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Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1

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Cellular & Molecular Immunology 2022年第4期19卷 516-526页

作者： Chaohu Pan Qiaomei Cai Xiaorong Li Lili Li Liping Yang Yu Chen Junxiao Liu Wancheng Liu Meiling Gao Tianqi Sui Xiaoyang Wang Huiming Fan jiayin ruan Yueyue Shi Saihua Chen Lucy S.Cheng Jiayong Liu Heng Yang Genhong Cheng Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College100005BeijingChina Suzhou Institute of Systems Medicine Suzhou215123JiangsuChina Institute of Systems Medicine Chinese Academy of Medical Sciences&Peking Union Medical College100005BeijingChina The Second Affiliated Hospital Zhejiang University School of Medicine310009HangzhouChina Heze Vocational College 274008HezeChina Affiliated Tumor Hospital of Nantong University 226000NantongChina Department of Dermatology University of Pittsburgh Medical Center3708 Fifth AvenueSuite 500.68PittsburghPA15213USA Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Bone and Soft Tissue TumorPeking University Cancer Hospital&Institute52 Fucheng Rd100142BeijingChina Department of Molecular and Medical Pharmacology and California NanoSystems Institute University of CaliforniaLos AngelesLos AngelesCA90095USA

Background In 2015,herpes simplex virus 1(HSV-1)-derived talimogene laherparepvec(T-VEC)was the first oncolytic virus approved by the US Food and Drug Administration as a therapeutic agent for cancer ***,its antitumor application is limited to local treatment of melanoma,and there is a lack of understanding of the mechanisms underlying the regulation of HSV-1 replication in cancer cells and the associated antitumor *** hypothesized that increasing the replication capacity of HSV-1 in tumor cells would enhance the antitumor effect of this *** We systematically identified IFN-stimulated genes induced by HSV-1 by performing functional screens and clarified the mechanism by which BACH1 acts against ***,we tested the effect of BACH1 deficiency on immunogenic cell death induced by ***,we investigated the antitumor effect of BACH1 deficiency on HSV-1 in MCA205 and B16 murine tumor *** We identified eight IFN-stimulated genes(ISGs)controlling HSV-1 replication,among which BTB and CNC homology 1(BACH1)suppressed HSV-1 replication by inhibiting the transcription of ICP4,ICP27,and *** of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis,HMGB1 secretion,and calreticulin exposure in tumor *** importantly,hemin,an FDA-approved drug known to downregulate BACH1,significantly enhanced HSV-1-mediated antitumor activity with increased T lymphocyte infiltration at the tumor *** Our studies uncovered a novel antiviral activity of BACH1 and provided a new strategy for improving the clinical efficiency of the oncolytic virus HSV-1.

关键词： IFN stimulated genes Bach1 HSV-1 Hemin Antitumor immunity

Dynamic Response of Foundations during Startup of High-Frequency Tunnel Equipment

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 821-844页

作者： Dawei ruan Mingwei Hu College of Civil and Transportation Engineering Shenzhen UniversityShenzhen518060China State Key Laboratory of Intelligent Geotechnics and Tunnelling Shenzhen UniversityShenzhen518060China Key Laboratory of Coastal Urban Resilient Infrastructures of Ministry of Education Shenzhen UniversityShenzhen518060China Underground Polis Academy Shenzhen UniversityShenzhen518060China Shenzhen Key Laboratory of Green Efficient and Intelligent Construction of Underground Metro StationShenzhen UniversityShenzhen518060China

The specialized equipment utilized in long-line tunnel engineering is evolving towards large-scale,multifunctional,and complex *** vibration caused by the high-frequency units during regular operation is supported by the foundation of the units,and the magnitude of vibration and the operating frequency fluctuate in different engineering contexts,leading to variations in the dynamic response of the *** high-frequency units yield significantly diverse outcomes under different startup conditions and times,resulting in failure to meet operational requirements,influencing the normal function of the tunnel,and causing harm to the foundation structure,personnel,and property in severe *** article formulates a finite element numerical computation model for solid elements using three-dimensional elastic body theory and integrates field measurements to substantiate and ascertain the crucial parameter configurations of the finite element *** proposing a comprehensive startup timing function for high-frequency dynamic machines under different startup conditions,simulating the frequency andmagnitude variations during the startup process,and suggesting functions for changes in frequency and magnitude,a simulated startup schedule function for high-frequency machines is created through *** into account the selection of the transient dynamic analysis step length,the dynamic response results for the lower dynamic foundation during its fundamental frequency crossing process are *** validation checks if the structural magnitude surpasses the safety threshold during the critical phase of unit startup traversing the structural resonance *** design recommendations for high-frequency units’dynamic foundations are provided,taking into account the startup process of the machine and ensuring the safe operation of the tunnel.

关键词： Tunnel equipment high-frequency units startup conditions transient dynamics dynamic response foundation design

A microphysical investigation of different convective cells during the precipitation event with sustained high-resolution observations

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Frontiers of Earth Science 2024年第2期18卷 279-295页

作者： Ziheng HUANG Zheng ruan Debin SU State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China College of Electronic Engineering Chengdu University of Information TechnologyChengdu 610225China Key Laboratory of Atmospheric Sounding China Meteorological AdministrationChengdu 610225China

The growth and breakup processes of raindrops within a cloud influence the rain intensity and the sizes of raindrops on the *** Doppler velocity spectrum acquired by a vertically pointing radar(VPR)contains information on atmospheric turbulence and the size classification of falling *** this study,the four types of Convective Cells(CC)during precipitation events with more than 700 mm of precipitation in southern China are *** characteristics of four types of CCs correspond to the isolated convection,the early stage,the mature stage,and the decline stage of organizational convection,in that *** analysis using retrieval of vertical air motion(Vair)and raindrop evolution in clouds from Doppler velocity spectra collected by C-band VPR revealed the growth and breakup of falling raindrops with dynamic *** raindrops appear in the early stages and are accompanied by ice particles,which are impacted by the falling path᾽s *** aggregation,which is primarily related to the alternation of updraft and downdraft,accounts for the mature stage᾽s high efficiency of surface *** CCs in the decline stage originate from the shallow uplift in the weak and broad downdraft under conditions of enough water *** updraft dominates the stage of isolated *** of convective cells could be more accurately represented in model evaluations.

关键词： cloud microphysics convective systems convective cell vertically pointing radar observations Doppler velocity spectrum

Emerging perovskite materials for supercapacitors:Structure,synthesis,modification,advanced characterization,theoretical calculation and electrochemical performance

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Journal of Energy Chemistry 2024年第2期89卷 41-70,I0003页

作者： Yuehua Qian Qingqing ruan Mengda Xue Lingyun Chen Department of Applied Chemistry School of Chemistry and Chemical EngineeringChongqing UniversityChongqing 401331China

As a new generation electrode materials for energy storage,perovskites have attracted wide attention because of their unique crystal structure,reversible active sites,rich oxygen vacancies,and good *** this review,the design and engineering progress of perovskite materials for supercapacitors(SCs)in recent years is ***,the review will focus on four types of perovskites,perovskite oxides,halide perovskites,fluoride perovskites,and multi-perovskites,within the context of their intrinsic structure and corresponding electrochemical performance.A series of experimental variables,such as synthesis,crystal structure,and electrochemical reaction mechanism,will be carefully analyzed by combining various advanced characterization techniques and theoretical *** applications of these materials as electrodes are then featured for various ***,we look forward to the prospects and challenges of perovskite-type SCs electrodes,as well as the future research direction.

关键词： Perovskite Modification engineering Oxygen vacancy Theoretical calculation methodology Supercapacitor

Black phosphorus quantum dots induce myocardial inflammatory responses and metabolic disorders in mice

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Journal of Environmental Sciences 2024年第3期137卷 53-64页

作者： Chao Shen Xiaoyan Ding Jinpeng ruan Fengkai ruan Weiping Hu Jiyi Huang Chengyong He Yi Yu Zhenghong Zuo Department of Nephrology State Key Laboratory of Cellular Stress BiologySchool of Life SciencesFaculty of Medicine and Life SciencesFujian Clinical Research Center for Chronic Glomerular DiseaseThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China

