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Kinetic study of the hydrocarbon generation from marine carbonate source rocks characterization of products of gas and liquid hydrocarbon

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Chinese Science Bulletin 2006年第23期51卷 2885-2891页

作者： GENG Xinhua GENG Ansong XIONG Yongqiang LIU jinzhong ZHANG Haizu zhao Qingfang The State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

The kinetic parameters of hydrocarbon generation from the marine carbonate source rocks were determined and calibrated through kinetic simulating experiment. The kinetic parameters of hydrocarbon generation then were extrapolated to geological condition by using the relative software. The result shows that gaseous hydrocarbons (C_1, C_2, C_3, C_(4-5)) were generated in condition of 150℃

关键词：烃相生动力学碳酸盐运动模拟地质情况

Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction

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Bioactive Materials 2021年第3期6卷 783-793页

作者： Jiangyu Cai Qianqian Zhang Jiebo Chen Jia Jiang Xiumei Mo Chuanglong He jinzhong zhao Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai200233China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620China

It is a big challenge to develop a polyethylene terephthalate(PET)artificial ligament with excellent osteogenetic activity to enhance graft-bone integration for ligament ***,we evaluated the effect of biomineralization(BM)and electrodeposition(ED)method for depositing calcium-phosphate(CaP)on the PET artificial ligament in vitro and in *** electron microscopy and energy-dispersive X-Ray spectrometer mapping analysis revealed that the ED-CaP had more uniform particles and element distribution(Ca,P and O),and thermogravimetric analysis showed there were more CaP on the PET/ED-CaP than the PET/BM-CaP ***,the hydrophilicity of PET scaffolds was significantly improved after CaP *** vitro study showed that CaP coating via BM or ED method could improve the attachment and proliferation of MC3T3-E1 cells,and ED-CaP coating significantly increased osteogenic differentiation of the cells,in which the Wnt/β-catenin signaling pathway might be *** addition,radiological,histological and immunohistochemical results of in vivo study in a rabbit anterior cruciate ligament(ACL)reconstruction model demonstrated that the PET/BM-CaP and PET/ED-CaP scaffolds significantly improved graft-bone integration process compared to the PET *** importantly,larger areas of new bone ingrowth and the formation of fibrocartilage tissue were observed at 12 weeks in the PET/ED-CaP group,and the biomechanical tests showed increased ultimate failure load and stiffness in PET/ED-CaP group compared to PET/BM-CaP and PET ***,ED of CaP is an effective strategy for the modification of PET artificial ligament and can enhance graft-bone integration both in vitro and in vivo.

关键词： Electrodeposition Calcium-phosphate Graft-bone integration Polyethylene terephthalate Artificial ligament

Evaluation of patches for rotator cuff repair:A systematic review and meta-analysis based on animal studies

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Bioactive Materials 2022年第4期7卷 474-491页

作者： Jinwei Yang Yuhao Kang Wanlu zhao Jia Jiang Yanbiao Jiang Bing zhao Mingyue Jiao Bo Yuan jinzhong zhao Bin Ma Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou730000China Reproductive Medicine Center Gansu Provincial Maternity and Child-Care HospitalLanzhou730050China Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China College of Biomedical Engineering Sichuan UniversityChengdu610064China National Engineering Research Center for Biomaterials Chengdu610064China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou730000China

Based on the published animal studies,we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation.74 animal studies were finally included,of which naturally derived biomaterials were applied the most widely(50.0%),rats were the most commonly used animal model(47.0%),and autologous tissue demonstrated the best outcomes in all animal *** biomechanical properties of naturally derived biomaterials(maximum failure load:WMD 18.68[95%CI 7.71-29.66];P=0.001,and stiffness:WMD 1.30[95%CI 0.01-2.60];P=0.048)was statistically significant in the rabbit *** rabbit model showed better outcomes even though the injury was severer compared with the rat model.

