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SP-141 targets Trs85 to inhibit rice blast fungus infection and functions as a potential broadspectrum antifungal agent

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Plant Communications 2024年第2期5卷 169-184页

作者： Xi-Yu Wu Bo Dong Xue-Ming Zhu Ying-Ying Cai lin li Jian-Ping Lu Bin Yu jing-li cheng Fei Xu Jian-Dong Bao Ying Wang Xiao-Hong liu Fu-cheng lin State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of BiotechnologyZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310058Zhejiang ProvinceChina Department of Pharmacology and Nutritional Science College of MedicineThe University of KentuckyLexingtonKY 40506USA Markey Cancer Center College of MedicineThe University of KentuckyLexingtonKY 40506USA College of life Sciences Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Institute of Pesticide and Environmental Toxicology Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and InsectsZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Institute of Edible Fungi Shanghai Academy of Agricultural SciencesShanghai 201106ShanghaiChina

Rice blast is a devastating disease worldwide,threatening rice production and food *** blast fun-gus Magnaporthe oryzae invades the host via the appressorium,a specialized pressure-generating struc-ture that generates enormous turgor pressure to penetrate the host ***,owing to ongoing evolution of fungicide resistance,it is vitally important to identify new targets and ***,we show that Trs85,a subunit of the transport protein particle III complex,is essential for appressorium-mediated infection in *** explain how Trs85 regulates autophagy through Ypt1(a small guano-sine triphosphatase protein)in *** then identify a key conserved amphipathic a helix within Trs85 that is associated with pathogenicity of *** computer-aided screening,we identify a lead compound,SP-141,that affects autophagy and the Trs85–Ypt1 ***-141 demonstrates a substantial capacity to effectively inhibit infection caused by the rice blast fungus while also exhibiting wide-ranging potential as an antifungal agent with broad-spectrum *** together,our data show that Trs85 is a potential new target and that SP-141 has potential for the control of rice *** thus provide a novel strategy that may help in thefight against rice blast.

关键词： Magnaporthe oryzae rice blast TRAPPIII complex trs85 fungicide

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乡村治理视域下乡村文化建设路径研究——以R村为例

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安徽农业科学 2024年第10期52卷 244-247,265页

作者：李景成安徽城市管理职业学院安徽合肥230011

分析了当前乡村文化建设的现状及困境,基于乡村治理视角,以R村为例,从制定乡村文化建设发展规划、鼓励多元主体参与乡村文化建设、持续开展特色鲜明的村民文化活动、构建乡村文化融合与创新发展举措等多个方面,探索了乡村文化建设路径,... 详细信息

分析了当前乡村文化建设的现状及困境,基于乡村治理视角,以R村为例,从制定乡村文化建设发展规划、鼓励多元主体参与乡村文化建设、持续开展特色鲜明的村民文化活动、构建乡村文化融合与创新发展举措等多个方面,探索了乡村文化建设路径,以期提升乡村文化建设水平,满足农民的文化需求,增进农民的幸福感,提升乡村社会的文明程度。

关键词：乡村文化文化振兴乡村治理

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在“未来世界”中推究人类的生存方式和生命意义——吕杨杕小说《寓言家:赌徒、侦探与使者》阅读札记

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山东青年政治学院学报 2024年第4期40卷 90-96页

作者：张灵李京宬中国政法大学人文学院北京100088 南洋理工大学社会科学学院新加坡639798

2021年,“元宇宙”概念一下吸引了全球性的广泛关注。在高度发达的信息技术的支撑下,人类生产、生活、交往方式全面、深度地实现了媒介化表达与操控,这不仅意味着产业领域的巨大变革和新机遇的出现,而且人类未来的社会秩序和生活方式等... 详细信息

2021年,“元宇宙”概念一下吸引了全球性的广泛关注。在高度发达的信息技术的支撑下,人类生产、生活、交往方式全面、深度地实现了媒介化表达与操控,这不仅意味着产业领域的巨大变革和新机遇的出现,而且人类未来的社会秩序和生活方式等等也将发生深刻变化。然而元宇宙概念所潜含的科学命题和关于人类的本性与人类社会运转规律的认知等问题,很早就进入了人类的科学探索和文艺创造的悠久历程之中。文学新人吕杨杕创作的《寓言家:赌徒、侦探与使者》可以看作是对时代最前沿的元宇宙话语的一种小说想象与反思;作品用元宇宙时代的思维方式、世界景观来演绎、模拟人类未来社会生活,对世界人生的一些重大命题如“精英”治理的合法性、生命的意义、爱情与理性的关系等给予了富有深度的演绎、探求。小说不仅展示了新一代小说家们新颖的想象世界,而且显示了他们对人类社会和人生重大命题的严肃关切和别样思考。作品具有寓言、推理、科幻、言情等多重小说艺术元素。

