Synthesis and antifungal activity of trichodermin derivatives

作     者：Jing Li Cheng Yong Zhou Jin Hao Zhao Chu Long Zhang Fu Cheng Lin 

作者机构：Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of Pesticide and Environmental Toxicology Zhejiang University Hangzhou 310029 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2010年第21卷第9期

页      面：1037-1040页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(No.30700532) the Science and Technology Project of Zhejiang province(No.2008C02007-3) 

主　　题：Trichodermin derivatives Synthesis Antifungal activity 

摘      要：A series of derivatives were synthesized from trichodermin（1） which was an antifungal metabolite produced by Trichoderma taxi *** structures were confirmed by ~1H NMR,MS *** antifungal activities were evaluated in *** preliminary structure activity relationships（SAR） results indicated that the double bond,epoxide moiety and ester group were main pharmacophore elements,the stereochemistry of C4 position played a key role as well,and the compounds 1e-1g displayed stronger antifungal activity against Magnaporthe grisea than 1.