关键词： Rotator cuff patch Animal model Systematic review Meta-analysis Safety and effectiveness

Durable immunomodulatory hierarchical patch for rotator cuff repairing

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Bioactive Materials 2024年第7期37卷 477-492页

作者： Liren Wang Yonghang Liu Zhiqi Lin Huiang Chen Bowen Liu Xiaoyu Yan Tonghe Zhu Qin Zhang jinzhong zhao Department of Sports Medicine Department of OrthopedicsShanghai Institute of Microsurgery on ExtremitiesShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.600 Yishan RoadShanghai200233China Multidisciplinary Centre for Advanced Materials Institute for Frontier Medical TechnologySchool of Chemistry and Chemical EngineeringShanghai University of Engineering Science333 Longteng Rd.Shanghai201620China Institute of Translational Medicine Shanghai University99 Shangda Rd.Shanghai200444China Regenerative Sports Medicine and Translational Youth Science and Technology Innovation Workroom Shanghai Jiao Tong University School of MedicineNo.227 South Chongqing RoadShanghai200025China Bioarticure Medical Technology(Shanghai)Co. LtdShanghaiChina

Degradable rotator cuff patches,followed over five years,have been observed to exhibit high re-tear rates exceeding 50%,which is attributed to the inability of degradable polymers alone to restore the post-rotator cuff tear(RCT)inflammatory ***,poly(ester-ferulic acid-urethane)urea(PEFUU)was developed,featuring prolonged anti-inflammatory functionality,achieved by the integration of ferulic acid(FA)into the polyurethane repeating *** stably releases FA in vitro,reversing the inflammatory niche produced by M1 macrophages and restoring the directed differentiation of stem *** PEFUU,hierarchical composite nanofiber patch(HCNP)was fabricated,simulating the natural microstructure of the tendon-to-bone interface with an aligned-random *** incorporation of enzymatic hydrolysate derived from decellularized Wharton jelly tissue into the random layer could further enhance cartilage regeneration at the tendon-to-bone *** rat RCT repairing model,HCNP possessing prolonged anti-inflammatory properties uniquely facilitated physiological healing at the tendon-to-bone interface’s *** alignment of fibers was restored,and histologically,the characteristic tripartite distribution of collagen I-collagen II-collagen I was *** study offers a universal approach to the functionalization of degradable polymers and provides a foundational reference for their future applications in promoting the in vivo regeneration of musculoskeletal tissues.

关键词： Tendon-to-bone interface Inflammation Functional regeneration Bioactive polymer Bulk modification

Crimped nanofiber scaffold mimicking tendon-to-bone interface for fatty-infiltrated massive rotator cuff repair

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Bioactive Materials 2022年第10期7卷 149-161页

作者： Liren Wang Tonghe Zhu Yuhao Kang Jianguang Zhang Juan Du Haihan Gao Sihao Chen Jia Jiang jinzhong zhao Department of Sports Medicine Department of OrthopedicsShanghai Institute of Microsurgery on ExtremitiesShanghai Jiao Tong University Affiliated Sixth People’s HospitalNo.600 Yishan RoadShanghai200233China Regenerative Sports Medicine and Translational Youth Science and Technology Innovation Workroom Shanghai Jiao Tong University School of MedicineNo.227 South Chongqing RoadShanghai200025China Department of Medgen Group Research Laboratory 18 Qinglan 3 RdShenzhen518118China Biofunctional Materials Research Group College of Chemistry and Chemical EngineeringMultidisciplinary Center for Advanced MaterialsInstitute of Advanced StudiesShanghai University of Engineering ScienceNo.333 Longteng RdShanghai201620China Shanghai Jiao Tong University School of Medicine No.227 South Chongqing RoadShanghai200025China Regenerative Sports Medicine Lab of the Institute of Microsurgery on Extremities Shanghai Jiao Tong University Affiliated Sixth People’HospitalNo.600 Yishan RoadShanghai200233China

Electrospun fibers,with proven ability to promote tissue regeneration,are widely being explored for rotator cuff ***,without post treatment,the microstructure of the electrospun scaffold is vastly different from that of natural extracellular matrix(ECM).Moreover,during mechanical loading,the nanofibers slip that hampers the proliferation and differentiation of migrating stem ***,electrospun nanofiber scaffolds,with crimped nanofibers and welded joints to biomimic the intricate natural microstructure of tendon-to-bone insertion,were prepared using poly(ester-urethane)urea and gelatin via electrospinning and double crosslinking by a multi-bonding network densification *** crimped nanofiber scaffold(CNS)features bionic tensile stress and induces chondrogenic differentiation,laying credible basis for in vivo *** repairing a rabbit massive rotator cuff tear using a CNS for 3 months,the continuous translational tendon-to-bone interface was fully regenerated,and fatty infiltration was simultaneously *** of micro-CT,μCT was employed to visualize the integrity and intricateness of the three-dimensional microstructure of the CNS-induced-healed tendon-to-bone interface at an ultra-high resolution of less than 1μ*** study sheds light on the correlation between nanofiber post treatment and massive rotator cuff repair and provides a general strategy for crimped nanofiber preparation and tendon-to-bone interface imaging characterization.

