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First-principles calculations of Ni–(Co)–Mn–Cu–Ti all-d-metal Heusler alloy on martensitic transformation,mechanical and magnetic properties

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International Journal of Minerals,Metallurgy and Materials 2023年第5期30卷 930-938页

作者： Huaxin Qi jing Bai Miao Jin jiaxin Xu Xin Liu Ziqi Guan Jianglong Gu Daoyong Cong Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China

The martensitic transformation,mechanical,and magnetic properties of the Ni_(2)Mn_(1.5-x)Cu_(x)Ti_(0.5) (x=0.125,0.25,0.375,0.5) and Ni_(2-y)Co_(y)Mn_(1.5-x)Cu_(x)Ti_(0.5)[(x=0.125,y=0.125,0.25,0.375,0.5) and (x=0.125,0.25,0.375,y=0.625)]alloys were systematically studied by the first-principles *** the formation energy,the martensite is smaller than the austenite,the Ni–(Co)–Mn–Cu–Ti alloys studied in this work can undergo martensitic *** austenite and non-modulated (NM) martensite always present antiferromagnetic state in the Ni_(2)Mn_(1.5-x)Cu_(x)Ti_(0.5) and Ni_(2-y)Co_(y)Mn_(1.5-x)Cu_(x)Ti_(0.5) (y<0.625) *** y=0.625 in the Ni_(2-y)Co_(y)Mn_(1.5-x)Cu_(x)Ti_(0.5) series,the austenite presents ferromagnetic state while the NM martensite shows antiferromagnetic *** doping can decrease the thermal hysteresis and anisotropy of the Ni–(Co)–Mn–Ti *** Mn and decreasing Ti content can improve the shear resistance and normal stress resistance,but reduce the toughness in the Ni–Mn–Cu–Ti *** the ductility of the Co–Cu co-doping alloy is inferior to that of the Ni–Mn–Cu–Ti and Ni–Co–Mn–Ti *** electronic density of states was studied to reveal the essence of the mechanical and magnetic properties.

关键词： Ni–Mn–Ti-based all-d-metal Heusler alloys first-principles calculations mechanical properties martensitic transformation magnetic properties

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奇穴“断红”治疗崩漏的研究概况

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中医药临床杂志 2021年第10期33卷 2035-2038页

作者：杨东霞吴慢莉申儒霞霍玉霞王宁景佳欣李红梅黑龙江中医药大学第二附属医院黑龙江哈尔滨150000 黑龙江中医药大学黑龙江哈尔滨150000

崩漏是一种妇科常见病,亦是疑难急症,正如徐春甫所言"妇女崩漏,最为大病",在治疗上应本着"急则治其标,缓则治其本"的基本原则。断红穴是止崩漏下血之要穴,有着急则治标的功效,是近代医家发现治疗崩漏的经验要穴。该研究以断红穴为核心,... 详细信息

崩漏是一种妇科常见病,亦是疑难急症,正如徐春甫所言"妇女崩漏,最为大病",在治疗上应本着"急则治其标,缓则治其本"的基本原则。断红穴是止崩漏下血之要穴,有着急则治标的功效,是近代医家发现治疗崩漏的经验要穴。该研究以断红穴为核心,综合近年来断红穴治疗妇科崩漏疾病的文献,从针刺、艾灸、针药结合等方面对断红穴治疗崩漏进行详细综述,最后指出其目前不足之处以及今后的研究方向。

关键词：断红穴崩漏针灸研究概况

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Effects of Milling Methods on Rice Flour Properties and Rice Product Quality:A Review

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Rice science 2024年第1期31卷 33-46页

作者： TIAN Yu SUN jing LI jiaxin WANG Aixia NIE Mengzi GONG Xue WANG Lili LIU Liya WANG Fengzhong TONG Litao Institute of Food Science and Technology/Western Research Institute Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products ProcessingMinistry of Agriculture and Rural AffairsBeijing 100193China

High-quality rice flour is the foundation for the production of various rice-based *** is an essential step in obtaining rice flour,during which significant changes occur in the physicochemical and quality characteristics of the *** rice flour obtained through mainstream wet milling methods exhibits superior quality,low production efficiency and wastewater discharge limit the development of the *** milling,on the other hand,conserves water resources,but adversely affects flour performance due to excessive heat *** an emerging powder-making technique,semi-dry milling offers a promising solution by enhancing flour quality and reducing environmental *** is achieved by minimizing soaking time through hot air treatment while reducing mechanical energy consumption to reach saturated water absorption ***,continuous production remains a *** comprehensive review summarizes the effects of various milling technologies on rice flour properties and product *** also discusses key control indicators and technical considerations for rice flour processing equipment and processes.

