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Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme

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Nano Research 2024年第3期17卷 1827-1836页

作者： Daji Wang Jie Wang Dan Liu jiuyang he Meiying Wang Haibing Huang Guohui Nie Hui Ding Xiyun Yan Nanozyme Synthesis Center Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China Shenzhen Key Laboratory of nanozymes and Translational Cancer Research Department of Otolaryngologyand Shenzhen Institute of Translational MedicineShenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen 518035China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Department of Rheumatology and Immunology Shenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen 518055China

The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively *** continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its early *** this study,we successfully synthesized a single-atom nanozyme(SANzyme)through the application of iron-porphyrin based metal organic framework(MOF-FeP).The MOF-FeP possesses precisely-defined electronic and geometric structures that accurately mimic highly-evolved catalytic site of natural *** peroxidase-like activity of MOF-FeP enables it to catalyze the chemiluminescence of luminol *** integrating MOF-FeP into a traditional strip,we created a rapid and highly-sensitive evaluation tool for detecting ***,the MOF-FeP strip enables the simultaneous detection of three EBV-IgAs,greatly improving the accuracy of EBV-associated NPC *** sensitivities of the MOF-FeP strip(75.56%–93.30%)surpass those of current enzyme-linked immunosorbent assay(ELISA)methods(64.44%–82.22%).This test takes only 16 min to perform as opposed to the customary 1–2 h required for standard ***,the MOF-FeP strip is suitable for whole blood samples,thereby significantly simplifying the sample preparation and detection *** conclusion,the MOF-FeP strip combines the simplicity of traditional strip with the high catalytic activity of *** innovative MOF-FeP strip offers a new point-of-care strategy for EBV-IgAs detection,which is expected to markedly facilitate early screening for EBV-associated diseases.

关键词： iron-porphyrin single-atom nanozyme(SANzyme) chemiluminescence strips Epstein-Barr virus(EBV) nasopharyngeal carcinoma(NPC) antibody detection

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Functional Superoxide Dismutase Mimics Become Diverse: From Simple Compounds on Prebiotic Earth to Nanozymes

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生物化学与生物物理进展 2018年第2期45卷 148-169页

作者： Leon Bixenmann jiuyang he Minmin Liang Wolfgang Tremel Institut für Anorgmtische Chemie und Anolytisehe ChemieJobhanne Gutenberg UniversitiitMainz 55128Germany Key Laboratory of Protein and Peptide Pharmaceutical CAS-University of Tokyo Jnint Laboratory of Structural Virology and lmmunology Institu

Inorganic solids with enzyme-like activity are promising to overcome many restrictions of native enzymes in *** attractive are nanoparticles with superoxide dismutase(SOD)activity,due to their ability to reduce the damaging properties of reactive oxygen species within cells and *** review discusses the necessary requirements for nanoparticles to have SOD activity and reveals a close relationship between catalysis on prebiotic earth and the recent SOD *** review also aims to highlight the progress in the development of SOD mimicking *** give a broad overview of nanoparticles with SOD activity,based on their material make-up,to underline their increasing diversity.

关键词： Superoxide

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First-principles study of electronic structure and magnetic properties of Sr_(3)Fe_(2)O_(5) oxide

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Chinese Physics B 2021年第11期30卷 515-518页

作者： Mavlanjan Rahman jiuyang he School of Physics and Electronic Engineering Xinjiang Normal UniversityUrumqi 830054China

We investigate the electronic structure and magnetic properties of layered compound Sr_(3)Fe_(2)O_(5) based on firstprinciples calculations in the framework of density functional theory with GGA+U *** high pressure,the ladder-type layered structure of Sr_(3)Fe_(2)O_(5) is transformed into the infinite layered structure accompanied by a transition from G-type anti-ferromagnetic(AFM)insulator to ferromagnetic(FM)metal and a spin transition from S=2 to S=*** reproduce these transformations in our calculations and give a clear physical interpretation.