关键词： Massive rotator cuff tear Fatty infiltration Nanofiber scaffold Crimped structure Tendon-to-bone interface

Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound

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Bioactive Materials 2021年第9期6卷 2783-2800页

作者： Atta ur Rehman Khan Kai Huang Mina Shahriari Khalaji Fan Yu Xianrui Xie Tonghe Zhu Yosry Morsi zhao jinzhong Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Department of Sports Medicine Department of OrthopedicsShanghai Jiao Tong University Affiliated Sixth People’s HospitalNo.600 Yishan RoadShanghai200233PR China Microbiological Engineering and Industrial Biotechnology Group College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620PR China Multidisciplinary Centre for Advanced Materials of Shanghai University of Engineering Science College of Chemistry and Chemical EngineeringShanghai University of Engineering ScienceNo.333 Longteng RoadShanghai201620PR China Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC3122Australia

Diabetic wound(DW)healing is a major clinical challenge due to multifactorial complications leading to prolonged *** nanofibrous(NF)membranes,due to special structural features,are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled ***,we report a multifunctional composite NF membrane loaded with ZnO nanoparticles(NP)and oregano essential oil(OEO),employing a new loading strategy,capable to sustainedly co-deliver bioactive *** characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant ***,in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue *** angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor(VEGF).Moreover,the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin􀀀6(IL-6)and matrix metalloproteinases-9(MMP-9).In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.

关键词： Bioactive NF membrane Diabetic wound healing Antibacterial Antioxidant Anti-inflammatory Angiogenesis

Canine ACL reconstruction with an injectable hydroxyapatite/collagen paste for accelerated healing of tendon-bone interface

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Bioactive Materials 2023年第2期20卷 1-15页

作者： Qingsong Jiang Liren Wang Zhanhong Liu Jinlei Su Yajun Tang Peijie Tan Xiangdong Zhu Kai Zhang Xing Ma Jia Jiang jinzhong zhao Hai Lin Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan University29 Wangjiang RoadChengduSichuanChina Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yishan RoadShanghaiChina Department of Orthopaedics First Affiliated Hospital of Xi’an Jiaotong University277 West Yanta RoadXi’anShaanxiChina

Healing of an anterior cruciate ligament(ACL)autologous graft in a bone tunnel occurs through the formation of fibrovascular scar tissue,which is structurally and compositionally inferior to normal fibrocartilaginous insertion and thus may increase the reconstruction failure and the rate of failure *** this study,an injectable hydroxyapatite/type I collagen(HAp/Col I)paste was developed to construct a suitable local microenvironment to accelerate the healing of bone-tendon *** characterization demonstrated that the HAp/Col I paste was injectable,uniform and *** in vitro cell culture illustrated that the paste could promote MC3T3-E1 cells proliferation and osteogenic *** results of a canine ACL reconstruction study showed that the reconstructive ACL had similar texture and color as the native *** average width of the tunnel,total bone volume,bone volume/tissue volume and trabecular number acquired from micro-CT analysis suggested that the healing of tendon-bone interface in experimental group was better than that in control *** biomechanical test showed the maximal loads in experimental group achieved approximately half of native ACL’s maximal load at 24 *** to histological examination,Sharpey fibers could be observed as early as 12 weeks postoperatively while a typical four-layer transitional structure of insertion site was regenerated at 48 weeks in the experimental *** injectable HAp/Col I paste provided a biomimetic scaffold and microenvironment for early cell attachment and proliferation,further osteogenic expression and extracellular matrix deposition,and in vivo structural and functional regeneration of the tendon-bone interface.

关键词： Anterior cruciate ligament reconstruction Tendon-bone healing Injectable paste Hydroxyapatite Collagen

Fabrication of magnesium-doped porous polylactic acid microsphere for bone regeneration

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Biomaterials Translational 2023年第4期4卷 280-290页

作者： Ziwei Tao Ziyang Yuan Dong Zhou Lang Qin Lan Xiao Shihao Zhang Changsheng Liu jinzhong zhao Yulin Li Engineering Research Centre for Biomedical Materials of Ministry of Education Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghaiChina Department of Sports Medicine Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Chemistry and Chemical Engineering Nanchang UniversityNanchangJiangxi ProvinceChina School of Mechanical Medical and Process EngineeringCenter of Biomedical TechnologyQueensland University of TechnologyBrisbaneAustralia Wenzhou Institute of Shanghai University WenzhouZhejiang ProvinceChina

