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Electroacupuncture with different waveforms for primary dysmenorrhea:A randomized controlled trial

Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 357-362页

作者： Xiaona Wu Jingxue Yuan jinxia ni Xiuli Ma Ziniu Zhang Yini Hua Juwei Dong Bob Peng Wang Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China New Zealand College of Chinese Medicine Auckland 17467New Zealand

Objective To observe and compare the clinical effects of different electroacupuncture waveforms on primary *** This was a prospective,randomized,three-group,parallel-controlled *** with primary dysmenorrhea were randomly divided into dense-sparse wave,continuous wave,and discontinuous wave groups in a 1:1:1 *** lateral Ciliao(BL 32)points were *** three groups started treatment 3–5 days before menstruation,once a day for six sessions per course of treatment,one course of treatment per menstrual cycle,and three menstrual *** primary outcome measure was the proportion with an average visual analog scale(VAS)score reduction of≥50%from baseline for dysmenorrhea in the third menstrual cycle during *** secondary outcome measures included changes in dysmenorrhea VAS scores,Cox Menstrual Symptom Scale scores and the proportion of patients taking analgesic *** The proportion of cases where the average VAS score for dysmenorrhea decreased by≥50%from baseline in the third menstrual cycle was not statistically significant(P>.05).Precisely 30 min after acupuncture and regarding immediate analgesia on the most severe day of dysmenorrhea,there was a statistically significant difference in the dense-sparse wave group compared with the other two groups during the third menstrual cycle(Pnificant difference between the dense-sparse wave and discontinuous wave groups 24 h after acupuncture(P<.05).Conclusions Waveform electroacupuncture can alleviate primary dysmenorrhea and its related symptoms in *** three groups showed similar results in terms of short-and long-term analgesic efficacy and a reduction in the number of patients taking analgesic *** achieving immediate analgesia,the dense-sparse wave group was slightly better than the other two groups.

关键词： Waveforms Ciliao(BL 32) Electroacupuncture Primary dysmenorrhea Randomized controlled trial Dense-sparse waves Continuous waves Discontinuous waves

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Efficacy of acupuncture in refractory irritable bowel syndrome patients:a randomized controlled trial

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Frontiers of Medicine 2024年第4期18卷 678-689页

作者： Jun Zhao Hui Zheng Xin Wang Xuefei Wang Yunzhou Shi Chaorong Xie Qingfeng Tao Da Li Jingwen Sun Junjian Tian Junxia Gao Huimin Liu Suhua Shi jinxia ni Rongdan Xue Hui Hu Min Chen Shuguang Yu Zhigang Li School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing100029China The Third Hospital/Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu610000China Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing100010China Department of Acupuncture and Moxibustion Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing100700China Department of Rehabilitation The Third Affiliated Hospital of Beijing University of Chinese MedicineBeijing100029China Department of Acupuncture and Moxibustion Dongfang Hospital Affiliated with Beijing University of Chinese MedicineBeijing100078China Anorectal Disease Department Hospital of Chengdu University of Traditional Chinese MedicineChengdu610075China Department of Integrated Traditional and Western Medicine West China HospitalSichuan UniversityChengdu610044China

Previous studies have confirmed that acupuncture for irritable bowel syndrome(IBS)provided an additional benefit over usual care ***,we performed a multicenter,randomized,sham-controlled trial to assess the efficacy and safety of acupuncture versus sham acupuncture for refractory IBS in patients in the context of conventional *** in the acupuncture and sham acupuncture groups received real or sham acupuncture treatment in 3 sessions per week for a total of 12 *** primary outcome was a change in the IBS–Symptom Severity Scale(IBS-SSS)score from baseline to week 4.A total of 521 participants were screened,and 170 patients(85 patients per group)were enrolled and included in the intention-to-treat *** characteristics were comparable across the two *** baseline to 4 weeks,the IBS-SSS total score decreased by 140.0(95%CI:126.0 to 153.9)in the acupuncture group and 64.4(95%CI:50.4 to 78.3)in the sham acupuncture *** between-group difference was 75.6(95%CI:55.8 to 95.4).Acupuncture efficacy was maintained during the 4-week follow-up *** were no serious adverse *** conclusion,acupuncture provided benefits when combined with treatment as usual,providing more options for the treatment of refractory IBS.