关键词：元宇宙《寓言家:赌徒、侦探与使者》寓言预言家治理合法性爱科幻

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乡村振兴背景下农家书屋文旅融合研究——以大别山区G镇四景点农家书屋为例

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安徽农业科学 2024年第13期52卷 254-257,269页

作者：翁畅平李景成安徽广播影视职业技术学院安徽合肥230011 安徽城市管理职业学院安徽合肥230011

基于乡村振兴背景,从文化与旅游融合的视角,探讨了农家书屋融合乡村景点发展的必要性及可行性。以大别山区G镇四景点的农家书屋为例,从空间建设、资源建设、管理体制、服务创新等方面,研究农家书屋文旅融合建设的策略,以期提升旅游景点... 详细信息

基于乡村振兴背景,从文化与旅游融合的视角,探讨了农家书屋融合乡村景点发展的必要性及可行性。以大别山区G镇四景点的农家书屋为例,从空间建设、资源建设、管理体制、服务创新等方面,研究农家书屋文旅融合建设的策略,以期提升旅游景点的文化内涵,增加旅游景点的游客黏度,提高农家书屋的使用效率,增加农家书屋用户满意度,推动区域民俗文化发展与中华优秀传统文化的传承发展。

关键词：文旅融合农家书屋乡村景点

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Effects of exogenous salicylic acid on growth and H_2O_2-metabolizing enzymes in rice seedlings under lead stress

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Journal of Environmental Sciences 2007年第1期19卷 44-49页

作者： CHEN jing ZHU cheng li li-ping SUN Zhong-yang PAN Xue-bo State Key Laboratory of Plant Physiology and Biochemistry College of Life Sciences Zhejiang University Hangzhou 310029 China

Salicylic acid （SA） was an essential component of the plant resistance to pathogens and also plays an important role in mediating plant response to some abiotic stress. The possible effects of SA on the growth and H2O2-metabolizing enzymes in rice seedlings under lead stress were studied. When rice seedlings grown in nutrient solution containing Pb^2＋（0, 0.05, 0.15, 0.25 mmol/L） for 18 d, the plant biomass as well as the chlorophyll content of leaves decreased with increasing Pb concentration. The pre-treatment with SA （treated with 0.1 mmol/L SA for 48 h before Pb stress） partially protected seedlings from Pb toxicity. The chlorophyll contents were significant higher in leaves of Pb-exposed with SA pre-treatment seedlings than in Pb-exposed plants at the same Pb intensity. SA pre-treated alone could significantly increase the length of shoot and root of seedlings but the vigour difference was not marked under long-term exposure to Pb toxicity. SA pre-treated influence the H2O2 level in leaves of seedlings by up-regulating the activity of superoxide dismutase （SOD）, repressing the activity of catalase （CAT） and ascorbate peroxidase （APX） depending on the concentrations of Pb^2＋ in the growth medium. The results supported the conclusion that SA played a positive role in rice seedlings against Pb toxicity.

关键词： ascorbate peroxidase catalase H2O2 lead stress rice (Oryza sativa L.) salicylic acid superoxide dismutase

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lie-Form Invariance of a Type of Non-holonomic Singular Systems

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Communications in Theoretical Physics 2007年第3期47卷 409-412页

作者： WANG jing li Yuan-cheng HOU Qi-Bao XIA li-li College of Physical Science and Technology China University of Petroleum Dongying 257061 China

In this paper, the lie-form invariance of a type of non-holonomic singular systems is studied. The differential equations of motion of the systems are given. The definition and the criterions of the lie-form invariance for the systems are presented. The Hojman conserved quantity and the Mei conserved quantity are obtained. An example is given to illustrate the application of the results.

