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Chronic administration of triclosan leads to liver fibrosis through hepcidin-ferroportin axis-mediated iron overload

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Journal of Environmental Sciences 2024年第3期137卷 144-154页

作者： jing Liu Lecong Zhang fang Xu Ping Zhang yang Song College of Eco-Environmental Engineering Guizhou Minzu UniversityGuiyang 550025China The Institute of Karst Wetland Ecology Guizhou Minzu UniversityGuiyang 550025China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Triclosan(TCS)has been manufactured as an antibacterial compound for half a ***,it is widely used in various personal care products;however,its potential adverse effects raise a lot of ***,we create a long-term oral administration mouse model and identify the corresponding hepatotoxicity of *** discover that daily intragastric administration of 10 mg/kg TCS to mice for 12 weeks results in severe hepatic *** study displays that hepatic iron increased 18%,23%and 29%upon oral TCS treatment for4,8 and 12 weeks,*** by hepatic iron variation,splenic and duodenal iron are increased,which indicates systemic iron *** only excessive iron accumulated in the liver,abnormal hepatic malondialdehyde,prostaglandin synthase 2 and glutathione peroxidase 4 are pointed to *** study uncovers that hepcidin expression increases 7%,10%,4%in serum and 2.4-,4.8-,and 2.3-fold on transcriptional levels upon TCS exposure for 4,8 and 12 weeks,*** together,the mice in the TCS-treated group show disordered systemic iron homeostasis via the upregulated hepatic hepcidin-ferroportin ***,both hepatic iron overload(systemic level)and hepatocyte ferroptosis(cellular level)are accused of TCS-induced liver ***■,an iron scavenger,significantly ameliorates TCS-induced liver *** summary,this study confirms the impact of TCS on liver fibrosis;a critical signal pathway is also *** significance of the current study is to prompt us to reevaluate the“pros and cons”of TCS applications.

关键词： Triclosan Iron metabolism Hepcidin Hepatotoxicity Liver fibrosis

Flexible,efficient,and accurate tests for epidemics

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Science China Mathematics 2024年第8期67卷 1881-1898页

作者： Linjiajie fang Bing-Yi jing Shen Ling Qiyue Wang Qing yang Data Science and Analytics Thrust The Hong Kong University of Science and TechnologyHong KongChina Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055China Department of Mathematics and Statistics Dalhousie UniversityHalifaxNS B 3H 4R 2Canada Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina

Group testing involves discovering a small subset of distinguished subjects from a large population while efficiently reducing the total number of *** has been widely used for industrial testing,information technology,and biology,especially epidemic ***,in reality,are noisy for the presence of false *** tests are accurate but time-consuming,while others are cheaper but less *** which test to use is constrained by various considerations,such as availability,cost,accuracy,and *** this paper,we propose flexible,efficient,and accurate tests(FEATs).FEATs are based on group testing with simple but careful designs by incorporating ideas such as close contact cliques and repeated *** could dramatically improve the efficiency or accuracy of existing *** example,for accurate but slow tests,the FEAT can improve efficiency multiple times without compromising *** the other hand,for fast but inaccurate tests,the FEAT can sharply reduce the false-negative rate(FNR)and significantly increase *** justifications are *** point out some scenarios where the FEAT can be effectively employed.

关键词： epidemiology control blood testing testing efficiency testing accuracy

Repressing iron overload ameliorates central poststroke pain via the Hdac2-Kv1.2 axis in a rat model of hemorrhagic stroke

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Neural Regeneration Research 2024年第12期19卷 2708-2722页

作者： He fang Mengjie Li jingchen yang Shunping Ma Li Zhang Hongqi yang Qiongyan Tang jing Cao Weimin yang Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Nutrition The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Neuroscience Research Institute Zhengzhou University Academy of Medical SciencesZhengzhouHenan ProvinceChina

Thalamic hemorrhage can lead to the development of central post-stroke *** in histone acetylation levels,which are regulated by histone deacetylases,affect the excitability of neurons surrounding the hemorrhagic ***,the regulato ry mechanism of histone deacetylases in central post-stroke pain remains unclea ***,we show that iron overload leads to an increase in histone deacetylase 2expression in damaged ventral posterolateral nucleus *** this increase restored histone H3 acetylation in the Kcna2 promoter region of the voltage-dependent potassium(Kv)channel subunit gene in a rat model of central post-stroke pain,thereby increasing Kcna2expression and relieving central ***,in the absence of nerve injury,increasing histone deacetylase 2 expression decreased Kcna2expression,decreased Kv current,increased the excitability of neurons in the ventral posterolateral nucleus area,and led to neuropathic pain ***,treatment with the iron chelator deferiprone effectively reduced iron overload in the ventral posterolateral nucleus after intracerebral hemorrhage,reversed histone deacetylase 2 upregulation and Kv1.2 downregulation,and alleviated mechanical hypersensitivity in central post-stroke pain *** results suggest that histone deacetylase 2 upregulation and Kv1.2 downregulation,mediated by iron overload,are important factors in central post-stroke pain pathogenesis and co uld se rve as new to rgets for central poststroke pain treatment.