关键词： flour property milling equipment milling method rice flour rice product quality semi-dry milling

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Targeting small GTPases:emerging grasps on previously untamable *** by KRAS

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2856-2894页

作者： Guowei Yin jing Huang Johnny Petela Hongmei Jiang Yuetong Zhang Siqi Gong jiaxin Wu Bei Liu Jianyou Shi Yijun Gao The Seventh Affiliated Hospital of Sun Yat-sen University Shenzhen518107China State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou510060China Wake Forest University School of Medicine Winston-SalemNC27101USA School of Medicine Sun Yat-Sen UniversityShenzhen518107China National Biomedical Imaging Center School of Future TechnologyPeking UniversityBeijing100871China Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and TechnologyChengdu610072China

Small GTPases including Ras,Rho,Rab,Arf,and Ran are omnipresent molecular switches in regulating key cellular *** dysregulation is a therapeutic target for tumors,neurodegeneration,cardiomyopathies,and ***,small GTPases have been historically recognized as“undruggable”.Targeting KRAS,one of the most frequently mutated oncogenes,has only come into reality in the last decade due to the development of breakthrough strategies such as fragment-based screening,covalent ligands,macromolecule inhibitors,and *** KRAS^(G12C)covalent inhibitors have obtained accelerated approval for treating KRAS^(G12C)mutant lung cancer,and allele-specific hotspot mutations on G12D/S/R have been demonstrated as viable *** methods of targeting KRAS are quickly evolving,including transcription,immunogenic neoepitopes,and combinatory targeting with ***,the vast majority of small GTPases and hotspot mutations remain elusive,and clinical resistance to G12C inhibitors poses new *** this article,we summarize diversified biological functions,shared structural properties,and complex regulatory mechanisms of small GTPases and their relationships with human ***,we review the status of drug discovery for targeting small GTPases and the most recent strategic progress focused on targeting *** discovery of new regulatory mechanisms and development of targeting approaches will together promote drug discovery for small GTPases.

关键词： KRAS Targeting breakthrough

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Chimeric Newcastle Disease Virus-like Particles Containing DC-Binding Peptide-Fused Haemagglutinin Protect Chickens from Virulent Newcastle Disease Virus and H9N2 Avian Influenza Virus Challenge

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Virologica Sinica 2020年第4期35卷 455-467页

作者： Xiaohong Xu jing Qian Lingsong Qin Jindou Li Cong Xue jiaxin Ding Weiqi Wang Wei Ding Renfu Yin Ningyi Jin Zhuang Ding Laboratory of Infectious Diseases College of Veterinary MedicineKey Laboratory of Zoonosis ResearchMinistry of EducationJilin UniversityChangchun 130062China College of Basic Medical Science Jilin UniversityChangchun 130021China Institute of Veterinary Medicine Jiangsu Academy of Agricultural Sciences/Key Laboratory for Veterinary Bio-Product EngineeringMinistry of AgricultureNanjing 210014China College of Agriculture and Forestry Science Linyi UniversityLinyi 276000China

Newcastle disease virus(NDV)and H9N2 subtype Avian influenza virus(AIV)are two notorious avian respiratory pathogens that cause great losses in the poultry *** inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses,while an attenuated live vaccine bears the risk of *** cell(DC)targeting strategies are attractive for their potent mucosal and adaptive immune-stimulating ability against respiratory *** this study,DC-binding peptide(DCpep)-decorated chimeric virus-like particles(cVLPs),containing NDV haemagglutinin–neuraminidase(HN)and AIV haemagglutinin(HA),were developed as a DC-targeting mucosal vaccine ***-decorated cVLPs activated DCs in vitro,and induced potent immune stimulation in chickens,with enhanced secretory immunoglobulin A(sIgA)secretion and splenic T cell differentiation.40μg cVLPs can provide full protection against the challenge with homologous,heterologous NDV strains,and AIV *** addition,DCpep-decorated cVLPs could induce a better immune response when administered intranasally than intramuscularly,as indicated by robust s IgA secretion and a reduced virus shedding *** together,this chimericVLPs are a promising vaccine candidate to control NDV and AIV H9N2 and a useful platform bearing multivalent antigens.

