NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry

作     者：Tianyu Han Jiapeng Lei Yang Liu Yanan Wang Wenze Xun Qifan Hu Qi Peng Wei Zhang Tianyu Han;Jiapeng Lei;Yang Liu;Yanan Wang;Wenze Xun;Qifan Hu;Qi Peng;Wei Zhang

作者机构：Jiangxi Institute of Respiratory DiseaseThe First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Jiangxi Clinical Research Center for Respiratory DiseasesNanchangJiangxi 330006China Jiangxi Hospital of China-Japan Friendship HospitalNanchangJiangxi 330052China Department of BacteriologyThe First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第3期

页      面：723-726页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Clinical Research Cultivation Project of First Affiliated Hospital of Nanchang University(China)(No.YFYLCYJPY202001) 

主　　题：ACE2 NSP1 organs 

摘      要：Since the end of 2019,COVID-19 has caused worldwide ***-CoV-2,the culprit of this epidemic,binds to the host receptor Angiotensin converting enzyme 2(ACE2)using spike(S)protein for cell *** studies showed that ACE2 expressed at a low level in the main target organs such as lung and bronchial *** SARS-CoV-2 efficiently invades into the respiratory system or other organs with low levels of ACE2 is an urgent problem to be solved.