As an ultrasmall derivative of black phosphorus(BP)sheets,BP quantum dots(BP-QDs)have been effectively used in many ***,information on the cardiotoxicity induced by BP-QDs remains *** aimed to evaluate BP-QD-induced cardiac toxicity in *** examination of heart tissue sections was *** sequencing,real-time quantitative PCR(RT–qPCR),western blotting,and enzyme-linked immunosorbent assay(ELISA)assays were used to detect the m RNA and/or protein expression of proinfammatory cytokines,nuclear factor kappa B(NF-κB),phosphatidylinositol3 kinase-protein kinase B(PI3K-AKT),peroxisome proliferator-activated receptor gamma(PPARγ),and glucose/lipid metabolism pathway-related *** found that heart weight and heart/body weight index(HBI)were significantly reduced in mice after intragastric administration of 0.1 or 1 mg/kg BP-QDs for 28 *** addition,obvious infammatory cell infiltration and increased cardiomyocyte diameter were observed in the BP-QD-treated *** expression of proinfammatory cytokines and genes related to the NF-κB signaling pathway further confirmed that BP-QD exposure induced infammatory *** addition,BP-QD treatment also affected the PI3K-AKT,PPARγ,thermogenesis,oxidative phosphorylation,and cardiac muscle contraction signaling *** expression of genes related to glucose/lipid metabolism signaling pathways was dramatically affected by BP-QD exposure,and the effect was primarily mediated by the PPAR signaling *** study provides new insights into the toxicity of BP-QDs to human health.

关键词： BP-QDs Cardiac toxicity Infammatory responses NF-κB signaling pathway PPARγsignaling pathway Glucose/lipid metabolism

Dynamic thermal rating assessment of oil-immersed power transformers for multiple operating conditions

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High Voltage 2024年第1期9卷 195-205页

作者： Chen Zhang Xuzhu Dong Jiangjun ruan Yongqing Deng School of Electrical Engineering and Automation Wuhan UniversityWuhanHubeiChina

In this article,the dynamic thermal rating assessment method of oil-immersed power transformer with multiple operating conditions is proposed,considering the constraints of hot spot temperature(HST),top oil temperature,losses of life and the maximum allowable current of on-load tap changer(OLTC)or bushing,which can determine the dynamic load curves under different operating conditions and give the most sensitive constraints to limit the dynamic load *** improve the accuracy of HST estimation,the temperature estimation model is also improved and the thermal parameters are optimised using the HST measured by optical ***,several application examples are studied for transformers in different *** results show that the normal cyclic dynamic transformer rating(DTR)is mainly limited by the losses of life when the ambient temperature is high,and the average load factor can be increased to 0.82 with a maximum load capacity of *** main limiting factor of short-term DTR is the OLTC or bushing current constraint,and the average load factor can be increased to *** maximum load capacity of the transformer under both operating conditions is 23%and 50%higher than its rated load capacity,indicating that the transformer still has a large load potential available.

关键词： load thermal power

Emerging two-dimensional Mo-based materials for rechargeable metal-ion batteries:Advances and perspectives

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Journal of Energy Chemistry 2024年第2期89卷 487-518,I0012页

作者： Qingqing ruan Yuehua Qian Mengda Xue Lingyun Chen Qichun Zhang Department of Applied Chemistry School of Chemistry and Chemical EngineeringChongqing UniversityChongqing 401331China Department of Materials Science and Engineering City University of Hong Kong999077Hong KongChina

With the rapid development of rechargeable metal-ion batteries(MIBs)with safety,stability and high energy density,significant efforts have been devoted to exploring high-performance electrode *** recent years,two-dimensional(2D)molybdenum-based(Mo-based)materials have drawn considerable attention due to their exceptional characteristics,including low cost,unique crystal structure,high theoretical capacity and controllable chemical ***,like other transition metal compounds,Mo-based materials are facing thorny challenges to overcome,such as slow electron/ion transfer kinetics and substantial volume changes during the charge and discharge *** this review,we summarize the recent progress in developing emerging 2D Mo-based electrode materials for MIBs,encompassing oxides,sulfides,selenides,*** introducing the crystal structure and common synthesis methods,this review sheds light on the charge storage mechanism of several 2D Mo-based materials by various advanced characterization *** latest achievements in utilizing 2D Mo-based materials as electrode materials for various MIBs(including lithium-ion batteries(LIBs),sodium-ion batteries(SIBs)and zinc-ion batteries(ZIBs))are discussed in ***,the modulation strategies for enhancing the electrochemical performance of 2D Mo-based materials are highlighted,focusing on heteroatom doping,vacancies creation,composite coupling engineering and nanostructure ***,we present the existing challenges and future research directions for 2D Mo-based materials to realize high-performance energy storage systems.

