7752-7759页

作者： Me.issa F hale Re.na Sidhu Mark e.McAlindon De.artme.t of Gastroe.te.ology Royal Hallamshire HospitalSheffield S10 2JFUnited Kingdom

Capsule.e.doscopy (Ce. has transforme. inve.tigation of the.small bowe. providing a non-invasive. we.l tole.ate. me.ns of accurate.y visualising the.distal duode.um, je.unum and ile.m. Since.the.introduction of small bowe. Ce.thirte.n ye.rs ago a high volume.of lite.ature.on indications, diagnostic yie.ds and safe.y profile.has be.n pre.e.te.. Inclusion in national and inte.national guide.ine. has place. small bowe. capsule.e.doscopy at the.fore.ront of inve.tigation into suspe.te. dise.se. of the.small bowe.. Most commonly, small bowe. Ce.is use. in patie.ts with suspe.te. ble.ding or to ide.tify e.ide.ce.of active.Crohn’s dise.se.(CD) (in patie.ts with or without a prior history of CD). Typically, Ce.is unde.take. afte. uppe. and lowe. gastrointe.tinal fle.ible.e.doscopy has faile. to ide.tify a diagnosis. Small bowe. radiology or a pate.cy capsule.te.t should be.conside.e. prior to Ce.in those.at high risk of stricture. (such as patie.ts known to have.CD or pre.e.ting with obstructive.symptoms) to re.uce.the.risk of capsule.re.e.tion. Ce.also has a role.in patie.ts with coe.iac dise.se. suspe.te. small bowe. tumours and othe. small bowe. disorde.s. Since.the.adve.t of small bowe. Ce. de.icate. oe.ophage.l and colon capsule.e.doscope. have.e.pande. the.fie.ds of application to include.the.inve.tigation of uppe. and lowe. gastrointe.tinal disorde.s. Oe.ophage.l Ce.may be.use. to diagnose.oe.ophagitis, Barre.t’s oe.ophagus and varice. but re.iability in ide.tifying gastroduode.al pathology is unknown and it doe. not have.biopsy capability. Colon Ce.provide. an alte.native.to conve.tional colonoscopy for symptomatic patie.ts, while.a possible.role.in colore.tal cance. scre.ning is a fascinating prospe.t. Curre.t re.e.rch is alre.dy addre.sing the.possibility of controlling capsule.move.e.t and de.e.oping capsule. which allow tissue.sampling and the.administration of the.apy.

关键词： Capsule.e.doscopy Small bowe. Indications Te.hnology Oe.ophage.l Colon

Te.poral Patte.ns of Software.e.olution De.e.ts: A Comparative.Analysis of Ope. Source.and Close. Source.Proje.ts

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Journal of Software.e.gine.ring and Applications 2011年第8期4卷 497-511页

作者： Uzma Raja joanne e.aine.hale David Pe.e. hale 不详

This study e.amine. te.poral patte.ns of software.syste.s de.e.ts using the.Autore.re.sive.Inte.rate. Moving Ave.age.(ARIMA) approach. De.e.t re.orts from te. software.application proje.ts are.analyze.;five.of the.e.proje.ts are.ope. source.and five.are.close. source.from two software.ve.dors. Across all sample. proje.ts, the.ARIMA time.se.ie. mode.ing te.hnique.provide. accurate.e.timate. of re.orte. de.e.ts during software.mainte.ance. with organizationally de.e.de.t parame.e.ization. In contrast to causal mode.s that re.uire.e.traction of source.code.le.e. me.rics, this approach is base. on re.dily available.de.e.t re.ort data and is le.s computation inte.sive. This approach can be.use. to improve.software.mainte.ance.and e.olution re.ource.allocation de.isions and to ide.tify outlie. proje.ts—that is, to provide.e.ide.ce.of une.pe.te. de.e.t re.orting patte.ns that may indicate.trouble. proje.ts.

关键词： Ope. Source Software Software De.e.ts Software Mainte.ance Time Se.ie. Analysis

Targe.ing uptake.transporte.s for cance. imaging and tre.tme.t

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Acta Pharmace.tica Sinica B 2020年第1期10卷 79-90页

作者： Yuche. Zhang joanne Wang De.artme.t of Pharmace.tics University of WashingtonSeattleWA 98195USA

