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Environment and COVID-19 incidence: A critical review

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Journal of Environmental Sciences 2023年第2期124卷 933-951页

作者： jiatong han Jie Yin Xiaoxu Wu Danyang Wang Chenlu Li State Key Laboratory of Remote Sensing Science College of Global Change and Earth System ScienceBeijing Normal UniversityBeijing 100875China

The coronavirus disease 2019(COVID-19)pandemic is an unprecedented worldwide health crisis.Many previous research studies have found and investigated its links with one or some natural or human environmental factors.However,a review on the relationship between COVID-19 incidence and both the natural and human environment is still lacking.This review summarizes the inter-correlation between COVID-19 incidence and environmental factors.Based on keyword searching,we reviewed 100 relevant peer-reviewed articles and other research literature published since January 2020.This review is focused on three main findings.One,we found that individual environmental factors have impacts on COVID-19 incidence,but with spatial heterogeneity and uncertainty.Two,environmental factors exert interactive effects on COVID-19 incidence.In particular,the interactions of natural factors can affect COVID-19 transmission in micro-and macro-ways by impacting SARS-CoV-2 survival,as well as human mobility and behaviors.Three,the impact of COVID-19 incidence on the environment lies in the fact that COVID-19-induced lockdowns caused air quality improvement,wildlife shifts and socio-economic depression.The additional value of this review is that we recommend future research perspectives and adaptation strategies regarding the interactions of the environment and COVID-19.Future research should be extended to cover both the effects of the environment on the COVID-19 pandemic and COVID-19-induced impacts on the environment.Future adaptation strategies should focus on sustainable environmental and public policy responses.

关键词： COVID-19 Natural environment Human environment Interaction

Untargeted and targeted mass spectrometry reveal the effects of theanine on the central and peripheral metabolomics of chronic unpredictable mild stress-induced depression in juvenile rats

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Journal of Pharmaceutical Analysis 2023年第1期13卷 73-87页

作者： Yanru Zhu Feng Wang jiatong han Yunli Zhao Miao Yu Mingyan Ma Zhiguo Yu Laboratory of Pharmaceutical Analysis School of PharmacyZhejiang Pharmaceutical UniversityNingboZhejiang315100China Laboratory of Pharmaceutical Analysis School of PharmacyShenyang Pharmaceutical UniversityShenyang110016China

L-theanine has been shown to have a therapeutic effect on depression.However,whether L-theanine has an excellent preventive effect on depression in children and adolescents and what its mechanism is have not been well explained.Given the complexity of the pathogenesis of depression,this study investigated the preventive effect and mechanism of L-theanine on depression in juvenile rats by combining serum and hippocampal metabolomic strategies.Behavioral tests,hippocampal tissue sections,and serum and hippocampal biochemical indexes were studied,and the results confirmed the preventive effect of Ltheanine.Untargeted reversed-phase liquid chromatography-quadrupole-time-of-flight mass spectrometry and targeted hydrophilic interaction liquid chromatography-triple quadrupole mass spectrometry were developed to analyze the metabolism changes in the serum and hippocampus to screen for potential biomarkers related to L-theanine treatment.The results suggested that 28 abnormal metabolites in the serum and hippocampus that were considered as potential biomarkers returned to nearnormal levels after L-theanine administration.These biomarkers were involved in various metabolic pathways,mainly including amino acid metabolism and lipid metabolism.The levels of amino acids and neurotransmitters in the phenylalanine,tryptophan,and glutamic acid pathways were significantly reduced after L-theanine administration compared with chronic unpredictable mild stress-induced rats.In summary,L-theanine had a significant preventive effect on depression and achieved its preventive results on depression by regulating various aspects of the body,such as amino acids,lipids,and inflammation.This research systematically analyzed the mechanism of L-theanine in preventing depression and laid the foundation for applying L-theanine to prevent depression in children and adolescents.

