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O-glycosyltransferases from Homo sapiens contributes to the biosynthesis of glycyrrhetic Acid 3-O-mono-β-D-glucuronide and glycyrrhizin in Saccharomyces cerevisiae

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Synthetic and Systems Biotechnology 2021年第3期6卷 173-179页

作者： Ke Xu Yu-jia Zhao Nadeem Ahmad jing-nan Wang Bo Lv Ying Wang jun ge Chun Li Key Lab for Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing100084PR China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologyInstitute of Biochemical EngineeringSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081PR China Beijing Institute of Metrology Beijing100029PR China Tangshan Key Laboratory of Agricultural Pathogenic Fungi and Toxins Department of Life ScienceTangshan Normal UniversityTangshan063000PR China School of Pharmacy Tsinghua UniversityBeijing100084PR China

glycyrrhizin(gL)and glycyrrhetic Acid 3-O-mono-β-D-glucuronide(gaMg)are the typical triterpenoid glycosides found in the root of licorice,a popular medicinal plant that exhibits diverse physiological effects and pharmacological ***,only few reports are available on the glycosylation enzymes involved in the biosynthesis of these valuable compounds with low conversion yield so *** mammals,glycosyltransferases are involved in the phase II metabolism and may provide new solutions for us to engineer microbial strains to produce high valued compounds due to the substrate promiscuity of these *** this study,we mined the genomic databases of mammals and evaluated 22 candidate genes of O-glycosyltransferases by analyzing their catalytic potential for O-glycosylation of the native substrate,glycyrrhetinic acid(ga)for its *** of 22 selected glycosyltransferases,only UgT1A1 exhibited high catalytic performance for biosynthesis of the key licorice compounds gL and *** docking results proposed that the enzymatic activity of UgT1A1 was likely owing to the stable hydrogen bonding interactions and favorite conformations between the amino acid residues around substrate channels(P82~R85)and ***,the complete biosynthesis pathway of gL was reconstructed in Saccharomyces cerevisiae for the first time,resulting in the production of 5.98±0.47 mg/L and 2.31±0.21 mg/L of gL and gaMg,respectively.

关键词： O-glycosyltransferase Homo sapiens glycyrrhizin(gL) Saccharomyces cerevisiae glycyrrhetic Acid 3-O-mono-β-D-glucuronide(gaMg)

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The sirtuin family in health and disease

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Signal Transduction and Targeted Therapy 2023年第1期8卷 146-219页

作者： Qi-jun Wu Tie-Ning Zhang Huan-Huan Chen Xue-Fei Yu jia-Le Lv Yu-yang Liu ya-Shu Liu gang Zheng jun-Qi Zhao Yi-Fan Wei jing-Yi guo Fang-Hua Liu Qing Chang Yi-Xiao Zhang Cai-gang Liu Yu-Hong Zhao Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease Shengjing Hospital of China Medical UniversityShenyangChina Department of Clinical Epidemiology Shengjing Hospital of China Medical UniversityShenyangChina Department of Obstetrics and gynecology Shengjing Hospital of China Medical UniversityShenyangChina Clinical Research Center Shengjing Hospital of China Medical UniversityShenyangChina Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyangChina Department of Oncology Shengjing Hospital of China Medical UniversityShenyangChina Department of Urology Shengjing Hospital of China Medical UniversityShenyangChina Department of Cancer Breast Cancer CenterShengjing Hospital of China Medical UniversityShenyangChina

Sirtuins(SIRTs)are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes,and are involved in numerous biological ***,seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been *** evidence has suggested the vital roles of seven members of the SIRT family in health and disease ***,this protein family plays a variety of important roles in cellular biology such as inflammation,metabolism,oxidative stress,and apoptosis,etc.,thus,it is considered a potential therapeutic target for different kinds of pathologies including cancer,cardiovascular disease,respiratory disease,and other ***,identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules,which can modify SIRT ***,several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples,and supplementation of SIRT modulators might have diverse impact on physiological function in different *** this review,we introduce the history and structure of the SIRT protein family,discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family,elaborate on the regulatory roles of SIRTs in human disease,summarize SIRT inhibitors and activators,and review related clinical studies.

