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ZnO薄膜生长及声表面波性能研究

深圳大学学报（理工版） 2015年第1期32卷 17-24页

作者：罗景庭钟鑫朱茂东古迪柯鹏飞刘梓昇钟增培范平深圳大学物理科学与技术学院薄膜物理与应用研究所深圳市传感器技术重点实验室深圳518060

采用传统射频磁控溅射技术,通过引入Si O2缓冲层以及调节工作气压的方法,在Si衬底上制备具有高度(1120)择优取向的Zn O薄膜.采用X射线衍射技术和原子力显微镜分析Zn O薄膜的晶体特性和择优取向.研究发现,引入Si O2缓冲层能显著减小Zn O/... 详细信息

采用传统射频磁控溅射技术,通过引入Si O2缓冲层以及调节工作气压的方法,在Si衬底上制备具有高度(1120)择优取向的Zn O薄膜.采用X射线衍射技术和原子力显微镜分析Zn O薄膜的晶体特性和择优取向.研究发现,引入Si O2缓冲层能显著减小Zn O/Si O2/Si三层结构声表面波器件的温度延迟系数(temperature coefficient of delay,TCD),当Si O2缓冲层厚度为200 nm时,Zn O薄膜同时具有(0002)和(1120)择优取向,且TCD值仅为2×10-6℃-1左右,说明器件温度稳定性佳.当工作气压降低时,Zn O(1120)择优取向增强,相应的声表面波器件的机电耦合系数(K2)也增大.在大机电耦合系数和高温度稳定性的Zn O/Si O2/Si三层结构的基础上,有望制作出高性能的Love波声表面波生物传感器.

关键词：凝聚态物理 ZnO薄膜 ( 1120 ) 择优取向 Love波声表面波器件机电耦合系数温度延迟系数

强化本体感觉训练及等速肌力训练对前交叉韧带重建术患者康复效果的影响

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组织工程与重建外科 2023年第6期19卷 558-563页

作者：胥龙飞高丕明罗婧婷罗小兵四川省骨科医院四川省成都市610041

目的探讨强化本体感觉训练及等速肌力训练对前交叉韧带(ACL)重建术患者康复效果的影响。方法选取2020年1月至2022年12月在我院诊治的ACL重建术患者82例,随机分为2组,每组各41例。对照组给予常规训练,研究组给予强化本体感觉训练及等速... 详细信息

目的探讨强化本体感觉训练及等速肌力训练对前交叉韧带(ACL)重建术患者康复效果的影响。方法选取2020年1月至2022年12月在我院诊治的ACL重建术患者82例,随机分为2组,每组各41例。对照组给予常规训练,研究组给予强化本体感觉训练及等速肌力训练。比较两组训练前后的膝关节本体感觉功能、等速肌力、关节疼痛程度及膝关节稳定性,以及康复效果。结果训练后,两组患侧15°重现差值、患侧45°重现差值、患侧75°重现差值较训练前均降低(P<0.05),且研究组明显低于对照组(P<0.05)。训练后,两组伸屈膝相对峰力矩(PT/BW)、屈膝峰力矩值(PT)、伸膝PT、腘绳肌与股四头肌的肌力比值(H/Q)均较训练前升高(P<0.05),且研究组明显高于对照组(P<0.05)。训练后,两组视觉模拟评分法(VAS)评分、Lachman试验胫骨前移较训练前均降低(P<0.05),且研究组明显低于对照组(P<0.05)。研究组康复优良率为90.24%,明显高于对照组的73.17%(P<0.05)。结论强化本体感觉训练及等速肌力训练应用于ACL重建术患者,可有效改善膝关节本体感觉功能、等速肌力,降低关节疼痛程度,提高膝关节稳定性和康复效果。

关键词：强化本体感觉训练等速肌力训练前交叉韧带前交叉韧带重建术康复效果

Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues Yu luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian Tang Jiaying He Huihang Sun Jingjia luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： Shan luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li Jian luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

郑氏经验穴结合肩关节运动干预治疗肩峰撞击综合征临床研究

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陕西中医 2024年第6期45卷 846-849,854页

作者：张琳罗婧婷刘剑伟唐浩琛四川省骨科医院四川成都610041

目的:探究郑氏经验穴结合肩关节运动干预对肩峰撞击综合征(SIS)的临床疗效。方法:选取96例SIS患者,随机分为对照组和观察组各48例。对照组采用肩关节运动治疗,观察组采用郑氏经验穴结合肩关节运动治疗,1个治疗周期为3周。评估两组治疗... 详细信息

目的:探究郑氏经验穴结合肩关节运动干预对肩峰撞击综合征(SIS)的临床疗效。方法:选取96例SIS患者,随机分为对照组和观察组各48例。对照组采用肩关节运动治疗,观察组采用郑氏经验穴结合肩关节运动治疗,1个治疗周期为3周。评估两组治疗后治疗效果、肩关节活动度、肩部肌力及不良反应。结果:治疗3周后,观察组治疗有效率91.67%明显高于对照组的75.00%,治疗1、3周后观察组Constant-Murley评分显著高于对照组(P<0.05)。治疗3周后,观察组各关节活动度,肩部各部位肌力明显高于对照组(P<0.05)。观察组不良反应发生情况较少。结论:郑氏经验穴结合肩关节运动干预对SIS可以提高其临床治疗效果,缓解患者疼痛,有效提高肩关节活动度和肩部肌力,且较安全。

关键词：肩峰撞击综合征郑氏经验穴肩关节运动肩关节活动度肩部肌力

基于携婴者行为的公园母婴室空间认知及使用情况研究

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中外建筑 2022年第9期 94-99页

作者：黄海舟郑晓昕王璎婕罗靖婷叶菁福建农林大学风景园林与艺术学院

公园母婴室存在使用率低的问题,而针对此问题的相关研究较少。以福州市鼓楼区及其周边部分区域3种类型的5处公园内的母婴室作为研究对象,通过实地调研与问卷调查的方法对其使用情况与设施现状进行调查研究,分析公园母婴室存在的问题和... 详细信息

公园母婴室存在使用率低的问题,而针对此问题的相关研究较少。以福州市鼓楼区及其周边部分区域3种类型的5处公园内的母婴室作为研究对象,通过实地调研与问卷调查的方法对其使用情况与设施现状进行调查研究,分析公园母婴室存在的问题和造成使用率低的原因,进而提出相应的改进意见。结果表明,公园基本满足母婴室的配建需求,但由于携婴者认知度低,母婴室标识不明确以及卫生情况差与内部设施欠缺等原因,导致母婴室使用率较低。研究结论可为提高公园母婴室的使用率,优化母婴室的布局、设计和管理措施提供理论依据。

关键词：公园母婴室携婴者行为特征使用现状优化建议

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury