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LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein

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Science China(Life Sciences) 2022年第1期65卷 129-141页

作者： Siyuan Yang Weizhi Xu Cheng Liu jiaqi Jin Xueying Li Yuhan Jiang lei Zhang Xianbin Meng Jun Zhan Hongquan Zhang Department of Human Anatomy Histology and EmbryologyMOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China MOE Key Laboratory of Bioinformatics School of Life SciencesTsinghua UniversityBeijing 100084China

Large tumor suppressor 1(LATS1)is the key kinase controlling activation of Hippo signalling ***-translational modifications of LATS1 modulate its kinase ***,detailed mechanism underlying LATS1 stability and activation remains *** we report that LATS1 is acetylated by acetyltransferase CBP at K751 and is deacetylated by deacetylases SIRT3 and *** at K751 stabilized LATS1 by decreasing LATS1 ubiquitination and inhibited LATS1 activation by reducing its ***,LATS1 acetylation resulted in inhibition of YAP phosphorylation and degradation,leading to increased YAP nucleus translocation and promoted target gene ***,LATS1-K751 Q,the acetylation mimic mutant potentiated lung cancer cell migration,invasion and tumor growth,whereas LATS1-K751 R,the acetylation deficient mutant inhibited these *** together,we demonstrated a previously unidentified post-translational modification of LATS1 that converts LATS1 from a tumor suppressor to a tumor promoter by suppression of Hippo signalling through acetylation of LATS1.

关键词： LATS1 acetylation LATS1 activation and inhibition Hippo signalling pathway lung adenocarcinoma

Anlotinib-induced sick sinus syndrome:Two case reports

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World Journal of Clinical Cases 2025年第6期13卷 30-34页

作者： Cheng-Feng Fu Li-Fen Yang lei Tian Song Deng Qi Zhang Biao Yao Department of Oncology Tongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of Oncology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.

关键词： Lung cancer Anlotinib Sick sinus syndrome Cardiac pacemaker Adverse drug reaction Case report

In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition

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Chinese Chemical Letters 2020年第12期31卷 3107-3112页

作者： Ziming Chen Kuo Zhang jiaqi Fan Yu Fan Chao Yang Wen Tian Yuan Li Wenliang Li Jingping Zhang Hao Wang lei Wang Faculty of Chemistry Northeast Normal UniversityChangchun 130024China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid *** an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of *** designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and *** formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of *** vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy.

关键词： Self-assembly Integrinαvβ3 Peptide Anti-angiogenesis Tumor

Dative B–N bonds weaven toward two-dimensional purely organic materials for single crystals

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Science China Chemistry 2025年第1期 12-14页

作者： Wei-lei Zhou Siwei Wang Yong Chen College of Chemistry and Materials Science Inner Mongolia Key Laboratory of Chemistry for Nature Products and Synthesis for Functional Molecules Innovation Team of Optical Functional Molecular Devices Inner Mongolia Minzu University College of Chemistry Nankai University

Molecular topology is one of the important topics to study and understand the relationship between molecular structure and properties [1]. Particularly, two-dimensional (2D) materials with extremely high surface area and ultra-thin morphology have attracted considerable attention due to their unexpected properties in materials and chemistry [2,3].

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磁性纳米材料与磁场效应加速骨损伤修复

中国组织工程研究 2025年第4期29卷 827-838页

作者：肖放黄雷王琳华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心湖北省武汉市430022 华中科技大学同济医学院附属协和医院检验科湖北省武汉市430022