关键词： SIRT1 metabolism inflammation

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Early use of dexamethasone increases Nr4a1 in Kupffer cells ameliorating acute liver failure in mice in a glucocorticoid receptor-dependent manner

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Journal of Zhejia.g University-Science B(Biomedicine & Biotechnology) 2020年第9期21卷 727-739页

作者： jing-wen DENg Qin yaNg Xiao-peng CAI jia-ming ZHOU Wei-gao E yan-dong AN Qiu-xian ZHENg Meng HONg yan-li REN jun gUAN gang WANg Shu-jing LAI Zhi CHEN State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Center for Stem Cell and Regenerative Medicine Zhejiang University School of MedicineHangzhou 310058China Becton Dickinson and CompanyShanghai 200126China

Background and objective:Acute liver failure(ALF)is a type of disease with high mortality and rapid progression with no specific treatment methods currently *** exert beneficial clinical effects on therapy for ***,the mechanism of this effect remains unclear and when to use glucocorticoids in patients with ALF is difficult to *** purpose of this study was to investigate the specific immunological mechanism of dexamethasone(Dex)on treatment of ALF induced by lipopolysaccharide(LPS)/D-galactosamine(D-ga IN)in ***:Male C57 BL/6 mice were given LPS and D-ga IN by intraperitoneal injection to establish an animal model of *** was administrated to these mice and its therapeutic effect was *** and eosin(H&E)staining was used to determine liver *** flow cytometry,cytometric bead array(CBA)method,and next-generation sequencing were performed to detect changes of messenger RNA(m RNA)in immune cells,cytokines,and Kupffer cells,***:A mouse model of ALF can be constructed successfully using LPS/D-ga IN,which causes a cytokine storm in early disease *** immune cells change markedly with progression of liver *** use of Dex,at 0 h rather than 1 h,could significantly improve the progression of ALF induced by LPS/D-ga IN in *** of innate immune cells,especially Kupffer cells and neutrophils,increased significantly in the Dex-treated *** vivo experiments indicated that the therapeutic effect of Dex is exerted mainly via the glucocorticoid receptor(gr).Sequencing of Kupffer cells revealed that Dex could increase m RNA transcription level of nuclear receptor subfamily 4 group A member 1(Nr4 a1),and that this effect disappeared after gr ***:In LPS/D-ga IN-induced ALF mice,early administration of Dex improved ALF by increasing the numbers of innate immune cells,especially Kupffer cells and ***-dependent Nr4 a1 upregul

关键词： glucocorticoid Dexamethasone Kupffer cells Acute liver failure Nuclear receptor subfamily 4 group A member 1(Nr4a1)

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The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks

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Zoological Research 2021年第6期42卷 834-844页

作者： Min-Sheng Peng jian-Bo Li Zheng-Fei Cai Hang Liu Xiaolu Tang Ruochen Ying jia-Nan Zhang jia-jun Tao Ting-Ting Yin Tao Zhang jing-yang Hu Ru-Nian Wu Zhong-Yin Zhou Zhi-gang Zhang Li Yu Yong-gang yao Zheng-Li Shi Xue-Mei Lu jian Lu ya-Ping Zhang State Key Laboratory of genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan UniversityKunmingYunnan 650091China State Key Laboratory of Protein and Plant gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Molbreeding Biotechnology Co. Ltd.ShijiazhuangHebei 050035China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyKunmingYunnan 650201China CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhanHubei 430071China Center for Excellence in Animal Evolution and genetics Chinese Academy of SciencesKunmingYunnan 650201China

Understanding the zoonotic origin and evolution history of SARS-CoV-2 will provide critical insights for alerting and preventing future outbreaks.A significant gap remains for the possible role of pangolins as a reservoir of SARS-CoV-2 related coronaviruses(SC2r-CoVs).Here,we screened SC2r-CoVs in 172 samples from 163 pangolin individuals of four species,and detected positive signals in muscles of four Manis javanica and,for the first time,one *** analysis of pangolin mitochondrial DNA traced their origins from Southeast *** in-solution hybridization capture sequencing,we assembled a partial pangolin SC2r-CoV(pangolin-CoV)genome sequence of 22895 bp(MP20)from the *** *** analyses revealed MP20 was very closely related to pangolin-CoVs that were identified in *** seized by guangxi Customs.A genetic contribution of bat coronavirus to pangolin-CoVs via recombination was *** analysis revealed that the genetic diversity of pangolin-CoVs is substantially higher than previously *** the potential infectivity of pangolin-CoVs,the high genetic diversity of pangolin-CoVs alerts the ecological risk of zoonotic evolution and transmission of pathogenic SC2r-CoVs.

