Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients
Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients作者机构：Department of Endocrinology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Endocrinology Chinese People's Liberation Army 155 Hospital Kaifeng Henan 475003 China Department of Endocrinology The Second Affiliated Hospital Chongqing Medical University Chongqing 400010 China Department of Endocrinology China-JaPan Friendship Hospital Beijing 100029 China Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China Department of Endocrinology Peking University Third Hospital Beijing 100191 China Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First AffiliatedHospital China Medical University Shenyang Liaoning 110001 China Department of Endocrinology China Meitan General Hospital Belling 100028 China Department of Endocrinology and Metabolism Southwest Hospital Third Military Medical University Chongqing 400038 China Department of Endocrinology First Affiliated Hospital of Lanzhou University Lanzhou Gansu 730000 China Department of Endocrinology Beijing Yanhua Hospital Beiiing 102500 China Department of Endocrinology First Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China Department of Endocrinology Beijing Luhe Hospital Capital Medical University Beijing 101100 China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2016年第129卷第7期
页 面：778-784页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 080704[工学-流体机械及工程] 08[工学] 0807[工学-动力工程及工程热物理] 071007[理学-遗传学]
基 金：was supported by National Science and Technology Major Project
主 题：Obesity Risk Factor Type 2 Diabetes Mellitus Young
摘 要：Background： Type 2 diabetes mellitus （T2DM） has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors fbr diabetes mellitus. Methods： This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of 〈40 years were included, and the control group consisted of subjects aged 〈40 years with normal blood glucose level. Results： In patients with young-onset T2DM, the mean age and initial hemoglobin IAc at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio （odds ratio [OR] 446.99, 95% confidence interval [CI] 42.37±4714.87）, family history of diabetes mellitus （OR 23.46, CI71 14.47- 38.03）, dyslipidemia （OR 2.65, U1 1.54-4.56）, diastolic blood pressure （OR 1.02, CI 1.00 1.04）, and body mass index （OR 0.95, C1 0.92-0.99） are independent factors tbr early-onset T2DM. Conclusions： We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.
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