Biodegradable polymer microspheres that can be used as drug carriers are of great importance in biomedical applications,however,there are still challenges in controllable preparation of microsphere surface morphology and improvement of *** this paper,firstly,poly(L-lactic acid)(PLLA)was synthesised by ring-opening polymerisation under anhydrous anaerobic conditions and further combined with the emulsion method,biodegradable PLLA microspheres(PM)with sizes ranging from 60-100μm and with good sphericity were *** addition,to further improve the surface morphology of PLLA microspheres and enhance their bioactivity,functionalised porous PLLA microspheres loaded with magnesium oxide(MgO)/magnesium carbonate(MgCO_(3))(PMg)were also prepared by the emulsion *** results showed that the loading of MgO/MgCO_(3)resulted in the formation of a porous structure on the surface of the microspheres(PMg)and the dissolved Mg^(2+)could be released slowly during the degradation of *** vitro cellular experiments demonstrated the good biocompatibility of PM and PMg,while the released Mg^(2+)further enhanced the anti-inflammatory effect and osteogenic activity of *** PMg not only show promise for controlled preparation of drug carriers,but also have translational potential for bone regeneration.

关键词： magnesium ion osteogenesis polylactic acid porous microspheres

Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus

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Bioactive Materials 2021年第3期6卷 757-769页

作者： Xin Sun Zhenjiang Ma Xue zhao Wenjie Jin Chenyu Zhang Jie Ma Lei Qiang Wenhao Wang Qian Deng Han Yang jinzhong zhao Qianqian Liang Xiaojun Zhou Tao Li Jinwu Wang Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People's HospitalShanghai JiaoTong University School of MedicineNo.639 Zhizaoju RoadShanghai200011China Department of Radiology Shanghai Ninth People's HospitalShanghai JiaoTong University School of MedicineNo.639 Zhizaoju RoadShanghai200011China Department of Radiology Minhang Hospital of Fudan UniversityMinhang Central HospitalNo.170 Xinsong RoadShanghai 201100China Southwest JiaoTong University College of Medicine No.111 North 1st Section of Second Ring RoadChengdu610031China School of Biomedical Engineering Shanghai JiaoTong UniversityNo.1956 Huashan RoadShanghai200030China Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalNo.600Yishan RoadShanghai 200233China Spine Institute Shanghai University of Traditional Chinese MedicineNo.1200 Cailun RoadShanghai 200032China College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityNo.2999North Renmin RoadShanghai 201620China Department of Orthopaedics Xinhua Hospital affiliated to Shanghai Jiaotong University School of MedicineNo.1665 Kongjiang RoadShanghai200092China

Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in clinical treatment because of dysfunction of macrophage polarization and the inflammatory microenvironment in the bone defect ***-dimensional(3D)bioprinted scaffolds loaded with live cells and bioactive factors can improve cell viability and the inflammatory microenvironment and further accelerating bone ***,we used modified bioinks comprising gelatin,gelatin methacryloyl(GelMA),and 4-arm poly(ethylene glycol)acrylate(PEG)to fabricate 3D bioprinted scaffolds containing BMSCs,RAW264.7 macrophages,and BMP-4-loaded mesoporous silica nanoparticles(MSNs).Addition of MSNs effectively improved the mechanical strength of GelMA/gelatin/PEG ***,MSNs sustainably released BMP-4 for long-term *** 3D bioprinted scaffolds,BMP-4 promoted the polarization of RAW264.7 to M2 macrophages,which secrete anti-inflammatory factors and thereby reduce the levels of pro-inflammatory ***-4 released from MSNs and BMP-2 secreted from M2 macrophages collectively stimulated the osteogenic differentiation of BMSCs in the 3D bioprinted ***,in calvarial critical-size defect models of diabetic rats,3D bioprinted scaffolds loaded with MSNs/BMP-4 induced M2 macrophage polarization and improved the inflammatory *** 3D bioprinted scaffolds with MSNs/BMP-4,BMSCs,and RAW264.7 cells significantly accelerated bone *** conclusion,our results indicated that implanting 3D bioprinted scaffolds containing MSNs/BMP-4,BMSCs,and RAW264.7 cells in bone defects may be an effective method for improving diabetic bone repair,owing to the direct effects of BMP-4 on promoting osteogenesis of BMSCs and regulating M2 type macrophage polarization to improve the inflammatory microenvironment and secrete BMP-2.

关键词： Three-dimensional bioprinting Diabetic bone defect Bone morphogenic protein-4 Macrophage polarization Bone regeneration