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Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine

Signal Transduction and Targeted Therapy 2024年第1期9卷 47-50页

作者： Mengyu Guo Mingjing Cao jiufeng sun Ziwei Chen Xin Wang Lianpan Dai George F.Gao Yuliang Zhao Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijingChina Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyBeijingChina

Dear editor,Vaccines are the most efficient and effective means to prevent infectious diseases,but improving the long-term protective efficacy is still a major challenge in contemporary vaccine development.1 The waning immunity varies depending on the diversification of the pathogen and the number of booster doses.1 Strategies to overcome this warrant is using adjuvants that amplify the immune response,and drive the production of memory B and T cells or long-lived plasma cells that recognize the pathogen for durable protection.2–4 Although existing adjuvants have achieved promising results,research on generating durable protective immunity is lacking in promoting vaccine development and staying ahead of global pandemics such as coronavirus disease 2019(COVID-19).The precisely designed nanoadjuvants can enhance lymph node targeting and increase antigenpresenting cell(APCs)uptake,achieving the co-delivery of adjuvants and antigens and activating innate and adaptive immune responses.5 Previously,we reported a manganese nanoadjuvant(MnARK)and receptor-binding domain(RBD)monomer antigen formulated nanovaccine.6 MnARK transported antigens to lymph nodes,activated the STING pathway,elicited strong neutralizing abilities and increased immune memory T cell percentage against the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).6 Regarding the long-term protection potential of MnARK for subunit vaccine development,we further explored the durable immune regulation abilities of MnARK to a SARS-CoV-2 RBD dimer antigen,which has been used in an approved COVID-19 subunit vaccine ZF2001 with aluminum adjuvant(alum).7,8 TEM result revealed that RBD dimer could interact with BSA on MnARK surface and epitope can be well preserved(Supplementary Fig.1a).The size and zeta potential of MnARK-RBD dimer nanovaccine was~58 nm and-14 mV,respectively(Supplementary Fig.1b,c).

关键词： manganese immunity protective

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亚洲人群HPV疫苗免疫原性及安全性的Meta分析

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中国妇幼健康研究 2024年第1期35卷 58-66页

作者：胡熙明孙九峰赵卫南方医科大学公共卫生学院广东广州510515 广东省公共卫生研究院广东广州511400 广东省疾病预防控制中心广东广州511400

目的评估人乳头状瘤病毒(HPV)疫苗在亚洲人群中接种后的免疫原性和安全性。方法本研究分别检索英文数据库(PubMed、Embase、Web of Science、Clinical Trails、Cochrane library)和中文数据库(中国知网、万方、维普),自建库至2022年4月... 详细信息

目的评估人乳头状瘤病毒(HPV)疫苗在亚洲人群中接种后的免疫原性和安全性。方法本研究分别检索英文数据库(PubMed、Embase、Web of Science、Clinical Trails、Cochrane library)和中文数据库(中国知网、万方、维普),自建库至2022年4月,关于亚洲人群进行的HPV疫苗安全性和免疫原性临床试验文献。采用主题词与自由词灵活搭配检索并结合纳排标准筛选文献,对最终纳入文献进行质量评价并提取资料,应用Meta分析合并评估。结果最终纳入16篇随机对照试验(RCT)研究,累计研究对象25485人。Meta分析表明对于HPV疫苗免疫原性,HPV16型特异性血清转化率合并效应值RR为43.74(16.51~115.85),HPV18型特异性血清转化率合并效应值RR为45.72(8.78~238.13)。对于HPV疫苗安全性,二价与四价HPV疫苗接种局部不良事件风险试验组高于对照组,RR为1.52(1.34~1.73)和1.38(1.20~1.59)。二价HPV疫苗与四价HPV疫苗试验组发生全身性不良事件的风险也高于对照组,RR分别为1.21(1.11~1.32)和1.13(0.99~1.30)。结论接种亚洲人群HPV疫苗后血清抗体阳转率高于未接种者,提示接种HPV疫苗可以提高个体特异性抗体水平,接种HPV疫苗发生局部和全身性安全事件的风险均高于对照组,提示仍要高度重视HPV疫苗的安全性问题。

