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Mufangji tang ameliorates pulmonary arterial hypertension through improving vascular remodeling,inhibiting inflammatory response and oxidative stress,and inducing apoptosis

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Traditional Medicine Research 2024年第2期9卷 52-65页

作者： Yu-Ming Wang Hong-wei Tao Feng-Chan Wang {2. han Na Liu guo-Jing Zhao Hai-Bo hu Xue-Chao Lu College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of respiratory and Critical Care Medicine Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital)Qingdao 266000China.

Background:Mufangji tang(MFJT)is composed of Ramulus Cinnamomi,Radix Ginseng,Cocculus orbiculatus(Linn.)DC.,and *** clinical settings,MFJT has been effectively employed in addressing a range of respiratory disorders,notably including pulmonary arterial hypertension(PAH).However,the mechanism of action of MFJT on PAH remains ***:In this study,a monocrotaline-induced PAH rat model was established and treated with *** therapeutic effects of MFJT on PAH rat model were *** pharmacology was conducted to screen the possible targets for MFJT on PAH,and the molecular docking between the main active components and the core targets was carried *** key targets identified from network pharmacology were ***:Re{2.lts showed significant therapeutic effects of MFJT on PAH rat *** of network pharmacology revealed several potential targets related to apoptosis,inflammation,oxidative stress,and vascular *** docking showed that the key components were well docked with the core *** experimental validation re{2.lts that MFJT treatment induced apoptosis(downregulated Bcl-2.levels and upregulated Bax levels in lung tis{2.e),inhibited inflammatory response and oxdative stress(decreased the levels of IL-1β,TNF-α,inducible NOS,and malondialdehyde,and increased the levels of endothelial nitric oxide synthase,nitric oxide,glutathione and {2.peroxide dismutase),reduced the proliferation of pulmonary arterial smooth muscle cells(downregulated ET-1 andβ-catenin levels and ERK1/2.phosphorylation,increased GSK3βlevels).Conclusion:Our study revealed MFJT treatment could alleviate PAH in rats via induction of apoptosis,inhibition of inflammation and oxidative stress,and the prevention of vascular remodeling.

关键词： Mufangji tang pulmonary arterial hypertension apoptosis inflammatory response oxidative stress vascular remodeling

Long-term kidney transplant outcomes in Chinese patients with primary glomerulonephritis:A multicenter study in china

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Chinese Medical Journal 2024年第12期137卷 1492-1494页

作者： Kenan Xie Jinsong Chen Longshan Liu Rending Wang Baoshan Gao Xiaopeng {2. Xiaotian Tang Zheng Jin Ming Zhang Yong han Turen Song Jiqiu Wen jiong Zhang Department of Nephrology National Clinical Research Center of Kidney DiseasesJinling HospitalNanjing University School of MedicineNanjingJiangsu 210002China Department of Organ Transplantation The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Kidney disease The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China Department II of Urology First Hospital of Jilin UniversityChangchunJilin 130021China Department of Urology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Urology The Secend Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Renal Transplantation Hospital of NephrologyThe First Affiliated Hospital of Medical CollegeXi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Liver surgery Shanghai Jiaotong University School of Medicine Affiliated Renji HospitalShanghai 200127China Department of respiratory and Critical Care Medicine The Eighth Medical Center of PLA General HospitalBeijing Key Laboratory of OTIRBeijing 100091China Department of Urology West China Hospital of Sichuan UniversityChengduSichuan 610041China

To the Editor:The primary cause of end-stage kidney disease(ESKD)in china is chronic glomerulonephritis(GN),which accounts for 45%of ESKD patients.[1]There is currently no nationwide large-scale study on the longterm prognosis of kidney transplantation in patients with chronic GN in *** the past decade,however,few landmark studies from populations in Europe[2.3]and the United States[4]have provided important reference data for this ***,we propose to conduct a nationwide multicenter retrospective study,which was launched by the National Clinical Research Center of Kidney diseases,Jinling hospital,Nanjing University School of Medicine,from 2.17 to 2.2..

关键词： nationwide patients glomerulonephritis

survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up

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Neural Regeneration Research 2022年第7期17卷 1576-1581页

作者： Yan-Yao Du wei Zhao xiang-Lin Zhou Mu Zeng Dan-{2.i yang Xing-Zhi Xie Si-Hong {2.ang Ying-Jia Jiang Wen-han yang {2. guo {2.i sun Ji-yang Liu {12. Liu Zhi-guo Zhou Hong Luo Jun Liu Department of Radiology The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Pulmonary and Critical Care Medicine The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of respiratory Medicine The First Hospital of ChangshaChangshaHunan ProvinceChina Clinical Research Center for Medical Imaging in hunan Province ChangshaHunan ProvinceChina Department of Radiology Quality Control Center Hunan ProvinceChangshaHunan ProvinceChina

Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2.19(COVID-19)exhibit anxiety,depression,and altered brain microstructure,their long-term physical problems,neuropsychiatric sequelae,and changes in brain function remain *** observational cohort study collected 1-year follow-up data from 2. patients who had been {2.ized with COVID-19(8 males and 11 females,aged 54.2.8.7 years).Fatigue and myalgia were persistent symptoms at the 1-year *** resting state functional magnetic resonance imaging revealed that compared with 2. healthy controls(7 males and 18 females,aged 50.5±11.6 years),COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation(ALFF)values in the left precentral gyrus,middle frontal gyrus,inferior frontal gyrus of operculum,inferior frontal gyrus of triangle,insula,hippocampus,parahippocampal gyrus,fusiform gyrus,postcentral gyrus,inferior parietal angular gyrus,supramarginal gyrus,angular gyrus,thalamus,middle temporal gyrus,inferior temporal gyrus,caudate,and *** values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores,and those in the left precentral gyrus were positively correlated with neutrophil count during *** long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 *** can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric *** study was approved by the Ethics Committee of the Second {2.ya {2. of Central South University(approval No.2.2. S004)on March 19,2.2..

关键词： amplitude of low-frequency fluctuation clinical study coronavirus disease 2.19 follow-up functional magnetic resonance imaging long-term physical consequences neuropsychiatric sequelae resting‐state function

NSP16 promotes the expression of TMPRSS2.to enhance SARS-CoV-2.cell entry

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Genes & diseases 2023年第3期10卷 723-726页

作者： Tianyu han Jiapeng Lei yang Liu Yanan Wang Wenze Xun Qifan {2. Qi Peng wei Zhang Jiangxi Institute of respiratory disease The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Jiangxi Clinical Research Center for respiratory diseases NanchangJiangxi 330006China Jiangxi hospital of china-Japan Friendship hospital NanchangJiangxi 330052China Department of Bacteriology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Since the end of 2.19,COVID-19 has caused worldwide ***-CoV-2.the culprit of this epidemic,binds to the host receptor Angiotensin converting enzyme 2.ACE2.using spike(S)protein for cell *** studies showed that ACE2.expressed at a low level in the main target organs such as lung and bronchial *** SARS-CoV-2.efficiently invades into the respiratory system or other organs with low levels of ACE2.is an urgent problem to be solved.

关键词： ACE2 NSP1 organs

生脉散合杏苏二陈方辅助西医基础治疗气阴两虚兼痰浊证急性加重期慢性阻塞性肺疾病患者的临床观察

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世界中西医结合杂志 2024年第5期19卷 946-951页

作者：胡小玉王士汉孙琮张阳阳杨兴嫕王芳刘伟男六安市中医院呼吸内一科安徽六安237006

目的探讨生脉散合杏苏二陈方辅助西医基础治疗气阴两虚兼痰浊证急性加重期慢性阻塞性肺疾病(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效。方法选取2.2.年3月—2.2.年3月期间六安市中医院收... 详细信息

目的探讨生脉散合杏苏二陈方辅助西医基础治疗气阴两虚兼痰浊证急性加重期慢性阻塞性肺疾病(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效。方法选取2.2.年3月—2.2.年3月期间六安市中医院收治的气阴两虚兼痰浊AECOPD患者80例,按照随机数字表法分为对照组和研究组,每组各40例。对照组采用常规西医基础疗法,研究组在对照组基础上联合生脉散合杏苏二陈汤。治疗1个月后,观察比较两组患者临床疗效,治疗前后中医证候评分、动脉血气指标[血氧饱和度(Oxygen saturation,SaO_(2.)、动脉血氧分压(Partial pressure of oxygen,PaO_(2.)、动脉血二氧化碳分压(Arterial carbon dioxide partial pressure,PaO_(2.)]、炎症相关指标[白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、降钙素原(Procalcitonin,PCT)]及肺通气功能相关指标[第1秒用力呼气容积(Forced expiratory volume in one second,FEV_(1))、用力肺活量(Forced Vital Capacity,FVC)、一秒率(Forced expiratory volume in one second/Forced Vital Capacity,FEV_(1)/FVC)]表达水平。结果治疗后两组患者咳嗽、咳痰、喘息、发热、食欲下降、大便干结评分均较治疗前降低,差异有统计学意义(P2.、PaO_(2.指标均较治疗前升高,PaCO_(2.指标均较治疗前降低,差异有统计学意义(P2.、PaO_(2.指标均较对照组明显升高,PaCO_(2.指标较对照组明显降低,差异有统计学意义(P2.50%(37/40)明显高于对照组75.00%(30/40),差异有统计学意义(P<0.05)。结论生脉散合杏苏二陈汤通过改善气阴两虚兼痰浊证AECOPD患者的肺通气功能,同时还可调节机体免疫炎症反应,从而提高整体治疗效果。