关键词： non-holonomic constraint singular system symmetry conserved quantity

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Form Invariance and Conserved Quantity for Non-holonomic Systems with Variable Mass and Unilateral Constraints

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Communications in Theoretical Physics 2007年第2期47卷 213-216页

作者： WANG jing li Yuan-cheng HOU Qi-Bao XIA li-li College of Physical Science and Technology University of Petroleum China Dongying 257061 China

The paper studies the form invariance and a type of non-Noether conserved quantity called Mei conserved quantity for non-holonomic systems with variable mass and unilateral constraints. Acoording to the invariance of the form of differential equations of motion under infinitesimal transformations, this paper gives the definition and criterion of the form invariance for non-holonomic systems with variable mass and unilateral constraints. The condition under which a form invariance can lead to Mei conservation quantity and the form of the conservation quantity are deduced. An example is given to illustrate the application of the results.

关键词： variable mass unilateral constraint non-holonomic system form invaxiance conserved quantity

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Research on cultural algorithm for solving routing problem of mobile agent

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The Journal of China Universities of Posts and Telecommunications 2008年第4期15卷 121-125页

作者： MA Jun ZHANG Jian-pei YANG jing cheng li-li College of Computer Science and Technology Harbin Engineering University Harbin 150001 China

The key idea behind cultural algorithm is to explicitly acquire problem-solving knowledge from the evolving population and in return apply that knowledge to guide the search. In this article, cultural algorithm-simulated annealing is proposed to solve the routing problem of mobile agent. The optimal individual is accepted to improve the belief space＇s evolution of cultural algorithms by simulated annealing. The step size in search is used as situational knowledge to guide the search of optimal solution in the population space. Because of this feature, the search time is reduced. Experimental results show that the algorithm proposed in this article can ensure the quality of optimal solutions, and also has better convergence speed. The operation efficiency of the system is considerably improved.

关键词： cultural algorithm mobile agent routing simulated annealing

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Room-temperature ferrimagnetism and size-modulated electronic structures in two-dimensional cluster-based metal-organic frameworks

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Science China Chemistry 2024年第4期67卷 1334-1340页

作者： jing cheng Xingxing li Jinlong Yang Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of ChinaHefei 230026China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Cluster-assembled materials have attracted particular attention for their complex hierarchical structures and unique ***,the majority of cluster-based assemblies developed so far are either non-magnetic or only exhibit magnetic ordering with a relatively low Curie temperature,limiting their applications in ***,two-dimensional(2D)cluster-assembled materials with room-temperature magnetism remain highly *** this purpose,based on first principles calculations,we design a series of thermodynamically stable 2D cluster-based metal-organic frameworks(MOFs)Fe_(n)-(pyz)(n=1-6)by utilizing Fenmetal clusters as nodes and nitrogen-containing pyrazine ligands as organic *** 2D cluster-based MOFs exhibit robust ferrimagnetic ordering due to the strong d-p direct exchange interaction between d-electron spin of Fe_(n)(n=1-6)clusters and charge transfer-induced p-electron spin of pyrazine *** particular,the ferrimagnetic Curie temperatures are well above room temperature(up to 836 K).Additionally,altering the size of Fe_(n)clusters in Fe_(n)-(pyz)(n=1-6)MOFs results in diverse functional spintronic properties,including bipolar magnetic semiconductors,half semiconductors and Dirac half ***,these 2D assembled MOFs possess sizable magnetic anisotropy energies,up to 9.16 me V per formula.

关键词： metal-organic framework two-dimensional material half metal bipolar magnetic semiconductor magnet

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Synthesis and antifungal activity of trichodermin derivatives

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Chinese Chemical Letters 2010年第9期21卷 1037-1040页

作者： jing li cheng Yong Zhou Jin Hao Zhao Chu Long Zhang Fu cheng lin Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of Pesticide and Environmental Toxicology Zhejiang University Hangzhou 310029 China

A series of derivatives were synthesized from trichodermin（1） which was an antifungal metabolite produced by Trichoderma taxi *** structures were confirmed by ~1H NMR,MS *** antifungal activities were evaluated in *** preliminary structure activity relationships（SAR） results indicated that the double bond,epoxide moiety and ester group were main pharmacophore elements,the stereochemistry of C4 position played a key role as well,and the compounds 1e-1g displayed stronger antifungal activity against Magnaporthe grisea than 1.

关键词： Trichodermin derivatives Synthesis Antifungal activity

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