关键词： acupuncture functional gastrointestinal disorders irritable bowel syndrome clinical trial

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Effect of cluster needling at scalp acupoints on differential protein expression in rat brain tissue after acute focal cerebral ischemia

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Journal of Traditional Chinese Medical Sciences 2020年第3期7卷 316-324页

作者： Xiaona Wu jinxia ni Huiyan An Yintong Gao Miaomiao Li Zhenzhen Huang Jingni Xu Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China

Objective:To explore the function of cluster needling at scalp points therapy on regulating differential protein's expression at different time points in middle cerebral artery occlusion(MCAO)model ***:Fifty-four rats were divided into three groups randomly and 18 rats in each *** groups respectively were the model group(group M,n=18),cluster needling at scalp points group(group C,n=18),false operation group(group F,n=18).Each group was then assigned in three subgroups,including 24-h,7-day,and 14-day *** rats in each *** at Baihui(GV20)and 2 points beside Baihui,which was 3 e4 mm away from the *** score was used to evaluated neurological *** methods were used to identify differentially expression proteins with a standard of fold change greater than 1.5 and Pnificant changes in expression after *** expression levels of Cdc42 and GFAP were increased,and Mag,Shank2,and MBP levels were *** the Gene Ontology analysis,the cellular component consisted of the terms cytoplasm,cytoskeleton,lysosome,and plasma *** main related biological processes were cellecell signaling,protein transport,aging,and cell *** synaptic and metabolic pathways were found by KEGG ***:Cluster needling at scalp acupoints can improve the nerve function score and improve dyskinesia in MCAO model *** needling at scalp acupoints can regulate the expression of 414 proteins,including Cdc42,GFAP,Mag,Shank2,and MBP,which are related to cerebral *** differential proteins are major concentration in cytoplasm,cytoskeleton,lysosomes,and plasma membrane,participate

关键词： Cluster needling at scalp acupoints Cerebral ischemia Rats Nerve function scoring Differentially expressed proteins

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Effects of cluster needling of scalp acupuncture on neurofilament protein 200 and signal transducer and activator of transcription 3 in rats with acute cerebral ischemia

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Journal of Traditional Chinese Medical Sciences 2020年第1期7卷 82-86页

作者： Xue Fang jinxia ni Buyi Su Huiyan An Miaomiao Li Jie Wang Xiaona Wu Department of Acupuncture and Moxibustion Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan250011China Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Rehabilitation Center Shenyang Jishuitan HospitalShenyang110000China

Objective:Cluster needling at scalp acupoints has showed satisfying effects with acute cerebral ischemia in clinic whereas the mechanisms are not yet clear *** study investigated the influence of cluster needling at scalp acupoints on neurological function,as well as on neurofilament protein 200(NF200)and signal transducer and activator of transcription 3(STAT3)expression,in rats with acute cerebral ***:Fifty-four Sprague-Dawley rats were randomly assigned in equal numbers to the false operation(group F),model(group M),or cluster needling scalp acupuncture(group C)*** group was divided into three subgroups,of six rats each,by acupuncture treatment time(24 h,7 days,and 14 days).The rat local cerebral ischemia model was prepared using a modified suture occlusion *** C rats were treated by cluster needling scalp acupuncture,while groups F and M did not receive acupuncture *** effects were evaluated using the Longa ***200 and STAT3 expression were measured by western ***:At 24 h,there were no statistical difference between group C and group M in nerve function(P>.05).On days 7 and 14,nerve function scores in group C were significantly lower than that in group M(respectively were Pnificantly higher in group C compared with group M(Pnificant(both P>.05).Conclusion:Cluster needling scalp acupuncture were efficient in improving nerve function scores in rats with cerebral ischemia,and promoting the recovery of motor *** improvements were associated with increases in NF200 and STAT3 expression.

关键词： Cluster needling scalp acupuncture Acute cerebral ischemia NF200 STAT3 Suture occlusion method Rat model

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耳周三穴深刺与浅刺治疗主观性耳鸣:随机对照研究

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中国针灸 2015年第10期35卷 1015-1019页

作者：尹韬倪金霞朱文增深圳市中医院针灸科广东深圳518033 北京中医药大学东直门医院针灸科中国中医科学院广安门医院针灸科北京100053

目的：对比耳周三穴深刺与浅刺治疗主观性耳鸣的疗效差异。方法：将50例主观性耳鸣患者随机分为深刺组和浅刺组,每组25例,最后深刺组22例、浅刺组20例纳入统计。两组治疗均选取耳周三穴和远端取穴相结合的方法,取患侧翳风、听会、耳门... 详细信息

