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Spatio-temporal evolution and topographic gradient effect of land use and ecosystem service value in the Lhasa River Basin

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Journal of Mountain Science 2024年第6期21卷 2059-2074页

作者： ZHOU Jianwei feng Bin WU Hua XU Tong CHEN Linna ZHAO Xinyong GUO Qiyun LI Jiatong ZHANG Chenguang ZHU Kangcheng kong Yuzhong School of Ecology and Environment Tibet UniversityLhasa 850000China School of Engineering Tibet UniversityLhasa 850000China Joint Laboratory of Plateau Surface Remote Sensing Tibet UniversityLhasa 850000China

The Lhasa River Basin forms an essential human settlement area in the southern part of the Qinghai-Tibet *** study employed ecosystem service value(ESV)evaluation model,terrain gradient grading,and Geodetector to analyze land use and ESV in the Lhasa River Basin from 1985 to *** findings reveal that:(1)From 1985 to 2020,grassland was the dominant land *** was a trend of grassland reduction and the expansion of other land types.(2)ESV has increased over the research period(with a total increase of 0.84%),with higher values in the southeast and lower values in the *** contributed the most to ESV,and climate regulation and hydrological regulation were the ecosystem services that contribute the most to ESV.(3)Natural factors like NDVI and altitude,as well as economic factors like population density and distance from roads,influenced the spatial differentiation of ESV,the explanatory power of NDVI reached up to *** interaction between factors had a greater impact than individual *** research results can provide theoretical support for national spatial planning and ecological environment protection in the Lhasa River Basin and other similar areas.

关键词： Ecosystem services value Land use Terrain gradient effect Lhasa River Basin Driving factors

Conversion of Lignin into Porous Carbons for High-Performance Supercapacitors via Spray Drying and KOH Activation: Structure-Properties Relationship and Reaction Mechanism

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Journal of Renewable Materials 2024年第7期12卷 1207-1218页

作者： Shihao feng Qin Ouyang jing Huang Xilin Zhang Zhongjun Ma Kun Liang Qing Huang Zhejiang Key Laboratory of Data-Driven High-Safety Energy Materials and Applications Ningbo Key Laboratory of Special Energy Materials and ChemistryNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China Engineering Laboratory of Advanced Energy Materials Qianwan Institute of CNITECHNingbo315336China School of Physics Henan Normal UniversityXinxiang453007China School of Environment Henan Normal UniversityXinxiang453007China

Lignin-derived porous carbons have emerged as promising electrode materials for ***,the challenge remains in designing and controlling their structure to achieve ideal electrochemical performance due to the complex molecular structure of lignin and its intricate chemical reactions during the activation *** this study,three porous carbons were synthesized from lignin by spray drying and chemical activation with vary-ing KOH *** speciﬁc surface area and structural order of the prepared porous carbon continued to increase with the increase of the KOH ***-mass spectrometry(TG-MS)was employed to track the molecular fragments generated during the pyrolysis of KOH-activated lignin,and the mechanism of the thermochemical conversion was *** the thermochemical conversion of lignin,KOH facili-tated the removal of H2 and CO,leading to the formation of not only more micropores and mesopores,but also more ordered carbon *** pore structure exhibited a greater impact than the carbon structure on the electrochemical performance of porous *** optimized porous carbon exhibited a capacitance of 256 F g-1 at a current density of 0.2 A g-1,making it an ideal electrode material for high-performance supercapacitors.

关键词： Lignin porous carbon KOH activation mechanism supercapacitor

A biocompatible Horner-Wadsworth-Emmons(HWE)reaction triggered by a bioorthogonal proximity-induced platform

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Chinese Chemical Letters 2024年第8期35卷 217-220页

作者： Yayue Wang Haojie Yang Jie Li Qiao kong Siming Zhou Hongbao Sun Lili Pan Qiyong Gong Ping feng Haoxing Wu Department of Radiology and Huaxi MR Research Center(HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan ProvinceFrontiers Science Center for Disease Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan UniversityChengdu 610041China Department of Nuclear Medicine Laboratory of Clinical Nuclear MedicineWest China HospitalSichuan UniversityChengdu 610041China Reseacrch Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu 610041China Department of Pharmacy West China HospitalSichuan UniversityChengdu 610041China Clinical Trial Center and National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs West China HospitalSichuan UniversityChengdu 610041China

Here,we present a novel bioorthogonal platform that enables precise positioning of attached moieties in close proximity,thereby facilitating the discovery and optimization of biocompatible *** this platform,we achieve a Horner-Wadsworth-Emmons(HWE)reaction under physiological conditions,generating a fluorophore in situ with a yield of up to 93%.This proximity platform should facilitate the discovery of various types of biocompatible reactions,making it a versatile tool for biomedical applica-tions.