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进... 详细信息

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进展。方法:在PubMed和Web of Science数据库中进行相关文献检索,检索词为“magnetic nanomaterials,magnetic field,bone repair,bone tissue engineering,stem cell,osteoblast,osteoclast”。检索文献时限为2003-2023年,将其进行筛选和分析,最终纳入98篇文献进行分析。结果与结论:①磁性纳米材料具有促成骨细胞分化、抑制破骨细胞形成和调节免疫微环境等生物效应;此外,磁性纳米材料可调节组织工程支架的机械性能和表面形貌等理化性质,并赋予其磁性,有利于调控干细胞的黏附、增殖与成骨分化。②磁场具有调控细胞内多条信号通路发挥促成骨细胞分化、抑制破骨细胞形成和刺激血管生成等生物学效应,从而加速损伤的骨组织愈合。③磁性纳米材料与磁场的联合应用,通过激活机械转导、增加细胞内磁性纳米粒子含量、增强微磁场效应等加速骨损伤修复,为骨组织工程的研究提供了新的思路。④磁场在临床骨折、骨质疏松症和骨关节炎疾病的治疗中展现出确切疗效,促进骨组织生长、减轻骨质流失和缓解疼痛,改善患者的生活质量。⑤磁性纳米材料与磁场在骨损伤修复与再生中应用潜力大,但磁性纳米材料、磁场和细胞之间的相互作用机制尚未完全阐明,而且磁场调控细胞内分子事件的关键参数,包括磁场类型、强度、频率、作用时间和作用方式等,以及特定磁场对骨细胞的精确生物效应和潜在机制仍有待明确。⑥未来需要进一步关注其对损伤组织微环境中的破骨细胞、神经、血管和免疫细胞的影响,而关于磁性材料用于人体安全性问题,有待系统性研究其分布、代谢以及急性和慢性毒性等。

关键词：磁性纳米材料磁场骨修复骨组织工程干细胞成骨细胞破骨细胞

Legionella pneumophila temporally regulates the activity of ADP/ATP translocases by reversible ADP-ribosylation

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mLife 2022年第1期1卷 51-65页

作者： jiaqi Fu Pengwei Li Hongxin Guan Dan Huang lei Song Songying Ouyang Zhao-Qing Luo Department of Biological Sciences Purdue Institute for InflammationImmunology and Infectious DiseasePurdue UniversityWest LafayetteIndianaUSA Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation The Key Laboratory of Innate Immune Biology of Fujian ProvinceBiomedical Research Center of South ChinaKey Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of EducationCollege of Life SciencesFujian Normal UniversityFuzhouChina Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education State Key Laboratory of Zoonotic DiseasesDepartment of Respiratory MedicineCenter for Pathogen Biology and Infectious DiseasesThe First Hospital of Jilin UniversityChangchunChina

The mitochondrion is an important signaling hub that governs diverse cellular functions,including metabolism,energy production,and *** the hundreds of effectors translocated into host cells by the Dot/Icm system of Legionella pneumophila,several are targeted to mitochondria but the function of most of them remains *** recent study found that the effector Ceg3 inhibits the activity of ADP/ATP translocases(ANTs)by ADP-ribosylation(ADPR).Here,we show that the effect of Ceg3 is antagonized by Larg1,an effector encoded by lpg0081,a gene that is situated next to ***1 functions to reverse Ceg3-mediated ADPR of ANTs by cleaving the N-glycosidic bond between the ADPR moiety and the modified arginine residues in ANTs,leading to restoration of their activity in ADP/ATP *** analysis of Larg1 and its complex with ADPR reveals that this ADPR glycohydrolase harbors a unique macrodomain that catalyzes the removal of ADPR modification on *** results also demonstrate that together with Ceg3,Larg1 imposes temporal regulation of the activity of ANTs by reversible ADPR during *** infection.

关键词： energy metabolism metaeffector mitochondria type IV secretion

Antibacterial properties of extracts of Solidago canadensis and their potential use as dietary supplements in red swamp crayfish(Procambarus clarkii)

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Frontiers of Agricultural Science and Engineering 2015年第4期2卷 327-334页

作者： Manhong YE lei ZHANG jiaqi GE Haifeng SUN Jingjing NI Shengmei YANG Wanhong WEI College of Bioscience and Biotechnology Yangzhou UniversityYangzhou 225000China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou UniversityYangzhou 225000China

Canadian goldenrod(Solidago canadensis)is one of the most destructive invasive weeds in Southeastern *** evaluate its potential application as dietary supplement in red swamp crayfish(Procambarus clarkii),the antibacterial properties of aqueous and ethanol extracts of this plant against three major pathogenic bacteria in crayfish aquaculture were *** zone tests and determination of minimum inhibitory concentration revealed that the extracts had lower antibacterial activity than extracts from two traditional medicinal plants that possess antibacterial properties,garlic(Allium sativum)and cortex phellodendri(Phellodendron chinense).However,they did exhibit greater antibacterial effects than extracts from another widely used medicinal plant,Sophora flavescens,and an aquatic weed,Alternanthera *** extracts of Canadian goldenrod gave greater inhibition than the ethanol *** fed a diet with 2%these aqueous extracts exhibited significantly higher enzyme activity of alkaline phosphatase,catalase and phenoloxidase(P<0.05).Based on the results of this study,we conclude that aqueous extracts of Canadian goldenrod are highly promising for the development of new dietary supplement for use in crayfish aquaculture.