关键词： L-theanine Depression Metabolomics Liquid chromatography-mass spectrometry

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《灵枢经》中转喻的临床叙事功能

中国中医基础医学杂志 2024年第3期30卷 468-471页

作者：韩佳桐王昊杨秋莉中国中医科学院中医临床基础医学研究所北京100700

《灵枢经》是中医学理论原典,其著述年代的语言特征与当今差别大,常出现理解歧义。本文试通过认知语言学转喻原则分析语词转喻的叙事目的,突出语言的临床启示意义。本文归纳《灵枢经》中常用的转喻代指关系、阐释转喻的临床叙事功能,发... 详细信息

《灵枢经》是中医学理论原典,其著述年代的语言特征与当今差别大,常出现理解歧义。本文试通过认知语言学转喻原则分析语词转喻的叙事目的,突出语言的临床启示意义。本文归纳《灵枢经》中常用的转喻代指关系、阐释转喻的临床叙事功能,发现《灵枢经》中转喻在体质、病机、治则治法的论述中均见运用,重点在于展现生理、病理之“象”内部和“象”之间的相互关系,为象思维的临床应用提供实例。《灵枢经》中转喻是用于说明临证思想的叙事行为,承担了提取生病理本质特征、连贯诊治路径、整合临床理论体系的重要叙事功能,对后世医籍产生了广泛的叙事影响。

关键词：《灵枢经》转喻叙事

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中国组织工程研究 2025年第2期29卷 279-285页

作者：侯成志韩佳童魏光成卓泽川李秋月赵勇俞张镜泽中国中医科学院望京医院北京市100102

背景:已有研究表明,骨疏康通过调节核苷酸、氨基酸代谢和免疫机制影响骨骼代谢,目前骨疏康治疗骨质疏松症的机制研究主要聚焦于调控成骨细胞,对破骨细胞的关注较少。目的:以RAW 264.7细胞为实验对象,从破骨细胞角度探讨骨疏康治疗骨质... 详细信息

背景:已有研究表明,骨疏康通过调节核苷酸、氨基酸代谢和免疫机制影响骨骼代谢,目前骨疏康治疗骨质疏松症的机制研究主要聚焦于调控成骨细胞,对破骨细胞的关注较少。目的:以RAW 264.7细胞为实验对象,从破骨细胞角度探讨骨疏康治疗骨质疏松症的机制。方法:取8周龄雌性SD大鼠24只,采用随机数字表法分为4组(n=6),3个实验组分别灌胃给予1,2,4 g/kg的骨疏康药液(2次/d),对照组灌胃给予等量蒸馏水(2次/d),连续灌胃7 d后抽取大鼠主动脉血,离心收集血清,同组血清合并,获得低、中、高浓度的骨疏康含药血清及正常血清,进行后续实验。①将RAW 264.7细胞分6组培养:对照组加入正常血清,低、中、高浓度组分别加入低、中、高浓度的骨疏康含药血清,Nrf2抑制剂组加入核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)抑制剂ML385,Nrf2激活剂组加入Nrf2激活剂t-BHQ,采用CCK8法检测细胞相对活性。②将第3代RAW 264.7细胞分5组培养:空白对照组加入正常血清,破骨组加入核因子κB受体活化因子配体(receptor activator of nuclear factorκB ligand,RANKL),低、中、高浓度组在加入RANKL的基础上分别加入低、中、高浓度的骨疏康含药血清,培养5 d后进行抗酒石酸酸性磷酸染色。③将RAW 264.7细胞分5组培养:空白对照组加入正常血清,破骨组加入正常血清与RANKL,高浓度+破骨组加入RANKL+高浓度骨疏康含药血清,破骨+Nrf2激动剂组加入RANKL+t-BHQ,高浓度+破骨+Nrf2抑制剂组加入RANKL+高浓度骨疏康含药血清+ML385,培养5 d后进行Western Blot与活性氧含量检测。结果与结论:①CCK8检测结果显示,骨疏康含药血清及Nrf2抑制剂、激动剂对RAW 264.7细胞活力无明显影响;②抗酒石酸酸性磷酸染色结果显示,骨疏康含药血清呈浓度依赖性抑制破骨细胞的分化;③Western Blot与活性氧含量检测结果显示,与空白对照组比较,破骨组Nrf2蛋白表达降低(P<0.05),c-Fos、NFATc1蛋白表达与活性氧含量升高(P<0.05);与破骨组比较,高浓度+破骨组、破骨+Nrf2激动剂组、高浓度+破骨+Nrf2抑制剂组Nrf2蛋白表达升高、活性氧含量降低(P<0.05),高浓度+破骨组、破骨+Nrf2激动剂组c-Fos、NFATc1蛋白表达降低(P<0.05);与高浓度+破骨组比较,高浓度+破骨+Nrf2抑制剂组Nrf2蛋白表达降低(P<0.05),活性氧含量升高(P<0.05);④结果表明,骨疏康通过激活Nrf2减少活性氧生成,进而抑制下游c-Fos/NFATc1通路表达和破骨细胞分化。