关键词： Molybdenum-based materials Two-dimensional materials Lithium-ion batteries Sodium-ion batteries Zinc-ion batteries

Multiplayer Reach-Avoid Differential Games in 3D Space Inspired by Harris'Hawks'Cooperative Hunting Tactics

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Research 2024年第2期2023卷 41-54页

作者： Wanying ruan Haibin Duan Yongbin Sun Wanmai Yuan Jie Xia State Key Laboratory of Virtual Reality Technology and Systems School of Automation Science and Electrical EngineeringBeihang UniversityBeijingChina Peng Cheng Laboratory ShenzhenChina Information Science Academy of CETC BeijingChina

This paper investigates a multiplayer reach-avoid differential game in 3-dimensional(3D)space,which involves multiple pursuers,multiple evaders,and a designated target *** evaders aim to reach the target region,while the pursuers attempt to guard the target region by capturing the *** class of research holds significant practical ***,the complexity of the problem escalates substantially with the growing number of players,rendering its solution extremely *** this paper,the multiplayer game is divided into many subgames considering the cooperation among pursuers,reducing the computational burden,and obtaining numerically tractable strategies for ***,the Apollonius sphere,a fundamental geometric tool for analyzing the 3D differential game,is formulated,and its properties are *** on this,the optimal interception point for the pursuer to capture the evader is derived and the winning conditions for the pursuer and evader are ***,based on the Apollonius sphere,the optimal state feedback strategies of players are designed,and simultaneously,the optimal one-to-one pairings are ***,the Value function of the multiplayer reach-avoid differential game is explicitly given and is proved to satisfy Hamilton-Jacobi-Isaacs(HJI)***,the matching algorithm for the case with pursuers outnumbered evaders is provided through constructing a weighted bipartite graph,and the cooperative tactics for multiple pursuers are proposed,inspired by the Harris'Hawks intelligent cooperative hunting ***,numerical simulations are conducted to illustrate the effectiveness of the theoretical results for both cases where the number of adversary players is equal and unequal between the 2 groups.

关键词： holds satisfy rendering

A solution using only electromagnetic coils for relative pose control in satellite docking

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Chinese Journal of Aeronautics 2024年第3期37卷 258-281页

作者： Guangzheng ruan Lijian WU Bo WANG Yaobing WANG Runqi HAN College of Electrical Engineering Zhejiang UniversityHangzhou 310012China Beijing Institute of Spacecraft System Engineering Beijing 100094China

This paper proposes an electromagnetic coil topology and its control strategy,which can be incorporated into the electromagnetic docking device to achieve relative pose control in satellite *** target satellite has a main coil;the chaser satellite possesses a main coil of the same size accompanied by six and four evenly arranged secondary coils inside and outside the main coil,*** coil on the target satellite is DC energized,while the currents in the coils of the chaser satellite are *** remove the coupling between the pitch/yaw torque and translational force,the internal and external secondary coils of the chaser satellite interact with the main coil of the target satellite to perform the control of relative pitch/yaw and relative translation,respectively,so relative pose control can be *** torque and force vectors exerted by the secondary coils of the chaser satellite are synthesized onto the pitch and yaw axes of the body *** to their spatial composition relationship,the formulas are proposed,which obtain the magnetic moment vectors of the coils from the set torques and *** controllers regulating pitch/yaw,translation,and distance utilize a three-loop cascaded structure that consists of an outer position loop,a middle velocity loop and an inner current *** control strategy is verified by dynamics simulation.

关键词： Electromagnetic docking 6 degree of freedom Relative pose control Coil array Far field model Motion decoupling