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cellular strategies to induce immune tolerance after liver transplantation:clinical perspectives

World Journal of Gastroenterology 2024年第13期30卷 1791-1800页

作者： ai-wei Zhou jing jin Yuan Liu Department of Liver Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Nursing Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Liver Transplantation Shanghai Immune Therapy InstituteShanghai 200127China

Liver transplantation(LT)has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative ***,long-term side-effects of immunosuppressants,like infection,metabolic disorders and malignant tumor are gaining more *** tolerance is the status in which LT recipients no longer need to take any immunosuppressants,but the liver function and intrahepatic histology maintain *** approaches to achieve immune tolerance after transplantation include spontaneous,operational and induced *** first two means require no specific intervention but withdrawing immunosuppressant gradually during *** clinical factors or biomarkers so far could accurately predict who are suitable for immunosuppressant withdraw after *** the understanding to the underlying mechanisms of immune tolerance,many strategies have been developed to induce tolerance in LT *** strategy is one of the most promising methods for immune tolerance induction,including chimerism induced by hematopoietic stem cells and adoptive transfer of regulatory immune *** safety and efficacy of various cell products have been evaluated by prospective preclinical and clinical trials,while obstacles still exist before translating into clinical ***,we will summarize the latest perspectives and concerns on the clinical application of cellular strategies in LT recipients.

关键词： cellular therapy Induced tolerance Liver transplantation Regulatory T cells Regulatory dendritic cells

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combustion mechanism of benzene in iron ore sintering process:experimental and simulation

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Journal of Iron and Steel Research International 2024年第1期31卷 195-203页

作者： Zhi-gang Que jin-ming Shi Xian-bin ai Institute of Energy Research Jiangxi Academy of ScienceNanchang330096JiangxiChina Jiangxi carbon Neutralization Research center Nanchang330096JiangxiChina

Benzene is a typical component of volatile organic compounds(VOcs)in the iron ore sintering flue *** combustion behavior of benzene directly affects the emission of VOcs in iron ore sintering *** effects of temperature,benzene,and oxygen concentrations on the conversion ratio of benzene were investigated by experiments and numerical *** experiments were carried out in a tube reactor at temperatures of 773-1098 K,benzene concentrations of 0.01-0.03 vol.%,and oxygen concentrations of 10-21 vol.%.The numerical simulation was performed with the plug flow model in the cHEMKIN program based on a kinetic model that consists of 132 chemical species and 772 elementary step-like *** experimental results reveal that increasing the temperature and benzene concentration could signifi-cantly promote benzene *** is attributed to the increase in the reaction rates of all steps in the pathway for forming cO_(2)and H_(2)*** addition,due to the large equivalent ratio of oxygen to benzene,the conversion ratio of benzene remained constant at different oxygen *** simulation results were in good agreement with the experimental results and indicated that six elementary reactions dominated the formations of cO_(2)and H_(2)*** oxidations of c_(6)H_(5)O,cO,and c_(5)H_(4)O intermediates to cO_(2)were the limiting steps in the reaction pathways.

关键词： Benzene Volatile organic compound Iron ore sinter combustion Simulation Temperature Oxygen

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Tuning interfacial charge transfer for efficient visible-light-driven photodegradation and simultaneous H_(2)evolution

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Journal of Materials Science & Technology 2024年第1期168卷 35-49页

作者： Zhiyang Li Yaogang chen Yinghe Zhang wei ai Qian Lei Tingjun Yao Dan Zhong Wenjie Liu Wenbiao jin Lei Yang State Key Laboratory of Urban Water Resource and Environment Shenzhen Key Laboratory of Organic Pollution Prevention and ControlSchool of Civil and Environmental EngineeringHarbin Institute of Technology ShenzhenShenzhen 518055China Key Laboratory of Northwest Water Resources Environment and EcologyMinistry of EducationSchool of Environmental and Municipal EngineeringXi’an University of Architecture and TechnologyXi’an 710055China cNAS Accredited Test center Guangdong Engineering Technology Research Center of Air PurificationHealthlead Co.Ltd.Shenzhen 518055China School of Science Harbin Institute of Technology ShenzhenShenzhen 518055China

The edge-graphitized carbon nitride(c_(3)N_(4)-c g)was prepared by secondary pyrolysis to construct ZnO/c_(3)N_(4)-c g(ZcN)type-Ⅱheterojunction photocatalyst via a facile sonication dispersion method,which achieved∼7.04-fold and∼18.3-fold enhanced visible-light-driven photocatalytic performance for refrac-tory micropollutant removal and simultaneous hydrogen(H_(2))evolution respectively compared to con-ventional ZnO/g-c_(3)N_(4)Step-scheme *** apparent quantum efficiency of the ZcN_(0.4)het-erojunction reaches 0.92%(λ=420 nm).Such excellent performance stems from that the edge-graphene moieties stitched onto the interface of heterojunction extend light absorption to the full visible spec-trum,meanwhile,the built-in electric field generated during Fermi level alignment accompanying fa-vorable band-bending structure provides an effective pathway for the rapid migration of photoinduced electrons via the edge graphene channel to improve interfacial charge separation ***,the midgap states introduced in ZcN heterojunction could temporarily retain photoexcited electrons to effectively inhibit the in situ carrier recombination for improved photocatalytic H_(2)***,ZcN/peroxymonosulfate system exhibited excellent anti-interference performance against complex water bodies under visible illumination due to the synergistic effect between the co-existing anions and organic ***,the eco-friendly nature of the ZcN/peroxymonosulfate system showed no biotoxicity of reaction filtrate on cell proliferation after treatment,which avoided secondary ***-ering the outstanding performance in photocatalysis,the ZcN system exhibits broad potential for practical applications in water pollution control and green energy production.