关键词： Sr3Fe2O5 first-principles calculation electronic structure magnetism

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Nanozyme:A promising tool from clinical diagnosis and environmental monitoring to wastewater treatment

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Particuology 2022年第12期71卷 90-107页

作者： Chaoyi Hong Xiangqin Meng jiuyang he Kelong Fan Xiyun Yan CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Future Technology University of Chinese Academy of SciencesBeijing 101408China Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450052China

Natural enzymes,owing to their outstanding catalytic efficiency and substrate specificity,have been used in a variety of applications including clinical diagnosis,environmental monitoring and wastewater ***,they face inevitable problems such as relatively high cost and lack of stability,dramatically hindering their practical applications in the ***,a class of nanomaterial that possesses intrinsic enzyme-like properties,nanozyme,has emerged exhibiting numerous advantages over its natural counterpart and has been used as a viable enzyme *** the past decade there are many reviews on *** previous discussions tend to view nanozyme as a type of nanomaterial rather than an ***,it is the enzyme-like activity of nanozymes that provides foundation for their application and nanozymes with the same enzymatic activity usually have some regularity in ***,in this review,we attempt to classify nanozymes by their enzyme-like activity to explain the application principle and relevant cases of nanozymes in clinical diagnosis,environmental monitoring and wastewater treatment,expecting to promote deeper thinking of nanozymes as enzyme mimics and provide useful guidance for future research.

关键词： Nanozyme Enzymatic activity Clinical diagnosis Environmental monitoring Wastewater treatment

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Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

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Nano Research 2019年第4期12卷 863-868页

作者： Tao Wang jiuyang he Demin Duan Bing Jiang Peixia Wang Kelong Fan Minmin Liang Xiyun Yan Department of Neurosurgery Peking University Third Hospital Beijing 100191 China Savaid Medical School University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Protein and Peptide Pharmaceutical Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Atherosclerotic plaque rupture results in thrombus formation and vessel occlusion, and is the leading cause of death worldwide. There is a pressi ng need to identify plaque vuln erability for the treatment of carotid and coronary artery diseases. Nano materials with en zyme-like properties have attracted significant interest by providing biological, diagnostic and prognostic information about the diseases. here we showed that bioe ngin eered mag netoferritin nan oparticles (M-HFn NPs) functionally mimic peroxidase en zyme and can intrin sically recog nize plaque-infiltrated active macrophages, which drive atherosclerotic plaque progression and rupture and are significantly associated with the plaque vulnerability. The M-HFn nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that visualizes the recognized active macrophages for one-step pathological identification of plaque vulnerability. We examined 50 carotid endarterectomy specimens from patients with symptomatic carotid disease and demonstrated that the M-HFn nanozymes could distinguish active macrophage infiltration in ruptured and high-risk plaque tissues, and M-HFn staining displayed a significant correlation with plaque vulnerability (r= 0.89, P< 0.0001).

关键词： atherosclerosis high-risk plaques ruptured plaques magnetoferritin nanoparticles nanozymes pathological diagnosis

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Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting

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Science China(Life Sciences) 2022年第2期65卷 328-340页

作者： Bing Jiang Xiaohua Jia Tianjiao Ji Meng Zhou jiuyang he Kun Wang Jie Tian Xiyun Yan Kelong Fan Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory of Molecular Imaging of Chinese Academy of Sciences Institute of AutomationChinese Academy of SciencesBeijing 100190China CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100191China