关键词： antibacterial activity Canadian goldenrod antioxidant enzyme crayfish

Work Function Optimization Technology of Indium Tin Oxide Films

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Journal of Harbin Institute of Technology(New Series) 2021年第4期28卷 33-39页

作者： Bo Zhang Zhibo Zhang Xintao Guo Ya’nan Yang Ying Liu lei Yang jiaqi Zhu Department of Materials Research AVIC Manufacturing Technology InstituteBeijing 100024China National Key Laboratory of Science and Technology on Advanced Composite in Special Environments Harbin Institute of TechnologyHarbin 150001China Center of Analysis and Measurement Harbin Institute of TechnologyHarbin 150001China

Indium tin oxide(In_(2)O_(3)∶Sn)film is one of the most potential materials in the field of semiconductor ***,untreated In2O3∶Sn film has a low work function which can result in a high energy barrier that hinders the passage of carriers through the interface,thus leading to poor overall performance of directly prepared *** this study,crystalline transparent conductive In_(2)O_(3)∶Sn films were prepared by plasma exposure assisted magnetron sputtering under room *** on multiple testing methods,it can be found that the low temperature crystallization characteristics of In_(2)O_(3)∶Sn film were enhanced and the work function was effectively improved after Ar^(+)plasma *** increase of the work function of In_(2)O_(3)∶Sn film was due to the increment of Sn⁃O bond on the surface brought by the transition from low oxidation state Sn^(2+)to high oxidation state Sn^(4+)under the action of high exposure.

关键词： work function indium tin oxide low temperature crystallization plasma exposure

Multi-color mechano-luminescence of LaGaO_(3):Sm^(3+),Tb^(3+) via trap sharing for anti-counterfeiting and encryption

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Journal of Rare Earths 2023年第12期41卷 1869-1875,I0002页

作者： Ziyang Li Yajing Yan Ting Wang Shaoqing Wang Longchao Guo Wei Feng lei Zhao Ziqi Wang Feng Zhao jiaqi Chen Zhanhui Zhang Xuhui Xu Xue Yu School of Mechanical Engineering Institute for Advanced MaterialsChengdu UniversityChengdu610106China Clinical Medical College&Affiliated Hospital of Chengdu University Chengdu610106China College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu610059China College of Materials Science and Engineering Baoji University of Arts and SciencesBaoji721013China Key Laboratory of Plasma Chemistry and Advanced Materials of Hubei Province Wuhan Institute of TechnologyWuhan430205China College of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China

Mechano-luminescence(ML) has been found diverse applications such as stress sensing,3-D signature,energy harvesting,and anti-counterfeiting,due to the unique properties of the corresponding ML phosphors performing in-situ and real-time response to mechanical ***-controlled ML materials realize reproducible,quantitative mechano-optical conversion resulting from the released carriers for the trap-mediated charge storage and ***,modulating traps matters the controllable ML behavior for their promising *** this work,a deep trap distributed ranging from 0.9 to 1,3 eV is realized consecutively for the introduction of Sm^(3+)ions into LaGaO_(3) matrix,which contributes to the red emission at 600 nm under mechanical ***,tunable ML emission modulated from 600to 545 nm is successfully achieved for the codopant of Tb^(3+)*** is unambiguously indicated that the released carriers from the trap sharing rather than an additional constructed trap contribute to the modulated ML ***,multi-mode anti-counterfeiting and encryption are achieved with the as-explored Sm^(3+),Tb^(3+)co-activated ML phosphor.

关键词： LaGaO_(3):Sm^(3+) Tb^(3+)phosphors Mechano-luminescence Trap sharing Multi-color Rare earths