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AZGP1P2/UBA1/RBM15 Cascade Mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPM1 m6A Modification

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Research 2024年第3期6卷 151-167页

作者： Hong Wang jj liu Xiaojun Zhu Bin Yang Zuping He Xudong Yao Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Urologic Cancer Institute School of MedicineTongji UniversityShanghaiChina. Department of Urology Surgery The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina. The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province School of MedicineHunan Normal UniversityThe Engineering Research Center of Reproduction and Translational Medicine of Hunan ProvinceChangshaChina Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghaiChina.

Prostate cancer(PCa)is a common malignant tumor with high morbidity and mortality *** prostate cancer stem cell(PCSC)model provides novel insights into the pathogenesis of PCa and its therapeutic ***,the roles and molecular mechanisms of specific genes in mediating fate decisions of PCSCs and carcinogenesis of PCa remain to be *** this study,we have explored the expression,function,and mechanism of AZGP1P2,a pseudogene of AZGP1,in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer(CRPC).We revealed that AZGP1P2 was downregulated in CRPC cell lines and PCSCs,while it was positively associated with progression-free *** of the AZGP1P2 enhanced the sensitivity of docetaxel treatment in CRPCs via inhibiting their *** pull-down associated with mass spectrometry analysis,co-immunoprecipitation assay,and RNA immunoprecipitation assay demonstrated that AZGP1P2 could bind to UBA1 and RBM15 as a“writer”of methyltransferase to form a ***1,an E1 ubiquitin-activating enzyme,contributed to RBM15 protein degradation via ubiquitination *** RNA immunoprecipitation assay displayed that RBM15 controlled the mRNA decay of TPM1 in m6A ***,a xenograft mouse model and patient-derived organoids showed that the therapeutic effect of docetaxel in CRPC was increased by AZGP1P2 in ***,these results imply that AZGP1P2 mediates the stemness and apoptosis of PCSCs and promotes docetaxel therapeutic effect by suppressing tumor growth and metastasis via UBA1/RBM15-mediated TPM1 mRNA decay in CRPC.

关键词： Prostate TPM1 m6A

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Persistent Currents in Toroidal Single-wall Carbon Nanotubes

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Journal of Materials Science & Technology 1999年第4期15卷 342-344页

作者： liu, jj Zhang, G Gu, BL Tsing Hua Univ Dept Phys Beijing 100084 Peoples R China

In this paper the persistent currents of ideal toroidal single-wall carbon nanotubes (TSWNTs) are calculated from the tight-binding model and the periodic boundary conditions. The electronic structure and persistent current of a TSWNT strongly depend on its helicity and longitudinal circumference, making the TSWNTs a geometry-sensitive kind of materials. The interatomic carbonic interactions other than pp pi-type are also studied and are found to introduce more steps to the persistent current. The diamagnetic-paramagnetic transitions occur more frequently, and the persistent current depends on the interaction energy values, while the periodicity of magnetic flux preserves.

关键词： Nanotubes

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Laboratory Assessment of Lubricants for Wheel/Rail Lubrication

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Journal of Materials Science & Technology 1997年第1期13卷 57-60页

作者： Zhao, XZ liu, jj Zhu, BL Wang, CY ZHENGZHOU RES INST MECH ENGN ZHENGZHOU 450052PEOPLES R CHINA

The antiwear properties of two wheel/rail lubricating oils were tested and compared on an Amsler machine. Under same testing conditions, oil A (developed by authors) showed much better wear resistance and higher load-carrying capacity than oil B (imported from abroad). The X-ray diffraction (XRD) analyses of the worn surfaces showed that different extreme pressure (EP) lubricating films were formed on the surfaces when the rollers were lubricated with different oils under boundary lubrication condition. The EP film of oil A was a composite film containing three compounds, FeO, FeSx and FeP, while oil B formed only a simple EP film of FePO4. The composite EP film showed lower shear strength and better antiwear property than the simple EP film, which brought about different wear resistance df the two wheel/rail lubricating oils.