关键词：骨质疏松症骨疏康含药血清破骨细胞 Nrf2 c-Fos/NFATc1通路 RAW 264.7细胞

Combined effects of sea urchin-like structure and mixed Cu^(+)/Cu^(0)states on promoting C_(2)formation in electrocatalytic CO_(2)reduction

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 63-73页

作者： Mengqing Shan Dongsheng Lu jiatong Dong Shen Yan Jinyu han Hua Wang Collaborative Innovation Center of Chemical Science and Engineering Key Laboratory for Green Chemical Technology of the Ministry of EducationSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300354China

Surface engineering and Cu valence regulation are essential factors in improving the C_(2)selectivity during the electrochemical reduction of CO_(2).Herein,we present a sea urchin-like CuO/Cu_(2)O catalyst derived from rhombic dodecahedra Cu_(2)O through one-step oxidation/etching method where the mixed Cu^(+)/Cu^(0)states are formed via in situ reduction during electrocatalysis.The combined effects of the morphology and the mixed Cu^(+)/Cu^(0)states on C–C coupling are evaluated by the Faradaic efficiency of C_(2)and the C_(2)/C1 ratio obtained in an H-cell.R-Cu^(O)/Cu_(2)O exhibited 49.5%Faradaic efficiency of C_(2)with a C_(2)/C1 ratio of 3.1 at−1.4 V vs.reversible hydrogen electrode,which are 1.5 and 3.2 times higher than those of R-Cu_(2)O,respectively.Using a flow-cell,68.0%Faradaic efficiency of C_(2)is achieved at a current density of 500 mA·cm^(−2).The formation of the mixed Cu^(+)/Cu^(0)states was confirmed by in situ Raman spectra.Additionally,the sea urchin-like structure provides more active sites and enables faster electron transfer.As a result,the excellent C_(2)production on R-CuO/Cu_(2)O is primarily attributed to the synergistic effects of the sea urchin-like structure and the stable mixed Cu^(+)/Cu^(0)states.Therefore,this work presents an integrated strategy for developing Cu-based electrocatalysts for C_(2)production through electrochemical CO_(2)reduction.

关键词： CO_(2)electrolysis sea urchin-like structure Cu^(+)/Cu^(0) C_(2)products

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加味醒酒汤解酒作用的研究

沈阳药科大学学报 2024年第2期41卷 149-153页

作者：乔龙梅韩佳彤任航康瑞娟王睿于治国赵云丽沈阳药科大学药学院

目的研究加味醒酒汤对醉酒小鼠的解酒作用。方法根据建立的小鼠醉酒模型,通过测定小鼠醉酒潜伏期与醒酒时间,确定加味醒酒汤的最佳工艺;通过测定小鼠血液乙醇浓度的含量及肝脏乙醇代谢酶的活性来观察加味醒酒汤的解酒效果。结果加味醒... 详细信息

目的研究加味醒酒汤对醉酒小鼠的解酒作用。方法根据建立的小鼠醉酒模型,通过测定小鼠醉酒潜伏期与醒酒时间,确定加味醒酒汤的最佳工艺;通过测定小鼠血液乙醇浓度的含量及肝脏乙醇代谢酶的活性来观察加味醒酒汤的解酒效果。结果加味醒酒汤能够增加小鼠对酒精的耐受时间,同时缩短小鼠的醒酒时间,降低血液中的乙醇浓度,提高肝脏中ADH、ALDH与GSH-Px的活性。结论加味醒酒汤对醉酒小鼠具有解酒作用,其机制可能与提高乙醇代谢酶的活性有关。