关键词： ZnO c_(3)N_(4)-c g Heterojunction Photodegradation Hydrogen evolution

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Design of an automated robotic microinjection system for batch injection of zebrafish embryos and larvae

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Microsystems & Nanoengineering 2024年第1期10卷 89-103页

作者： Zhongyi Guo Nana ai wei Ge Qingsong Xu Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Department of Biomedical Sciences and centre of Reproduction Development and Aging(CRDA)Faculty of Health SciencesUniversity of MacaoMacaoChina

This paper presents the design of a vision-based automated robotic microinjection system for batch injection of both zebrafish embryos and larvae.A novel visual recognition algorithm based on an automatic threshold and excessive dilatation is introduced to accurately identify the center of zebrafish embryos and larval yolks.A corresponding software system is developed using the producer-consumer model as the framework structure,and a friendly user interface is designed to allow operators to choose from a range of desired functions according to their different *** addition,a novel microstructural agarose device is designed and fabricated to simultaneously immobilize mixed batches of embryos and ***,a prototype microinjection system is fabricated by integrating hardware devices with visual *** experimental study is conducted to verify the performance of the robotic microinjection *** results show that the reported system can accurately identify zebrafish embryos and larvae and efficiently complete batch microinjection tasks of the mixtures with an injection success rate of 92.05%in 13.88 s per *** with manual and existing microinjection systems,the proposed system demonstrates the merits of versatility,excellent efficiency,high success rate,high survival rate,and sufficient stability.

关键词： zebra automated hardware

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Building Semantic communication System via Molecules:An End-to-End Training Approach

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china communications 2024年第7期21卷 113-124页

作者： cheng Yukun chen wei ai Bo School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100091China Frontiers Science center for Smart High-speed Railway System Beijing Jiaotong UniversityBeijing 100091China Key Laboratory of Railway Industry of Broadband Mobile Information communications Beijing Jiaotong UniversityBeijing 100091China Beijing Engineering Research center of High-speed Railway Broadband Mobile communications Beijing Jiaotong UniversityBeijing 100091China School of Information Engineering Zhengzhou UniversityZhengzhou 450001China

The concept of semantic communication provides a novel approach for applications in scenarios with limited communication *** this paper,we propose an end-to-end(E2E)semantic molecular communication system,aiming to enhance the efficiency of molecular communication systems by reducing the transmitted ***,following the joint source channel coding paradigm,the network is designed to encode the task-relevant information into the concentration of the information molecules,which is robust to the degradation of the molecular communication ***,we propose a channel network to enable the E2E learning over the non-differentiable molecular *** results demonstrate the superior performance of the semantic molecular communication system over the conventional methods in classification tasks.

关键词： deep learning end-to-end learning molecular communication semantic communication

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Leaching behavior and microstructure of phosphorus in converter slag

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Journal of Iron and Steel Research International 2024年第7期31卷 1646-1660页

作者： chao-gang Zhou jin-yue Li Qing-gong chen Yin-ye Yang wei Gong Li-qun ai Shu-huan Wang Bei-yue Ma college of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210HebeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina college of Materials Science and Engineering Guizhou Minzu UniversityGuiyang 550025GuizhouChina School of Materials and Architectural Engineering Guizhou Normal UniversityGuiyang 550025GuizhouChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

converter slag is a by-product of the steelmaking process and contains a large amount of ca,Fe,P and other *** the phosphorus in the converter slag can be effectively extracted,the resulting phosphorus can be used as a phosphate *** in converter slag is mainly enriched in 2caO·SiO_(2)-3caO·P_(2)O_(5)(c_(2)S-c_(3)P)solid solution and is easily dissolved in ***,acid leaching method was used to dissolve the solid solution to extract phosphorus in converter slag,so as to realize the recycling of phosphorus resources in converter *** leaching behavior of three actual converter slags from different steel mills in acid leaching solutions composed of citric acid,sodium hydroxide,hydrochloric acid and deionized water was studied by X-ray diffraction,scanning electron microscopy combined with energy dispersive spectrometry,Fourier transform infrared spectroscopy and Raman spectroscopy to reveal the change in object image structure as well as SiO_(4) and PO_(4) tetrahedron before and after acid *** results show that only a small amount of phosphorus in converter slag with too low basicity is enriched in c_(2)S-c_(3)P solid solution,resulting in poor leaching *** the converter slag has a high basicity,the removal effect of phosphorus is 70.64%-81.88%.In addition,when the basicity of converter slag is roughly the same,the dephosphorization effect of slag with high FeO content is relatively *** acid leaching will cause depolymerization behavior of SiO_(4) and PO_(4) tetrahedron,so that the mole fraction of Q0(Si)(asymmetric stretching vibration of Si-O bond in SiO_(4) tetrahedron with bridge oxygen number of 0)and NBO/Si(non-bridging oxygen in silicate tetrahedra)will ***-containing solids can be obtained from the solution after acid leaching through static precipitation,and the solids have the potential to make phosphate fertilizers.

