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Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia

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Genes & Diseases 2024年第5期11卷 374-389页

作者： Zijun Yan Jie Xia Ziyang Cao Hongyang Zhang jinxia.wang Tienan Feng Yi Shu Lin Zou Clinical Research Unit Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Institute of Pediatric Infection Immunityand Critical Care MedicineShanghai Jiao Tong University School of MedicineShanghai 200062China Center for Clinical Molecular Laboratory Medicine of Children’s Hospital of Chongqing Medical University Chongqing 400014China Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghai 200025China Bioinformatics and BioMedical Bigdata Mining Laboratory School of Big HealthGuizhou Medical UniversityGuiyangGuizhou 554300China

T-cell acute lymphoblastic leukemia(T-ALL),a heterogeneous hematological malignancy,is caused by the developmental arrest of normal T-cell *** development of targeted therapeutic regimens is impeded by poor knowledge of the stage-specific aberrances in this *** this study,we performed multi-omics integration analysis,which included mRNA expression,chromatin accessibility,and gene-dependency database analyses,to identify potential stage-specific druggable targets and repositioned drugs for this *** multi-omics integration helped identify 29 potential pathological genes for *** genes exhibited tissue-specific expression profiles and were enriched in the cell cycle,hematopoietic stem cell differentiation,and the AMPK signaling *** these,four known druggable targets(CDK6,TUBA1A,TUBB,and TYMS)showed dysregulated and stage-specific expression in malignant T cells and may serve as stage-specific targets in *** TUBA1A expression level was higher in the early T cell precursor(ETP)-ALL cells,while TUBB and TYMS were mainly highly expressed in malignant T cells arrested at the CD4 and CD8 double-positive or single-positive ***6 exhibited a U-shaped expression pattern in malignant T cells along the naıve to maturation ***,mebendazole and gemcitabine,which target TUBA1A and TYMS,respectively,exerted stage-specific inhibitory effects on T-ALL cell lines,indicating their potential stage-specific antileukemic role in ***,our findings might aid in identifying potential stage-specific druggable targets and are promising for achieving more precise therapeutic strategies for T-ALL.

关键词： Multi-omics Stage-specific druggable targets Targeted therapeutic strategies T-cell acute lymphoblastic leukemia Drug repositioning

Towards growth of pure AB-stacked bilayer graphene single crystals

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Nano Research 2024年第5期17卷 4616-4621页

作者： Xiaowen Zhang Tao Zhou Yunlong Ren Zuo Feng Ruixi Qiao Qinghe wang Bin wang jinxia Bai Muhong Wu Zhilie Tang Xu Zhou Kaihui Liu Xiaozhi Xu Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum MaterialsSchool of PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter School of PhysicsSouth China Normal UniversityGuangzhou 510006China Physical Science and Engineering Division King Abdullah University of Science and TechnologyThuwal 23955–6900Saudi Arabia State Key Laboratory for Mesoscopic Physics Frontiers Science Center for Nano-optoelectronicsSchool of PhysicsPeking UniversityBeijing 100871China Institute for Frontier Science Nanjing University of Aeronautics and AstronauticsNanjing 210094China International Centre for Quantum Materials Collaborative Innovation Centre of Quantum MatterPeking UniversityBeijing 100871China Songshan Lake Materials Laboratory Institute of PhysicsChinese Academy of SciencesDongguan 523808China

Given its intriguing band structure and unique tunable bandgap,AB-stacked bilayer graphene has great potentials in the applications of high-end electronics,optoelectronics and *** epitaxial growth of AB-stacked single-crystal bilayer graphene films requires a strict AB-stacked lattice,identical orientations and seamless stitching of bilayer graphene ***,the particles inevitably present on the metal surface that produced during high temperature growth would induce random orientations,twisted stacking islands,and uncontrollable multilayers,which is a great challenge to ***,we propose a heat-resisting-box assisted strategy to produce nearly pure AB-stacked bilayer graphene single-crystal films on Cu/Ni(111)*** our technique,the particles on the Cu/Ni(111)surface are effectively eliminated,which greatly minimizes the occurrence of randomly twisted islands and uncontrollable *** as-grown AB-stacked bilayer graphene films show>99%alignment and>99%AB stacking *** work provides a promising method towards the growth of pure AB-stacked bilayer graphene single crystals and would accelerate its device applications.

