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Neural Regeneration Research 2021年第1期16卷 123-124页

作者： Carlos Bueno salvador Martínez Instituto de Neurociencias de Alicante(UMH-CSIC) San JuanAlicanteSpain

Human neurological disorders and spinal cord injuries are caused by a loss of neurons and glial cells in the brain or spinal cord.The proof-ofprinciple of cell therapy is that replacing damaged cells with new healthy ones will restore the lost function.Isolating and manipulating autologous neural stem cells(NSCs)could provide an ideal source of cells for use in cell replacement and the transfer of genes to a diseased central nervous system.NSCs are immature cells present,not only during embryonic development,but also in the adult brain of all mammalian species,including humans.The presence of NSCs in the adult mammalian brain has been described in two neurogenic niches,the ventricular-subventricular zone(V-SVZ)of the anterolateral ventricle wall and the subgranular zone of the hippocampal dentate gyrus.Typically,NSCs are defined as self-renewing multipotent cells that can generate neurons,astrocytes and oligodendrocytes.The major barrier to isolating adult NSCs in humans is the inaccessibility of living tissue.For this reason,an enormous effort has been made to derive neurons from human adult stem cells isolated from various tissue sources.

关键词： injuries ventricular adult

A proctolin-like peptide is regulated after baculovirus infection and mediates in caterpillar locomotion and digestion

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Insect Science 2022年第1期29卷 230-244页

作者： Angel Llopis-Giménez Stefano Parenti Yue Han Vera I.D.Ros salvador Herrero Department of Genetics and Institut Universitari en Biotecnologia i Biomedicina(BIOTECMED) Universitat de ValenciaValenciaSpain Laboratory of Virology Wageningen University and ResearchWageningenthe Netherlands Current address.Department of Pathology University of CambridgeCambridgeUK

Baculoviruses constitute a large group of invertebrate DNA viruses, predominantly infecting larvae of the insect order Lepidoptera. During a baculovirus infection, the virus spreads throughout the insect body producing a systemic infection in multiple larval tissues, included the central nervous system (CNS). As a main component of the CNS, neuropeptides are small protein-like molecules functioning as neurohormones, neurotransmitters, or neuromodulators. These peptides are involved in regulating animal physiology and behavior and could be altered after baculovirus infection. In this study, we have investigated the effect of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) infection on expression of Spodoptera exigua neuropeptides and neuropeptide-like genes. Expression of the gene encoding a polypeptide that resembles the well-known insect neuropeptide proctolin and named as proctolin-like peptide (PLP), was downregulated in the larval brain following infection and was chosen for further analysis. A recombinant Autographa californica multiple nucleopolyhedrovirus (AcMNPV) overexpressing the C-terminal part of the PLP was generated and used in bioassays using S. exigua larvae to study its influence on the viral infection and insect behavior. AcMNPV-PLP-infected larvae showed less locomotion activity and a reduction in growth compared to larvae infected with wild type AcMNPV or mock-infected larvae. These results are indicative of this new peptide as a neuromodulator that regulates visceral and skeletal muscle contractions and offers a novel effector involved in the behavioral changes during baculovirus infection.

关键词： beet armyworm behavior neuromodulator neuropeptide physiology SeM-NPV

Optimizing urban traffic control using a rational agent

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第12期15卷 1123-1137页

作者： salvador IBARRA-MARTínez José A.CASTN-ROCHA Julio LARIA-MENCHACA Engineering School Autonomous University of Tamaulipas

This paper is devoted to developing and evaluating a set of technologies with the objective of designing a methodology for the implementation of sophisticated traffic lights by means of rational agents. These devices would be capable of optimizing the behavior of a junction with multiple traffic signals, reaching a higher level of autonomy without losing reliability, accuracy, or efficiency in the offered services. In particular, each rational agent in a traffic signal will be able to analyze the requirements and constraints of the road, in order to know its level of demand. With such information, the rational agent will adapt its light cycles with the view of accomplishing more fluid traffic patterns and minimizing the pollutant environmental emissions produced by vehicles while they are stopped at a red light, through using a case-based reasoning(CBR) adaptation. This paper also integrates a microscopic simulator developed to run a set of tests in order to compare the presented methodology with traditional traffic control methods. Two study cases are shown to demonstrate the efficiency of the introduced approach, increasing vehicular mobility and reducing harmful activity for the environment. For instance, in the first scenario, taking into account the studied traffic volumes, our approach increases mobility by 23% and reduces emissions by 35%. When the roads are managed by sophisticated traffic lights, a better level of service and considerable environmental benefits are achieved, demonstrating the utility of the presented approach.

关键词： Rational agents Traffic light control Optimization Traffic mobility

Incidence of cystoid macular edema after Descemet's stripping automated endothelial keratoplasty

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1081-1087页

作者： Eduard Pedemonte-Sarrias Toni salvador Playà Irene Sassot Cladera Oscar Gris Joan Ribas Martínez José García-Arumí Núria Giménez Ophthalmology Department Hospital Universitari Mútua TerrassaFundació Docència i Recerca Mútua TerrassaUniversitat de Barcelona Ophthalmology Department Hospital Universitari Germans Trias i PujolHealth Sciences Research Institute Germans Trias i Pujol Foundation Surgery Department Universitat Autònoma de Barcelona Instituto de Microcirugía Ocular (IMO) Ophthalmology Department Hospital Sant Antoni Abat Ophthalmology Department Hospital Universitari Vall d’HebronUniversitat Autònoma de Barcelona Research Unit Fundació Docència i Recerca Mútua TerrassaUniversitat de Barcelona Laboratory of Toxicology Universitat Autònoma de Barcelona

AIM： To determine the incidence of cystoid macular edema（CME） after Descemet＇s stripping automated endothelial keratoplasty（DSAEK）.METHODS： This study included all consecutive patients operated in a Spanish tertiary reference hospital over a period of four years. A total of 55 eyes from 47 patients matched the selection criteria. CME was diagnosed clinically at the slit-lamp and confirmed by optical coherence tomography. RESULTS： Six cases of CME were diagnosed postoperatively, which represented an incidence of 11%. Three patients had previously undergone DSAEK alone（7%; 3/41） and the other three, DSAEK combined with phacoemulsification（21%; 3/14）. Five out of six patients with CME responded to standard therapy.CONCLUSION： CME is a possible complication after DSAEK and can be treated with standard therapy. CME appears more frequently when DSAEK is combined with phacoemulsification and posterior chamber（PC） intraocular lens（IOL） implantation. Intraoperative damage to the corneal endothelial cells might play a role in the pathogenesis of CME. As long as the causes remain unclear, we recommend administering prophylaxis when risk factors are present or when combined surgery is planned.

关键词： Descemet membrane endothelial keratoplasty Descemet stripping automated endothelial keratoplasty combined with phacoemulsification Descemet stripping endothelial keratoplasty macular edema postoperative complications

One ring is sufficient to inhibit α-synuclein aggregation

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Neural Regeneration Research 2022年第3期17卷 508-511页

作者： Samuel Peña-Díaz salvador Ventura Institut de Biotecnologia i Biomedicina Universitat Autònoma de BarcelonaBellaterraSpain Departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraSpain InstitucióCatalana de Recerca i Estudis Avançats(ICREA) BarcelonaSpain

Parkinson's disease,the second most prevalent neurodegenerative disorder worldwide,is characterized by a progressive loss of dopaminergic neurons in substantia nigra pars compacta,causing motor symptoms.This disorder's main hallmark is the formation of intraneuronal protein inclusions,named Lewy bodies and neurites.The major component of these arrangements is α-synuclein,an intrinsically disordered and soluble protein that,in pathological conditions,can form toxic and cell-to-cell transmissible amyloid structures.Preventing α-synuclein aggregation has attracted significant effort in the search for a disease-modifying therapy for Parkinson's disease.Small molecules like Synu Clean-D,epigallocatechin gallate,trodusquemine,or anle138 b exemplify this therapeutic potential.Here,we describe a subset of compounds containing a single aromatic ring,like dopamine,ZPDm,gallic acid,or entacapone,which act as molecular chaperones against α-synuclein aggregation.The simplicity of their structures contrasts with the complexity of the aggregation process,yet the block efficiently α-synuclein assembly into amyloid fibrils,in many cases,redirecting the reaction towards the formation of non-toxic off-pathway oligomers.Moreover,some of these compounds can disentangle mature α-synuclein amyloid fibrils.Their simple structures allow structure-activity relationship analysis to elucidate the role of different functional groups in the inhibition of α-synuclein aggregation and fibril dismantling,making them informative lead scaffolds for the rational development of efficient drugs.

关键词： amyloid aromatic rings dopamine inhibition neurodegeneration oligomers Parkinson's disease protein aggregation α-synuclein

LL-37 and CsgC exemplify the crosstalk between anti-amyloid, antimicrobial, and anti-biofilm protein activities

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Neural Regeneration Research 2023年第5期18卷 1027-1028页

作者： Jaime Santos salvador Ventura Irantzu Pallares Institut de Biotecnologia i Biomedicina Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona

Protein misfolding and aggregation into amyloid fibrils is the main pathological hallmark of neurodegenerative diseases,including Alzheimer’s,Parkinson’s,Huntington’s,and prion diseases(Chiti and Dobson,2017).These insoluble fibrillar deposits possess a common structure characterized by a cross-β-sheet conformation in which β-strands run transversely to the fiber axis and form an intermolecular network of hydrogen bonds.