关键词： Newcastle disease virus-like particles DC-binding peptide H9N2 Secretory immunoglobulin A(sIgA) Candidate vaccine

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Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis:a retrospective study

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Gastroenterology Report 2016年第4期4卷 315-319,I0003页

作者： jing Li Xingshun Qi Han Deng Ying Peng Lichun Shao jiaxin Ma Xiaolin Sun Hongyu Li Xiaozhong Guo Liver Cirrhosis Study Group Department of GastroenterologyGeneral Hospital of Shenyang Military AreaShenyangChina Postgraduate College Dalian Medical UniversityDalianChina Department of Gastroenterology No.463 Hospital of Chinese PLAShenyangChina

Objective:A retrospective study was performed to compare the difference in platelet count(PLT),prothrombin time(PT),international normalized ratio(INR),and activated partial thromboplastin time(APTT),between cirrhotic patients with and without acute upper gastrointestinal bleeding(AUGIB)or acute oesophageal variceal bleeding(AEVB).Methods:Between January 2012 and June 2014,a total of 1734 cirrhotic patients were enrolled and were classified into‘AUGIB’(n=497)and‘no AUGIB’(n=1237)groups according to their disease *** were further divided into‘AEVB’(n=297)and‘no AEVB’(n=1259)groups according to the endoscopic ***,178 patients with AUGIB were not assigned to either the‘AEVB’or‘no AEVB’groups due to the absence of any endoscopic ***:Compared with the‘no AUGIB’group,the‘AUGIB’group had similar PLT(99.99689.90 vs.101.47683.03;P=0.734)and APTT(42.96±15.20 vs.43.77611.01;P=0.219),but significantly higher PT(17.30±5.62 vs.16.03±64.68;P<0.001)and INR(1.45±0.69 vs.1.316±0.59;P<0.001).A lower PT was independently associated with the absence of AUGIB(OR=0.968;95%CI:0.942–0.994).Compared with the‘no AEVB’group,the‘AEVB’group had significantly lower PLT(86.87662.14 vs.101.74683.62;P=0.004)and APTT(40.98±67.9 vs.43.72±10.97;P<0.001),but similar PT(16.53±3.71 vs.16.04±4.68;P=0.088)and INR(1.35±0.41 vs.1.31±0.59;P=0.225).A higher PLT was independently associated with the absence of AEVB(OR=1.004;95%CI:1.002–1.006;P=0.001).Conclusions:PLT was associated with the occurrence of portal hypertension-related bleeding in liver cirrhosis.

关键词： coagulation bleeding liver cirrhosis platelets prothrombin

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Spatiotemporal heterogeneity of schistosomiasis in China's Mainland:Evidence from a multi-stage continuous downscaling sentinel monitoring

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Asian Pacific Journal of Tropical Medicine 2022年第1期15卷 26-34页

作者： Yanfeng Gong jiaxin Feng Zhuowei Luo jingbo Xue Zhaoyu Guo Lijuan Zhang Shang Xia Shan Lv jing Xu Shizhu Li National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghai 200025China Chinese Center for Tropical Diseases Research Shanghai 200025China NHC Key Laboratory of Parasite and Vector Biology Shanghai 200025China WHO Collaborating Centre for Tropical Diseases Shanghai 200025China National Center for International Research on Tropical Diseases Shanghai 200025China School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective:To determine the spatiotemporal distribution of Schistosoma(S.)japonicum infections in humans,livestock,and Oncomelania(O.)hupensis across the endemic foci of ***:Based on multi-stage continuous downscaling of sentinel monitoring,county-based schistosomiasis surveillance data were captured from the national schistosomiasis surveillance sites of China from 2005 to *** data included *** infections in humans,livestock,and *** spatiotemporal trends for schistosomiasis were detected using a Joinpoint regression model,with a standard deviational ellipse(SDE)tool,which determined the central tendency and dispersion in the spatial distribution of ***,more spatiotemporal clusters of *** infections in humans,livestock,and *** were evaluated by the Poisson ***:The prevalence of *** human infections decreased from 2.06%to zero based on data of the national schistosomiasis surveillance sites of China from 2005 to 2019,with a reduction from 9.42%to zero for the prevalence of *** infections in livestock,and from 0.26%to zero for the prevalence of *** infections in *** using an SDE tool showed that schistosomiasis-affected regions were reduced yearly from 2005 to 2014 in the endemic provinces of Hunan,Hubei,Jiangxi,and Anhui,as well as in the Poyang and Dongting Lake *** model revealed 11 clusters of *** human infections,six clusters of *** infections in livestock,and nine clusters of *** infections in *** clusters of human infection were highly consistent with clusters of *** infections in livestock and *** were in the 5 provinces of Hunan,Hubei,Jiangxi,Anhui,and Jiangsu,as well as along the middle and lower reaches of the Yangtze ***,livestock,and *** infections with *** were mainly concentrated in the north of the Hunan Province,south of the Hubei Province,north