关键词： bilayer graphene AB stacking uniform growth heat-resisting box

CoFe_(2)O_(4) decorated graphene/C_(18)-functionalized mesoporous silica nanocomposites prepared for magnetic enrichment and electrochemical detection of promethazine in beef

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Chinese Chemical Letters 2024年第3期35卷 208-213页

作者： Xingdong Yang Shi-Ming Ying Sen Zhang jinxia Dai Wei Gao Tian-Qi wang Jun-Qin Qiao Hong-Zhen Lian Li Mao State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry&Chemical Engineering and Centre of Materials AnalysisNanjing UniversityNanjing 210023China Ministry of Education(MOE)Key Laboratory of Modern Toxicology School of Public HealthNanjing Medical UniversityNanjing 211166China

Promethazine(PHZ)is used as a sedative in veterinary medicine,and its residue can threaten the health of *** electrochemical detection of PHZ is suitable method for application in the ***,the traditional electroanalysis is difficult to perform directly in meat samples due to matrix *** work integrates magnetic solid-phase extraction and differential pulse voltammetry for highly sensitive and selective determination of PHZ in beef and beef liver for the first ***_(2)O_(4)/graphene coated with C_(18)-functionalized mesoporous silica(MG@mSiO_(2)-C_(18))is synthesized as dispersed magnetic adsorbent to extract *** glassy carbon electrode modified with nitrogen-doped hollow carbon microspheres(HCM)attracts the MG@mSiO_(2)-C_(18)with PHZ,and directly detects the PHZ without elution ***@mSiO_(2)-C_(18)can separate PHZ to avoid the interference of impurities on following detection,and also concentrate PHZ on magnetic ***,the electrode modification with HCM can amplify the electrochemical signal of ***,the integrated PHZ determination method exhibits a wide linear range from 0.08μmol/L to 300μmol/L with a low limit of detection of 9.8 nmol/*** beef sample analysis presents excellent recovery,demonstrating that this protocol is promising for the rapid and onsite detection of PHZ in real meat samples。

关键词： Promethazine(PHZ) Drug residue Magnetic solid phase extraction Electrochemical detection Beef

Unveiling the therapeutic potential:KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitro

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Oncology Research 2024年第11期32卷 1791-1802页

作者： jinxia CHEN SULI DAI GENG ZHANG SISI WEI XUETAO ZHAO YANG ZHENG YAOJIE wang XIAOHAN wang YUNJIANG LIU LIANMEI ZHAO Research Center The Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Key Laboratory of Tumor Gene Diagnosis Prevention and TherapyClinical Oncology Research CenterShijiazhuang050000China Department of Blood Transfusion The Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Breast Center Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Hebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance Hebei Medical UniversityShijiazhuang050000China

Background:Triple-negative breast cancer(TNBC)is a heterogeneous,recurring cancer characterized by a high rate of metastasis,poor prognosis,and lack of efficient ***2046,a small molecule inhibitor,can inhibit cell motility in malignant tumors,including breast ***,the specific targets and the corresponding mechanism of its function remain ***:In this study,we employed(3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium)(MTS)assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in ***-Seq was used to explore the targets of KBU2046 that inhibit the motility of ***,confirmed the predicted important signaling pathways through RT-qPCR and western ***:In this study,we found that KBU2046 functioned as a novel transforming growth factor-β(TGF-β1)inhibitor,effectively suppressing tumor cell motility in ***,it directly down-regulated leucine-rich repeat-containing 8 family,member E(LRRC8E),latent TGFβ-binding protein 3(LTBP3),dynein light chain 1(DNAL1),and MAF family of bZIP transcription factors(MAFF)genes,along with reduced protein expression of the integrin ***,KBU2046 decreased phosphorylation levels of Raf and *** deactivation of the ERK signaling pathway impeded cancer invasion and ***:In summary,these findings advocate for the utilization of TGF-β1 as a diagnostic and prognostic biomarker and as a therapeutic target in ***,our data underscore the potential of KBU2046 as a novel therapeutic strategy for combating cancer metastasis.