Engineered nanocarriers have been widely developed for tumor ***,the delivery of imaging probes or therapeutic drugs to the tumor pre-formation site for early and accurate detection and therapy remains a major ***,by using tailor-functionalized human H-ferritin(HFn),we developed a triple-modality nanoprobe IRdye800-M-HFn and achieved the early imaging of tumor cells before the formation of solid tumor ***,we developed an HFn-doxorubicin(Dox)drug delivery system by loading Dox into the HFn protein cage and achieved early-stage tumor *** intravenous injection of HFn nanoprobes enabled the imaging of tumor cells as early as two days after tumor implantation,and the triple-modality imaging techniques,namely,near-infrared fluorescence molecular imaging(NIR-FMI),magnetic resonance imaging(MRI),and photoacoustic imaging(PAI),ensured the accuracy of *** exploration indicated that HFn could specifically penetrate into pre-solid tumor sites by tumor-associated inflammation-mediated blood vessel leakage,followed by effective accumulation in tumor cells by the specific targeting property of HFn to transferrin receptor ***,the HFn-Dox drug delivery system delivered Dox into the tumor pre-formation site and effectively killed tumor cells at early ***800-M-HFn nanoprobes and HFn-Dox provide promising strategies for early-stage tumor diagnosis and constructive implications for early-stage tumor treatment.

关键词： ferritin nanocage early theranostics tumor-associated inflammation multimodality tumor imaging drug delivery

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The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide's biocompatibility

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Journal of Environmental Sciences 2013年第5期25卷 873-881页

作者： Guangbo Qu Xiaoyan Wang Qian Liu Rui Liu Nuoya Yin Juan Ma Liqun Chen jiuyang he Sijin Liu Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences Department of Biomedical Engineering Tufts UniversityMedfordMassachusetts 02155USA

Graphene oxide（GO）displays promising properties for biomedical applications including drug delivery and cancer ***,GO exposure also raises safety concerns such as potential side effects on ***,the biological effects of GO suspended in phosphate buffered saline（PBS）with or without 1% nonionic surfactant Tween 80 were *** on the ex vivo experiments,Tween 80 significantly affected the interaction between GO and peripheral blood from *** suspension in PBS tended to provoke the aggregation of diluted blood cells,which could be prevented by the addition of Tween *** intravenous administration,GO suspension with or without 1% Tween 80 was quickly eliminated by the mononuclear phagocyte ***,GO suspension without Tween 80 showed greater accumulation in lungs than that containing 1% Tween *** contrast,less GO was found in livers for GO suspension compared to Tween 80 assisted GO *** including hearts,livers,lungs,spleens,kidneys,brains,and testes did not reveal histological *** indexes of peripheral blood showed no change upon GO *** results together demonstrated that Tween 80 could greatly alter GO＇s biological performance and determine the pattern of its biodistribution in mice.

关键词： graphene oxide biological performance nonionic surfactant Tween 80 intravenous injection

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Dy^3+掺杂Ga-Sb-La-S新型硫系玻璃和光纤制备及中红外发光特性

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硅酸盐通报 2020年第4期39卷 1283-1288页

作者：杨志杰杨安平任和何久洋艾尔肯·斯地克新疆师范大学物理与电子工程学院新疆矿物发光材料及其微结构实验室新型光源与微纳光学实验室乌鲁木齐830054 江苏师范大学物理与电子工程学院江苏省先进激光材料与器件重点实验室徐州221116

制备了一系列新型Ga2S3-Sb2S3-La2S3硫系玻璃,研究了玻璃的热学和光学性能;向优化的玻璃中掺杂Dy3+,研究了玻璃的中红外发光性能;基于优化的玻璃组成,拉制了纤芯/包层结构光纤,评估了其作为中红外激光增益介质的潜力。实验结果表明,Ga2S... 详细信息

制备了一系列新型Ga2S3-Sb2S3-La2S3硫系玻璃,研究了玻璃的热学和光学性能;向优化的玻璃中掺杂Dy3+,研究了玻璃的中红外发光性能;基于优化的玻璃组成,拉制了纤芯/包层结构光纤,评估了其作为中红外激光增益介质的潜力。实验结果表明,Ga2S3-Sb2S3-La2S3玻璃具有宽的红外透过范围(约0.7~13.6μm)和高的线性折射率(约2.655~2.707),组成为20Ga2S3-75Sb2S3-5La2S3的玻璃具有最佳的抗析晶热稳定性。Dy3+掺杂的玻璃在2.95μm和4.40μm具有较高的发光量子效率和较大的受激发射截面。拉制的20Ga2S3-75Sb2S3-5La2S3∶0.05wt%Dy3+/20Ga2S3-74Sb2S3-6La2S3光纤透光范围为2~8μm,其背景损耗<8 dB/m。在1.32μm波长激发时,光纤显示出强的中红外发光。这些优异性能表明该玻璃光纤有望成为一种高效的中红外激光增益材料。