关键词： central post-stroke pain hemorrhagic stroke histone deacetylase iron overload voltage-gated potassium ion channel 1.2

DYT1 MUTATIONS AMONGST EARLY ONSET PRIMARY DYSTONIA PATIENTS IN CHINA

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Chinese Medical Sciences Journal 2008年第1期23卷 38-43页

作者： jing-fang yang Jian-yu Li Yong-jie Li Tao Wu Yan-li Zhang Biao Chen Department of Neurobiology Beijing 100053 Department of Functional Neurosurgery Key Laboratory for Neurodegenerative Disease of Ministry of Education Xuanwu Hospital of Capital Medical University Beijing 100053

Objective To investigate the frequency of GAG deletion in the DYT1 gene among early onset primary dystonia patients in China. Methods Thirteen patients with early onset primary torsion dystonia were screened for mutation in exon 5 of the DYT1 gene using denaturing high-performance liquid chromatography （DHPLC） and DNA sequencing, and the results were confirmed with polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results The GAG deletion mutation which results in Glu302del in exon 5 of the DYT1 gene was found in 5 patients. The detecting results were consistent between with DHPLC and PCR-RFLP. We did not find any other mutations in the DYT1 gene. Conel^iotm The GAG deletion in the DYT1 gene is common amongst early onset primary torsion dystonia patients in Chin＆ The frequency of DYT1 mutation is not significantly different between European and Asian patients with early onset primary dystonia.

关键词： primary torsion dystonia DYT1 gene denaturing high-performance liquid chromatography

Total Synthesis and Stereochemical Assignment of Talaroconvolutin A and Talarofuranone: Gram-scale Synthesis of Ferroptosis Inducer Talaroconvolutin A

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Chinese Journal of Chemistry 2024年第13期42卷 1509-1514页

作者： Ming Yao Wei yang jing Li Chengyun Huang Jin fang Sulu Qin Shuzhi Liu Xiaolong yang School of Pharmaceutical Sciences South-Central Minzu UniversityWuhanHubei 430074China

The first total synthesis of talaroconvolutin A(1.1 g obtained)and talarofuranone has been achieved using accessible materials(12 steps,7.5%and 8.2%yields,respectively).Convergent routes involved intramolecular Diels-Alder reactions in two approaches for creating the decalin ***,an unprecedented DMP-mediated domino reaction resulted in the deoxy-tetramic acid *** syntheses not only establish the absolute configuration of talaroconvolutin A but also enable further collaborative studies of this typeofferroptosisinducers.

关键词： Natural products Aldehydes Total synthesis Domino reactions Biological activity Antitumor agents Ferroptosis Diels-Alder reaction Talaroconvolutin A

From common biomass materials to high-performance tissue engineering scaffold: Biomimetic preparation, properties characterization, in vitro and in vivo evaluations

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Journal of Bioresources and Bioproducts 2024年第2期9卷 185-196页

作者： Zongpu Xu fang He jing Yu Zhangze yang Yu Zhu Rong Liao Ruyin Lyu Mei yang Liangjun Zhu Mingying yang Institute of Applied Bioresources College of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Neurosurgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Converting common biomass materials to high-performance biomedical products could not only reduce the environmental pressure associated with the large-scale use of synthetic materials,but also increase the economic *** as a very promising candidate has drawn considerable attention owing to its abundant sources and remarkable ***,pure chitosan materials usually exhibit insufficient mechanical properties and excessive swelling ratio,which seriously affected their in vivo stability and integrity when applied as tissue engineering ***,simultaneously improving the mechanical strength and biological compatibility of pure chitosan(CS)scaffolds becomes very ***,inspired by the fiber-reinforced con-struction of natural extracellular matrix and the porous structure of cancellous bone,we built silk microfibers/chitosan composite scaffolds via ice-templating *** biomimetic strategy achieved 500%of mechanical improvement to pure chitosan,and meanwhile still maintaining high porosity(>87%).In addition,the increased roughness of chitosan pore walls by embedded silk microfibers significantly promoted cell adhesion and *** importantly,after subcutaneous implantation in mice for four weeks,the composite scaffold showed greater struc-tural integrity,as well as better collagenation,angiogenesis,and osteogenesis abilities,suggesting its great potential in biomedicine.