关键词： KBU2046 TGF-β1(transforming growth factor-β1) LRRC(leucine-rich repeat-containing) LTBP(leucine-rich repeat-containing) Breast cancer(BC) Integrinαv Integrinα6

Electroacupuncture with different waveforms for primary dysmenorrhea:A randomized controlled trial

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 357-362页

作者： Xiaona Wu Jingxue Yuan jinxia Ni Xiuli Ma Ziniu Zhang Yini Hua Juwei Dong Bob Peng wang Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China New Zealand College of Chinese Medicine Auckland 17467New Zealand

Objective To observe and compare the clinical effects of different electroacupuncture waveforms on primary *** This was a prospective,randomized,three-group,parallel-controlled *** with primary dysmenorrhea were randomly divided into dense-sparse wave,continuous wave,and discontinuous wave groups in a 1:1:1 *** lateral Ciliao(BL 32)points were *** three groups started treatment 3–5 days before menstruation,once a day for six sessions per course of treatment,one course of treatment per menstrual cycle,and three menstrual *** primary outcome measure was the proportion with an average visual analog scale(VAS)score reduction of≥50%from baseline for dysmenorrhea in the third menstrual cycle during *** secondary outcome measures included changes in dysmenorrhea VAS scores,Cox Menstrual Symptom Scale scores and the proportion of patients taking analgesic *** The proportion of cases where the average VAS score for dysmenorrhea decreased by≥50%from baseline in the third menstrual cycle was not statistically significant(P>.05).Precisely 30 min after acupuncture and regarding immediate analgesia on the most severe day of dysmenorrhea,there was a statistically significant difference in the dense-sparse wave group compared with the other two groups during the third menstrual cycle(P<.05).Additionally,there was a statistically significant difference between the dense-sparse wave and discontinuous wave groups 24 h after acupuncture(P<.05).Conclusions Waveform electroacupuncture can alleviate primary dysmenorrhea and its related symptoms in *** three groups showed similar results in terms of short-and long-term analgesic efficacy and a reduction in the number of patients taking analgesic *** achieving immediate analgesia,the dense-sparse wave group was slightly better than the other two groups.

关键词： Waveforms Ciliao(BL 32) Electroacupuncture Primary dysmenorrhea Randomized controlled trial Dense-sparse waves Continuous waves Discontinuous waves

A New Merged Product Reveals Precipitation Features over Drylands in China

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Advances in Atmospheric Sciences 2024年第10期41卷 2079-2091页

作者： Min LUO Yuzhi LIU Jie GAO Run LUO jinxia ZHANG Ziyuan TAN Siyu CHEN Khan ALAM Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China Collaborative Innovation Center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China Department of Physics University of PeshawarPeshawar 25120Pakistan

Due to the considerable uncertainties inherent in the datasets describing the spatiotemporal distributions of precipitation in the drylands of China,this study presents a new merged monthly precipitation product with a spatial resolution of approximately 0.2°×0.2°during 1980–*** newly developed precipitation product was validated at different temporal scales(e.g.,monthly,seasonally,and annually).The results show that the new product consistently aligns with the spatiotemporal distributions reported by the Chinese Meteorological Administration Land Data Assimilation System(CLDAS)product and Multi-Source Weighted Ensemble Precipitation(MSWEP).The merged product exhibits exceptional quality in describing the drylands of China,with a bias of–2.19 mm month^(–1)relative to *** addition,the annual trend of the merged product(0.09 mm month^(–1)yr^(−1))also closely aligns with that of the MSWEP(0.11 mm month^(–1)yr^(−1))during 1980–*** increasing trend indicates that the water cycle and wetting process intensified in the drylands of China during this *** particular,there was an increase in wetting during the period from 2001–***,the merged product exhibits potential value for improving our understanding of the climate and water cycle in the drylands of China.

关键词： precipitation merged dataset drylands water cycle

Biochar induced trade-offs and synergies between ecosystem services and crop productivity

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Journal of Integrative Agriculture 2024年第11期23卷 3882-3895页

作者： jinxia.wang Qiu Huang Kai Peng Dayang Yang Guozhen Wei Yunfei Ren Yixuan wang Xiukang wang Nangia Vinay Shikun Sun Yanming Yang Fei Mo College of Agronomy Northwest A&F University Agricultural and Animal Husbandry Technology Extension Center College of Life Sciences Yan'an University International Center for Agricultural Research in the Dry Areas (ICARDA) College of Water Resources and Architectural Engineering Northwest A&F University College of Agronomy Inner Mongolia Agricultural University