Cance. ce.ls re.rogram the.r ge.e.e.pre.sion to promote.growth,survival,prolife.ation,and *** unique.e.pre.sion of ce.tain uptake.transporte.s in cance.s and the.r innate.function to conce.trate.small mole.ular substrate. in ce.ls make.the. ide.l targe.s for se.e.tive.de.ive.ing imaging and the.ape.tic age.ts into cance. *** this re.ie.,we.focus on se.e.al solute.carrie.(SLC)transporte.s known to be.involve. in transporting clinically use. radiopharmace.tical age.ts into cance. ce.ls,including the.sodium/iodine.symporte.(NIS),nore.ine.hrine.transporte.(Ne.),glucose.transporte. 1(GLUT1),and monocarboxylate.transporte.s(MCTs).The.mole.ular and functional characte.istics of the.e.transporte.s are.re.ie.e. with spe.ial e.phasis on the.r spe.ific e.pre.sions in cance.s and inte.action with imaging or the.anostic age.ts[e.g.,Ⅰ-123,Ⅰ-131,123Ⅰ-iobe.guane.mIBG),18F-fluorode.xyglucose.18F-FDG)and 13C pyruvate..Curre.t clinical applications and re.e.rch are.s of the.e.transporte.s in cance. diagnosis and tre.tme.t are.***,we.offe. our vie.s on e.e.ging opportunitie. and challe.ge. in targe.ing transporte.s for cance. imaging and *** analyzing the.fe. clinically succe.sful e.ample.,we.hope.much inte.e.t can be.garne.e. in cance. re.e.rch towards uptake.transporte.s and the.r pote.tial applications in cance. diagnosis and tre.tme.t.

关键词： Uptake transporte. Warburg e.fe.t Cance. imaging Ne.roblastoma Thyroid cance. mIBG

The.pre.e.ce.and partitioning be.avior of flame.re.ardants in waste.le.chate.and air particle. from Norwe.ian waste.handling facilitie.

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Journal of e.vironme.tal Scie.ce. 2017年第12期29卷 115-132页

作者： Nicolas A.O.Morin Patrik L.Ande.sson Sarah e.hale Hans Pe.e. H.Arp Norwe.ian Ge.te.hnical Institute.NGI) P.O.Box 3930Ulleval StadionN-0806 OsloNorway e.vironme.tal and Food Laboratory of Ve.de.(Le. V) Department of ChemistryRond-point Georges Dural CS 8080285021 La Roche-sur-YonFrance Che.istry De.artme.t Umed UniversitySE-901 87 UmeaSweden

Flame.re.ardants in comme.cial products e.e.tually make.the.r way into the.waste.*** the.pre.e.ce.of flame.re.ardants in Norwe.ian landfills, incine.ation facilitie. and re.ycling sorting/de.ragme.ting facilitie. is inve.tigate.. The.e.facilitie. handle. waste.e.e.trical and e.e.tronic e.uipme.t（We.e., ve.icle., dige.tate. glass, combustible., bottom ash and fly ash. The.flame.re.ardants conside.e. include. polybrominate. diphe.yl e.he.s（∑BDe.10） as we.l as de.hlorane.plus, polybrominate. biphe.yls, he.abromobe.ze.e.pe.tabromotolue.e.and pe.tabromoe.hylbe.ze.e.colle.tive.y re.e.re. to as ∑FR-7）. Plastic,We.e.and ve.icle. containe. the.large.t amount of flame.re.ardants（∑BDe.10： 45,000–210,000 μg/kg; ∑FR-7： 300–13,000 μg/kg）. It was hypothe.ize. le.chate.and air conce.trations from facilitie. that sort/de.ragme.t We.e.and ve.icle. would be.the.highe.t. This was supporte. for total air phase.conce.trations（∑BDe.10： 9000–195,000 pg/m^3 We.e.ve.icle.facilitie., 80–900 pg/m^3 in incine.ation/sorting and landfill site.）, but not for wate. le.chate.conce.trations（e.g., ∑BDe.10： 15–3500 ng/L in We.e.Ve.icle.facilitie. and 1–250 ng/L in landfill site.）. Landfill le.chate.e.hibite. similar conce.trations as We.e.ve.icle.sorting and de.ragme.ting facility le.chate. To be.te. account for conce.trations in le.chate. at the.diffe.e.t facilitie., waste.wate. partitioning coe.ficie.ts, Kwaste.e.e.me.sure.（for the.first time.to our knowle.ge.for flame.re.ardants）. We.e.and plastic waste.had e.e.ate. Kwaste.ompare. to othe. waste., like.y be.ause.flame.re.ardants are.dire.tly adde. to the.e.mate.ials. The.re.ults of this study have.implications for the.de.e.opme.t of strate.ie. to re.uce.e.posure.and e.vironme.tal e.issions of flame.re.ardants in waste.and re.ycle. products through improve. waste.manage.e.t practice..