关键词： amyloid Huntington diseases

Analysis of Querétaro-Celaya Highway Applying Queueing Theory

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Journal of Traffic and Transportation Engineering 2018年第2期6卷 97-107页

作者： Gabriel Guzmán-Sáenz salvador Hernández-González JoséAlfredo jiménez-García Vicente Figueroa-Fernández Miguel Angel Melchor-Navarro Tecnológico Nacional de México en Minatitlán Minatitlán City96848Mexico Tecnológico Nacional de México en Celaya Celaya City38010Mexico

Querétaro-Celaya highway is the obligatory road to the center of Mexico;the establishment of new companies in the area has generated the need to study the dynamics of the vehicular flow that transits this route.Given that the flow of traffic on a highway is a stochastic phenomenon,it is necessary to apply tools that take into account the randomness of the system to measure performance.Queueing theory models capture the random nature of the phenomenon and provide direct information about the relationship between the variables of the system.In this work,the flow of vehicles on the Querétaro-Celaya highway is analyzed with a macroscopic approach and using analytical models of queueing theory;it is concluded that currently the flow on this road is non-congested.The method is an alternative for institutions that do not have specialized packages to carry out studies of this nature.

关键词： Traffic flow fundamental diagram queueing theory cycle time

Inner ear hair cell regeneration A look from the past to the future

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Neural Regeneration Research 2013年第24期8卷 2284-2289页

作者： Francisco Santaolalla Carlos salvador Agustín Martínez Jose María Sánchez Ana Sánchez del Rey Department of Otorhinolaryngology Basurto University Hospital Department of Dermatology Ophthalmology and Otorhinolaryngology School of Medicine University of the Basque Country (UPV/EHU)

Most recent studies on regeneration of inner ear hair cells focus on use of stem cells, gene therapy and neurotrophic factors. Cochlear gene therapy has been successfully used in the treatment of neu- rosensory hearing loss. This suggests that cochlear hair cell regeneration is possible. The objective of this paper is to review research and clinical application of inner near hair cell regeneration.

关键词： neural regeneration reviews hearing loss hair cells cochlea genes stem cells viral vectors regeneration neuroregeneration

What is the prognosis of emphysematous pyelonephritis associated with extended-spectrum beta-lactamases producing microorganisms?

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Asian Journal of Urology 2022年第2期9卷 146-151页

作者： JoséIván Robles-Torres Marco Alberto Ocaña-Munguía JoséGustavo Arrambide-Herrera Adrián Mauricio Martínez-Fernández Rodrigo Romero-Mata Lauro salvador Gómez-Guerra Urology Department Hospital Universitario"Dr.Jose´Eleuterio Gonza´lez"Universidad Auto´noma de Nuevo LeonMonterreyNuevo LeonMexico

Objective:To describe the microbiological characteristics in emphysematous pyelonephritis(EPN),demonstrate the frequency of extended-spectrum beta-lactamase(ESBL)microorganisms,and determine if these microorganisms are associated with the prognosis of patients with EPN.Methods:We conducted a retrospective study in patients with a diagnosis of EPN in a tertiary care hospital of the northeast region of Mexico during the period from January 2011 to January 2016.Clinical variables were analyzed to determine association with the presence of ESBL-producing microorganisms.Statistical significance was set with p<0.05.Results:A total of 63 patients were included;55(87.3%)of them were females,with a median age of 55(interquartile range:45-65)years.Conservative management was indicated in 38.1%;42.9%were treated with ureteral stent;12.7%with open or percutaneous drainage;15.8%with early nephrectomy;and 9.5%with delayed nephrectomy.Reported mortality was 13(20.6%)cases;23(36.5%)cases required admission to the intensive care unit.The most frequent microorganism isolated was Escherichia coli(n=34,53.9%).ESBL microorganisms were found in 31.7%of the population.No significant association of ESBL was found with admission to the intensive care unit,or with increased mortality.Conclusions:To our knowledge,this is the first study that evaluates ESBL microorganisms as a prognostic factor in EPN.Risk factors associated with a poor prognosis in patients with EPN have been described.The microbiological factors,specifically ESBL-producing bacteria,do not seem to influence in the prognosis of these patients.

关键词： Emphysematous pyelonephritis Extended spectrum betalactamase Mortality Intensive care unit admission