关键词：人乳头瘤病毒 HPV疫苗 Meta分析免疫原性安全性

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百日咳的流行、发病与治疗进展

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华南预防医学 2024年第4期50卷 296-298,303页

作者：钱姿霞孙九峰广东药科大学广东广州510310 广东省疾病预防控制中心广东省公共卫生研究院

百日咳(pertussis)是由百日咳杆菌感染引起的呼吸系统疾病,是一种疫苗可预防性传染病,自20世纪90年代开始全球大范围疫苗接种后维持在低流行水平,但近年来多国相继报道“百日咳再现”。为提高百日咳的防治水平,本文系统综述了百日咳与... 详细信息

百日咳(pertussis)是由百日咳杆菌感染引起的呼吸系统疾病,是一种疫苗可预防性传染病,自20世纪90年代开始全球大范围疫苗接种后维持在低流行水平,但近年来多国相继报道“百日咳再现”。为提高百日咳的防治水平,本文系统综述了百日咳与其疫苗简史、百日咳的临床表现、流行病学、病原体特征以及发病机制和临床治疗进展。

关键词：百日咳研究进展百日咳治疗

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疫苗循证研究进展

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华南预防医学 2024年第7期50卷 591-593页

作者：熊灿梁晓峰孙九峰暨南大学广东广州510632 广东省疾病预防控制中心广东省公共卫生研究院

疫苗循证是指通过科学的方法和程序,在疫苗研发、生产和临床应用中均应获取并应用最佳的证据进行全面、客观、科学的评估以保障疫苗的安全性、有效性和质量可控性。疫苗循证是对特定疫苗上市前及纳入免疫规划进行综合评价的一种不可或... 详细信息

疫苗循证是指通过科学的方法和程序,在疫苗研发、生产和临床应用中均应获取并应用最佳的证据进行全面、客观、科学的评估以保障疫苗的安全性、有效性和质量可控性。疫苗循证是对特定疫苗上市前及纳入免疫规划进行综合评价的一种不可或缺的方法。本研究从疫苗循证定义、疫苗上市前后的国内外疫苗循证、疫苗循证的技术进展及我国疫苗循证现状等进行综述。

关键词：疫苗循证疫苗循证医学

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STING and TLR9 agonists synergistically enhance the immunogenicity of SARS-CoV-2 subunit vaccine

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Nano Research 2023年第12期16卷 13322-13334页

作者： Yang Li Ziwei Chen Xinyi Lu jiufeng sun Mengyu Guo Huige Zhou Ru Bai Yuliang Zhao Chunying Chen Yaling Wang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou 511430China Research Unit of Nanoscience and Technology Chinese Academy of Medical SciencesBeijing 100049China

Vaccines that are reliable and efficacious are essential in the fight against the COVID-19 *** this study,we designed a dual-adjuvant system with two pathogen-associated molecular patterns(PAMPs),MnOx and *** system can improve the retention of antigens at the injection site,facilitate pro-inflammatory cytokines secretion,further recruit and activate dendritic cells(DCs).As a result,antigens can be delivered to lymph nodes specifically,and adaptive immunity was *** immunized group showed an enhanced and broadened humoral and cellular immune response in systemic immunity and lung protection when combined with a tandem repeat-linked dimeric antigen version of the SARS-CoV-2 receptor binding domain(RBDdimer).Remarkably,even with a significant reduction in antigen dosage(three times lower)and a decrease in injection frequencies,our nanovaccine was able to produce the highest neutralizing antibody titers against various *** titers were four-fold higher for the wild-type strain and two-fold higher for both the Beta and Omicron variants in comparison with those elicited by the Alum adjuvant *** conclusion,our dual-adjuvant formulation presents a promising protein subunit-based candidate vaccine against SARS-CoV-2.