关键词： Schistosomiasis Sentinel surveillance Spatiotemporal heterogeneity China

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从湿热瘀治疗子宫内膜异位症研究进展

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中医药学报 2021年第7期49卷 116-120页

作者：杨东霞王宁霍玉霞申儒霞景佳欣吴慢莉李红梅马宝璋黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001 黑龙江中医药大学附属第一医院黑龙江哈尔滨150040

子宫内膜异位症是临床常见妇科疾病之一,中医理论中将其归于“痛经”“月经不调”“癥瘕”“不孕”等病症。其根本病机为“瘀血阻滞冲任、胞宫”,多由感受外邪、内伤情志、劳逸失调、饮食不节等原因所致,主要证型有肾虚血瘀、寒凝血瘀... 详细信息

子宫内膜异位症是临床常见妇科疾病之一,中医理论中将其归于“痛经”“月经不调”“癥瘕”“不孕”等病症。其根本病机为“瘀血阻滞冲任、胞宫”,多由感受外邪、内伤情志、劳逸失调、饮食不节等原因所致,主要证型有肾虚血瘀、寒凝血瘀、气滞血瘀、气虚血瘀、痰凝血瘀、湿热瘀阻等。结合临床发现由湿热蕴结致病为数甚多,湿热相缠导致病情日久难愈、反复发作。在内异症的治疗中,中医通过口服中药及中药灌肠、中药塌渍、针刺治疗等外治法展现了其独到的优势,并取得良好临床效果。

关键词：子宫内膜异位症中医病机湿热瘀结

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Human milk phospholipid substitutes improve mice’s cognitive behavior and brain lipid profile

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Food Science and Human Wellness 2024年

作者： Teng Wei Yanping Wu jiaxin Shen Manman Zhang Yong Sun Zeyuan Deng jing Li State Key Laboratory of Food Science and Technology， Nanchang University College of Food Science and Engineering， Jiangxi Agricultural University International Institute of Food Innovation， Nanchang University National Center of Technology Innovation for Dairy

Although human milk fat substitute (HMFS) has been wildly applied in infant formula (IF)， there are still some differences in fat composition between human milk and IF， which is extremely attributed to the phospholipid composition. We therefore designed a human milk phospholipid substitute (HMPS)， and investigated its nutritional outcomes on brain development using C57BL/6J mice. Results showed that HMPS improved mice’s cognitive behavior and dendritic development compared to soybean phospholipids (SPL) and no-phospholipid diets. Based on the lipidomics， we revealed that these beneficial outcomes were potentially associated with the increased biosynthesis of N-acylethanolamines (NAE)， phosphatidylethanolamine (PE)， and Ether PE， and the decreased metabolism of diacylglycerol (DG) and hexosylceramide (HexCer) in brain. It was further found in KEGG analysis that glycerophospholipid metabolic pathway participated in the improvement of HMPS on mice’s neurodevelopment. In conclusion， this study demonstrated that HMPS improves mice’s neurodevelopment， and the glycerophospholipid metabolic pathway plays a major role in this beneficial result， and provided evidence for future application of HMPS in commercial IF.

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数据驱动的智库知识服务流程优化

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图书情报知识 2021年第4期38卷 114-124页

作者：申静杨家鑫北京大学信息管理系北京100871

[目的/意义]将数据驱动思想应用于智库的知识服务实践,优化智库的知识服务流程,提高智库的工作效率和服务水平。[研究设计/方法]结合文献回顾和网络调研分析智库知识服务流程及具体环节;针对存在的问题,引入大数据思维和大数据分析技术... 详细信息

[目的/意义]将数据驱动思想应用于智库的知识服务实践,优化智库的知识服务流程,提高智库的工作效率和服务水平。[研究设计/方法]结合文献回顾和网络调研分析智库知识服务流程及具体环节;针对存在的问题,引入大数据思维和大数据分析技术,采用标杆分析法对智库知识服务的具体环节进行优化,提出数据驱动的智库知识服务流程优化框架,并分析该框架应用的最佳实践。[结论/发现]服务流程优化后的智库可以同时开展数据驱动的精准型知识服务、主动型知识服务和客户自主型知识服务,这三类知识服务不仅可以提高智库的工作效率和服务水平,还能更好满足客户了解社会热点、应急决策和创新服务等多样化知识服务需求。[创新/价值]运用数据驱动思想,基于用户需求,引入大数据思维和大数据分析技术对智库的知识服务流程进行了系统优化,为大数据时代的智库知识服务实现数字化转型提供了参考。

关键词：智库知识服务流程优化数据驱动大数据分析

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