关键词： Lubricating oils

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Sliding Wear of Ceramic/Metal Pairs under Boundary Lubrication of Water and Oil

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Journal of Materials Science & Technology 1997年第5期13卷 409-415页

作者： Zhao, XZ liu, jj Zhu, BL Luo, ZB Miao, HZ Tribology Research Institute Tsinghua University Beijing 100084 China

In order to reveal the wear mechanism of ceramic cutting tools in real cutting process, a simulation test was carried out on a block-on-ring tribometer. The investigation was conducted at ambient temperature to determine the wear behaviour of ceramic/metal tribe-systems under boundary lubrication of water and oil. In this test, the boundary lubrication conditions were provided by dropping oil or water into contact area at a rate of 5 drops per minute (about 0.1 ml/min). The tested materials are Al2O3-Ti(CN) composite ceramic, Al(purity>99.5 wt pet), Fe(C<0.04 wt pet) and a stainless steel (ASTM 302), which combined into three ceramic/metal frictional pairs. The test results indicate that wear loss of the materials increases with load and speed. Compared with unlubricated conditions, the boundary lubrication condition made the materials wear more serious, which show that lubricating method is very important to a tribe system, and unsuitable lubricating method could increase the wear of materials instead of reducing it. The surfaces of the ceramic and the metallic samples were analysed by using a scanning electron microscope with energy-dispersive X-ray attachment, which indicate that material transfer occurred between the ceramic and metallic materials. The wear mechanism was discussed.

关键词： Ceramic cutting tools

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ANTI-CANCER　DRUGS　COMPOSED　OF　NONNOBLEMETAL　COORDINATION　COMPOUNDS

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Chinese Chemical Letters 1995年第9期6卷 771-772页

作者： liu, jj Wang, YZ Han, R liu, HY Nankai Univ Tianjin 300071 Peoples R China Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China

Abstract: The designed and synthesized compounds are the coordination compounds between MCl2(M = Cu, Co,Mn) and the Mannich base made by methyl piperizine and tetracycline bydrochloride. The cancer cells or HCT-8, KB,A2780, MGC80-1 and Be17402 are signincantly inhibited by the drugs in vitro. The inhibition ratio or s-180 tumor by the compound or M - Cu is 30% on ling / kglevel or feed the in vivo experiments or female white mice.

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Effect of Helicobacter pylori infection on gastric epithelial cell proliferation

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World Journal of Gastroenterology 2000年第3期6卷 442-444页

作者： Gao H Wang JY Shen XZ liu jj Shanghai Med Univ Zhongshan Hosp Dept Internal Med Shanghai 200032 Peoples R China

INTRODUCTION Helicobacter pylori(***)infection is one ofthe main pathogens of chronic gastritis and duodenalulcer(DU),and it may be considered as a riskfactor in the incidence of gastric *** infection may lead to the anomaly of gastricepithelial cell proliferation which is closely relatedto the development of gastric ***(VacA)is an important virulence andvacA subtype determines the toxic *** to its signal sequence,it can be groupedinto type sla,slb,slc and *** harboringvacAsla are more closely related with digestivediseases and may be the strains with high *** effect of *** infection on

关键词： Helicobacter pylori cell proliferation vacAsla strain gastric epithelial cell

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Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver

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World Journal of Gastroenterology 2000年第4期6卷 526-531页

作者： Yang, CQ Wang, JY He, BM liu, jj Guo, JS Shanghai Med Univ Zhongshan Hosp Div Gastroenterol Shanghai 200032 Peoples R China

AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat *** After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by *** different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and *** The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three *** liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the *** G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver.