关键词： SARS-CoV-2 Pangolin Recombination Diversity Sequencing mtDNA

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Tenofovir disoproxil fumarate in Chinese chronic hepatitis B patients:Results of a multicenter,double-blind,double-dummy,clinical trial at 96 weeks

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World Journal of Clinical Cases 2021年第18期9卷 4690-4699页

作者： Xiao-Fan Chen ya-Nan Fan Chong-Wen Si yan-yan Yu jia Shang Zu-jia.g Yu Qing Mao Qing Xie Wei Zhao jun Li Zhi-Liang gao Shan-Ming Wu Hong Tang jun Cheng Xin-Yue Chen Wen-Hong Zhang Hao Wang Zhong-Nan Xu Ling Wang jun Dai jing-Hang Xu Department of Infectious Diseases Center for Liver DiseasesPeking University First HospitalBeijing 100034China Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Infectious Diseases Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Department of Infectious Diseases The Second Affiliated Hospital of Southeast UniversityNanjing 210011Jiangsu ProvinceChina Department of Infectious Diseases The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Infectious Diseases The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghai 201052China Department of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Center of Hepatology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of International Medical Beijing Youan HospitalCapital Medical UniversityBeijing 10069China Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of Infectious Diseases Peking University People's HospitalBeijing 100044China Clinical Center Jiangsu Chia-tai Tianqing Pharmaceutical Co.LtdNanjing 210000Jiangsu ProvinceChina

BACKgROUND Tenofovir disoproxil fumarate(TDF)is a prodrug of a nucleotide *** an antiviral drug,TDF has been proposed in the first-line treatment of chronic hepatitis B(CHB).Qingzhong,a brand name of TDF,commercialized by jia.gsu Chia-tai Tianqing Pharmaceutical Co Ltd.,and Viread,another brand name of TDF,commercialized by glaxoSmithKline,have both been approved by the State Food and Drug Administration,*** To investigate the efficacy and safety of the two TDF agents in the treatment of Chinese CHB *** This trial was registered at *** with the identifier number of NCT02287857.A total of 330 Chinese CHB patients,among which 232 were hepatitis B e antigen(HBeAg)-positive,were included in this 5-year-long,multicenter,double-blinded,double-dummy,randomized-controlled,noninferiority phase III *** participants were initially randomized into two groups:group A(n=161),in which the participants received 300 mg Qingzhong once a day for 48 wk;and group B,in which the participants received 300 mg Viread once a day for 48 *** from week 49,all the participants in groups A and B received 300 mg Qingzhong once a day until the 96th *** this study,the primary endpoint was the decrease in plasma level of hepatitis B virus(HBV)DNA at the 96th week,while the secondary endpoints were suppression of HBV replication,alanine aminotransferase(ALT)normalization,HBeAg loss,and HBeAg seroconversion *** For the participants with HBeAg-positive CHB,the decrease in mean HBV DNA level relative to the baseline value was comparable between groups A and B(5.77 vs 5.73 log10 IU/mL,P>0.05)at the 96th *** addition,similar percentages of HBeAg-positive participants in the two groups exhibited undetectable levels of HBV DNA,HBeAg loss,and HBeAg seroconversion(71.05%vs 77.97%,31.00%vs 27.27%,and 20.22%vs 15.79%,respectively,in group A vs group B;P>0.05).For the participants with HBeAg-negative CHB,the decrease in mean HBV DNA level r

关键词： Chronic hepatitis B Hepatitis B virus infection Chronic Tenofovir disoproxil

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专业村集聚的空间表达——以河南省专业村为例

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经济地理 2014年第6期34卷 142-148页

作者：乔家君李亚静河南大学黄河文明与可持续发展研究中心中国河南开封475001 河南大学环境与规划学院中国河南开封475001

在河南省发展实力最强的1 200个村域经济指标评判的基础上,筛选出487个专业村进行调研,形成487×71属性数据矩阵。通过gIS可视化分析,进行专业村集聚的空间表达。①河南省专业村集聚空间上极不均衡,具有明显的中心—外围特征;②农业主... 详细信息

