Targeting uptake transporters for cancer imaging and treatment

作     者：Yuchen Zhang Joanne Wang Yuchen Zhang;Joanne Wang

作者机构：Department of PharmaceuticsUniversity of WashingtonSeattleWA 98195USA 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第1期

页      面：79-90页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Institutes of Health(NIH)National Institute of General Medical Sciences(Grant R01 GM066233 USA) 

主　　题：Uptake transporter Warburg effect Cancer imaging Neuroblastoma Thyroid cancer mIBG 

摘      要：Cancer cells reprogram their gene expression to promote growth,survival,proliferation,and *** unique expression of certain uptake transporters in cancers and their innate function to concentrate small molecular substrates in cells make them ideal targets for selective delivering imaging and therapeutic agents into cancer *** this review,we focus on several solute carrier(SLC)transporters known to be involved in transporting clinically used radiopharmaceutical agents into cancer cells,including the sodium/iodine symporter(NIS),norepinephrine transporter(NET),glucose transporter 1(GLUT1),and monocarboxylate transporters(MCTs).The molecular and functional characteristics of these transporters are reviewed with special emphasis on their specific expressions in cancers and interaction with imaging or theranostic agents[e.g.,Ⅰ-123,Ⅰ-131,123Ⅰ-iobenguane(mIBG),18F-fluorodeoxyglucose(18F-FDG)and 13C pyruvate].Current clinical applications and research areas of these transporters in cancer diagnosis and treatment are ***,we offer our views on emerging opportunities and challenges in targeting transporters for cancer imaging and *** analyzing the few clinically successful examples,we hope much interest can be garnered in cancer research towards uptake transporters and their potential applications in cancer diagnosis and treatment.