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In vivo label-free measurement of blood flow velocity symmetry based on dual line scanning third-harmonic generation microscopy excited at the 1700 nm window

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 61-68页

作者： Hui Cheng jincheng Zhong Ping Qiu Ke Wang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 P.R.China

Measurement of bloodflow velocity is key to understanding physiology and pathology in *** most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the instantaneous bloodflow velocity *** is mainly due to the lack of measurement technology with high spatial and temporal ***,we tackle this problem with our recently developed dual-wavelength line-scan third-harmonic generation(THG)imaging *** acquisition of dual-wavelength THG line-scanning signals enables measurement of bloodflow velocities at two radially symmetric positions in both venules and arterioles in mouse brain in *** results clearly show that the instantaneous bloodflow velocity is not symmetric under general conditions.

关键词： 1700 nm-Window third-harmonic generation imaging blood flow velocity

Liquid metal biomaterials: translational medicines,challenges and perspectives

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National Science Review 2024年第2期11卷 264-284页

作者： Hanchi Xu jincheng Lu Yikuang Xi Xuelin Wang Jing Liu Department of Biomedical Engineering School of Medicine Tsinghua University Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Shanghai World Foreign Language Academy Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering MedicineBeihang University Beijing Key Lab of Cryo-Biomedical Engineering and Key Lab of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Until now, significant healthcare challenges and growing urgent clinical requirements remain incompletely addressed by presently available biomedical materials. This is due to their inadequate mechanical compatibility, suboptimal physical and chemical properties, susceptibility to immune rejection, and concerns about long-term biological safety. As an alternative, liquid metal(LM) opens up a promising class of biomaterials with unique advantages like biocompatibility, flexibility, excellent electrical conductivity,and ease of functionalization. However, despite the unique advantages and successful explorations of LM in biomedical fields, widespread clinical translations and applications of LM-based medical products remain limited. This article summarizes the current status and future prospects of LM biomaterials, interprets their applications in healthcare, medical imaging, bone repair, nerve interface, and tumor therapy, *** to translate LM materials into medicine and obstacles encountered in practices are *** that, we outline a blueprint for LM clinics, emphasizing their potential in making new-generation artificial organs. Last, the core challenges of LM biomaterials in clinical translation, including bio-safety,material stability, and ethical concerns are also discussed. Overall, the current progress, translational medicine bottlenecks, and perspectives of LM biomaterials signify their immense potential to drive future medical breakthroughs and thus open up novel avenues for upcoming clinical practices.

关键词： liquid metal biomaterials translational medicine clinical device healthcare therapeutics

Transfer relation between subgrade frost heave and slab track deformation and vehicle dynamic response in seasonally frozen ground

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第2期25卷 130-146页

作者： Juanjuan REN Junhong DU Kaiyao ZHANG Bin YAN jincheng TIAN MOE Key Laboratory of High-speed Railway Engineering Southwest Jiaotong UniversityChengdu610031China School of Civil Engineering Southwest Jiaotong UniversityChengdu610031China School of Civil Engineering Central South UniversityChangsha410075China Airport Planning and Design Institute POWERCHINA Kunming Engineering Corporation LimitedKunming650051China

Subgrade frost heave in seasonally frozen ground can greatly influence the safety and smooth running of high-speed trains and the service performance of track *** this study,we used a static model to:(1)investigate track-subgrade frost heave and develop a dynamic model of vehicle-track-subgrade frost heave;(2)explore the transfer relation between subgrade frost heave and track structure deformation;(3)examine the characteristics of interlayer debonding;(4)study the influence of subgrade frost heave on the dynamic response of vehicles in high-speed railways in seasonally frozen regions.A Fourier series was used to fit the frost heave waveform and simulate the behavior of subgrade uneven frost heave using data collected *** results show:(i)The position of frost heave significantly affects the transfer of deformation to a slab *** largest deformation of the track slab,with the amplitude transfer ratio reaching 20%,was recorded when the frost heave occurred near the joint of the base plate.(ii)At the same frost heave amplitude,long-wave frost heave causes smaller deformation and debonding of the track structure than short-wave frost *** the wavelength range of 10-30 m,the main frequency of the acceleration spectral density was concentrated between 3.5 and 3.7 Hz,with larger frost heave wavelengths producing smaller superposition on the vertical acceleration of the vehicle.(ii)The maximum wheel-rail force occurs when the front bogie passes the frost heave peak,with greater frost heave amplitudes producing greater wheel-rail *** these results,we conclude there is a clear need to control the frost heave deformation of the track to reduce the dynamic response of the vehicle and in turn improve train operatSubgrade frost heave in seasonally frozen ground can greatly influence the safety and smooth running of high-speed trains and the service performance of track *** this study,we used a static model to:(1)investigate track`-subgr

