Impaired Spatial Firing Representations of Neurons in the Medial Entorhinal Cortex of the Epileptic Rat Using Microelectrode Arrays
作者机构：State Key Laboratory of Transducer TechnologyAerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of SciencesBeijing 100049China
出 版 物：《Research》 (研究（英文）)
年 卷 期：2024年第2023卷第2期
页 面：541-552页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：funded by the National Natural Science Foundation of China(nos.L2224042,T2293731,62121003,61960206012,61973292,62171434,61975206,and 61971400) the Frontier Interdisciplinary Project of the Chinese Academy of Sciences(no.XK2022XXC003) the National Key Research and Development Program of China(nos.2022YFC2402501 and 2022YFB3205602) Major Program of Scientific and Technical Innovation 2030(no.2021ZD02016030) the Scientific Instrument Developing Project of the Chinese Academy of Sciences(no.GJJSTD20210004)
主 题：epilepsy impaired involvement
摘 要：Epilepsy severely impairs the cognitive behavior of *** remains unclear whether epilepsy-induced cognitive impairment is associated with neuronal activities in the medial entorhinal cortex(MEC),a region known for its involvement in spatial *** explore this neural mechanism,we recorded the spikes and local field potentials from MEC neurons in lithium-pilocarpine-induced epileptic rats using self-designed microelectrode *** the open field test,we identified spatial cells exhibiting spatially selective firing properties and assessed their spatial representations in relation to the progression of ***,we analyzed theta oscillations and theta modulation in both excitatory and inhibitory ***,we used a novel object recognition test to evaluate changes in spatial cognitive ability of epileptic *** the epilepsy modeling,the spatial tuning of various types of spatial cells had suffered a rapid and pronounced damage during the latent period(1 to 5 d).Subsequently,the firing characteristics and theta oscillations were *** the chronic period(10 d),the performance in the novel object experiment *** conclusion,our study demonstrates the detrimental effect on spatial representations and electrophysiological properties of MEC neurons in the epileptic latency,suggesting the potential use of these changes as afunctional biomarkerfor predicting cognitive impairment caused by epilepsy.
维普期刊数据库