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Rac1 Overexpression is correlated with Epithelial-Mesenchymal Transition and predicts poor prognosis of colon cancer

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Rac1 Overexpression is correlated with Epithelial-Mesenchyma...

PHB1 inhibits the proliferation of nasopharyngeal carcinoma cells via inactivation of the NF-κB signaling pathway

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Yujuan Zhou Longzheng Xia linda Oyang Heran Wang jingguan lin Shiming Tan Yutong Tian Min Su Xia Luo Xiaoyan Chen Hui Wang Qianjin Liao Key Laboratory of Translational Radiation Oncology Hunan ProvinceHunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University

Objective: Rac1 and epithelial-mesenchymal transition(EMT) is an important target in new cancer treatment strategies. We investigated the clinical significance of Rac1 and markers of EMT expression in colon cancer, and their possible correlation with EMT phenotype. Methods: Immunohistochemistry was used to assess the expressions of Rac1, Snail1, Twist1, N-cadherin(Ncad), Vimentin(Vim), and E-cadherin(E-cad) in 126 colon cancer paraffin-embedded specimens and 50 tumor-adjacent normal specimens. The association of Rac1 and EMT markers with clinicopathological characteristics and relationships between the protein levels and progression free survival(PFS) and overall survival(OS) were analyzed. Results: Compared with non-tumorous tissues, Rac1, Snail1, Twist1, N-cad, Vim levels were markedly increased in colon cancer tissues, whereas decreased E-cad levels were observed(P linicopathologic characteristics, multivariateanalysis indicated Rac1, Snail1, Twist1, N-cad, Vim, and E-cad expression respectively could be as an independent prognostic factor in colon cancer. Rac1 expression was positively correlated with Snail1, Twist1, N-cad, Vim levels(P<0.01) and negatively correlated with E-cadherin amounts(P<0.001) in colon cancer tissues. Conclusion: Rac1 may promote colon cancer progression and metastasis by involving EMT program, which may be considered a potential therapeutic target in colon cancer.

关键词： Rac1 colon cancer epithelial-mesenchymal transition prognosis metastasis

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PHB1 inhibits the proliferation of nasopharyngeal carcinoma ...

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Heran Wang Yujuan Zhou Longzheng Xia linda Oyang Shiming Tan jingguan lin Yutong Tian Min Su Ying Wang Xia Luo Yang Wu Xiaoyan Chen Pan Chen Hui Wang Qianjin Liao Key Laboratory of Translational Radiation Oncology Hunan ProvinceHunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University

Objective: PHB1 has been proved tumor-associated and functions as tumor suppressor in multiple cancer cells. This study aimed to investigate the effects of PHB1 on the proliferation in human nasopharyngeal carcinoma(NPC) cell lines and its mechanisms. Method: PHB1 was stably overexpressed in CNE1 and HNE1 cells. Cell proliferation was assessed by colony formation and CCK8 assay. Cell-cycle distribution and apoptosis were analyzed using flow cytometry. Luciferase reporter assays, immunofluorescent assay, western blot and quantitative RT-PCR were used to detect the NF-κB activity and downstream signaling pathway expression. Results: PHB1 significantly inhibited the proliferation of NPC cell lines CNE1 and HNE1 in vitro. PHB1 induced an apparent cell cycle arrest at the G1/S phase and apoptosis, which was accompanied by an obvious inactivation of the NF-κB signaling pathway. PHB1 led to a remarkable decrease the expression of NF-κB p65, IKKβ, cyclin D1, cyclin-dependent kinase(CDK) 4 and Bcl-2, obviously increased the expression of IκBα, p21, Bax at both mRNA and protein levels in NPC cells. In addition, PHB1 restrained the LPS-induced activation of NF-κB signaling via inhibiting p65 translocation into nuclear. Conclusion: PHB1 could inhibit cell proliferation in vitro via inactivation of the NF-κB signaling pathway. PHB1 maybe serve as a tumor suppressor gene and a potential therapeutic target against NPC.

关键词： Nasopharyngeal carcinoma PHB1 NF-κB cell proliferation signaling pathway

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胰腺癌综合治疗研究的进展

临床医学工程 2012年第9期19卷 1623-1625页

作者：左朝晖林劲冠朱海珍湖南省肿瘤医院胃胰腺外科湖南长沙410013 湖南大学生物学院癌症研究中心湖南长沙410082

目的探讨胰腺癌综合治疗研究的进展。方法复习相关文献,对国内外胰腺癌综合治疗进行综述。结果准确的胰腺癌术前评估是胰腺癌综合治疗方案实施的需要,个体化原则基础上进行的术前新辅助放化疗、术中规范化手术和术后辅助放化疗等多学科... 详细信息

目的探讨胰腺癌综合治疗研究的进展。方法复习相关文献,对国内外胰腺癌综合治疗进行综述。结果准确的胰腺癌术前评估是胰腺癌综合治疗方案实施的需要,个体化原则基础上进行的术前新辅助放化疗、术中规范化手术和术后辅助放化疗等多学科合作的综合治疗,可明显改善胰腺癌的疗效。结论多学科合作的综合治疗是胰腺癌最佳治疗的模式。

关键词：胰腺癌术前评估综合治疗根治性切除新辅助放化疗

字字痛刻骨,一洗艳与冶——论同光体诗人夏敬观

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韶关学院学报 2006年第5期27卷 1-4页

作者：贺国强魏中林苏州大学文学院江苏苏州215021 韶关学院院长办公室广东韶关512005

夏敬观为同光体江西派著名诗人,专学梅尧臣,为同光体之后劲。其诗歌理论重学问,主张学古求变。诗歌抒发了对苦难现实的愤慨,诉写其内心种种错综复杂的矛盾愤慨。其诗学梅一端,格调多类香山,命意之凄苦则类孟郊, 向往“由奇造淡雅”的境界。

关键词：夏敬光同光体梅宛陵映庵体

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小白菜耐抽薹品种及其馅用特性的比较研究

中国蔬菜 2009年第6期 41-45页

作者：李良俊鲁茂林徐强陈学好扬州大学园艺与植物保护学院扬州225009 扬州大学食品科学与工程学院扬州225001

对11个小白菜品种冬春季育苗移栽后的生长、耐抽薹性及馅用特性进行了研究。结果表明,春油1号、春油2号、京绿7号始终未抽薹;四月慢、五月慢和扬州青也具有较强的耐抽薹性;而寒笑、暑绿、京冠1号、苏州青、绿扬青极易抽薹,均不宜作冬春... 详细信息

对11个小白菜品种冬春季育苗移栽后的生长、耐抽薹性及馅用特性进行了研究。结果表明,春油1号、春油2号、京绿7号始终未抽薹;四月慢、五月慢和扬州青也具有较强的耐抽薹性;而寒笑、暑绿、京冠1号、苏州青、绿扬青极易抽薹,均不宜作冬春季大棵菜栽培。四月慢、春油1号和早春采收的京绿7号较适馅用,春油1号和京绿7号适宜初冬种植,早春收获;四月慢适于冬末种植。最适宜馅用小白菜原料的单株质量200g左右,叶片和叶柄的鲜质量比约为4∶10。

关键词：小白菜耐抽薹馅用