Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting

作     者：Bing Jiang Xiaohua Jia Tianjiao Ji Meng Zhou Jiuyang He Kun Wang Jie Tian Xiyun Yan Kelong Fan Bing Jiang;Xiaohua Jia;Tianjiao Ji;Meng Zhou;Jiuyang He;Kun Wang;Jie Tian;Xiyun Yan;Kelong Fan

作者机构：Nanozyme Medical CenterSchool of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China CAS Engineering Laboratory for NanozymeKey Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory of Molecular Imaging of Chinese Academy of SciencesInstitute of AutomationChinese Academy of SciencesBeijing 100190China CAS Key Laboratory for Biomedical Effects of Nanomaterials&NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Beijing Advanced Innovation Center for Big Data-Based Precision MedicineSchool of MedicineBeihang UniversityBeijing 100191China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2022年第65卷第2期

页      面：328-340页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China(31900981,62027901,and 32000996) the Strategic Priority Research Program of CAS(XDB29040101) CAS Inter-disciplinary Innovation Team(JCTD-2020-08) Chinese Academy of Sci-ences(YJKYYQ20180048) the Key Research Program of Frontier Sciences,CAS(QYZDY-SSW-SMC013) the National Key Research and Development Program of China(2017YFA0205501,2017YFA0205200) Youth Innovation Promotion Association of Chinese Academy of Sciences(2019093) China Postdoctoral Science Foundation(2020M682358) the China Postdoctoral Science Special Foundation(2020TQ0280) the Grant for International Joint Research Project of the Institute of Medical Science,the University of Tokyo(Extension-2019-K3005) the Beijing-Tianjin-Hebei Basic Research Cooperation Special Program(19JCZDJC65300) the CAS Key La-boratory of Mental Health Grant(KLMH2020K02) 

主　　题：ferritin nanocage early theranostics tumor-associated inflammation multimodality tumor imaging drug delivery 

摘      要：Engineered nanocarriers have been widely developed for tumor ***,the delivery of imaging probes or therapeutic drugs to the tumor pre-formation site for early and accurate detection and therapy remains a major ***,by using tailor-functionalized human H-ferritin(HFn),we developed a triple-modality nanoprobe IRdye800-M-HFn and achieved the early imaging of tumor cells before the formation of solid tumor ***,we developed an HFn-doxorubicin(Dox)drug delivery system by loading Dox into the HFn protein cage and achieved early-stage tumor *** intravenous injection of HFn nanoprobes enabled the imaging of tumor cells as early as two days after tumor implantation,and the triple-modality imaging techniques,namely,near-infrared fluorescence molecular imaging(NIR-FMI),magnetic resonance imaging(MRI),and photoacoustic imaging(PAI),ensured the accuracy of *** exploration indicated that HFn could specifically penetrate into pre-solid tumor sites by tumor-associated inflammation-mediated blood vessel leakage,followed by effective accumulation in tumor cells by the specific targeting property of HFn to transferrin receptor ***,the HFn-Dox drug delivery system delivered Dox into the tumor pre-formation site and effectively killed tumor cells at early ***800-M-HFn nanoprobes and HFn-Dox provide promising strategies for early-stage tumor diagnosis and constructive implications for early-stage tumor treatment.