关键词： Slab track Subgrade frost heave Transfer relation Vehicle-track-subgrade coupling Dynamic response

Video-Based Deception Detection with Non-Contact Heart Rate Monitoring and Multi-Modal Feature Selection

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Journal of Beijing Institute of Technology 2024年第3期33卷 175-185页

作者： Yanfeng Li jincheng Bian Yiqun Gao Rencheng Song Department of Biomedical Engineering Hefei University of TechnologyHefei 230009China

Deception detection plays a crucial role in criminal *** contain a wealth of information regarding apparent and physiological changes in individuals,and thus can serve as an effective means of deception *** this paper,we investigate video-based deception detection considering both apparent visual features such as eye gaze,head pose and facial action unit(AU),and non-contact heart rate detected by remote photoplethysmography(rPPG)*** wrapper-based feature selection methods combined with the K-nearest neighbor(KNN)and support vector machine(SVM)classifiers are employed to screen the most effective features for deception *** evaluate the performance of the proposed method on both a self-collected physiological-assisted visual deception detection(PV3D)dataset and a public bag-oflies(BOL)*** results demonstrate that the SVM classifier with symbiotic organisms search(SOS)feature selection yields the best overall performance,with an area under the curve(AUC)of 83.27%and accuracy(ACC)of 83.33%for PV3D,and an AUC of 71.18%and ACC of 70.33%for *** demonstrates the stability and effectiveness of the proposed method in video-based deception detection tasks.

关键词： deception detection apparent visual features remote photoplethysmography non-contact heart rate feature selection

Seismic safety assessment with non-Gaussian random processes for train-bridge coupled systems

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 241-260页

作者： Zhao Han Gao Lei Wei Biao Tan jincheng Guo Peidong Jiang Lizhong Xiang Ping Key Laboratory of Geomechanics and Embankment Engineering of Ministry of Education Hohai UniversityNanjing 210024China School of Civil Engineering Central South UniversityChangsha 410075China

Extensive high-speed railway(HSR)network resembled the intricate vascular system of the human body,crisscrossing *** events,known for their unpredictability,pose a significant threat to both trains and bridges,given the HSR’s extended operational ***,ensuring the running safety of train-bridge coupled(TBC)system,primarily composed of simply supported beam bridges,is *** methods like the Monte Carlo method fall short in analyzing this intricate system ***,efficient algorithm like the new point estimate method combined with moment expansion approximation(NPEM-MEA)is applied to study random responses of numerical simulation TBC *** of the NPEM-MEA’s feasibility is conducted using the Monte Carlo *** analysis confirms the accuracy and efficiency of the method,with a recommended truncation order of four to six for the ***,the influences of seismic magnitude and epicentral distance are discussed based on the random dynamic responses in the TBC *** methodology not only facilitates seismic safety assessments for TBC systems but also contributes to standard-setting for these systems under earthquake conditions.

关键词： train-bridge coupled(TBC)system random vibration new point estimate method(NPEM) seismic safety assessment moment expansion approximation(MEA) non-Gaussian distributions

Continuous adaptive gaits manipulation for three-fingered robotic hands via bioinspired fingertip contact events

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Biomimetic Intelligence & Robotics 2024年第1期4卷 59-69页

作者： Xiaolong Ma Jianhua Zhang Binrui Wang jincheng Huang Guanjun Bao College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou 310018China School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310023China

The remarkable skill of changing its grasp status and relocating its fingers to perform continuous in-hand manipulation is essential for a multifingered anthropomorphic hand.A commonly utilized method of manipulation involves a series of basic movements executed by a high-level ***,it remains unclear how these primitives evolve into sophisticated finger gaits during ***,we propose an adaptive finger gait-based manipulation method that offers real-time regulation by dynamically changing the primitive interval to ensure the force/moment balance of the *** manipulation relies on contact events that act as triggers for real-time online replanning of multifinger *** identify four basic motion primitives of finger gaits and create a heuristic finger gait that enables the continuous object rotation of a round *** experimental results verify the effectiveness of the proposed *** the constant breaking and reengaging of contact between the fingers and the object during manipulation,the robotic hand can reliably manipulate the object without *** when the object is subjected to interfering forces,the proposed method demonstrates robustness in managing *** work has great potential for application to the dexterous operation of anthropomorphic multifingered hands.