关键词： Biocompatible reactions Horner-Wadsworth-Emmons reaction Bioorthogonal reactions Tetrazines Proximity effects

A genetic variant study of bortezomib-induced peripheral neuropathy in Chinese multiple myeloma patients

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Oncology Research 2024年第5期32卷 955-963页

作者： YAN ZHANG HEYANG ZHANG jing WANG XIN WEI YI QU feng XU LIJUN ZHANG Department of Hematology The First Affiliated Hospital of China Medical UniversityShenyang110001China

Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response varies among *** factor may play an important role in ***:A nextgeneration sequencing(NGS)panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib *** expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR(RT-qPCR).Serum homocysteine(Hcy)levels were detected in 40 samples by chemiluminescent microparticle immunoassay(CMIA).Results:Compared with the non-BIPN group(n=89),a total of 8 significantly associated single nucleotide polymorphisms(SNPs)were identified in the BIPN group(n=115):MTHFR(rs1801131,rs1801133,rs17421511),EPHX1(rs1051740),MME(rs2016848),ALDH1A1(rs6151031),HTR7(rs1935349)and CYP2A6(rs8192720).The mRNA expression level of MTHFR in newly diagnosed patients with peripheral neuritis after treatment(NP group)was lower than that of newly diagnosed patients without peripheral neuritis after treatment(NnP group)(1.70±0.77 vs.2.81±0.97,p=0.009).Serum Hcy levels were significantly higher in BIPN group than in non-BIPN group(11.66±1.79μmol/L vs.8.52±3.29μmol/L,p=0.016)and healthy controls(11.66±1.79μmol/L vs.8.55±2.13μmol/L,p≤0.001).Conclusion:CYP2A6,EPHX1,MTHFR,ALDH1A1,HTR7,MME and BIPN are linked in Chinese MM *** is more likely to occur in patients with lower MTHFR mRNA expression,which might result in higher serum Hcy levels.

关键词： Multiple Myeloma Peripheral neuropathy Bortezomib Bortezomib-induced peripheral neuropathy Next-generation sequencing MTHFR Serum Hcy

Impaired Spatial Firing Representations of Neurons in the Medial Entorhinal Cortex of the Epileptic Rat Using Microelectrode Arrays

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Research 2024年第2期2023卷 541-552页

作者： Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan Botao Lu Wei Liang Fanli kong Luyi jing Wei Xu Juntao Liu Mixia Wang Yirong Wu Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Epilepsy severely impairs the cognitive behavior of *** remains unclear whether epilepsy-induced cognitive impairment is associated with neuronal activities in the medial entorhinal cortex(MEC),a region known for its involvement in spatial *** explore this neural mechanism,we recorded the spikes and local field potentials from MEC neurons in lithium-pilocarpine-induced epileptic rats using self-designed microelectrode *** the open field test,we identified spatial cells exhibiting spatially selective firing properties and assessed their spatial representations in relation to the progression of ***,we analyzed theta oscillations and theta modulation in both excitatory and inhibitory ***,we used a novel object recognition test to evaluate changes in spatial cognitive ability of epileptic *** the epilepsy modeling,the spatial tuning of various types of spatial cells had suffered a rapid and pronounced damage during the latent period(1 to 5 d).Subsequently,the firing characteristics and theta oscillations were *** the chronic period(>10 d),the performance in the novel object experiment *** conclusion,our study demonstrates the detrimental effect on spatial representations and electrophysiological properties of MEC neurons in the epileptic latency,suggesting the potential use of these changes as a"functional biomarker"for predicting cognitive impairment caused by epilepsy.

关键词： epilepsy impaired involvement

Male reproductive function before and after the adjustment of the COVID-19 prevention policy:a multicenter study in China

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Asian Journal of Andrology 2024年第3期26卷 308-314页

作者： Jian-Zheng Li Han Wu Li Wang Yun-Shan Wang feng kong Long-Qiao Cao Ming Liang Xiong Wang Ming-Zhen Yuan Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250000China Institute of Women Children and Reproductive HealthShandong UniversityJinan 250012China Engineering Laboratory of Urinary Organ and Functional Reconstruction of Shandong Province Jinan 250000China The First People’sHospital of Jining Jining 272000China Department of Reproductive Medicine The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000China Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000China

