Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial

作     者：Zhao, Jun Zheng, Hui Wang, Xin Wang, Xuefei Shi, Yunzhou Xie, Chaorong Tao, Qingfeng Li, Da Sun, Jingwen Tian, Junjian Gao, Junxia Liu, Huimin Shi, Suhua Ni, Jinxia Xue, Rongdan Hu, Hui Chen, Min Yu, Shuguang Li, Zhigang 

作者机构：Beijing Univ Chinese Med Sch Acupuncture Moxibust & Tuina Beijing 100029 Peoples R China Sichuan Univ West China Hosp Dept Integrated Tradit & Western Med Chengdu Peoples R China Chengdu Univ Tradit Chinese Med Hosp 3 Acupuncture & Tuina Sch Chengdu 610000 Peoples R China Capital Med Univ Beijing Hosp Tradit Chinese Med Beijing 100010 Peoples R China Beijing Univ Chinese Med Dept Acupuncture & Moxibust Dongzhimen Hosp Beijing 100700 Peoples R China Beijing Univ Chinese Med Affiliated Hosp 3 Dept Rehabil Beijing 100029 Peoples R China Beijing Univ Chinese Med Dongfang Hosp Dept Acupuncture & Moxibust Beijing 100078 Peoples R China Hosp Chengdu Univ Tradit Chinese Med Anorectal Dis Dept Chengdu 610075 Peoples R China 

出 版 物：《FRONTIERS OF MEDICINE》 (医学前沿（英文版）)

年 卷 期：2024年第18卷第4期

页      面：678-689页

核心收录：

学科分类：1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100502[医学-中医临床基础] 10[医学] 100602[医学-中西医结合临床] 

基　　金：National Key R&D Program of China [2019YFC1709004] 

主　　题：acupuncture functional gastrointestinal disorders irritable bowel syndrome clinical trial 

摘      要：Previous studies have confirmed that acupuncture for irritable bowel syndrome (IBS) provided an additional benefit over usual care alone. Therefore, we performed a multicenter, randomized, sham-controlled trial to assess the efficacy and safety of acupuncture versus sham acupuncture for refractory IBS in patients in the context of conventional treatments. Patients in the acupuncture and sham acupuncture groups received real or sham acupuncture treatment in 3 sessions per week for a total of 12 sessions. The primary outcome was a change in the IBS-Symptom Severity Scale (IBS-SSS) score from baseline to week 4. A total of 521 participants were screened, and 170 patients (85 patients per group) were enrolled and included in the intention-to-treat analysis. Baseline characteristics were comparable across the two groups. From baseline to 4 weeks, the IBS-SSS total score decreased by 140.0 (95% CI: 126.0 to 153.9) in the acupuncture group and 64.4 (95% CI: 50.4 to 78.3) in the sham acupuncture group. The between-group difference was 75.6 (95% CI: 55.8 to 95.4). Acupuncture efficacy was maintained during the 4-week follow-up period. There were no serious adverse events. In conclusion, acupuncture provided benefits when combined with treatment as usual, providing more options for the treatment of refractory IBS.