在河南省发展实力最强的1 200个村域经济指标评判的基础上,筛选出487个专业村进行调研,形成487×71属性数据矩阵。通过gIS可视化分析,进行专业村集聚的空间表达。①河南省专业村集聚空间上极不均衡,具有明显的中心—外围特征;②农业主导型专业村发生时间最早,数量最多,分布最为广泛,河南省有平原农区、山区、城郊三种空间集聚模式;③与农业主导型专业村集聚空间相反,工业主导型专业村主要分布于交通便利区;④服务业等其他类型专业村发展最晚,空间集聚态势目前尚不明显。

关键词：专业村集聚空间表达河南省

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Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients

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Chinese Medical Journal 2016年第7期129卷 778-784页

作者： Hui Yu Li-Fang Xie Kang Chen gang-Yi yang Xiao-yan Xing jia-jun Zhao Tian-pei Hong Zhong-yan Shan Hong-Mei Li Bing Chen Xu-Lei Tang Ling Qi jing yang Yuan Fang Ting Li Shuang-ShuangWang ya-Qi Yin Yi-Ming Mu Department of Endocrinology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Endocrinology Chinese People's Liberation Army 155 Hospital Kaifeng Henan 475003 China Department of Endocrinology The Second Affiliated Hospital Chongqing Medical University Chongqing 400010 China Department of Endocrinology China-JaPan Friendship Hospital Beijing 100029 China Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China Department of Endocrinology Peking University Third Hospital Beijing 100191 China Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First AffiliatedHospital China Medical University Shenyang Liaoning 110001 China Department of Endocrinology China Meitan General Hospital Belling 100028 China Department of Endocrinology and Metabolism Southwest Hospital Third Military Medical University Chongqing 400038 China Department of Endocrinology First Affiliated Hospital of Lanzhou University Lanzhou Gansu 730000 China Department of Endocrinology Beijing Yanhua Hospital Beiiing 102500 China Department of Endocrinology First Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China Department of Endocrinology Beijing Luhe Hospital Capital Medical University Beijing 101100 China

Background： Type 2 diabetes mellitus （T2DM） has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors fbr diabetes mellitus. Methods： This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of 〈40 years were included, and the control group consisted of subjects aged 〈40 years with normal blood glucose level. Results： In patients with young-onset T2DM, the mean age and initial hemoglobin IAc at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio （odds ratio [OR] 446.99, 95% confidence interval [CI] 42.37±4714.87）, family history of diabetes mellitus （OR 23.46, CI71 14.47- 38.03）, dyslipidemia （OR 2.65, U1 1.54-4.56）, diastolic blood pressure （OR 1.02, CI 1.00 1.04）, and body mass index （OR 0.95, C1 0.92-0.99） are independent factors tbr early-onset T2DM. Conclusions： We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.

关键词： Obesity Risk Factor Type 2 Diabetes Mellitus Young

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基于局部形状组合模型的人脸对齐

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计算机学报 2018年第9期41卷 2162-2174页

作者：万俊李晶常军吴玉佳肖雅夫武汉大学计算机学院武汉430072

近年来,在研究人脸对齐问题上提出了许多高效、精确的算法.其中,许多算法都采用平均脸作为初始化形状,然后采用不同的方法对人脸的最终形状进行预测,这些算法在人脸表情、头部姿势、光照差异较大的情况下没有很好的鲁棒性.文中提出基于... 详细信息

近年来,在研究人脸对齐问题上提出了许多高效、精确的算法.其中,许多算法都采用平均脸作为初始化形状,然后采用不同的方法对人脸的最终形状进行预测,这些算法在人脸表情、头部姿势、光照差异较大的情况下没有很好的鲁棒性.文中提出基于平均脸使用局部形状组合模型来构建一个更准确的人脸(组合脸).局部形状组合模型首先根据人脸基准点的分布特点把人脸形状划分为脸部轮廓、眉毛、眼睛、鼻子、嘴巴这5个部分,然后利用平均脸作为初始化形状,在每个局部形状包含的特征点的邻域内提取特征构建随机森林,对所有训练图片人脸的局部形状进行分类.叶子结点用来存放对应类的局部形状,其它结点存放分类的规则,局部形状组合模型针对5个局部形状总共构建了5个随机森林.对于每一个测试图片人脸,使用平均脸作为初始化形状,遍历随机森林去选择最像测试人脸的局部形状.平均脸和由轮廓决定的人脸其它局部形状的中心以及选择的局部形状将被用来构建组合脸.在大多数情况下,组合脸比平均脸具有更强的表示能力.因此文中提出一个基于组合二值特征的决策机制来选择组合脸和平均脸中更为合适的一个作为后续阶段的初始化形状.决策机制在训练阶段估计出预测结果和组合二值特征的关系,在测试阶段利用训练阶段估计的关系对选择结果进行预测.决策机制是一个二分类问题,可以利用支持向量机来解决.最后以级联回归的方式对该初始化形状进行优化以逼近标准形状.通过采用局部形状组合模型和基于组合二值特征的决策机制,可以防止:(1)最终预测的人脸由于初始化形状不理想而陷入局部最佳;(2)增强本算法对人脸表情、头部姿势、光照差异的鲁棒性.文中算法(LSBC算法)在300-W(68-pts)和Helen(194-pts)数据库下的误差(瞳孔间距归一化误差)分别为4.73%和4.68%,优于当前的LBF、ESR、SDM算法.

