Additive manufactured osseointegrated screws with hierarchical design

作     者：Wenbo Yang Hao Chen Haotian Bai Yifu Sun Aobo Zhang Yang Liu Yuchao Song Qing Han Jincheng Wang Wenbo Yang;Hao Chen;Haotian Bai;Yifu Sun;Aobo Zhang;Yang Liu;Yuchao Song;Qing Han;Jincheng Wang

作者机构：Department of OrthopedicsSecond Hospital of Jilin UniversityChangchun 130022China College of Biological and Agricultural EngineeringJilin UniversityChangchun 130022China School of Materials Science and EngineeringJilin UniversityChangchun 130022China 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2024年第7卷第2期

页      面：206-235页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(Nos.82272504 and 82072456) the National Key R&D Program of China(No.2018YFB1105100) the Department of Science and Technology of Jilin Province,China(Nos.20200404202YY,20200403086SF,20210101321JC,20210204104YY,20200201453JC,20220204119YY,202201ZYTS131,202201ZYTS129,20220401084YY,202201ZYTS505,and YDZJ202301ZYTS076) the Department of Finance of Jilin Province,China(No.2020SCZT037) the Jilin Provincial Development and Reform Commission,China(Nos.2018C010 and 2022C043-5) the Interdisciplinary Integration and Cultivation Project of Jilin University(No.JLUXKJC2020307) the Central University Basic Scientific Research Fund(No.2023-JCXK-04) 

主　　题：Bone screws Additive manufacturing Architecture design Surface modification 

摘      要：Bone screws are devices used to fix implants or bones to ***,conventional screws are mechanically fixed with thread and often face long-term failure due to poor *** improve osseointegration,screws are evolving from solid and smooth to porous and *** manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and *** paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw ***,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing *** the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore *** addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi *** the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated ***,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated *** osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.