目的：对比耳周三穴深刺与浅刺治疗主观性耳鸣的疗效差异。方法：将50例主观性耳鸣患者随机分为深刺组和浅刺组,每组25例,最后深刺组22例、浅刺组20例纳入统计。两组治疗均选取耳周三穴和远端取穴相结合的方法,取患侧翳风、听会、耳门、支沟、中渚、合谷等穴,深刺组深刺翳风、听会、耳门耳周三穴,深度为30~38mm,其余穴位均常规针刺;浅刺组则浅刺上述耳周三穴,深度15~20mm,其余穴位常规针刺。两组留针时间均为30min,每日1次,每周治疗5次,连续治疗4周。观察治疗前后患者耳鸣残疾评估量表（THI）评分、耳鸣程度分级、耳鸣声响程度视觉模拟评分（VAS）的变化情况,并比较两组疗效。结果：深刺组的总有效率为59.1%（13/22）,优于浅刺组的20.0%（4/20,P〈0.05）。深刺组THI评分、耳鸣程度分级、耳鸣声响程度VAS评分均较治疗前改善（均P〈0.05）;浅刺组THI评分、耳鸣程度分级、耳鸣声响程度VAS评分治疗前后比较,差异均无统计学意义（均P〉0.05）,且治疗后以上观察指标深刺组均优于浅刺组（均P〈0.05）。结论：深刺耳周三穴治疗主观性耳鸣可以明显改善耳鸣症状,降低耳鸣声响程度,疗效优于耳周三穴浅刺。

关键词：耳鸣针刺疗法针刺深度随机对照试验

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Towards growth of pure AB-stacked bilayer graphene single crystals

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Nano Research 2024年第5期17卷 4616-4621页

作者： Xiaowen Zhang Tao Zhou Yunlong Ren Zuo Feng Ruixi Qiao Qinghe Wang Bin Wang jinxia Bai Muhong Wu Zhilie Tang Xu Zhou Kaihui Liu Xiaozhi Xu Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum MaterialsSchool of PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter School of PhysicsSouth China Normal UniversityGuangzhou 510006China Physical Science and Engineering Division King Abdullah University of Science and TechnologyThuwal 23955–6900Saudi Arabia State Key Laboratory for Mesoscopic Physics Frontiers Science Center for Nano-optoelectronicsSchool of PhysicsPeking UniversityBeijing 100871China Institute for Frontier Science Nanjing University of Aeronautics and AstronauticsNanjing 210094China International Centre for Quantum Materials Collaborative Innovation Centre of Quantum MatterPeking UniversityBeijing 100871China Songshan Lake Materials Laboratory Institute of PhysicsChinese Academy of SciencesDongguan 523808China

Given its intriguing band structure and unique tunable bandgap,AB-stacked bilayer graphene has great potentials in the applications of high-end electronics,optoelectronics and *** epitaxial growth of AB-stacked single-crystal bilayer graphene films requires a strict AB-stacked lattice,identical orientations and seamless stitching of bilayer graphene ***,the particles inevitably present on the metal surface that produced during high temperature growth would induce random orientations,twisted stacking islands,and uncontrollable multilayers,which is a great challenge to ***,we propose a heat-resisting-box assisted strategy to produce nearly pure AB-stacked bilayer graphene single-crystal films on Cu/ni(111)*** our technique,the particles on the Cu/ni(111)surface are effectively eliminated,which greatly minimizes the occurrence of randomly twisted islands and uncontrollable *** as-grown AB-stacked bilayer graphene films show>99%alignment and>99%AB stacking *** work provides a promising method towards the growth of pure AB-stacked bilayer graphene single crystals and would accelerate its device applications.

关键词： bilayer graphene AB stacking uniform growth heat-resisting box

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基于“脑为髓海”理论浅议头穴丛刺法治疗中风思路

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辽宁中医药大学学报 2021年第8期23卷 79-82页

作者：陈佳华倪金霞北京中医药大学北京100029 北京中医药大学东直门医院北京100700

中风临床表现繁多,但其病位在脑,病机可总结为正虚邪盛、气血逆乱、阴阳失调、髓海失充、痰瘀闭阻脑络等。脑髓对全身脏腑有调节作用,临床上可以通过针刺头部穴位来达到调节头部气血,蓄灌髓海,平衡全身阴阳的作用。头穴丛刺法是于致顺... 详细信息

中风临床表现繁多,但其病位在脑,病机可总结为正虚邪盛、气血逆乱、阴阳失调、髓海失充、痰瘀闭阻脑络等。脑髓对全身脏腑有调节作用,临床上可以通过针刺头部穴位来达到调节头部气血,蓄灌髓海,平衡全身阴阳的作用。头穴丛刺法是于致顺教授在多年临床积累结合针灸基础理论的基础上创立的一种治疗中风的针刺手法,临床效果显著。文章基于四海理论中"脑为髓海"理论,结合脑与五脏之间的关系,参考头穴丛刺法的实验基础及临床应用,来探讨头穴丛刺法治疗中风的思路,为临床头穴丛刺法治疗中风提供理论依据。

