Evaluation of patches for rotator cuff repair:A systematic review and meta-analysis based on animal studies

作     者：Jinwei Yang Yuhao Kang Wanlu Zhao Jia Jiang Yanbiao Jiang Bing Zhao Mingyue Jiao Bo Yuan Jinzhong Zhao Bin Ma 

作者机构：Evidence-Based Medicine CenterSchool of Basic Medical SciencesLanzhou UniversityLanzhou730000China Reproductive Medicine CenterGansu Provincial Maternity and Child-Care HospitalLanzhou730050China Department of Sports MedicineShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China College of Biomedical EngineeringSichuan UniversityChengdu610064China National Engineering Research Center for BiomaterialsChengdu610064China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu ProvinceLanzhou730000China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第4期

页      面：474-491页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the Natural Science Foundation of China(Number:81873184) the National Innovation and Entrepreneurship Training Program for Undergraduate(No.202110730235) 

主　　题：Rotator cuff patch Animal model Systematic review Meta-analysis Safety and effectiveness 

摘      要：Based on the published animal studies,we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation.74 animal studies were finally included,of which naturally derived biomaterials were applied the most widely(50.0%),rats were the most commonly used animal model(47.0%),and autologous tissue demonstrated the best outcomes in all animal *** biomechanical properties of naturally derived biomaterials(maximum failure load:WMD 18.68[95%CI 7.71-29.66];P=0.001,and stiffness:WMD 1.30[95%CI 0.01-2.60];P=0.048)was statistically significant in the rabbit *** rabbit model showed better outcomes even though the injury was severer compared with the rat model.