At the end of 2022,the adjustment of the coronavirus disease 2019(COVID-19)pandemic control policy in China resulted in alarge-scale increase in public *** compare the fertility parameters of male patients before and after the adjustments ofthe COVID-19 pandemic control policy in China,we collected data on patients’medical histories and laboratory examinations ontheir first visits between June 2022 and March 2023 in five different *** were divided into five groups according tothe timeline of the policy *** data we collected from male patients included semen quality and serum reproductivehormone levels,and intergroup comparisons were made using the Mann–Whitney U and Chi-square *** total,16784 casesunderwent regular semen analysis,11180 had sperm morphology assessments,and 7200 had reproductive hormone *** showed declining trends in semen volume,sperm motility,and the progressive sperm motility rate after the policy *** comparison revealed an initial decrease and gradual recovery in progressive motility *** morphology analysisshowed increased neck and tail abnormalities after the policy *** significant change in hormone levels was *** the adjustment of the COVID-19 prevention policy in China,a decline in sperm motility and morphology was *** trend may gradually recover over 2 *** the policy adjustment,reproductive hormone levels were relatively stablethroughout,except for an increase in luteinizing hormone(LH).These changes in semen parameters suggest that the policyadjustment had a short-to medium-term impact on male reproductive function.

关键词： COVID-19 multicenter study reproduction SARS-CoV-2 semen analysis

Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2380-2393页

作者： Qi-feng Wang Zong-Wei Li Hai-feng Zhou Kun-Zhong Zhu Ya-jing Wang Ya-Qin Wang Yue-Wei Zhang Department of Hepatobiliary Pancreatic Center Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua UniversityBeijing 102218China Department of Hepatobiliary and Pancreatic Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina

Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy *** review summarized the ability of various markers to predict the efficacy of HAIC and provided a reference for clinical *** of October 25,2023,51 articles have been retrieved based on keyword predictions and *** eligible articles were selected for inclusion in this *** literature analysis found that methods used to predict the efficacy of HAIC include serological testing,gene testing,and imaging *** above indicators and their combined forms showed excellent predictive effects in retrospective *** review summarized the strategies currently used to predict the efficacy of HAIC in middle and advanced HCC,analyzed each marker's ability to predict HAIC efficacy,and provided a reference for the clinical application of the prediction system.

关键词： Hepatocellular carcinoma Hepatic artery infusion chemotherapy Prediction Prognosis Imaging Biomarkers Genomics

Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

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Journal of Pharmaceutical Analysis 2024年第3期14卷 431-434页

作者： Entezar Berik Zijia Zhang Wei Li Yawen Liu Sihan Chen Wenyong Wu Zhaojun Wang Xinqin kong Wenqiang Pei Huiqing Dong Huali Long Min Lei Jennifer Yiyang Wang Liangfeng Liu Jinjun Hou jing feng Zhaoxia Li Wanying Wu De-an Guo Beijing Key Lab of TCM Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing100069China National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210029China Limin Pharmaceutical Factory Livzon Group LimitedShaoguanGuangdong512028China Guangdong Corporate Key Laboratory of High-End Liquid Medicine R&D IndustrilizationShaoguanGuangdong512028China Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghai201203China

Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often *** drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine *** hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

关键词： injection drugs glucocorticoid chemotherapy

Effect of solidification mode on microstructure evolution and properties of magnesium alloy with long-period stacking ordered phase

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Journal of Iron and Steel Research International 2024年第5期31卷 1127-1138页

作者： Hao Li Hong-mei Chen Xu Zhang Qian-hao Zang jing Zhang Di feng Yan-xin Qiao Yu-hang Guo School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina School of Metallurgy and Materials Engineering Jiangsu University of Science and TechnologySuzhou215600JiangsuChina

The solidification methods of electromagnetic stirring(EMS)and non-electromagnetic stirring were employed to prepare Mg–6Gd–3Y–xZn–0.6Zr(x=1,1.5,2,3)*** evolution of alloy microstructures and the changes in properties were analyzed for different Zn *** has been observed that in alloys without electromagnetic stirring,as the Zn content increases,the alloy structure gradually *** primary second phase transitions from Mg5RE phase to long-period stacking ordered(LPSO)phase,resulting in improved hardness and *** alloys subjected to electromagnetic stirring,there is a relatively higher content of the second phase,primarily consisting of LPSO *** applying electromagnetic stirring,the quantity and the type of LPSO phase in the alloy *** alloy structure becomes more uniform with electromagnetic stirring,resulting in increased hardness and reduced hardness gradients within the *** mechanical properties of alloys with electromagnetic stirring are superior to those without electromagnetic stirring.

关键词： Rare earth magnesium alloy LPSO phase Electromagnetic stirring Casting Property