关键词：硫系玻璃光纤中红外发光

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Ca_(1-x)Al_(2+x)Si_2O_8中Eu^(3+)和Eu^(2+)的发光行为研究

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中国稀土学报 2017年第2期35卷 189-196页

作者：周芷萱吐沙姑.阿不都吾甫马媛媛何久洋艾尔肯.斯地克新疆师范大学新疆矿物发光材料及其微结构实验室新疆乌鲁木齐830054

采用高温固相法制备Ca_(1-x)Al_(2+x)Si_2O_8:12%(摩尔分数)Eu^(3+)荧光粉,在紫外激发下得到红色与蓝色混合系列发光材料。通过调控Ca和Al的比例,结果显示:当x=0.3,即Ca_(0.7)Al_(2.3)Si_2O_8:Eu^(3+)为此发光材料的最佳比例,在λ_(ex)=296 nm激发下Eu^(3+)发光强度最大,λ_(ex)=319 nm激发下Eu^(2+)发光强度最大。有趣的是,在Eu^(3+)的五个特征峰中~5D_0→~7F_4(682 nm)的强度在之前的研究中没有出现与~5D_0→~7F_2(614 nm)相接近,但在我们的实验中观察到在296和319 nm激发下,~5D_0→~7F_4的发光强度与~5D_0→~7F_2已非常接近。通过监测682 nm与614 nm处的荧光寿命分别为1.99和1.84 ms,得出它们属于一个发光中心。通过色坐标的测量,此样品在蓝光区与红光区可进行调节,因此这种材料作为白光LED中的蓝色与红色荧光粉存在潜在的应用前景。

关键词： Ca1-xAl2+xSi2O8 Ca/Al调控 Eu3+→Eu2+ LED

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1540nm发光增强∶Er掺杂β-FeSi_2/Si薄膜

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激光与光电子学进展 2015年第8期52卷 340-343页

作者：何久洋马媛媛万英阿孜古丽.热合曼艾尔肯.斯地克新疆师范大学物理与电子工程学院新疆矿物发光材料及其微结构实验室新疆乌鲁木齐830054

为了增强β-FeSi2薄膜的发光强度，通过脉冲激光轰击（PLD）β-FeSi2和Si靶材沉积于Si（111）面制备了优质的β—FeSi2／Si薄膜，薄膜表面光滑、平整，β—FeSi2颗粒尺寸在20～50nm左右。光致发光（PL）测试显示，β-FeSi2／Si薄膜在低... 详细信息

为了增强β-FeSi2薄膜的发光强度，通过脉冲激光轰击（PLD）β-FeSi2和Si靶材沉积于Si（111）面制备了优质的β—FeSi2／Si薄膜，薄膜表面光滑、平整，β—FeSi2颗粒尺寸在20～50nm左右。光致发光（PL）测试显示，β-FeSi2／Si薄膜在低温下（20K）在1540nm左右的近红外处有一较强发光峰，对应β-FeSi2带-带跃迁。对Si层进行掺杂Er^3＋处理，发现处理后的β-FeSi2／Si：Er薄膜发光强度得到明显地增强，掺入Er使β-FeSi2／Si薄膜非辐射复合中心得到有效地抑制，且β—FeSi2／Si：Er薄膜的红外发光来自Er^3＋离子的^4I13／2→^4I15/2的跃迁和β-FeSi2纳米颗粒带带复合的发光叠加。

关键词：薄膜 β-FeSi2/Si薄膜 Er^3+ 光致发光

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