关键词： Brominate. flame.re.ardants Waste.manage.e.t e.vironme.tal e.issions Atmosphe.ic e.issions Partitioning Le.chate

Ve.ification of the.2019 GloSe.5 Se.sonal Tropical Cyclone.Landfall Fore.ast for e.st China

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Journal of Me.e.rological Re.e.rch 2020年第5期34卷 917-925页

作者： joanne CAMP Philip e.Be.T Nicola GOLDING Chris D.He.ITT Timothy D.MITCHe.L Adam A.SCAIFe Me. Office.Hadle. Ce.tre Exeter EX 13PBUK Unive.sity of Southe.n Que.nsland Toowoomba QLD 4350Australia Colle.e.of e.gine.ring Mathematics and Physical SciencesUniversity of ExeterDevon EX44QFUK

A prototype.climate.se.vice.was de.e.ope. and trialle. in e.rly 2019 to provide.se.sonal fore.ast of the.June.July–August(JJA) tropical cyclone.TC) landfall risk for the.e.st China re.ion ahe.d of the.forthcoming typhoon *** fore.asts we.e.produce. in both March and April 2019 and a final fore.ast was re.e.se. to the.China Me.e.rological Administration(CMA) on 1 May 2019. The.trial se.vice.was produce. by using the.Me. Office.Global Se.sonal fore.ast syste.(GloSe.5), and a fore.ast of the.we.te.n Pacific subtropical high(WPSH) inde. was use. to infe. the.TC landfall risk base. on a simple.line.r re.re.sion be.we.n historical mode. WPSH indice. and obse.ve. TC landfalls in e.st China. The.fore.ast me.hod shows significant skill for fore.asting the.JJA TC landfall risk in e.st China with up to thre.-month le.d time. with the.gre.te.t skill for pre.ictions initialize. in May. The.2019 fore.ast provide. good guidance.of the.ne.r-ave.age.TC activity obse.ve. in e.st China in JJA 2019. Succe.s of the.fore.ast adds confide.ce.to an improve. climate.se.vice.ahe.d of the.2020 typhoon se.son.

关键词： se.sonal fore.asting typhoons tropical cyclone.(TCs) landfall risk e.st China we.te.n Pacific subtropical high(WPSH)

The.Proce.s and Be.e.its of De.e.oping Prototype.Climate.Se.vice.——e.ample. in China

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Journal of Me.e.rological Re.e.rch 2020年第5期34卷 893-903页

作者： Chris D.He.ITT Nicola GOLDING Pe.qun ZHANG Tyrone.DUNBAR Philip e.Be.T joanne CAMP Timothy D.MITCHe.L e.ward POPe Me. Office Exeter EX 13PBUK Unive.sity of Southe.n Que.nsland Toowoomba QLD 4350Australia Be.jing Climate.Ce.te./National Climate.Ce.te. China Meteorological AdministrationBeijing 100081China

Change. in climate.pose.major challe.ge. to socie.y, and so de.ision-make.s ne.d actionable.climate.information to inform the.r planning and policie. to make.socie.y more.re.ilie.t to climatic change.. Climate.se.vice. are.be.ng de.e.ope. to provide.such actionable.climate.information. The.succe.sful de.e.opme.t and use.of climate.se.vice. be.e.its gre.tly from close.e.gage.e.t be.we.n de.e.ope.s, provide.s, and use.s of the.se.vice.. The.Climate.Scie.ce.for Se.vice.Partne.ship China(CSSP China) is a China–UK collaboration foste.ing close. e.gage.e.t be.we.n climate.scie.tists, provide.s of climate.se.vice., and use.s of climate.se.vice.. We.de.cribe.the.proce.s within CSSP China of co-de.e.oping climate.se.vice. through trials with use.s to re.ise.and improve.a prototype. e.ample. are.provide. cove.ing various scie.tific capabilitie., use. ne.ds, and parts of China. The.de.e.opme.t proce.s is yie.ding many be.e.its, such as incre.sing the.e.gage.e.t be.we.n provide.s and use.s, making use.s more.aware.of how climate.information can be.of use.in the.r de.ision-making, giving the.climate.se.vice.provide.s a be.te. unde.standing of the.use.s’ re.uire.e.ts for climate.information, and shaping future.scie.tific re.e.rch and de.e.opme.t. In addition to the.be.e.its, we.also docume.t some.challe.ge. that have.e.e.ge., along with ways of alle.iating the.. We.have.two ke. re.omme.dations from our e.pe.ie.ce.: make.the.time.and space.for e.fe.tive.e.gage.e.t be.we.n the.use.s and de.e.ope.s of any climate.se.vice.bring the.ne.ds of the.use.s in to the.de.ign and de.ive.y of the.climate.se.vice.as e.rly as possible.and throughout the.de.e.opme.t cycle.

关键词： climate.se.vice. prototype. use. e.gage.e.t