Biochar amendment offers a chance for sustainable agriculture. However, the effectiveness of biochar relies on its physical and chemical properties, which are heavily affected by biochar production conditions and management practices. Therefore, substantial uncertainties regarding the use of biochar exist in agricultural systems *** study provides the first quantitative evaluation of the impacts of biochar characteristics and management practices on key ecosystem services by performing a second-order meta-analysis based on 34,628 paired observations in biochar-amended and unamended systems. Overall, biochar enhances phytotoxicity alleviation,physiology regulation, soil remediation and carbon sequestration, and microbial functional gene ***, some prominent trade-offs exist between crop productivity and ecosystem service deliveries including for nutrient cycling, microbial function, climate change mitigation, and the soil microbial community. The adoption of low C:N biochar produced at high pyrolysis temperatures from sewage sludge-derived feedstock, in combination with a moderate application rate and inorganic fertilizer input, shows potential for achieving synergistic promotion of crop productivity and ecosystem services. These outcomes highlight the need for judicious implementation of biochar-based solutions to site-specific soil constraints. The quantified synergy and tradeoff relationships will aid the establishment of a sustainable biochar development framework that strengthens necessary ecosystem services commensurate with food security assurance.

关键词： biochar soil remediation phytotoxicity alleviation carbon sequestration productivity

Determination of liquid viscosity based on dual-frequency-bandparticle tracking

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Chinese Physics B 2024年第9期33卷 359-364页

作者： Lihua Yan Boyin Xue Yuanji Li jinxia Feng Xingkang Wu Kuanshou Zhang State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006China

An optical-tweezers-based dual-frequency-band particle tracking system was designed and fabricated for liquid viscositydetection. On the basis of the liquid viscosity dependent model of the particle’s restricted Brownian motion with theFax´en correction taken into account, the liquid viscosity and optical trap stiffness were determined by fitting the theoreticalprediction with the measured power spectral densities of the particle’s displacement and velocity that were derived from thedual-frequency-band particle tracking data. When the SiO2 beads were employed as probe particles in the measurements ofdifferent kinds of liquids, the measurement results exhibit a good agreement with the reported results, as well as a detectionuncertainty better than 4.6%. This kind of noninvasive economical technique can be applied in diverse environments forboth in situ and ex situ viscosity detection of liquids.

关键词： liquid viscosity optical tweezers dual-frequency-band particle tracking power spectral density

Efficacy of acupuncture in refractory irritable bowel syndrome patients:a randomized controlled trial

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Frontiers of Medicine 2024年第4期18卷 678-689页

作者： Jun Zhao Hui Zheng Xin wang Xuefei wang Yunzhou Shi Chaorong Xie Qingfeng Tao Da Li Jingwen Sun Junjian Tian Junxia Gao Huimin Liu Suhua Shi jinxia Ni Rongdan Xue Hui Hu Min Chen Shuguang Yu Zhigang Li School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing100029China The Third Hospital/Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu610000China Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing100010China Department of Acupuncture and Moxibustion Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing100700China Department of Rehabilitation The Third Affiliated Hospital of Beijing University of Chinese MedicineBeijing100029China Department of Acupuncture and Moxibustion Dongfang Hospital Affiliated with Beijing University of Chinese MedicineBeijing100078China Anorectal Disease Department Hospital of Chengdu University of Traditional Chinese MedicineChengdu610075China Department of Integrated Traditional and Western Medicine West China HospitalSichuan UniversityChengdu610044China

Previous studies have confirmed that acupuncture for irritable bowel syndrome(IBS)provided an additional benefit over usual care ***,we performed a multicenter,randomized,sham-controlled trial to assess the efficacy and safety of acupuncture versus sham acupuncture for refractory IBS in patients in the context of conventional *** in the acupuncture and sham acupuncture groups received real or sham acupuncture treatment in 3 sessions per week for a total of 12 *** primary outcome was a change in the IBS–Symptom Severity Scale(IBS-SSS)score from baseline to week 4.A total of 521 participants were screened,and 170 patients(85 patients per group)were enrolled and included in the intention-to-treat *** characteristics were comparable across the two *** baseline to 4 weeks,the IBS-SSS total score decreased by 140.0(95%CI:126.0 to 153.9)in the acupuncture group and 64.4(95%CI:50.4 to 78.3)in the sham acupuncture *** between-group difference was 75.6(95%CI:55.8 to 95.4).Acupuncture efficacy was maintained during the 4-week follow-up *** were no serious adverse *** conclusion,acupuncture provided benefits when combined with treatment as usual,providing more options for the treatment of refractory IBS.

关键词： acupuncture functional gastrointestinal disorders irritable bowel syndrome clinical trial