关键词： Dephosphorization converter slag Acid leaching Phosphorus Solid solution Slag structure

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MD Simulation of Diffusion Behaviors in collision Welding Processes of Al-cu, Al-Al, cu-cu

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computers, Materials & continua 2024年第6期79卷 3455-3468页

作者： Dingyi jin Guo wei School of Intelligent Manufacturing Hunan First Normal UniversityChangsha410082China School of Physics and Technology Center for Ion Beam ApplicationHubei Nuclear Solid Physics Key LaboratoryWuhan UniversityWuhan430072China

To investigate the effects of material combinations and velocity conditions on atomic diffusion behavior near collision interfaces,this study simulates the atomic diffusion behavior near collision interfaces in cu-Al,Al-Al and cu-cu combinations fabricated through collision welding using molecular dynamic(MD)*** atomic diffusion behaviors are compared between similar metal combinations(Al-Al,cu-cu)and dissimilar metal combinations(Al-cu).By combining the simulation results and classical diffusion theory,the diffusion coefficients for similar and dissimilar metal material combinations under different velocity conditions are *** effects of material combinations and collision velocity on diffusion behaviors are also *** diffusion behaviors of dissimilar material combinations strongly depend on the transverse velocity,whereas those of the similar material combinations are more dependent on the longitudinal *** findings can provide guidance for optimizing welding parameters.

关键词： Atomic diffusion behavior molecular dynamics collision welding

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cluster-Based Massive Access for Massive MIMO Systems

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china communications 2024年第1期21卷 24-33页

作者： Shiyu Liang wei chen Zhongwen Sun Ao chen Bo ai State Key Laboratory of Advanced Rail Autonomous Operation Beijing Jiaotong UniversityBeijing 100091China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100091China Frontiers Science center for Smart High-speed Railway System Beijing Jiaotong UniversityBeijing 100091China Key Laboratory of Railway Industry of Broadband Mobile Information communications Beijing Jiaotong UniversityBeijing 100091China Beijing Engineering Research center of High-speed Railway Broadband Mobile communications Beijing Jiaotong UniversityBeijing 100091China School of Information Engineering Zhengzhou UniversityZhengzhou 450001China

Massive machine type communication aims to support the connection of massive devices,which is still an important scenario in *** this paper,a novel cluster-based massive access method is proposed for massive multiple input multiple output *** exploiting the angular domain characteristics,devices are separated into multiple clusters with a learned cluster-specific dictionary,which enhances the identification of active *** detected active devices whose data recovery fails,power domain nonorthogonal multiple access with successive interference cancellation is employed to recover their data via *** results show that the proposed scheme and algorithm achieve improved performance on active user detection and data recovery.

关键词： compressive sensing dictionary learning multiuser detection random access

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Two-Staged Method for Ice channel Identification Based on Image Segmentation and corner Point Regression

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china Ocean Engineering 2024年第2期38卷 313-325页

作者： DONG Wen-bo ZHOU Li DING Shi-feng WANG ai-ming cai jin-yan School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of *** the Arctic,merchant ships with low ice class often navigate in channels opened up by *** in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large *** ship may get stuck if steered into ice fields off the *** this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable *** this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point *** first stage employs the image segmentation method to extract channel *** the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression *** training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel *** evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second.

关键词： ice channel ship navigation identification image segmentation corner point regression

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Infrared microspectroscopy beamline BL06B at SSRF

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Nuclear Science and Techniques 2024年第1期35卷 10-17页

作者： Te Ji Hua-chun Zhu wei-wei Peng Jie Wang Hong-wei Zhao ai-Guo Li Min chen Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The infrared microspectroscopy beamline(BL06B) is a phase Ⅱ beamline project at the Shanghai Synchrotron Radiation Facility(SSRF). The construction and optical alignment of BL06B were completed by the end of 2020. By 2021, it became accessible to users. The synchrotron radiation infrared(SRIR) source included edge radiation(ER) and bending magnet radiation(BMR). The extracted angles in the horizontal and vertical directions were 40 and 20 mrad, respectively. The photon flux, spectral resolution, and focused spot size were measured at the BL06B endstation, and the experimental results were consistent with theoretical calculations. SRIR light has a small divergence angle, high brightness, and a wide wavelength range. As a source of IR microscopy, it can easily focus on a diffraction-limited spatial resolution with a high signal-to-noise ratio(SNR). The BL06B endstation can be applied in a wide range of research fields, including materials, chemistry, biology, geophysics, and pharmacology.

关键词： Synchrotron radiation Infrared beamline Infrared microspectroscopy

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