关键词： liposomes glyco-poly-L-lysine targeted liver uptake exogenous gene

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A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine

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World Journal of Gastroenterology 2000年第4期6卷 508-512页

作者： Yang CQ Wang JY Fang GT liu jj Guo JS Shanghai Med Univ Zhongshan Hosp Div Gastroenterol Shanghai 200032 Peoples R China

AIM To compare the effects of intravenous routeand peritoneal route on liver targeted uptake andexpression of plasmid delivered by galactose-terminal glyco-poly-L-lysine(G-PLL).METHODS The plasmid pTM/MMP-1 which couldbe expressed in eukaryotic cells was bound to G-PLL,and was then transferred into Wistar rats byintravenous and intraperitoneal *** and distribution of the plasmid wereobserved at different time periods by in situhybridization and *** The plasmid could be expressedsignificantly within 24 h after being transferred invivo by both intravenous and *** week later the expression began todecrease,and could still be observed three *** both the intravenous andintraperitoneal route could target-specificallydeliver the plasmid to the liver,the effect of theformer was better as compared to that of the *** Intravenous route is better for livertargeted uptake and expression of G-PLL-boundplasmids than the peritoneal route.

关键词： intraperitoneal injection intraperitoneal injection glyco-poly-L-lysine lwcr targeted uptake

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A visible-light-assisted Pd/TiO_(2)gas sensor with carbon nanotubes electrodes for trace formaldehyde detection

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Rare Metals 2024年第1期43卷 257-266页

作者： Can liu Qiao-Qiao Zou Bin liu Yong Zhang School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

Owing to the ppb-level detection standard toward the toxic and harmful gas,the detection of trace gases has become an important subject in the field of indoor environment ***,the traditional resistive gas sensors hardly meet the requirement due to the weak signal generated by trace gas molecules that are difficult to ***,a visible-light-assisted Pd/TiO_(2)gas sensor is proposed to endow the effective detection of trace formaldehyde(HCHO)gas without heating *** from the enhanced photocatalytic properties of TiO_(2)by Pd decoration,the visible-light-assisted Pd/TiO_(2)gas sensor can detect the HCHO gas as low as80×10^(–9)at room *** successful preparation of nanoscale TiO_(2)sensing layer is facilitated by the ultrathin carbon nanotube interdigital electrode in the gas sensor,which avoids the discontinuity of the sensing layer caused by the excessive thickness of the traditional metal *** addition,the whole preparation process of the Pd/TiO_(2)gas sensor with carbon nanotube electrodes is compatible with mainstream CMOS fabrication technology,which is expected to realize the batch fabrication and micro-integrated application of gas *** is expected that our work can provide a new strategy for the batch preparation of high-performance trace HCHO gas sensors and their future applications in portable electronic devices such as smartphones.

关键词： Visible-light-assisted gas sensor Pd/TiO_(2) Trace HCHO detection Carbon nanotubes electrodes

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Effect of Al_(2)O_(3)fiber on twin intersections-induced dynamic recrystallization in fine-grained TiAl matrix composite

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Journal of Materials Science & Technology 2024年第5期172卷 1-14页

作者： Yaofeng Luo Yan Wang Li Wang Bin liu Yong liu State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Dynamic recrystallization(DRX)is of great significance for the thermomechanical processing and microstructural regulation of TiAl ***,the underlying DRX mechanism remains poorly *** this study,an Avrami kinetics model for DRX was established,which was capable of predicting the DRX fraction *** addition,the effect of Al_(2)O_(3)short fiber on the DRX mechanisms of TiAl matrix composite during the isothermal compression was investigated for the first *** re-sults showed that other than inhibiting DRX by particles in the TiAl matrix composites,the addition of Al_(2)O_(3)short fiber accelerated a novel DRX process,which was induced by twinning and twin intersec-tions(TDRX).Thus,this composite exhibited a higher DRX rate than that of the as-cast TiAl monolithic *** origin of the twin intersection and TDRX for the composite was *** stress concentration near the Al_(2)O_(3)fiber was above the critical shear stress for twinning and thus was favorable for the formation of twinning and twin *** high stored strain energy at the regions of twins and twin intersections provided the driving force for *** accelerated the grain refinement in the TiAl matrix near the Al_(2)O_(3)*** present findings would provide a new perspective on DRX mechanisms,and provide the scientific guidance for optimizing the microstructures of TiAl matrix composites.

关键词： TiAl matrix composite Al_(2)O_(3)fiber Twin intersection Dynamic recrystallization

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