SP-141 targets Trs85 to inhibit rice blast fungus infection and functions as a potential broadspectrum antifungal agent
作者机构：State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-productsInstitute of BiotechnologyZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-productsInstitute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310058Zhejiang ProvinceChina Department of Pharmacology and Nutritional ScienceCollege of MedicineThe University of KentuckyLexingtonKY 40506USA Markey Cancer CenterCollege of MedicineThe University of KentuckyLexingtonKY 40506USA College of Life SciencesZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Institute of Pesticide and Environmental ToxicologyMinistry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and InsectsZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina Institute of Edible FungiShanghai Academy of Agricultural SciencesShanghai 201106ShanghaiChina
出 版 物：《Plant Communications》 (植物通讯（英文）)
年 卷 期：2024年第5卷第2期
页 面：169-184页
核心收录：
学科分类：09[农学] 0904[农学-植物保护] 090401[农学-植物病理学] 090402[农学-农业昆虫与害虫防治]
基 金：supported by the Key Research and Development Project of Zhejiang Province,China (2021C02010) the National Natural Science Foundation of China (32270201,31972216,and 31970140) the Special Project for the Selection and Breeding of New Agricultural Varieties in Zhejiang Province,China (2021C02064) supported by a grant,Organism Interaction,from Zhejiang Xianghu Laboratory (to F.-C.L.)
主 题：Magnaporthe oryzae rice blast TRAPPIII complex trs85 fungicide
摘 要：Rice blast is a devastating disease worldwide,threatening rice production and food *** blast fun-gus Magnaporthe oryzae invades the host via the appressorium,a specialized pressure-generating struc-ture that generates enormous turgor pressure to penetrate the host ***,owing to ongoing evolution of fungicide resistance,it is vitally important to identify new targets and ***,we show that Trs85,a subunit of the transport protein particle III complex,is essential for appressorium-mediated infection in *** explain how Trs85 regulates autophagy through Ypt1(a small guano-sine triphosphatase protein)in *** then identify a key conserved amphipathic a helix within Trs85 that is associated with pathogenicity of *** computer-aided screening,we identify a lead compound,SP-141,that affects autophagy and the Trs85–Ypt1 ***-141 demonstrates a substantial capacity to effectively inhibit infection caused by the rice blast fungus while also exhibiting wide-ranging potential as an antifungal agent with broad-spectrum *** together,our data show that Trs85 is a potential new target and that SP-141 has potential for the control of rice *** thus provide a novel strategy that may help in thefight against rice blast.
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