关键词： dual-adjuvant system synergistic immune activation antigen dosage reducing variants neutralizing

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Experiences and Lessons of Combating COVID-19 that Chinese Experts Shared with the World

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China CDC weekly 2020年第43期2卷 848-850页

作者： Tao Liu jiufeng sun Miaoyun Wen Youping Zhang Xiaodan Luo Xiangxin Liu Shifang Yang Jun Li Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina School of Public Health Southern Medical UniversityGuangzhouChina Guangdong Provincial People’s Hospital GuangzhouChina Guangdong Provincial Hospital of Traditional Chinese Medicine GuangzhouChina

At the end of 2019,a novel viral pneumonia was detected in Wuhan City(1)and has spread rapidly throughout 215 countries,areas,and territories with more than 3.8 million cases and over 260,000 deaths as of May 8,*** pn... 详细信息

关键词： Combat COV Wuhan

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Environmental siblings of black agents of human chromoblastomycosis

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Fungal Diversity 2014年第2期65卷 47-63页

作者： V.A.Vicente M.J.Najafzadeh jiufeng sun R.R.Gomes D.Robl S.G.Marques C.M.P.S.Azevedo G.S.de Hoog CBS-KNAW Fungal Biodiversity Centre P.O.Box 851673508AD UtrechtThe Netherlands Microbiology Parasitology and Pathology Post-graduation ProgramDepartment of Basic PathologyFederal University of ParanáCuritibaPRBrazil Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Peking University Health Science Center Research Center for Medical MycologyBeijingChina sun-Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina Second Medical Military University ShanghaiChina King Abdulassiz University Jeddah JeddahSaudi Arabia Department of Parasitology and Mycology and Cancer Molecular Pathology Research CenterGhaem HospitalSchool of MedicineMashhad University of Medical SciencesMashhadIran Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina Federal University of Maranhão University Hospital of the Federal University of MaranhãoSão LuísBrazil Cedro Laboratory and University Hospital of the Federal University of Maranhão São LuísBrazil Institute of Biomedical Sciences University of São Paulo(USP)CEP 05508-900 São PauloBrazil

Agents of human chromoblastomycosis,a skin disease almost exclusively caused by members of the order Chaetothyriales,are assumed to be traumatically inoculated into the skin with sharp environmental materials such as plant thorns or wooden splinters carrying the respective *** the supposition that such fungi should have their main habitat in the environment,we investigated the occurrence of black fungi in living areas of patients with *** South America Fonsecaea agents are prevalent as agents of the disease,while also related Cladophialophora species,known from other types of skin infections,are known from the *** environmental isolates were preliminarily selected as possible agents of chromoblastomycosis,based on *** from ITS sequence data isolates were attributed to the genera Cladophialophora,Cyphellophora,Exophiala,Fonsecaea,Phialophora,and Veronaea.A total of 45 fungi morphologically identified as Fonsecaea or Cladophialophora isolated from debris and thorns of living prickly plants in Brazil were processed for taxonomic *** analysis revealed that the isolates indeed belonged to the Chaetothyriales,but only rarely an agent of chromoblastomycosis was concerned;only two strains of *** and one *** were isolated from debris *** remaining isolates belonged to hitherto unknown molecular siblings of *** novel taxa are introduced.

关键词： Black yeasts Environmental isolation Chromoblastomycosis Opportunistic fungi Virulence Infection route

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Cyphellophora and its relatives in Phialophora: biodiversity and possible role in human infection

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Fungal Diversity 2014年第2期65卷 17-45页

作者： Peiying Feng Qiaoyun Lu M.J.Najafzadeh A.H.G.Gerrits van den Ende jiufeng sun Ruoyu Li Liyan Xi V.A.Vicente Wei Lai Chun Lu G.S.de Hoog Third Affiliated Hospital Sun Yat-sen UniversityGuangzhouChina Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity CentreP.O.Box 851673508 AD Utrechtthe Netherlands Xiangyang Central Hospital XiangyangChina Peking University Health Science Center Research Center for Medical MycologyBeijingChina Department of Parasitology and Mycology and Cancer Molecular Pathology Research CenterGhaem HospitalSchool of MedicineMashhad University of Medical SciencesMashhadIran Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamthe Netherlands Key Laboratory of Tropical Disease Control Department of ParasitologyZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina Department of Basic Pathology Federal University of ParanáCuritibaPRBrazil