关键词：级联回归局部形状组合模型组合脸平均脸决策机制组合二值特征

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Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates

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Virologica Sinica 2021年第5期36卷 879-889页

作者： yan-Feng yao Ze-jun Wang Ren-Di jia.g Xue Hu Hua-jun Zhang Yi-Wu Zhou ge gao Ying Chen Yun Peng Mei-Qin Liu ya-Nan Zhang Juan Min jia Lu Xiao-Xiao gao jing guo Cheng Peng Xu-Rui Shen Qian Li Kai Zhao Lian yang Xin Wan Bo Zhang Wen-Hui Wang jia Wu Peng Zhou Xing-Lou yang Shuo Shen Chao Shan Zhi-Ming Yuan Zheng-Li Shi Center for Biosafety Mega-Science Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Wuhan Institute of Biological Products Co.Ltd Jiangxia DistrictWuhan 430024China University of Chinese Academy of Sciences Beijing 100049China Department of Forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430074China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so ***,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative *** is the most effective approach to eradicate a *** tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human *** we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human *** data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested *** addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in *** results warranted positive outcomes in future clinical trials in humans.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Inactivated vaccine Transgenic mouse Non-human primate

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Treatment of acne vulgaris with auricular acupoint pricking-bloodletting plus auricular point sticking therapy: a randomized controlled study

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Journal of Acupuncture and Tuina Science 2019年第3期17卷 196-202页

作者： Song ya-jing Fan Xi-sheng Li Meng-yun Zhang Jie geng jing-ran Liang Xiao Zhang jun-cha Zhang Xiao-qi Zhou Shu-bo Wang Nan Zhang jia-xu Song Xiao-dan She yan-fen Zhang Fu-qing Hebei University of Chinese Medicine Shijiazhuang 050091 China 不详

Objective: To observe the clinical efficacy of auricular point pricking-bloodletting plus auricular point sticking therapy for acne vulgaris. Methods: A total of 66 patients with acne vulgaris were randomized into an observation group and a control group by the random number table, with 33 cases in each group. The observation group was treated with auricular point pricking-bloodletting plus auricular point sticking therapy, and the control group was treated only with auricular point sticking therapy. The treatments of both groups were performed twice a week, 4 weeks as a course of treatment, for 3 courses in total. The scores of skin lesions and dermatology life quality index (DLQI) scores were recorded before and after treatment to assess the clinical efficacy. Results: During the trial, there were 3 cases of drop-out both in the observation group and the control group. After 3 courses of treatment, the total effective rate of the observation group was 96.7%, while that of the control group was 76.7%. The difference between the two groups was statistically significant (Pgroup comparison showed that the scores of skin lesion and DLQI were both decreased with the increase of treatment times, that was, the scores were lower than those at the previous time point (allPgroups were statistically different from those of the same group before treatment (allPg the treatment, the scores of skin lesion and DLQI of the observation group were lower than those of the control group, and the differences between the two groups were statistically significant (all Pg-bloodletting plus auricular point sticking has a better curative effect than auricular point sticking therapy alone in the treatment of acne vulgaris, and has a time-effect correlation.

关键词： Acupoint Therapy Auricular Point Sticking Bloodletting Therapy Otopoint, Cheek (LO5) Point, Erjian (EX-HN 6) Otopoint, Lung (CO14) Otopoint, Shenmen (TF4) Acne

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