关键词： Chitosan Biomimetic strategy Fiber-reinforced composite Mechanical property Biocompatibility

Co-Harvest Phase-Change Enthalpy and Isomerization Energy for High-Energy Heat Output by Controlling Crystallization of Alkyl-Grafted Azobenzene Molecules

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Energy & Environmental Materials 2024年第3期7卷 415-424页

作者： Jian Gao Yiyu Feng Wenyu fang Hui Wang jing Ge Xiaoyu yang Huitao Yu Mengmeng Qin Wei Feng School of Materials Science and Engineering Tianjin UniversityTianjin 300350China Key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou 450002China

Photoisomerization-induced phase change are important for co-harvesting the latent heat and isomerization energy of azobenzene *** optimizing heat output and energy delivery at alternating temperatures are challenging because of the differences in crystallizability and *** article reports two series of asymmetrically alkyl-grafted azobenzene(Azo-g),with and without a methyl group,that have an optically triggered phase *** exothermic modes were designed to utilize crystallization enthalpy(△H_(c))and photothermal(isomerization)energy(△H_(p))at different temperatures determined by the ***-g has high heat output(275-303 J g^(-1))by synchronously releasing△H_(c)and△H_(p)over a wide temperature range(-79℃to 25℃).We fabricated a new distributed energy utilization and delivery system to realize a temperature increase of 6.6℃at a temperature of-8℃.The findings offer insight into selective utilization of latent heat and isomerization energy by molecular optimization of crystallization and isomerization processes.

关键词： crystallizability distributed energy utilization system energy density exothermic modes isomerization

Relative exchangeable copper, a high-quality biomarker for differentiation of Traditional Chinese Medicine syndrome in Wilson's disease

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Journal of Traditional Chinese Medicine 2024年第05期44卷 1017-1023页

作者： DING Yufeng yang Wenming CHENG Yuan yang Yulong ZHU Jun LU Yachun fang Xiang ZHANG jing Department of Neurology the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine Department of clinical laboratory the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine

OBJECTIVE: To investigate the value of relative exchangeable copper(REC) in diagnosing Wilson's disease(WD) and to determine its significance in the differentiation of Traditional Chinese Medicine(TCM) ***: A total of 78 patients with WD were recruited on the same day of the medical visit, and among them,32 were suffering from non-WD(N-WD) and 37 were heterozygous ATP7B carriers(HC) enrolled as *** genetic testing was performed for diagnosing WD and HC. Additionally, REC levels in different TCM syndromes were investigated. The correlation between REC and serum ceruloplasmin(Cp), serum copper oxidase(CO), and 24-h urinary copper was analyzed using the Global Assessment Scale and Unified Wilson's Disease Rating Scale and the significance of REC in WD diagnosis was investigated. Resting-state functional magnetic resonance imaging was used to assess the clinical symptoms of WD and analyze its severity in different TCM ***: REC determination helped in significantly distinguishing patients with N-WD or HC from those with WD with a cut-off of 21.15%. Furthermore, the comparative analysis of REC ratios among different TCM syndromes showed markedly high REC levels in the dampness-heat internal accumulation syndrome ***, the seed-based functional connectivity value from the putamen to the cerebellum was significantly correlated with TCM ***: REC level is a high-quality biomarker for diagnosing WD that effectively reflects disease severity and plays an essential role in deciding on treatment strategies and prognosis. Furthermore, REC levels are closely related to TCM syndromes in WD; thus, it is a potential objective quantitative indicator for distinguishing TCM syndromes in WD.

关键词： Global Assessment Scale Traditional Chinese Medicine syndrome Wilson’s disease relative exchangeable copper the Unified Wilson’s Disease Rating Scale

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Lorentz violation induces isospectrality breaking in Einstein-bumblebee gravity theory

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 87-96页

作者： Wentao Liu Xiongjun fang Jiliang jing Jieci Wang Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationSynergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China

In this study,we investigate the quasinormal modes(QNMs)of a Lorentz-violating spacetime,factoring in a cosmological constant,within the framework of Einstein-bumblebee *** findings reveal that the interaction of spacetime with an anisotropic bumblebee field imparts distinct contributions to the axial and polar sectors of the vector *** subsequently breaks the isospectrality typically observed in vector *** evidence strongly indicates isospectral breaking in the vector modes of Einstein-bumblebee black holes:a pronounced breakage in the real part of the frequencies,while the imaginary component seems less *** isospectral breaking indicates the existence of two different waveforms in the Ringdown phase of the black hole,which provides a potential signal of quantum gravity observable in current experiments.

关键词： Lorentz-violating isospectral breaking quasinormal modes

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