关键词：生脉散合杏苏二陈汤慢性阻塞性肺疾病急性加重期气阴两虚痰浊

俯卧位经鼻高流量氧疗对轻中度急性呼吸窘迫综合征患者跨肺压的改善作用

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中华实用诊断与治疗杂志 2024年第5期38卷 498-502页

作者：魏然贾金广朱婉凌韩蕾忽新刚郑州人民医院呼吸与危重症医学科河南郑州450053 河南省人民医院郑州大学人民医院全科医学科河南郑州450003 河南省人民医院郑州大学人民医院呼吸与危重症医学科河南郑州450003

目的探讨轻中度急性呼吸窘迫综合征(ARDS)患者采用俯卧位经鼻高流量氧疗在改善氧合、跨肺压中的作用。方法 2.16年1月—2.19年12.河南省人民医院行经鼻高流量氧疗的轻中度ARDS患者46例,2.例采用俯卧位者为观察组,2.例采用平卧位或侧... 详细信息

目的探讨轻中度急性呼吸窘迫综合征(ARDS)患者采用俯卧位经鼻高流量氧疗在改善氧合、跨肺压中的作用。方法 2.16年1月—2.19年12.河南省人民医院行经鼻高流量氧疗的轻中度ARDS患者46例,2.例采用俯卧位者为观察组,2.例采用平卧位或侧卧位者为对照组。2.入院后均根据病情给予抗感染、治疗原发病、气道管理等常规治疗,保证血流动力学和内环境稳定,应用小剂量激素、中性粒细胞弹性蛋白酶抑制剂等治疗ARDS。2.上机后均经鼻腔置入食管测压管,监测食道压和气道压,计算上机12.2. h时吸气末跨肺压、呼气末跨肺压、跨肺驱动压;应用肺部电阻抗断层成像监测仪记录上机12.2. h时非重力依赖区、重力依赖区机械能。比较2.ARDS病因、ARDS程度、入院时急性生理学及慢性健康状况Ⅱ(APACHEⅡ)评分等临床资料;记录上机12.2. h时pa(O_(2.)、pa(CO_(2.)、氧合指数。结果 (1)2.男性及中度ARDS比率、年龄、ARDS病因、入院时APACHEⅡ评分、ARDS治疗药物比较差异均无统计学意义(P>0.05)。(2.上机12.2. h时,观察组pa(O_(2.)[(62.01±2.66)、(64.68±2.87)mmHg]、氧合指数[(141.69±7.98)、(159.83±11.87)mmHg]、重力依赖区机械能[(5.56±0.59)、(7.56±0.94)mJ]均高于对照组[(60.05±4.51)、(62.44±2.35)mmHg;(135.05±8.53)、(139.62.12.63)mmHg;(3.92.0.56)、(4.70±0.67)mJ](P2.)[(44.07±2.87)、(41.73±2.87)mmHg]、吸气末跨肺压[(11.2.±1.98)、(6.77±1.77)cmH_(2.O]、呼气末跨肺压[(1.58±0.30)、(-1.88±0.66)cmH_(2.O]、跨肺驱动压[(8.55±2.19)、(7.44±1.84)cmH_(2.O]均低于对照组[(49.45±2.66)、(48.30±2.50)mmHg;(12.98±1.96)、(10.40±2.40)cmH_(2.O;(1.98±0.60)、(-1.59±0.18)cmH_(2.O;(11.77±2.71)、(10.49±2.37)cmH_(2.O](P0.05)。2.上机2. h时pa(O_(2.)、pa(CO_(2.)、氧合指数、吸气末跨肺压、呼气末跨肺压、跨肺驱动压、重力依赖区机械能改善均优于12.h时(P12.h时比较差异无统计学意义(P>0.05)。结论轻中度ARDS患者采用俯卧位经鼻高流量氧疗可进一步改善氧合,减少胸腔压力差,利于重力依赖区肺部通气。

关键词：急性呼吸窘迫综合征经鼻高流量氧疗俯卧位电阻抗成像技术跨肺压

Peripheral Tc17 and Tc17/Interferon-γ Cells are Increased and Associated with Lung Function in Patients with Chronic Obstructive Pulmonary disease

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Chinese Medical Journal 2016年第8期129卷 909-916页

作者： wei-han Xu Xiao-Ling {2. Xiao-Fang Liu Peng Bai Yong-Chang sun Department of respiratory Medicine Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of respiratory and Critical Care Medicine Peking University Third Hospital Beijing 100191 China