Cyphellophora is a genus of black yeast-like fungi characterised by having simple phialides with multiseptate,curved *** from SSU and LSU data,Cyphellophora was found to be located in a well-supported clade within the Chaetothyriales comprising a number of species occurring on human skin and *** is phylogenetically close to Phialophora europaea,*** and ***,though morphologically these species produce singlecelled phialoconidia rather than multiseptate *** suttonii and *** have dark colonies and phylogenetically fit in with Cyphellophora;the type species of Pseudomicrodochium,***,has similar,septate conidia but has a hyaline *** the present study,multilocus phylogenetic analyses were combined with morphology and *** of the internal transcribed spacer region,the DNA dependent RNA polymerase II largest subunit and the partial beta tubulin gene were analysed for a set of 30 *** novel species,Cyphellophora pauciseptata and Phialophora ambigua were *** eucalypti was reduced to synonymy of *** role of the studied fungi between colonization and infection of human skin was *** virulence factors for these black yeast-like fungi were hypothesized to be the ability to assimilate monoaromatic hydrocarbons,to produce melanin pigments,and to tolerate the temperature of epidermal human skin.

关键词： Black yeasts Chaetothyriales Cyphellophora Phialophora Superficial infection Taxonomy

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Spatial and temporal dynamics of Dengue in Guangdong, China

Spatial and temporal dynamics of Dengue in Guangdong, China

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第一届全国生物信息与传染病交叉论坛

作者： jiufeng sun De Wu Chumin Liang Lilian Zeng Changwen Ke Wei Zhao Lifang Jiang Zhiqiang Peng Lifeng Lin Guangdong Provincial Center for Disease Control and Prevention Southern Medical University sun Yat-Sen University

＜正＞Guangdong Province is a hyper-endemic areas of arboviruses located in Southern China, where both Aedes albopictus and aegypti mosquitoes are encountered simultaneously. Dengue occurred here annually. Chikungunya was occasionally imported and caused a local outbreak in 2010. All four serotypes of DENV are have been detected in these areas since 1978. During the past four decades, three large-scale dengue outbreaks occurred in 1980, 1986, 2014, and result in more than

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广东省2009-2011年鼠伤寒沙门菌监测及菌株分子分型的研究

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中华流行病学杂志 2014年第8期35卷 917-924页

作者：黄燕惠柯碧霞孙九峰何冬梅陈清柯昌文俞守义南方医科大学公共卫生与热带医学学院流行病学系深圳市宝安区慢性病防治院皮肤性病防治科广州510515 广东省疾病预防控制中心广东省公共卫生研究院南方医科大学公共卫生与热带医学学院流行病学系广州510515

目的了解广东省鼠伤寒沙门菌监测现况及菌株分子分型特点,并初步建立数据库,为食源性疾病暴发追踪污染源及传播途径提供基线数据.方法参考国际PulseNet公布的沙门菌脉冲场凝胶电泳（PFGE）分型方案及7个位点的鼠伤寒沙门菌多位点可变... 详细信息

目的了解广东省鼠伤寒沙门菌监测现况及菌株分子分型特点,并初步建立数据库,为食源性疾病暴发追踪污染源及传播途径提供基线数据.方法参考国际PulseNet公布的沙门菌脉冲场凝胶电泳（PFGE）分型方案及7个位点的鼠伤寒沙门菌多位点可变数目串联重复序列分析（MLVA）方法,分析广东省2009-2011年10个市275株鼠伤寒沙门菌分型特点,利用BioNumerics软件建立分子分型数据库.结果 2009-2011年广东省沙门菌年均检出率为4.03％;鼠伤寒沙门菌年均检出率和构成比分别为1.38％和34.29％,均呈双峰形分布趋势,流行高峰为5和9月.275株鼠伤寒沙门菌经Xba Ⅰ酶切和PFGE分析,获得124种带型,其分型D值为0.928 6,而MLVA分型获得143种型别,D值为0.966 5,分辨能力高于单酶切的PFGE分型.对其中＞3株的相同带型进一步采用PFGE-XbaⅠ-Bln Ⅰ双酶切分型,获得分型共174种,D值为0.989l,与采用MLVA方法相同,即对同一菌株的分辨结果具有较高一致性.结论广东省鼠伤寒沙门菌具有遗传多样性.初步建立的菌株分子分型数据库显示采用MLVA分型方法可完成菌株聚集性分析,以确认鼠伤寒沙门菌引起的暴发.

关键词：鼠伤寒沙门菌加强监测分子分型

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