关键词： Adaptive switch Contact event Continuous manipulation Multifinger gait Primitive

Simultaneous detection of flare-associated kink oscillations and extreme-ultraviolet waves

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Science China(Technological Sciences) 2024年第5期67卷 1592-1601页

作者： LI Dong HOU ZhenYong BAI XianYong LI Chuan FANG Matthew ZHAO HaiSheng WANG jincheng NING ZongJun Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing210023China Yunnan Key Laboratory of the Solar Physics and Space Science Kunming650216China School of Earth and Space Sciences Peking UniversityBeijing100871China National Astronomical Observatories Chinese Academy of SciencesBeijing100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing100049China School of Astronomy and Space Science Nanjing UniversityNanjing210023China Key Laboratory of Modern Astronomy and Astrophysics Ministry of EducationNanjing UniversityNanjing210023China Columbus Academy GahannaOhio43230USA Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Yunnan Observatories Chinese Academy of SciencesKunming650216China

Kink oscillations,which are frequently observed in coronal loops and prominences,are often accompanied by extreme-ultraviolet(EUV)***,much more needs to be explored regarding the causal relationships between kink oscillations and EUV *** this article,we report the simultaneous detection of kink oscillations and EUV waves that are both associated with an X2.1 flare on 2023 March 03(SOL2023-03-03T17:39).The kink oscillations,which are almost perpendicular to the axes of loop-like structures,are observed in three coronal loops and one *** short loop shows in-phase oscillation within the same period of 5.2 min at three *** oscillation could be triggered by the pushing of an expanding loop and interpreted as the standing kink *** lags are found between the kink oscillations of the short loop and two long loops,suggesting that the kink wave travels in different *** kink oscillations of one long loop and the prominence are possibly driven by the disturbance of the coronal mass ejection(CME),and that of another long loop might be attributed to the interaction of the EUV *** onset time of the kink oscillation of the short loop is nearly same as the beginning of an EUV *** fact demonstrates that they are almost *** EUV wave is most likely excited by the expanding loop structure and shows two *** leading component is a fast coronal wave,and the trailing one could be due to the stretching magnetic field lines.

关键词： coronal loops solar flares solar prominence solar oscillations extreme-ultraviolet wave magnetohydrodynamic

Nanotherapeutics targeting autophagy regulation for improved cancer therapy

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2447-2474页

作者： Yunmeng Liu Yaxin Wang jincheng Zhang Qikai Peng Xingdong Wang Xiyue Xiao Kai Shi College of Pharmacy Nankai UniversityTianjin 300350China

The clinical efficacy of current cancer therapies falls short,and there is a pressing demand to integrate new targets with conventional ***,a highly conserved self-degradation process,has received considerable attention as an emerging therapeutic target for *** the rapid development of nanomedicine,nanomaterials have been widely utilized in cancer therapy due to their unrivaled delivery ***,considering the potential benefits of integrating autophagy and nanotechnology in cancer therapy,we outline the latest advances in autophagy-based *** on a brief background related to autophagy and nanotherapeutics and their impact on tumor progression,the feasibility of autophagy-based nanotherapeutics for cancer treatment is ***,emerging nanotherapeutics developed to modulate autophagy are reviewed from the perspective of cell signaling pathways,including modulation of the mammalian target of rapamycin(mTOR)pathway,autophagy-related(ATG)and its complex expression,reactive oxygen species(ROS)and mitophagy,interference with autophagosome-lysosome fusion,and inhibition of hypoxia-mediated *** addition,combination therapies in which nano-autophagy modulation is combined with chemotherapy,phototherapy,and immunotherapy are also ***,the prospects and challenges of autophagy-based nanotherapeutics for efficient cancer treatment are envisioned.

关键词： Autophagy regulation Nanotherapeutic Combination strategies Cancer therapy Signal transduction pathway Delivery strategies Dual effects Nanomaterials

Additive manufactured osseointegrated screws with hierarchical design

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Bio-Design and Manufacturing 2024年第2期7卷 206-235页

作者： Wenbo Yang Hao Chen Haotian Bai Yifu Sun Aobo Zhang Yang Liu Yuchao Song Qing Han jincheng Wang Department of Orthopedics Second Hospital of Jilin UniversityChangchun 130022China College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China School of Materials Science and Engineering Jilin UniversityChangchun 130022China

Bone screws are devices used to fix implants or bones to ***,conventional screws are mechanically fixed with thread and often face long-term failure due to poor *** improve osseointegration,screws are evolving from solid and smooth to porous and *** manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and *** paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw ***,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing *** the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore *** addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi *** the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated ***,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated *** osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.

关键词： Bone screws Additive manufacturing Architecture design Surface modification