Nanotherapeutics targeting autophagy regulation for improved cancer therapy
作者机构：College of PharmacyNankai UniversityTianjin 300350China
出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)
年 卷 期：2024年第14卷第6期
页 面：2447-2474页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the National Natural Science Foundation of China(No.81971729)for financial support
主 题：Autophagy regulation Nanotherapeutic Combination strategies Cancer therapy Signal transduction pathway Delivery strategies Dual effects Nanomaterials
摘 要：The clinical efficacy of current cancer therapies falls short,and there is a pressing demand to integrate new targets with conventional ***,a highly conserved self-degradation process,has received considerable attention as an emerging therapeutic target for *** the rapid development of nanomedicine,nanomaterials have been widely utilized in cancer therapy due to their unrivaled delivery ***,considering the potential benefits of integrating autophagy and nanotechnology in cancer therapy,we outline the latest advances in autophagy-based *** on a brief background related to autophagy and nanotherapeutics and their impact on tumor progression,the feasibility of autophagy-based nanotherapeutics for cancer treatment is ***,emerging nanotherapeutics developed to modulate autophagy are reviewed from the perspective of cell signaling pathways,including modulation of the mammalian target of rapamycin(mTOR)pathway,autophagy-related(ATG)and its complex expression,reactive oxygen species(ROS)and mitophagy,interference with autophagosome-lysosome fusion,and inhibition of hypoxia-mediated *** addition,combination therapies in which nano-autophagy modulation is combined with chemotherapy,phototherapy,and immunotherapy are also ***,the prospects and challenges of autophagy-based nanotherapeutics for efficient cancer treatment are envisioned.
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