关键词：枳椇子解酒乙醇浓度醉酒时间醒酒时间

Research on Marketing Strategies of Pinduoduo Based on SWOT Analysis

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Psychology Research 2023年第3期13卷 155-159页

作者： FU Zishan han jiatong Qingdao No.1 International School of Shandong Province QingdaoChina Nanjing University of Aeronautics and Astronautics NanjingChina

The development of the Internet has led to a dramatic increase in online shopping users.E-commerce enterprises have been rising and becoming very successful in China in recent years.As an e-commerce platform established in 2015 and going public in 2018,Pinduoduo has become one of the three biggest e-commerce in China in a short period of time.This attract many people’s attention,which drives people to explore the reason behind it.SWOT analysis is a model that enables us to analyze the strengths,weaknesses,opportunities,and threats of an enterprise.In this study,we use SWOT analysis model to analyze the marketing strategy of Pinduoduo,summarize the current status of Pinduoduo,and give some suggestion for itself and the other e-commerce platforms.

关键词： Pinduoduo SWOT analysis e-commerce marketing strategies

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碳市场与有色金属期货市场时变溢出效应研究

工业技术经济 2022年第7期41卷 113-123页

作者：韩佳彤江彦博天津财经大学金融学院天津300222

碳市场与有色金属市场关系密切,但对两类市场间风险溢出效应的强度和方向研究较少。本文通过Paasche指数方法构建了国内碳市场统一价格指数,采用TVP-VAR模型对EUA期货市场、国内碳交易市场以及有色金属期货市场的时变溢出效应进行了研究... 详细信息

碳市场与有色金属市场关系密切,但对两类市场间风险溢出效应的强度和方向研究较少。本文通过Paasche指数方法构建了国内碳市场统一价格指数,采用TVP-VAR模型对EUA期货市场、国内碳交易市场以及有色金属期货市场的时变溢出效应进行了研究,并进一步利用基于TVP-VAR模型的时变波动溢出指数研究了三者之间的风险溢出强度和方向。实证研究发现:碳市场和有色金属期货市场之间溢出效应的强度和方向具有时变和非对称的特征。碳市场和有色金属期货市场之间的时变溢出效应在滞后1期最为显著,但随着时间的推移,溢出效应逐渐减弱。相比于国内碳交易市场,EUA期货市场是有色金属期货市场风险波动的主要来源。研究结果对投资者规避投资风险、相关企业发展以及决策部门实施有效政策具有积极意义。同时,也有助于完善国内碳交易市场,以实现国内低碳经济转型。

关键词：碳交易市场有色金属 TVP-VAR模型波动溢出指数投资风险低碳经济

中小板主板合并对中小板股票收益率的影响分析

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金融经济学研究 2022年第6期37卷 113-126页

作者：熊熊刘诗萌高雅韩佳彤天津大学管理与经济学部天津300072 大连理工大学经济管理学院辽宁大连116024 天津财经大学金融学院天津300222

中小板和主板合并是中国资本市场改革的重要举措,对于优化中国资本市场结构具有重要意义。运用事件研究法对证监会批准两板合并和两板正式合并对中小板企业股票收益率的影响进行分析,结果表明,两次事件都在短期内对中小板企业产生显著影... 详细信息

中小板和主板合并是中国资本市场改革的重要举措,对于优化中国资本市场结构具有重要意义。运用事件研究法对证监会批准两板合并和两板正式合并对中小板企业股票收益率的影响进行分析,结果表明,两次事件都在短期内对中小板企业产生显著影响,使股票收益率先降后升,这种影响主要是由投资者情绪、关注等行为因素导致的。进一步分析发现,不同特征的中小板企业受到两板合并的影响存在差异。从微观层面验证两板合并政策实施后的板块优化效应,有助于进一步完善多层次资本市场建设。

关键词：两板合并股票收益率事件研究投资者情绪