Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis:a retrospective study

作     者：Jing Li Xingshun Qi Han Deng Ying Peng Lichun Shao Jiaxin Ma Xiaolin Sun Hongyu Li Xiaozhong Guo 

作者机构：Liver Cirrhosis Study GroupDepartment of GastroenterologyGeneral Hospital of Shenyang Military AreaShenyangChina Postgraduate CollegeDalian Medical UniversityDalianChina Department of GastroenterologyNo.463 Hospital of Chinese PLAShenyangChina 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2016年第4卷第4期

页      面：315-319,I0003页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was partially supported by the grant from the National Natural Science Foundation of China(no.81500474) Natural Science Foundation of Liaoning Province(no.2015020409) 

主　　题：coagulation bleeding liver cirrhosis platelets prothrombin 

摘      要：Objective:A retrospective study was performed to compare the difference in platelet count(PLT),prothrombin time(PT),international normalized ratio(INR),and activated partial thromboplastin time(APTT),between cirrhotic patients with and without acute upper gastrointestinal bleeding(AUGIB)or acute oesophageal variceal bleeding(AEVB).Methods:Between January 2012 and June 2014,a total of 1734 cirrhotic patients were enrolled and were classified into‘AUGIB’(n=497)and‘no AUGIB’(n=1237)groups according to their disease *** were further divided into‘AEVB’(n=297)and‘no AEVB’(n=1259)groups according to the endoscopic ***,178 patients with AUGIB were not assigned to either the‘AEVB’or‘no AEVB’groups due to the absence of any endoscopic ***:Compared with the‘no AUGIB’group,the‘AUGIB’group had similar PLT(99.99689.90 vs.101.47683.03;P=0.734)and APTT(42.96±15.20 vs.43.77611.01;P=0.219),but significantly higher PT(17.30±5.62 vs.16.03±64.68;P0.001)and INR(1.45±0.69 vs.1.316±0.59;P0.001).A lower PT was independently associated with the absence of AUGIB(OR=0.968;95%CI:0.942–0.994).Compared with the‘no AEVB’group,the‘AEVB’group had significantly lower PLT(86.87662.14 vs.101.74683.62;P=0.004)and APTT(40.98±67.9 vs.43.72±10.97;P0.001),but similar PT(16.53±3.71 vs.16.04±4.68;P=0.088)and INR(1.35±0.41 vs.1.31±0.59;P=0.225).A higher PLT was independently associated with the absence of AEVB(OR=1.004;95%CI:1.002–1.006;P=0.001).Conclusions:PLT was associated with the occurrence of portal hypertension-related bleeding in liver cirrhosis.