关键词：脑为髓海脑五脏头穴丛刺法中风

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中国劳动力市场中的年龄歧视及其影响——基于中国社会状况综合调查(CSS)数据的分析

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人口与经济 2024年第3期 97-110页

作者：蔚金霞高文书倪晨旭中国社会科学院大学经济学院北京102488 中国社会科学院大学北京102488

劳动力市场歧视不利于实现平等就业和高质量充分就业,损害了人力资源的有效配置,也不利于劳动者福利的增进。近年来,“35岁就业危机”现象引起社会广泛关注,然而,目前针对国内劳动力市场中年龄歧视的系统研究还十分缺乏。基于人力资本... 详细信息

劳动力市场歧视不利于实现平等就业和高质量充分就业,损害了人力资源的有效配置,也不利于劳动者福利的增进。近年来,“35岁就业危机”现象引起社会广泛关注,然而,目前针对国内劳动力市场中年龄歧视的系统研究还十分缺乏。基于人力资本理论和歧视理论,首先分析了年龄歧视的现状及来自劳动供需双方的成因。研究发现,与发达国家不同,中国劳动力市场的年龄歧视高峰期较早,主要集中在步入中年后的35—40岁,这主要与劳动力市场对技能更新的青壮年群体的偏好有关。进一步运用中国社会状况综合调查数据,实证检验了年龄歧视的劳动力市场后果。采用工具变量的估计结果表明,年龄歧视显著提高了劳动者的失业风险,降低了其劳动收入水平。就业类型方面,年龄歧视显著降低了劳动者进入正规部门的可能性。此外,年龄歧视还对劳动者的心理健康和生活满意度产生了负向影响。研究揭示了中国年龄歧视的特殊性、普遍性和不利影响,指出了这种与人力资本结构变迁和雇主用工策略相关的中青年偏好可能造成的社会经济成本和福利损失。基于此,提出了消除年龄歧视的政策建议,包括规范用人单位的招聘行为,加强反歧视法律建设,以及完善职业培训和再就业机制等。

关键词：年龄歧视劳动力市场歧视中年危机就业

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李志刚教授针灸治疗难治性腹泻型肠易激综合征经验撷英

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天津中医药大学学报 2022年第1期41卷 18-21页

作者：李达倪金霞李志刚北京中医药大学东直门医院北京100700 北京中医药大学北京100029

文章总结李志刚教授针灸治疗难治性腹泻型肠易激综合征的临证经验。李教授尊崇中医经典理论,师古不泥,治病必求于本,谨守“中气不运,木郁不达”之病机,强调先后天之本于该病中的重要意义,重视调神,善通调膀胱气化而利小便以实大便。主... 详细信息

文章总结李志刚教授针灸治疗难治性腹泻型肠易激综合征的临证经验。李教授尊崇中医经典理论,师古不泥,治病必求于本,谨守“中气不运,木郁不达”之病机,强调先后天之本于该病中的重要意义,重视调神,善通调膀胱气化而利小便以实大便。主取脾、胃、大肠经输穴、募穴及下合穴,配以调神及利水组穴,重者随症配伍多种疗法,共奏疏肝健脾、和胃止泻之功。

关键词：难治性腹泻型肠易激综合征针灸名医经验李志刚

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深刺针法治疗顽固性三叉神经痛医案1则

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新中医 2019年第10期51卷 265-266页

作者：尹韬倪金霞朱文增深圳市中医院针灸科广东深圳518033 北京中医药大学东直门医院针灸科北京100027 中国中医科学院广安门医院针灸科北京100053

三叉神经痛是指在头面部三叉神经分布区域内,突然发生的短暂、剧烈性疼痛。本病有反复发作、疼痛剧烈的特点,严重影响患者的正常工作与生活。目前主要以止痛药物对症治疗,存在药物不良反应大、病情易反复等不足。针灸常用于治疗神经性疼... 详细信息

三叉神经痛是指在头面部三叉神经分布区域内,突然发生的短暂、剧烈性疼痛。本病有反复发作、疼痛剧烈的特点,严重影响患者的正常工作与生活。目前主要以止痛药物对症治疗,存在药物不良反应大、病情易反复等不足。针灸常用于治疗神经性疼痛,疗效显著。深刺针法出自《灵枢·终始》'痛而以手按之不得者,阴也,深刺之'。

关键词：三叉神经痛针刺疗法深刺针法

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