Background：Chronic obstructive pulmonary disease （COPD） is characterized by progressive loss of lung function and local and systemic inflammation,in which CD8＋ T-cells are believed to play a key *** CD8＋ T-cells differentiate into distinct subpopulations,including interferon-γ（IFN-γ）-producing Tc 1 and interleukin （IL）-17-producing Tc 1 7 *** evidence indicates that Tc 17 cells exhibit considerable plasticity and may convert into IL-17/IFN-γ-double producing （Tc1 7/IFN-γ） cells when driven by inflammatory *** aim of this study was to investigate the Tc 17/IFN-γ subpopulation in peripheral blood of patients with COPD and to evaluate their potential roles in this ***：Peripheral blood samples were collected from 15 never-smokers,2. smokers with normal lung function,and 2. patients with COPD （Global Initiative for Chronic Obstructive Lung disease 2.4）.Proportions of the IL-17/IFN-γ-double expressing subpopulation were assessed using flow *** concentrations of cytokines favoring Tc 17/IFN-γ differentiation were measured by enzymelinked immunosorbent ***：Patients with COPD had higher proportions of Tc17 cells and Tc17/IFN-γ cells in the peripheral blood than smokers and *** plasticity of Tc 17 cells was higher than that of Th 17 *** percentages ofTc 17 cells and Tc 17/IFN-γcells showed negative correlations with forced expiratory volume in 1 s % predicted value （r =-0.418,P =0.03;r =-0.596,P =0.002.respectively）.The plasma concentrations of IL-6,transforming growth factor-β1,and IL-12.were significantly higher in patients with COPD compared with smokers and ***：Peripheral Tc17 cells are increased and more likely to convert to Tc17/IFN-γ cells in COPD,suggesting that Tc17 cell plasticity may be involved in persistent inflammation of the disease.

关键词： CD8^+ T-cells: Interferon-y Interleukin-I 7 Plasticity

Clinical characteristics of 132. patients with coronavirus disease 2.19(COVID-19)in the largest Fangcang shelter hospital in {2.

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Chinese Medical Journal 2021年第2期134卷 241-242页

作者： Chong Lu han-Yu Wang Xiao Chen Zi-Ling Wu Shan Meng {2. He Kai-Song Xu Xin-Qiao Fu Yu hu Chao yang hui sun Department of Breast and Thyroid surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Outpatient Department Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Vascular surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

To the Editor:Coronavirus disease 2.19(COVID-19),a result of severe acute {2. syndrome coronavirus 2.SARS-CoV-2.infection,is highly infectious.[1]As COVID-19 spreads rapidly,and the majority of the patients develop mild to moderate form of the disease,we aimed to study the clinical characteristics of these patients admitted to Jianghan Fangcang shelter hospital,the largest Fangcang shelter hospital in wuhan,china.

关键词： patients admitted acute

Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial

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Frontiers of Medicine 2021年第3期15卷 486-494页

作者： Dongsheng Wang Binqing Fu Zhen Peng Dongliang yang Mingfeng han Min Li Yun yang Tianjun yang Liangye sun wei Li wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen hu Xiaodong Mei Haiming wei Xiaoling Xu Department of Pulmonary and Critical Care Medicine the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Hefei 230001China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230027China Intensive Care Unit the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Hefei 230001China Drug Clinical Trail Institution the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Infectious diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Department of respiratory Medicine the Second People’s Hospital of FuyangFuyang 236000China Department of respiratory Medicine National Key Clinical SpecialtyBranch of National Clinical Research Center for Respiratory DiseaseXiangya HospitalCentral South UniversityXiangya Lung Cancer CenterXiangya HospitalCentral South UniversityHunan Provincial Clinical Research Center for Respiratory DiseasesChangsha 410000China Lu’an People’s hospital Affiliated to Anhui Medical University Lu’an 237005China Department of Pulmonary and Critical Care Medicine the First Affiliated Hospital of Bengbu Medical CollegeClinical Research Center for Respiratory Disease(tumor)in Anhui ProvinceBengbu 233004China Department of respiratory Medicine Anqing Hospital Affiliated to Anhui Medical UniversityAnqing 246000China The First Affiliated hospital of Nanjing Medical University Nanjing 210000China Department of Rheumatology and Immunology the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Hefei 230001China Department of Oncology the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)Hefei 230001China Department of Endocrinology

Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 *** attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this *** conducted a randomized,controlled,open-label multicenter trial among COVID-19 *** patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care *** cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were ***-three patients were randomized to the tocilizumab group,and 32.patients to the control *** cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12.vs.87.10%,rate difference 95%CI−7.19%–2..2.%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12.P=0.0359).In moderate {2. patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12.8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.02.7).No severe adverse events *** mild temporary adverse events were recorded in tocilizumab recipients(2./34,58.82.)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes *** patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome.

关键词： tocilizumab coronavirus disease 2.19(COVID-19) cytokine storm